Skip to content

mapping-commons/lmha-obo-mappings

Folders and files

NameName
Last commit message
Last commit date

Latest commit

 

History

11 Commits
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

Repository files navigation

Not much time to document this, sorry...

All mappings are in SSSOM format

They are generated automatically using rdf_matcher, but using existing xrefs as priors. These have high confidence, as the assumption is that previously curated xrefs are high quality, but the prior weightings can be altered

E.g

subject_id subject_label subject_category predicate_id object_id object_label object_category match_type subject_source object_source mapping_tool confidence subject_match_field object_match_field match_string comment
LMHA:00090 basophil Respiratory_System owl:equivalentClass CL:0000767 basophil cell Lexical LMHA CL rdf_matcher 0.9783866146851686 oio:hasDbXref dc:identifier CL:0000767 .
LMHA:00179 granulocyte Respiratory_System owl:equivalentClass CL:0000094 granulocyte cell Lexical LMHA CL rdf_matcher 0.9784559180850925 oio:hasDbXref dc:identifier CL:0000094 .

If there is a match using something like a synonym or shared xref then this will get lower confidence:

subject_id subject_label subject_category predicate_id object_id object_label object_category match_type subject_source object_source mapping_tool confidence subject_match_field object_match_field match_string comment
LMHA:00183 hyaline cartilage general_tissue_structures owl:equivalentClass UBERON:0001994 hyaline cartilage tissue uberon Lexical LMHA UBERON rdf_matcher 0.4482245494091784 rdfs:label oio:hasExactSynonym hyaline cartilage .

Note I deliberately included all candidate mappings, e.g. there are 3 matches for LMHA:00150

subject_id subject_label subject_category predicate_id object_id object_label object_category match_type subject_source object_source mapping_tool confidence subject_match_field object_match_field match_string comment
LMHA:00150 dendritic cell Cell owl:equivalentClass CL:0000451 dendritic cell cell Lexical LMHA CL rdf_matcher 0.4827360284687321 rdfs:label rdfs:label dendritic cell .
LMHA:00150 dendritic cell Cell owl:equivalentClass CL:0001056 dendritic cell, human cell Lexical LMHA CL rdf_matcher 0.16884322574902352 rdfs:label oio:hasBroadSynonym dendritic cell .
LMHA:00150 dendritic cell Cell owl:equivalentClass CL:0000738 leukocyte cell Lexical LMHA CL rdf_matcher 0.9577300291303523 oio:hasDbXref dc:identifier CL:0000738 .
  • The lowest match to 'human dendritic cell' has a confidence of ~0.16, and this one is too specific (although arguably this is the correct one since LMHA is human, however, CL does not consistent populate human-specific groupings, so it is better to map to the same level of generality)
  • the middle match (confidence 0.48) is the correct one
  • interestingly the "best" match (confidence 0.96) is to leukocyte. This is clearly incorrect. But it highlights the fact that there is an incorrect curated xref in the LMHA ontology, and we should downweight these

It would be possible for me to do something more advanced to filter and better prioritize these but for now I think it is informative and transparent to show all candidate mappings to give curators a sense of the issues

unmapped LMHA terms

ones for which neither xref nor lexical match found:

This is being used to gapfill: #1

TODO

  • make a useful report that shows which mappings are likely yet not present in source LMHA (trivial)
  • configuring mapping weights
  • run boomer

Releases

No releases published

Packages

No packages published