diff --git a/assets/index-BeZ2s21u.js b/assets/index-CNZOlbQj.js
similarity index 99%
rename from assets/index-BeZ2s21u.js
rename to assets/index-CNZOlbQj.js
index 19c888e..347a0e8 100644
--- a/assets/index-BeZ2s21u.js
+++ b/assets/index-CNZOlbQj.js
@@ -1825,6 +1825,6 @@ void main(void) {
             <\/script>
           </body>
         </html>`}async saveHTML(u="untitled.html",h="gl1",g){const S=await this.generateHTML(h,g);return NVUtilities.download(S,u,"application/html")}json(){return this.document.opts=this.opts,this.document.scene=this.scene,this.document.volumes=this.volumes,this.document.meshes=this.meshes,this.drawScene(),this.document.previewImageDataURL=this.canvas.toDataURL(),this.document.json()}async saveDocument(u="untitled.nvd",h=!0){return this.document.title=u,log.debug("saveDocument",this.volumes[0]),this.drawScene(),this.document.previewImageDataURL=this.canvas.toDataURL(),this.document.volumes=this.volumes,this.document.meshes=this.meshes,this.document.download(u,h)}async loadVolumes(u){if(this.loadingText="loading...",this.drawScene(),this.thumbnailVisible)return this.deferredVolumes=u,this;if(this.volumes=[],this.gl.clearColor(0,0,0,1),this.gl.clear(this.gl.COLOR_BUFFER_BIT),u.length>1)return await this.addVolumesFromUrl(u),this;const h={url:u[0].url,headers:u[0].headers,name:u[0].name,colormap:u[0].colormap?u[0].colormap:u[0].colorMap,colormapNegative:u[0].colormapNegative?u[0].colormapNegative:u[0].colorMapNegative,opacity:u[0].opacity,urlImgData:u[0].urlImgData,cal_min:u[0].cal_min,cal_max:u[0].cal_max,trustCalMinMax:this.opts.trustCalMinMax,isManifest:u[0].isManifest,frame4D:u[0].frame4D,limitFrames4D:u[0].limitFrames4D||this.opts.limitFrames4D,colorbarVisible:u[0].colorbarVisible};return await this.addVolumeFromUrl(h),this}async addMeshFromUrl(u){const h=this.getFileExt(u.url);if(h==="JCON"||h==="JSON"){const v=await(await fetch(u.url,{})).json(),w=this.loadConnectomeAsMesh(v);return this.mediaUrlMap.set(w,u.url),this.onMeshAddedFromUrl(u,w),this.addMesh(w),w}const g=await NVMesh2.loadFromUrl({...u,gl:this.gl});return this.mediaUrlMap.set(g,u.url),this.onMeshAddedFromUrl(u,g),this.addMesh(g),g}async addMeshesFromUrl(u){const h=u.map(async S=>{const v=this.getFileExt(S.url);if(v==="JCON"||v==="JSON"){const _=await(await fetch(S.url,{})).json(),P=this.loadConnectomeAsMesh(_);return this.mediaUrlMap.set(P,S.url),this.onMeshAddedFromUrl(S,P),P}const w=await NVMesh2.loadFromUrl({...S,gl:this.gl});return this.mediaUrlMap.set(w,S.url),this.onMeshAddedFromUrl(S,w),w}),g=await Promise.all(h);for(let S=0;S<g.length;S++)this.addMesh(g[S]);return g}async loadMeshes(u){return this.loadingText="loading...",this.drawScene(),this.thumbnailVisible?(this.deferredMeshes=u,this):(this.initialized,this.meshes=[],this.gl.clearColor(0,0,0,1),this.gl.clear(this.gl.COLOR_BUFFER_BIT),u.length>1?(await this.addMeshesFromUrl(u),this.updateGLVolume(),this.drawScene(),this):(await this.addMeshFromUrl(u[0]),this.updateGLVolume(),this.drawScene(),this))}async loadConnectomeFromUrl(u,h={}){const S=await(await fetch(u,{headers:h})).json();return this.loadConnectome(S)}async loadFreeSurferConnectomeFromUrl(u,h={}){const S=await(await fetch(u,{headers:h})).json();return this.loadFreeSurferConnectome(S)}async loadFreeSurferConnectome(u){const h=NVConnectome.convertFreeSurferConnectome(u);return this.loadConnectome(h)}handleNodeAdded(u){const h=u.detail.node,g=[1,1,1,1];this.addLabel(h.name,{textColor:g,bulletScale:1,bulletColor:g,lineWidth:0,lineColor:g,lineTerminator:"none",textScale:1},[h.x,h.y,h.z]),this.drawScene()}loadConnectomeAsMesh(u){let h=u;if("data_type"in u&&u.data_type==="fs_pointset")h=NVConnectome.convertFreeSurferConnectome(u),log.warn("converted FreeSurfer connectome",h);else if("nodes"in u){const g=u.nodes;"names"in g&&"X"in g&&"Y"in g&&"Z"in g&&"Color"in g&&"Size"in g&&(h=NVConnectome.convertLegacyConnectome(u),log.warn("converted legacy connectome",h))}else throw new Error("not a known connectome format");return new NVConnectome(this.gl,h)}loadConnectome(u){this.loadingText="loading...",this.drawScene(),this.meshes=[],this.gl.clearColor(0,0,0,1),this.gl.clear(this.gl.COLOR_BUFFER_BIT);const h=this.loadConnectomeAsMesh(u);return this.addMesh(h),this.drawScene(),this}createEmptyDrawing(){if(this.back===null||!this.back.dims||Math.min(Math.min(this.back.dims[1],this.back.dims[2]),this.back.dims[3])<1)return;const h=this.back.dims[1]*this.back.dims[2]*this.back.dims[3];this.drawBitmap=new Uint8Array(h),this.drawClearAllUndoBitmaps(),this.drawAddUndoBitmap(),this.drawTexture=this.r8Tex(this.drawTexture,TEXTURE7_DRAW,this.back.dims,!0),this.refreshDrawing(!1)}r16Tex(u,h,g,S){u&&this.gl.deleteTexture(u),u=this.gl.createTexture(),this.gl.activeTexture(h),this.gl.bindTexture(this.gl.TEXTURE_3D,u),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_MIN_FILTER,this.gl.NEAREST),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_MAG_FILTER,this.gl.NEAREST),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_WRAP_R,this.gl.CLAMP_TO_EDGE),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_WRAP_S,this.gl.CLAMP_TO_EDGE),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_WRAP_T,this.gl.CLAMP_TO_EDGE),this.gl.pixelStorei(this.gl.UNPACK_ALIGNMENT,1),this.gl.texStorage3D(this.gl.TEXTURE_3D,1,this.gl.R16I,g[1],g[2],g[3]);const v=g[1]*g[2]*g[3];return S.length!==v&&(S=new Int16Array(v)),this.gl.texSubImage3D(this.gl.TEXTURE_3D,0,0,0,0,g[1],g[2],g[3],this.gl.RED_INTEGER,this.gl.SHORT,S),u}drawGrowCut(){if(!this.back||!this.back.dims)throw new Error("back not defined");const u=this.back.hdr,h=this.gl,g=u.dims[1]*u.dims[2]*u.dims[3];if(!this.drawBitmap||this.drawBitmap.length!==g){log.debug("bitmap dims are wrong");return}const S=h.createFramebuffer();h.bindFramebuffer(h.FRAMEBUFFER,S),h.disable(h.CULL_FACE),h.viewport(0,0,this.back.dims[1],this.back.dims[2]),h.disable(h.BLEND);let v=img2ras16(this.back);const w=this.r16Tex(null,TEXTURE11_GC_BACK,this.back.dims,v);for(let Y=1;Y<g;Y++)v[Y]=this.drawBitmap[Y];const D=this.r16Tex(null,TEXTURE14_GC_LABEL0,this.back.dims,v),_=this.r16Tex(null,TEXTURE15_GC_LABEL1,this.back.dims,v),P=1e4;for(let Y=1;Y<g;Y++)v[Y]>0&&(v[Y]=P);const L=this.r16Tex(null,TEXTURE12_GC_STRENGTH0,this.back.dims,v),m=this.r16Tex(null,TEXTURE13_GC_STRENGTH1,this.back.dims,v);h.bindVertexArray(this.genericVAO);const k=this.growCutShader;k.use(h);const e=128;h.uniform1i(k.uniforms.finalPass,0),h.uniform1i(k.uniforms.backTex,11);for(let Y=0;Y<e;Y++){h.uniform1i(k.uniforms.labelTex,14),h.uniform1i(k.uniforms.strengthTex,12);for(let G=0;G<this.back.dims[3];G++){const Z=1/this.back.dims[3]*(G+.5);h.uniform1f(k.uniforms.coordZ,Z),h.framebufferTextureLayer(h.FRAMEBUFFER,h.COLOR_ATTACHMENT0,_,0,G),h.framebufferTextureLayer(h.FRAMEBUFFER,h.COLOR_ATTACHMENT1,m,0,G),h.drawBuffers([h.COLOR_ATTACHMENT0,h.COLOR_ATTACHMENT1]),h.checkFramebufferStatus(h.FRAMEBUFFER)!==h.FRAMEBUFFER_COMPLETE&&log.error("Incomplete framebuffer"),h.drawArrays(h.TRIANGLE_STRIP,0,4)}Y===e-1&&h.uniform1i(k.uniforms.finalPass,1),h.uniform1i(k.uniforms.labelTex,15),h.uniform1i(k.uniforms.strengthTex,13);for(let G=0;G<this.back.dims[3];G++){const Z=1/this.back.dims[3]*(G+.5);h.uniform1f(k.uniforms.coordZ,Z),h.framebufferTextureLayer(h.FRAMEBUFFER,h.COLOR_ATTACHMENT0,D,0,G),h.framebufferTextureLayer(h.FRAMEBUFFER,h.COLOR_ATTACHMENT1,L,0,G),h.drawBuffers([h.COLOR_ATTACHMENT0,h.COLOR_ATTACHMENT1]),h.checkFramebufferStatus(h.FRAMEBUFFER)!==h.FRAMEBUFFER_COMPLETE&&log.error("Incomplete framebuffer"),h.drawArrays(h.TRIANGLE_STRIP,0,4)}}h.drawBuffers([h.COLOR_ATTACHMENT0]);const N=h.COLOR_ATTACHMENT1,B=D;h.readBuffer(N);const Q=h.getParameter(h.IMPLEMENTATION_COLOR_READ_FORMAT),e0=h.getParameter(h.IMPLEMENTATION_COLOR_READ_TYPE);(Q!==h.RED_INTEGER||e0!==h.SHORT)&&log.debug("readPixels will fail."),v=new Int16Array;const j=this.back.dims[1]*this.back.dims[2],H=new Int16Array(j);for(let Y=0;Y<this.back.dims[3];Y++)h.framebufferTextureLayer(h.FRAMEBUFFER,N,B,0,Y),h.readPixels(0,0,this.back.dims[1],this.back.dims[2],Q,e0,H),v=Int16Array.from([...v,...H]);let y=v[0];for(let Y=0;Y<v.length;Y++)y=Math.max(y,v[Y]);for(let Y=1;Y<g;Y++)this.drawBitmap[Y]=v[Y];h.deleteTexture(w),h.deleteTexture(L),h.deleteTexture(m),h.deleteTexture(D),h.deleteTexture(_),h.bindVertexArray(this.unusedVAO),h.viewport(0,0,h.canvas.width,h.canvas.height),h.bindFramebuffer(h.FRAMEBUFFER,null),h.deleteFramebuffer(S),this.drawAddUndoBitmap(),this.refreshDrawing(!0)}drawPt(u,h,g,S){var _;if(!((_=this.back)!=null&&_.dims))throw new Error("back.dims not set");const v=this.back.dims[1],w=this.back.dims[2],D=this.back.dims[3];u=Math.min(Math.max(u,0),v-1),h=Math.min(Math.max(h,0),w-1),g=Math.min(Math.max(g,0),D-1),this.drawBitmap[u+h*v+g*v*w]=S}drawPenLine(u,h,g){const S=Math.abs(u[0]-h[0]),v=Math.abs(u[1]-h[1]),w=Math.abs(u[2]-h[2]);let D=-1,_=-1,P=-1;h[0]>u[0]&&(D=1),h[1]>u[1]&&(_=1),h[2]>u[2]&&(P=1);let L=u[0],m=u[1],k=u[2];const e=h[0],N=h[1],B=h[2];if(S>=v&&S>=w){let Q=2*v-S,e0=2*w-S;for(;L!==e;)L+=D,Q>=0&&(m+=_,Q-=2*S),e0>=0&&(k+=P,e0-=2*S),Q+=2*v,e0+=2*w,this.drawPt(L,m,k,g)}else if(v>=S&&v>=w){let Q=2*S-v,e0=2*w-v;for(;m!==N;)m+=_,Q>=0&&(L+=D,Q-=2*v),e0>=0&&(k+=P,e0-=2*v),Q+=2*S,e0+=2*w,this.drawPt(L,m,k,g)}else{let Q=2*v-w,e0=2*S-w;for(;k!==B;)k+=P,Q>=0&&(m+=_,Q-=2*w),e0>=0&&(L+=D,e0-=2*w),Q+=2*v,e0+=2*S,this.drawPt(L,m,k,g)}}drawFloodFillCore(u,h,g=6){var L;if(!((L=this.back)!=null&&L.dims))throw new Error("back.dims undefined");const S=[this.back.dims[1],this.back.dims[2],this.back.dims[3]],v=S[0],w=v*S[1];function D(m){return m[0]+m[1]*v+m[2]*w}function _(m){const k=Math.floor(m/w),e=Math.floor((m-k*w)/v);return[Math.floor(m%v),e,k]}const P=[];for(P.push(h),u[h]=2;P.length>0;){let m=function(N){const B=e.slice();if(B[0]+=N[0],B[1]+=N[1],B[2]+=N[2],B[0]<0||B[1]<0||B[2]<0||B[0]>=S[0]||B[1]>=S[1]||B[2]>=S[2])return;const Q=D(B);u[Q]===1&&(u[Q]=2,P.push(Q))};const k=P[0];P.shift();const e=_(k);m([0,0,-1]),m([0,0,1]),m([0,-1,0]),m([0,1,0]),m([-1,0,0]),m([1,0,0]),!(g<=6)&&(m([-1,-1,0]),m([1,1,0]),m([-1,1,0]),m([1,1,0]),m([0,-1,-1]),m([0,1,-1]),m([-1,0,-1]),m([1,0,-1]),m([0,-1,1]),m([0,1,1]),m([-1,0,1]),m([1,0,1]),!(g<=18)&&(m([-1,-1,-1]),m([1,-1,-1]),m([-1,1,-1]),m([1,1,-1]),m([-1,-1,1]),m([1,-1,1]),m([-1,1,1]),m([1,1,1])))}}drawFloodFill(u,h=0,g=0,S=NaN,v=NaN,w=6){var B;if(!this.drawBitmap)throw new Error("drawBitmap undefined");if(!((B=this.back)!=null&&B.dims))throw new Error("back.dims undefined");h=Math.abs(h);const D=[this.back.dims[1],this.back.dims[2],this.back.dims[3]];if(u[0]<0||u[1]<0||u[2]<0||u[0]>=D[0]||u[1]>=D[1]||u[2]>=D[2])return;const _=D[0],P=_*D[1],L=P*D[2],m=this.drawBitmap.slice();if(m.length!==P*D[2])return;function k(Q){return Q[0]+Q[1]*_+Q[2]*P}const e=k(u),N=m[e];if(N===h){g!==0?log.debug("drawFloodFill selected voxel is not part of a drawing"):log.debug("drawFloodFill selected voxel is already desired color");return}for(let Q=1;Q<L;Q++)m[Q]=0,this.drawBitmap[Q]===N&&(m[Q]=1);if(this.drawFloodFillCore(m,e,w),g!==0){const Q=this.volumes[0].img2RAS();let e0=Q[e],j=e0;if(isFinite(v)&&isFinite(S))e0=v,j=S;else{for(let H=1;H<L;H++)m[H]===2&&(e0=Math.max(e0,Q[H]),j=Math.min(j,Q[H]));g===Number.POSITIVE_INFINITY&&(e0=g),g===Number.NEGATIVE_INFINITY&&(j=g)}log.debug("Intensity range of selected cluster :",j,e0);for(let H=1;H<L;H++)m[H]=0,Q[H]>=j&&Q[H]<=e0&&(m[H]=1);this.drawFloodFillCore(m,e,w),h=N}for(let Q=1;Q<L;Q++)m[Q]===2&&(this.drawBitmap[Q]=h);this.drawAddUndoBitmap(),this.refreshDrawing(!1)}drawPenFilled(){var N;const u=this.drawPenFillPts.length;if(u<2){this.drawPenFillPts=[];return}const h=this.drawPenAxCorSag;let g=0,S=1;if(h===1&&(S=2),h===2&&(g=1,S=2),!((N=this.back)!=null&&N.dims))throw new Error("back.dims undefined");const v=[this.back.dims[g+1],this.back.dims[S+1]],w=new Uint8Array(v[0]*v[1]);let D=1;function _(B,Q){const e0=Math.abs(B[0]-Q[0]),j=Math.abs(B[1]-Q[1]);w[B[0]+B[1]*v[0]]=D,w[Q[0]+Q[1]*v[0]]=D;let H=-1,y=-1;Q[0]>B[0]&&(H=1),Q[1]>B[1]&&(y=1);let Y=B[0],G=B[1];const Z=Q[0],i0=Q[1];if(e0>=j){let z=2*j-e0;for(;Y!==Z;)Y+=H,z>=0&&(G+=y,z-=2*e0),z+=2*j,w[Y+G*v[0]]=D}else{let z=2*e0-j;for(;G!==i0;)G+=y,z>=0&&(Y+=H,z-=2*j),z+=2*e0,w[Y+G*v[0]]=D}}const P=[this.drawPenFillPts[0][g],this.drawPenFillPts[0][S]];let L=P;for(let B=1;B<u;B++){const Q=[this.drawPenFillPts[B][g],this.drawPenFillPts[B][S]];_(L,Q),L=Q}_(P,L);const m=[];function k(B){if(B[0]<0||B[1]<0||B[0]>=v[0]||B[1]>=v[1])return;const Q=B[0]+B[1]*v[0];w[Q]===0&&(m.push(B),w[Q]=2)}for(let B=0;B<v[0];B++)k([B,0]);for(let B=0;B<v[0];B++)k([B,v[1]-1]);for(let B=0;B<v[1];B++)k([0,B]);for(let B=0;B<v[1];B++)k([v[0]-1,B]);for(;m.length>0;){const B=m.shift();k([B[0]-1,B[1]]),k([B[0]+1,B[1]]),k([B[0],B[1]-1]),k([B[0],B[1]+1])}D=this.opts.penValue;const e=this.drawPenFillPts[0][3-(g+S)];if(!this.drawBitmap)throw new Error("drawBitmap undefined");if(h===0){const B=e*v[0]*v[1];for(let Q=0;Q<v[0]*v[1];Q++)w[Q]!==2&&(this.drawBitmap[Q+B]=D)}else{let B=1;const Q=this.back.dims[1]*this.back.dims[2];let e0=e*this.back.dims[1];h===2&&(B=this.back.dims[1],e0=e);let j=0;for(let H=0;H<v[1];H++)for(let y=0;y<v[0];y++)w[j]!==2&&(this.drawBitmap[y*B+H*Q+e0]=D),j++}if(!this.drawFillOverwrites&&this.drawUndoBitmaps[this.currentDrawUndoBitmap].length>0){const B=this.drawBitmap.length,Q=decodeRLE(this.drawUndoBitmaps[this.currentDrawUndoBitmap],B);for(let e0=0;e0<B;e0++)Q[e0]!==0&&(this.drawBitmap[e0]=Q[e0])}this.drawPenFillPts=[],this.drawAddUndoBitmap(),this.refreshDrawing(!1)}closeDrawing(){this.drawClearAllUndoBitmaps(),this.rgbaTex(this.drawTexture,TEXTURE7_DRAW,[2,2,2,2],!0),this.drawBitmap=null,this.drawScene()}refreshDrawing(u=!0){var S;if(!((S=this.back)!=null&&S.dims))throw new Error("back.dims undefined");if(!this.drawBitmap)throw new Error("drawBitmap undefined");const h=this.back.dims.slice(),g=this.back.dims[1]*this.back.dims[2]*this.back.dims[3];this.drawBitmap.length===8?(h[1]=2,h[2]=2,h[3]=2):g!==this.drawBitmap.length&&log.warn("Drawing bitmap must match the background image"),this.gl.activeTexture(TEXTURE7_DRAW),this.gl.bindTexture(this.gl.TEXTURE_3D,this.drawTexture),this.gl.texSubImage3D(this.gl.TEXTURE_3D,0,0,0,0,h[1],h[2],h[3],this.gl.RED,this.gl.UNSIGNED_BYTE,this.drawBitmap),u&&this.drawScene()}r8Tex(u,h,g,S=!1){if(u&&this.gl.deleteTexture(u),u=this.gl.createTexture(),this.gl.activeTexture(h),this.gl.bindTexture(this.gl.TEXTURE_3D,u),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_MIN_FILTER,this.gl.NEAREST),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_MAG_FILTER,this.gl.NEAREST),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_WRAP_R,this.gl.CLAMP_TO_EDGE),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_WRAP_S,this.gl.CLAMP_TO_EDGE),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_WRAP_T,this.gl.CLAMP_TO_EDGE),this.gl.pixelStorei(this.gl.UNPACK_ALIGNMENT,1),this.gl.texStorage3D(this.gl.TEXTURE_3D,1,this.gl.R8,g[1],g[2],g[3]),S){const v=new Uint8Array(g[1]*g[2]*g[3]);this.gl.texSubImage3D(this.gl.TEXTURE_3D,0,0,0,0,g[1],g[2],g[3],this.gl.RED,this.gl.UNSIGNED_BYTE,v)}return u}rgbaTex(u,h,g,S=!1){if(u&&this.gl.deleteTexture(u),u=this.gl.createTexture(),this.gl.activeTexture(h),this.gl.bindTexture(this.gl.TEXTURE_3D,u),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_MIN_FILTER,this.gl.LINEAR),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_MAG_FILTER,this.gl.LINEAR),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_WRAP_R,this.gl.CLAMP_TO_EDGE),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_WRAP_S,this.gl.CLAMP_TO_EDGE),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_WRAP_T,this.gl.CLAMP_TO_EDGE),this.gl.pixelStorei(this.gl.UNPACK_ALIGNMENT,1),this.gl.texStorage3D(this.gl.TEXTURE_3D,1,this.gl.RGBA8,g[1],g[2],g[3]),S){const v=new Uint8Array(g[1]*g[2]*g[3]*4);this.gl.texSubImage3D(this.gl.TEXTURE_3D,0,0,0,0,g[1],g[2],g[3],this.gl.RGBA,this.gl.UNSIGNED_BYTE,v)}return u}requestCORSIfNotSameOrigin(u,h){new URL(h,window.location.href).origin!==window.location.origin&&(u.crossOrigin="")}async loadPngAsTexture(u,h){return new Promise((g,S)=>{const v=new Image;v.onload=()=>{if(!this.bmpShader)return;let w;h===4?(this.bmpTexture!==null&&this.gl.deleteTexture(this.bmpTexture),this.bmpTexture=this.gl.createTexture(),w=this.bmpTexture,this.bmpTextureWH=v.width/v.height,this.gl.activeTexture(TEXTURE4_THUMBNAIL),this.bmpShader.use(this.gl),this.gl.uniform1i(this.bmpShader.uniforms.bmpTexture,4)):h===5?(this.gl.activeTexture(TEXTURE5_MATCAP),this.matCapTexture!==null&&this.gl.deleteTexture(this.matCapTexture),this.matCapTexture=this.gl.createTexture(),w=this.matCapTexture):(this.fontShader.use(this.gl),this.gl.activeTexture(TEXTURE3_FONT),this.gl.uniform1i(this.fontShader.uniforms.fontTexture,3),this.fontTexture!==null&&this.gl.deleteTexture(this.fontTexture),this.fontTexture=this.gl.createTexture(),w=this.fontTexture),this.gl.bindTexture(this.gl.TEXTURE_2D,w),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_WRAP_S,this.gl.CLAMP_TO_EDGE),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_WRAP_T,this.gl.CLAMP_TO_EDGE),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MIN_FILTER,this.gl.LINEAR),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MAG_FILTER,this.gl.LINEAR),this.gl.texImage2D(this.gl.TEXTURE_2D,0,this.gl.RGBA,this.gl.RGBA,this.gl.UNSIGNED_BYTE,v),g(w),h!==4&&this.drawScene()},v.onerror=S,this.requestCORSIfNotSameOrigin(v,u),v.src=u})}async loadFontTexture(u){return this.loadPngAsTexture(u,3)}async loadBmpTexture(u){return this.loadPngAsTexture(u,4)}async loadMatCapTexture(u){return this.loadPngAsTexture(u,5)}initFontMets(){if(!this.fontMetrics)throw new Error("fontMetrics undefined");this.fontMets={distanceRange:this.fontMetrics.atlas.distanceRange,size:this.fontMetrics.atlas.size,mets:{}};for(let g=0;g<256;g++)this.fontMets.mets[g]={xadv:0,uv_lbwh:[0,0,0,0],lbwh:[0,0,0,0]};const u=this.fontMetrics.atlas.width,h=this.fontMetrics.atlas.height;for(let g=0;g<this.fontMetrics.glyphs.length;g++){const S=this.fontMetrics.glyphs[g],v=S.unicode;if(this.fontMets.mets[v].xadv=S.advance,S.planeBounds===void 0)continue;let w=S.atlasBounds.left/u,D=(h-S.atlasBounds.top)/h,_=(S.atlasBounds.right-S.atlasBounds.left)/u,P=(S.atlasBounds.top-S.atlasBounds.bottom)/h;this.fontMets.mets[v].uv_lbwh=[w,D,_,P],w=S.planeBounds.left,D=S.planeBounds.bottom,_=S.planeBounds.right-S.planeBounds.left,P=S.planeBounds.top-S.planeBounds.bottom,this.fontMets.mets[v].lbwh=[w,D,_,P]}}async loadFont(u=Roboto_Regular_default,h=Roboto_Regular_default2){await this.loadFontTexture(u);const g=await fetch(h);if(!g.ok)throw Error(g.statusText);const S=await g.text();this.fontMetrics=JSON.parse(S),this.initFontMets(),this.fontShader.use(this.gl),this.drawScene()}async loadDefaultMatCap(){return this.loadMatCapTexture(Shiny_default)}async loadDefaultFont(){await this.loadFontTexture(this.DEFAULT_FONT_GLYPH_SHEET),this.fontMetrics=this.DEFAULT_FONT_METRICS,this.initFontMets()}async initText(){this.fontShader=new Shader(this.gl,vertFontShader,fragFontShader),this.fontShader.use(this.gl),await this.loadDefaultFont(),await this.loadDefaultMatCap(),this.drawLoadingText(this.loadingText)}meshShaderNameToNumber(u="Phong"){const h=u.toLowerCase();for(let g=0;g<this.meshShaders.length;g++)if(this.meshShaders[g].Name.toLowerCase()===h)return g}setMeshShader(u,h=2){let g=0;if(typeof h=="number"?g=h:g=this.meshShaderNameToNumber(h),g===void 0)throw new Error("shaderIndex undefined");g=Math.min(g,this.meshShaders.length-1),g=Math.max(g,0);const S=this.getMeshIndexByID(u);if(S>=this.meshes.length){log.debug("Unable to change shader until mesh is loaded (maybe you need async)");return}this.meshes[S].meshShaderIndex=g,this.updateGLVolume(),this.onMeshShaderChanged(S,g)}createCustomMeshShader(u,h="Custom"){if(!u)throw new Error("Need fragment shader");const g=this.meshShaderNameToNumber(h);g>=0&&(this.gl.deleteProgram(this.meshShaders[g].shader.program),this.meshShaders.splice(g,1));const S=new Shader(this.gl,vertMeshShader,u);return S.use(this.gl),{Name:h,Frag:u,shader:S}}setCustomMeshShader(u="",h="Custom"){const g=this.createCustomMeshShader(u,h);return this.meshShaders.push(g),this.onCustomMeshShaderAdded(u,h),this.meshShaders.length-1}meshShaderNames(u=!0){const h=[];for(let g=0;g<this.meshShaders.length;g++)h.push(this.meshShaders[g].Name);return u===!0?h.sort():h}initRenderShader(u,h=0){u.use(this.gl),this.gl.uniform1i(u.uniforms.volume,0),this.gl.uniform1i(u.uniforms.colormap,1),this.gl.uniform1i(u.uniforms.overlay,2),this.gl.uniform1i(u.uniforms.drawing,7),this.gl.uniform1fv(u.uniforms.renderDrawAmbientOcclusion,[this.renderDrawAmbientOcclusion,1]),this.gl.uniform1f(u.uniforms.gradientAmount,h)}async init(){const u=this.gl.getExtension("WEBGL_debug_renderer_info");if(u){const w=this.gl.getParameter(u.UNMASKED_VENDOR_WEBGL),D=this.gl.getParameter(u.UNMASKED_RENDERER_WEBGL);log.info("renderer vendor: ",w),log.info("renderer: ",D)}else log.info("debug_renderer_info unavailable");const h=this.gl.getParameter(this.gl.RENDERER);log.info("firefox renderer: ",h),this.gl.clearDepth(0),this.gl.enable(this.gl.CULL_FACE),this.gl.cullFace(this.gl.FRONT),this.gl.enable(this.gl.BLEND),this.gl.blendFunc(this.gl.SRC_ALPHA,this.gl.ONE_MINUS_SRC_ALPHA),this.volumeTexture=this.rgbaTex(this.volumeTexture,TEXTURE0_BACK_VOL,[2,2,2,2],!0),this.overlayTexture=this.rgbaTex(this.overlayTexture,TEXTURE2_OVERLAY_VOL,[2,2,2,2],!0),this.drawTexture=this.r8Tex(this.drawTexture,TEXTURE7_DRAW,[2,2,2,2],!0);const g=[1,1,0,1,0,0,0,1,0,0,0,0],S=this.gl;this.cuboidVertexBuffer=S.createBuffer(),S.bindBuffer(S.ARRAY_BUFFER,this.cuboidVertexBuffer),S.bufferData(S.ARRAY_BUFFER,new Float32Array(g),S.STATIC_DRAW),this.genericVAO=S.createVertexArray(),S.bindVertexArray(this.genericVAO),S.bindBuffer(S.ARRAY_BUFFER,this.cuboidVertexBuffer),S.enableVertexAttribArray(0),S.vertexAttribPointer(0,3,S.FLOAT,!1,0,0),S.bindVertexArray(this.unusedVAO),this.pickingMeshShader=new Shader(S,vertMeshShader,fragMeshDepthShader),this.pickingMeshShader.use(S),this.pickingImageShader=new Shader(S,vertRenderShader,fragVolumePickingShader),this.pickingImageShader.use(S),S.uniform1i(this.pickingImageShader.uniforms.volume,0),S.uniform1i(this.pickingImageShader.uniforms.colormap,1),S.uniform1i(this.pickingImageShader.uniforms.overlay,2),S.uniform1i(this.pickingImageShader.uniforms.drawing,7),this.sliceMMShader=new Shader(S,vertSliceMMShader,fragSliceMMShader),this.sliceMMShader.use(S),S.uniform1i(this.sliceMMShader.uniforms.volume,0),S.uniform1i(this.sliceMMShader.uniforms.colormap,1),S.uniform1i(this.sliceMMShader.uniforms.overlay,2),S.uniform1i(this.sliceMMShader.uniforms.drawing,7),S.uniform1f(this.sliceMMShader.uniforms.drawOpacity,this.drawOpacity),this.sliceV1Shader=new Shader(S,vertSliceMMShader,fragSliceV1Shader),this.sliceV1Shader.use(S),S.uniform1i(this.sliceV1Shader.uniforms.volume,0),S.uniform1i(this.sliceV1Shader.uniforms.colormap,1),S.uniform1i(this.sliceV1Shader.uniforms.overlay,2),S.uniform1i(this.sliceV1Shader.uniforms.drawing,7),S.uniform1f(this.sliceV1Shader.uniforms.drawOpacity,this.drawOpacity),this.orientCubeShader=new Shader(S,vertOrientCubeShader,fragOrientCubeShader),this.orientCubeShaderVAO=S.createVertexArray(),S.bindVertexArray(this.orientCubeShaderVAO);const v=S.createBuffer();S.enableVertexAttribArray(0),S.enableVertexAttribArray(1),S.bindBuffer(S.ARRAY_BUFFER,v),S.bufferData(S.ARRAY_BUFFER,orientCube,S.STATIC_DRAW),S.vertexAttribPointer(0,3,S.FLOAT,!1,24,0),S.enableVertexAttribArray(1),S.vertexAttribPointer(1,3,S.FLOAT,!1,24,12),S.bindVertexArray(this.unusedVAO),this.rectShader=new Shader(S,vertRectShader,fragRectShader),this.rectShader.use(S),this.lineShader=new Shader(S,vertLineShader,fragRectShader),this.lineShader.use(S),this.line3DShader=new Shader(S,vertLine3DShader,fragRectShader),this.line3DShader.use(S),this.circleShader=new Shader(S,vertCircleShader,fragCircleShader),this.circleShader.use(S),this.renderVolumeShader=new Shader(S,vertRenderShader,fragRenderShader),this.initRenderShader(this.renderVolumeShader),this.renderSliceShader=new Shader(S,vertRenderShader,fragRenderSliceShader),this.initRenderShader(this.renderSliceShader),this.renderGradientShader=new Shader(S,vertRenderShader,fragRenderGradientShader),this.initRenderShader(this.renderGradientShader,.3),S.uniform1i(this.renderGradientShader.uniforms.matCap,5),S.uniform1i(this.renderGradientShader.uniforms.gradient,6),this.renderShader=this.renderVolumeShader,this.colorbarShader=new Shader(S,vertColorbarShader,fragColorbarShader),this.colorbarShader.use(S),S.uniform1i(this.colorbarShader.uniforms.colormap,1),this.blurShader=new Shader(S,blurVertShader,blurFragShader),this.sobelShader=new Shader(S,blurVertShader,sobelFragShader),this.growCutShader=new Shader(S,vertGrowCutShader,fragGrowCutShader),this.passThroughShader=new Shader(S,vertPassThroughShader,fragPassThroughShader),this.orientShaderAtlasU=new Shader(S,vertOrientShader,fragOrientShaderU.concat(fragOrientShaderAtlas)),this.orientShaderAtlasI=new Shader(S,vertOrientShader,fragOrientShaderI.concat(fragOrientShaderAtlas)),this.orientShaderU=new Shader(S,vertOrientShader,fragOrientShaderU.concat(fragOrientShader)),this.orientShaderI=new Shader(S,vertOrientShader,fragOrientShaderI.concat(fragOrientShader)),this.orientShaderF=new Shader(S,vertOrientShader,fragOrientShaderF.concat(fragOrientShader)),this.orientShaderRGBU=new Shader(S,vertOrientShader,fragOrientShaderU.concat(fragRGBOrientShader)),this.surfaceShader=new Shader(S,vertSurfaceShader,fragSurfaceShader),this.surfaceShader.use(S),this.fiberShader=new Shader(S,vertFiberShader,fragFiberShader),this.pickingImageShader.use(S);for(let w=0;w<this.meshShaders.length;w++){const D=this.meshShaders[w];D.Name==="Flat"?D.shader=new Shader(S,vertFlatMeshShader,fragFlatMeshShader):D.shader=new Shader(S,vertMeshShader,D.Frag),D.shader.use(S),D.shader.isMatcap=D.Name==="Matcap",D.shader.isMatcap&&S.uniform1i(D.shader.uniforms.matCap,5)}return this.bmpShader=new Shader(S,vertBmpShader,fragBmpShader),await this.initText(),this.opts.thumbnail.length>0&&(await this.loadBmpTexture(this.opts.thumbnail),this.thumbnailVisible=!0),this.updateGLVolume(),this.initialized=!0,this.resizeListener(),this.drawScene(),this}gradientGL(u){const h=this.gl,g=[0,0,0,0,1,0,1,0,0,1,1,0],S=h.createVertexArray();h.bindVertexArray(S);const v=h.createBuffer();h.bindBuffer(h.ARRAY_BUFFER,v),h.bufferData(h.ARRAY_BUFFER,new Float32Array(g),h.STATIC_DRAW),h.enableVertexAttribArray(0),h.vertexAttribPointer(0,3,h.FLOAT,!1,0,0);const w=h.createFramebuffer();h.bindFramebuffer(h.FRAMEBUFFER,w),h.disable(h.CULL_FACE),h.viewport(0,0,u.dims[1],u.dims[2]),h.disable(h.BLEND);const D=this.rgbaTex(null,TEXTURE8_GRADIENT_TEMP,u.dims),_=this.blurShader;_.use(h),h.activeTexture(TEXTURE0_BACK_VOL),h.bindTexture(h.TEXTURE_3D,this.volumeTexture);const P=.7;h.uniform1i(_.uniforms.intensityVol,0),h.uniform1f(_.uniforms.dX,P/u.dims[1]),h.uniform1f(_.uniforms.dY,P/u.dims[2]),h.uniform1f(_.uniforms.dZ,P/u.dims[3]),h.bindVertexArray(S);for(let k=0;k<u.dims[3]-1;k++){const e=1/u.dims[3]*(k+.5);h.uniform1f(_.uniforms.coordZ,e),h.framebufferTextureLayer(h.FRAMEBUFFER,h.COLOR_ATTACHMENT0,D,0,k),h.clear(h.DEPTH_BUFFER_BIT),h.drawArrays(h.TRIANGLE_STRIP,0,g.length/3)}const L=this.sobelShader;L.use(h),h.activeTexture(TEXTURE8_GRADIENT_TEMP),h.bindTexture(h.TEXTURE_3D,D),h.uniform1i(L.uniforms.intensityVol,8);const m=.7;h.uniform1f(L.uniforms.dX,m/u.dims[1]),h.uniform1f(L.uniforms.dY,m/u.dims[2]),h.uniform1f(L.uniforms.dZ,m/u.dims[3]),h.uniform1f(L.uniforms.coordZ,.5),h.bindVertexArray(S),h.activeTexture(TEXTURE0_BACK_VOL),this.gradientTexture!==null&&h.deleteTexture(this.gradientTexture),this.gradientTexture=this.rgbaTex(this.gradientTexture,TEXTURE6_GRADIENT,u.dims);for(let k=0;k<u.dims[3]-1;k++){const e=1/u.dims[3]*(k+.5);h.uniform1f(L.uniforms.coordZ,e),h.framebufferTextureLayer(h.FRAMEBUFFER,h.COLOR_ATTACHMENT0,this.gradientTexture,0,k),h.clear(h.DEPTH_BUFFER_BIT),h.drawArrays(h.TRIANGLE_STRIP,0,g.length/3)}h.deleteFramebuffer(w),h.deleteTexture(D),h.deleteBuffer(v),h.bindFramebuffer(h.FRAMEBUFFER,null)}updateGLVolume(){let u=0;const h=this.volumes.length;this.refreshColormaps();for(let g=0;g<h;g++)this.volumes[g].toRAS&&(this.refreshLayers(this.volumes[g],u),u++);if(this.furthestVertexFromOrigin=0,h>0&&(this.furthestVertexFromOrigin=this.volumeObject3D.furthestVertexFromOrigin),this.meshes)for(let g=0;g<this.meshes.length;g++)this.furthestVertexFromOrigin=Math.max(this.furthestVertexFromOrigin,this.meshes[g].furthestVertexFromOrigin);this.onVolumeUpdated&&this.onVolumeUpdated(),this.drawScene()}getDescriptives(u=0,h=[],g=!1){const S=this.volumes[u].hdr;let v=S.scl_slope;isNaN(v)&&(v=1);let w=S.scl_inter;isNaN(w)&&(w=1);const D=this.volumes[u].img,_=D.length,P=new Float32Array(_);for(let Z=0;Z<_;Z++)P[Z]=D[Z]*v+w;const L=new Uint8Array(_);for(let Z=0;Z<_;Z++)L[Z]=1;if(h.length>0)for(let Z=0;Z<h.length;Z++){const i0=this.volumes[h[Z]].img;if(i0.length!==_){log.debug("Mask resolution does not match image. Skipping masking layer "+h[Z]);continue}for(let z=0;z<_;z++)(i0[z]===0||isNaN(i0[z]))&&(L[z]=0)}else if(h.length<1&&g)for(let Z=0;Z<_;Z++)(this.drawBitmap[Z]===0||isNaN(this.drawBitmap[Z]))&&(L[Z]=0);let m=0,k=0,e=0,N=Number.NEGATIVE_INFINITY,B=Number.POSITIVE_INFINITY,Q=0,e0=0,j=0;for(let Z=0;Z<_;Z++){if(L[Z]<1)continue;const i0=P[Z];m++;let z=k+(i0-k)/m;e=e+(i0-k)*(i0-z),k=z,i0!==0&&(Q++,z=e0+(i0-e0)/Q,j=j+(i0-e0)*(i0-z),e0=z,B=Math.min(i0,N),N=Math.max(i0,N))}const H=Math.sqrt(e/(m-1)),y=Math.sqrt(j/(Q-1)),Y=B,G=N;return m!==Q&&(B=Math.min(0,N),N=Math.max(0,N)),{mean:k,stdev:H,nvox:m,volumeMM3:m*S.pixDims[1]*S.pixDims[2]*S.pixDims[3],volumeML:m*S.pixDims[1]*S.pixDims[2]*S.pixDims[3]*.001,min:B,max:N,meanNot0:e0,stdevNot0:y,nvoxNot0:Q,minNot0:Y,maxNot0:G,cal_min:this.volumes[u].cal_min,cal_max:this.volumes[u].cal_max,robust_min:this.volumes[u].robust_min,robust_max:this.volumes[u].robust_max}}refreshLayers(u,h){var Y;if(this.refreshColormaps(),this.volumes.length<1)return;const g=u.hdr;let S=u.img;u.frame4D>0&&u.frame4D<u.nFrame4D&&(S=u.img.slice(u.frame4D*u.nVox3D,(u.frame4D+1)*u.nVox3D));const v=u.opacity;if(h>1&&v===0)return;let w=null;if(!this.back)throw new Error("back undefined");this.gl.bindVertexArray(this.unusedVAO),this.crosshairs3D&&(this.crosshairs3D.mm[0]=NaN);let D=clone$2(u.toRAS);if(h===0){this.volumeObject3D=u.toNiivueObject3D(this.VOLUME_ID,this.gl),invert(D,D),this.back.matRAS=u.matRAS,this.back.dims=u.dimsRAS,this.back.pixDims=u.pixDimsRAS,w=this.rgbaTex(this.volumeTexture,TEXTURE0_BACK_VOL,u.dimsRAS);const{volScale:G,vox:Z}=this.sliceScale(!0);if(this.volScale=G,this.vox=Z,this.volumeObject3D.scale=G,!this.renderShader)throw new Error("renderShader undefined");this.renderShader.use(this.gl),this.gl.uniform3fv(this.renderShader.uniforms.texVox,Z),this.gl.uniform3fv(this.renderShader.uniforms.volScale,G);const i0=this.pickingImageShader;i0.use(this.gl),this.gl.uniform1i(i0.uniforms.volume,0),this.gl.uniform1i(i0.uniforms.colormap,1),this.gl.uniform1i(i0.uniforms.overlay,2),this.gl.uniform3fv(i0.uniforms.volScale,G),log.debug(this.volumeObject3D)}else{((Y=this.back)==null?void 0:Y.dims)===void 0&&log.error("Fatal error: Unable to render overlay: background dimensions not defined!");const G=this.mm2frac(u.mm000,0,!0);let Z=this.mm2frac(u.mm100,0,!0),i0=this.mm2frac(u.mm010,0,!0),z=this.mm2frac(u.mm001,0,!0);Z=subtract$1(Z,Z,G),i0=subtract$1(i0,i0,G),z=subtract$1(z,z,G),D=fromValues$3(Z[0],i0[0],z[0],G[0],Z[1],i0[1],z[1],G[1],Z[2],i0[2],z[2],G[2],0,0,0,1),invert(D,D),h===1?(w=this.rgbaTex(this.overlayTexture,TEXTURE2_OVERLAY_VOL,this.back.dims),this.overlayTexture=w,this.overlayTextureID=w):w=this.overlayTextureID}const _=this.gl.createFramebuffer();this.gl.bindFramebuffer(this.gl.FRAMEBUFFER,_),this.gl.disable(this.gl.CULL_FACE),this.gl.viewport(0,0,this.back.dims[1],this.back.dims[2]),this.gl.disable(this.gl.BLEND);const P=this.gl.createTexture();this.gl.activeTexture(TEXTURE9_ORIENT),this.gl.bindTexture(this.gl.TEXTURE_3D,P),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_MIN_FILTER,this.gl.NEAREST),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_MAG_FILTER,this.gl.NEAREST),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_WRAP_R,this.gl.CLAMP_TO_EDGE),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_WRAP_S,this.gl.CLAMP_TO_EDGE),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_WRAP_T,this.gl.CLAMP_TO_EDGE),this.gl.pixelStorei(this.gl.UNPACK_ALIGNMENT,1);let L=this.orientShaderU;if(!g)throw new Error("hdr undefined");if(!S)throw new Error("img undefined");if(g.datatypeCode===2)g.intent_code===1002&&(L=this.orientShaderAtlasU),this.gl.texStorage3D(this.gl.TEXTURE_3D,1,this.gl.R8UI,g.dims[1],g.dims[2],g.dims[3]),this.gl.texSubImage3D(this.gl.TEXTURE_3D,0,0,0,0,g.dims[1],g.dims[2],g.dims[3],this.gl.RED_INTEGER,this.gl.UNSIGNED_BYTE,S);else if(g.datatypeCode===4)L=this.orientShaderI,g.intent_code===1002&&(L=this.orientShaderAtlasI),this.gl.texStorage3D(this.gl.TEXTURE_3D,1,this.gl.R16I,g.dims[1],g.dims[2],g.dims[3]),this.gl.texSubImage3D(this.gl.TEXTURE_3D,0,0,0,0,g.dims[1],g.dims[2],g.dims[3],this.gl.RED_INTEGER,this.gl.SHORT,S);else if(g.datatypeCode===16)this.gl.texStorage3D(this.gl.TEXTURE_3D,1,this.gl.R32F,g.dims[1],g.dims[2],g.dims[3]),this.gl.texSubImage3D(this.gl.TEXTURE_3D,0,0,0,0,g.dims[1],g.dims[2],g.dims[3],this.gl.RED,this.gl.FLOAT,S),L=this.orientShaderF;else if(g.datatypeCode===64){let G=new Float32Array;G=Float32Array.from(S),this.gl.texStorage3D(this.gl.TEXTURE_3D,1,this.gl.R32F,g.dims[1],g.dims[2],g.dims[3]),this.gl.texSubImage3D(this.gl.TEXTURE_3D,0,0,0,0,g.dims[1],g.dims[2],g.dims[3],this.gl.RED,this.gl.FLOAT,G),L=this.orientShaderF}else g.datatypeCode===128?(L=this.orientShaderRGBU,L.use(this.gl),this.gl.uniform1i(L.uniforms.hasAlpha,0),this.gl.texStorage3D(this.gl.TEXTURE_3D,1,this.gl.RGB8UI,g.dims[1],g.dims[2],g.dims[3]),this.gl.texSubImage3D(this.gl.TEXTURE_3D,0,0,0,0,g.dims[1],g.dims[2],g.dims[3],this.gl.RGB_INTEGER,this.gl.UNSIGNED_BYTE,S)):g.datatypeCode===512?(g.intent_code===1002&&(L=this.orientShaderAtlasU),this.gl.texStorage3D(this.gl.TEXTURE_3D,1,this.gl.R16UI,g.dims[1],g.dims[2],g.dims[3]),this.gl.texSubImage3D(this.gl.TEXTURE_3D,0,0,0,0,g.dims[1],g.dims[2],g.dims[3],this.gl.RED_INTEGER,this.gl.UNSIGNED_SHORT,S)):g.datatypeCode===2304&&(L=this.orientShaderRGBU,L.use(this.gl),this.gl.uniform1i(L.uniforms.hasAlpha,1),this.gl.texStorage3D(this.gl.TEXTURE_3D,1,this.gl.RGBA8UI,g.dims[1],g.dims[2],g.dims[3]),this.gl.texSubImage3D(this.gl.TEXTURE_3D,0,0,0,0,g.dims[1],g.dims[2],g.dims[3],this.gl.RGBA_INTEGER,this.gl.UNSIGNED_BYTE,S));u.global_min===void 0&&u.calMinMax();let m=null;if(this.gl.bindVertexArray(this.genericVAO),h>1){if(!this.back.dims)throw new Error("back.dims undefined");m=this.rgbaTex(m,TEXTURE10_BLEND,this.back.dims),this.gl.bindTexture(this.gl.TEXTURE_3D,m);const G=this.passThroughShader;G.use(this.gl),this.gl.uniform1i(G.uniforms.in3D,2);for(let Z=0;Z<this.back.dims[3];Z++){const i0=1/this.back.dims[3]*(Z+.5);this.gl.uniform1f(G.uniforms.coordZ,i0),this.gl.framebufferTextureLayer(this.gl.FRAMEBUFFER,this.gl.COLOR_ATTACHMENT0,m,0,Z),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4)}}else m=this.rgbaTex(m,TEXTURE10_BLEND,[2,2,2,2]);L.use(this.gl),this.gl.activeTexture(TEXTURE1_COLORMAPS);let k=null;if(u.colormapLabel!==null&&u.colormapLabel.lut.length>7){const G=u.colormapLabel.max-u.colormapLabel.min+1;k=this.createColormapTexture(k,1,G),this.gl.texSubImage2D(this.gl.TEXTURE_2D,0,0,0,G,1,this.gl.RGBA,this.gl.UNSIGNED_BYTE,u.colormapLabel.lut),this.gl.uniform1f(L.uniforms.cal_min,u.colormapLabel.min-.5),this.gl.uniform1f(L.uniforms.cal_max,u.colormapLabel.max+.5),this.gl.bindTexture(this.gl.TEXTURE_2D,k)}else this.gl.bindTexture(this.gl.TEXTURE_2D,this.colormapTexture),this.gl.uniform1f(L.uniforms.cal_min,u.cal_min),this.gl.uniform1f(L.uniforms.cal_max,u.cal_max);this.gl.uniform1i(L.uniforms.isAlphaThreshold,u.alphaThreshold),this.gl.uniform1i(L.uniforms.isAdditiveBlend,this.opts.isAdditiveBlend?1:0);let e=Number.POSITIVE_INFINITY,N=Number.NEGATIVE_INFINITY;if(u.colormapNegative.length>0&&(e=Math.min(-u.cal_min,-u.cal_max),N=Math.max(-u.cal_min,-u.cal_max),isFinite(u.cal_minNeg)&&isFinite(u.cal_maxNeg)&&(e=Math.min(u.cal_minNeg,u.cal_maxNeg),N=Math.max(u.cal_minNeg,u.cal_maxNeg))),!L)throw new Error("orientShader undefined");this.gl.uniform1f(L.uniforms.layer??null,h),this.gl.uniform1f(L.uniforms.cal_minNeg??null,e),this.gl.uniform1f(L.uniforms.cal_maxNeg??null,N),this.gl.bindTexture(this.gl.TEXTURE_3D,P),this.gl.uniform1i(L.uniforms.intensityVol??null,9),this.gl.uniform1i(L.uniforms.blend3D??null,10),this.gl.uniform1i(L.uniforms.colormap??null,1),this.gl.uniform1f(L.uniforms.scl_inter??null,g.scl_inter),this.gl.uniform1f(L.uniforms.scl_slope??null,g.scl_slope),this.gl.uniform1f(L.uniforms.opacity??null,v),this.gl.uniform1i(L.uniforms.modulationVol??null,7);let B=null;if(u.modulationImage!==null&&u.modulationImage>=0&&u.modulationImage<this.volumes.length){log.debug("modulating",this.volumes);const G=this.volumes[u.modulationImage].hdr;if(G.dims[1]===g.dims[1]&&G.dims[2]===g.dims[2]&&G.dims[3]===g.dims[3]){u.modulateAlpha?(this.gl.uniform1i(L.uniforms.modulation,2),this.gl.uniform1f(L.uniforms.opacity,1)):this.gl.uniform1i(L.uniforms.modulation,1),B=this.r8Tex(B,this.gl.TEXTURE7,g.dims,!0),this.gl.activeTexture(this.gl.TEXTURE7),this.gl.bindTexture(this.gl.TEXTURE_3D,B);const Z=g.dims[1]*g.dims[2]*g.dims[3],i0=new Uint8Array(Z),z=this.volumes[u.modulationImage].cal_min,f=1/(this.volumes[u.modulationImage].cal_max-z),f0=this.volumes[u.modulationImage].img.buffer;let o0=new Uint8Array(f0);switch(G.datatypeCode){case 4:o0=new Int16Array(f0);break;case 16:o0=new Float32Array(f0);break;case 64:o0=new Float64Array(f0);break;case 128:o0=new Uint8Array(f0);break;case 512:o0=new Uint16Array(f0);break}log.debug(this.volumes[u.modulationImage]);const c0=this.volumes[u.modulationImage].colormapNegative.length>0;let d0=this.volumes[u.modulationImage].cal_min,v0=this.volumes[u.modulationImage].cal_max;isFinite(this.volumes[u.modulationImage].cal_minNeg)&&isFinite(this.volumes[u.modulationImage].cal_maxNeg)&&(d0=this.volumes[u.modulationImage].cal_minNeg,v0=this.volumes[u.modulationImage].cal_minNeg),d0=Math.abs(d0),v0=Math.abs(v0),d0>v0&&([d0,v0]=[v0,d0]);const g0=1/(v0-d0);let T0=Math.abs(u.modulateAlpha);T0=Math.max(T0,1);const x0=this.volumes[u.modulationImage].frame4D*Z;for(let M0=0;M0<Z;M0++){const ee=o0[M0+x0]*G.scl_slope+G.scl_inter;let re=(ee-z)*f;c0&&ee<0&&(re=(Math.abs(ee)-d0)*g0),re=Math.min(Math.max(re,0),1),re=Math.pow(re,T0)*255,i0[M0]=re}this.gl.texSubImage3D(this.gl.TEXTURE_3D,0,0,0,0,g.dims[1],g.dims[2],g.dims[3],this.gl.RED,this.gl.UNSIGNED_BYTE,i0)}else log.debug("Modulation image dimensions do not match target")}else this.gl.uniform1i(L.uniforms.modulation,0);if(this.gl.uniformMatrix4fv(L.uniforms.mtx,!1,D),!this.back.dims)throw new Error("back.dims undefined");let Q=0;g.intent_code===1002&&(Q=this.opts.atlasOutline),this.gl.uniform4fv(L.uniforms.xyzaFrac,[1/this.back.dims[1],1/this.back.dims[2],1/this.back.dims[3],Q]),log.debug("back dims: ",this.back.dims);for(let G=0;G<this.back.dims[3];G++){const Z=1/this.back.dims[3]*(G+.5);this.gl.uniform1f(L.uniforms.coordZ,Z),this.gl.framebufferTextureLayer(this.gl.FRAMEBUFFER,this.gl.COLOR_ATTACHMENT0,w,0,G),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4)}if(this.gl.bindVertexArray(this.unusedVAO),this.gl.deleteTexture(P),this.gl.deleteTexture(B),this.gl.deleteTexture(m),this.gl.viewport(0,0,this.gl.canvas.width,this.gl.canvas.height),this.gl.bindFramebuffer(this.gl.FRAMEBUFFER,null),this.gl.deleteFramebuffer(_),h===0&&(this.volumeTexture=w,this.gradientTextureAmount>0?this.gradientGL(g):(this.gradientTexture!==null&&this.gl.deleteTexture(this.gradientTexture),this.gradientTexture=null)),!this.renderShader)throw new Error("renderShader undefined");this.renderShader.use(this.gl);const e0=this.sliceScale(!0),j=e0.vox,H=e0.volScale;if(this.gl.uniform1f(this.renderShader.uniforms.overlays,this.overlays),this.gl.uniform4fv(this.renderShader.uniforms.clipPlaneColor,this.opts.clipPlaneColor),this.gl.uniform1f(this.renderShader.uniforms.clipThick,this.opts.clipThick),this.gl.uniform3fv(this.renderShader.uniforms.clipLo,this.opts.clipVolumeLow),this.gl.uniform3fv(this.renderShader.uniforms.clipHi,this.opts.clipVolumeHigh),this.gl.uniform1f(this.renderShader.uniforms.backOpacity,this.volumes[0].opacity),this.gl.uniform1f(this.renderShader.uniforms.renderOverlayBlend,this.opts.renderOverlayBlend),this.gl.uniform4fv(this.renderShader.uniforms.clipPlane,this.scene.clipPlane),this.gl.uniform3fv(this.renderShader.uniforms.texVox,j),this.gl.uniform3fv(this.renderShader.uniforms.volScale,H),!this.pickingImageShader)throw new Error("pickingImageShader undefined");this.pickingImageShader.use(this.gl),this.gl.uniform1f(this.pickingImageShader.uniforms.overlays,this.overlays.length),this.gl.uniform3fv(this.pickingImageShader.uniforms.texVox,j),this.gl.uniform3fv(this.pickingImageShader.uniforms.clipLo,this.opts.clipVolumeLow),this.gl.uniform3fv(this.pickingImageShader.uniforms.clipHi,this.opts.clipVolumeHigh);let y=this.sliceMMShader;if(this.opts.isV1SliceShader&&(y=this.sliceV1Shader),!y)throw new Error("slice shader undefined");y.use(this.gl),this.gl.uniform1f(y.uniforms.overlays,this.overlays.length),this.gl.uniform1f(y.uniforms.drawOpacity,this.drawOpacity),k!==null&&(this.gl.deleteTexture(k),this.gl.activeTexture(TEXTURE1_COLORMAPS),this.gl.bindTexture(this.gl.TEXTURE_2D,this.colormapTexture)),this.gl.uniform1i(y.uniforms.drawing,7),this.gl.activeTexture(TEXTURE7_DRAW),this.gl.bindTexture(this.gl.TEXTURE_3D,this.drawTexture),this.updateInterpolation(h)}colormaps(){return cmapper.colormaps()}addColormap(u,h){cmapper.addColormap(u,h)}setColormap(u,h){const g=this.getVolumeIndexByID(u);this.volumes[g].colormap=h,this.updateGLVolume()}idx(u,h,g,S){return g*S[0]*S[1]+h*S[0]+u}check_previous_slice(u,h,g,S,v,w,D,_){const P=new Uint32Array(27);let L=0;if(!v)return 0;const m=u[this.idx(g,S,v,w)];if(D>=6){const k=this.idx(g,S,v-1,w);m===u[k]&&(P[L++]=h[k])}if(D>=18){if(g){const k=this.idx(g-1,S,v-1,w);m===u[k]&&(P[L++]=h[k])}if(S){const k=this.idx(g,S-1,v-1,w);m===u[k]&&(P[L++]=h[k])}if(g<w[0]-1){const k=this.idx(g+1,S,v-1,w);m===u[k]&&(P[L++]=h[k])}if(S<w[1]-1){const k=this.idx(g,S+1,v-1,w);m===u[k]&&(P[L++]=h[k])}}if(D===26){if(g&&S){const k=this.idx(g-1,S-1,v-1,w);m===u[k]&&(P[L++]=h[k])}if(g<w[0]-1&&S){const k=this.idx(g+1,S-1,v-1,w);m===u[k]&&(P[L++]=h[k])}if(g&&S<w[1]-1){const k=this.idx(g-1,S+1,v-1,w);m===u[k]&&(P[L++]=h[k])}if(g<w[0]-1&&S<w[1]-1){const k=this.idx(g+1,S+1,v-1,w);m===u[k]&&(P[L++]=h[k])}}return L?(this.fill_tratab(_,P,L),P[0]):0}do_initial_labelling(u,h,g){let S=1;const v=8192;let w=v,D=new Uint32Array(w).fill(0);const _=new Uint32Array(h[0]*h[1]*h[2]).fill(0),P=new Uint32Array(27);for(let L=0;L<h[2];L++)for(let m=0;m<h[1];m++)for(let k=0;k<h[0];k++){let e=0;const N=u[this.idx(k,m,L,h)];if(N!==0){if(P[0]=this.check_previous_slice(u,_,k,m,L,h,g,D),P[0]&&(e+=1),g>=6){if(k){const B=this.idx(k-1,m,L,h);N===u[B]&&(P[e++]=_[B])}if(m){const B=this.idx(k,m-1,L,h);N===u[B]&&(P[e++]=_[B])}}if(g>=18){if(m&&k){const B=this.idx(k-1,m-1,L,h);N===u[B]&&(P[e++]=_[B])}if(m&&k<h[0]-1){const B=this.idx(k+1,m-1,L,h);N===u[B]&&(P[e++]=_[B])}}if(e)_[this.idx(k,m,L,h)]=P[0],this.fill_tratab(D,P,e);else{if(_[this.idx(k,m,L,h)]=S,S>=w){w+=v;const B=new Uint32Array(w);B.set(D),D=B}D[S-1]=S,S++}}}for(let L=0;L<S-1;L++){let m=L;for(;D[m]!==m+1;)m=D[m]-1;D[L]=m+1}return[S-1,D,_]}fill_tratab(u,h,g){let S=0;const v=new Uint32Array(g+5).fill(0);let D=2147483647;for(let _=0;_<g;_++){let P=h[_];for(S=0;u[P-1]!==P;)if(P=u[P-1],S++,S>100){log.info(`
-Ooh no!!`);break}v[_]=P,D=Math.min(D,P)}for(let _=0;_<g;_++)u[v[_]-1]=D}translate_labels(u,h,g,S){const v=h[0]*h[1]*h[2];let w=0;const D=new Uint32Array(v).fill(0);for(let L=0;L<S;L++)w=Math.max(w,g[L]);const _=new Uint32Array(w).fill(0);let P=0;for(let L=0;L<v;L++)u[L]&&(_[g[u[L]-1]-1]||(P+=1,_[g[u[L]-1]-1]=P),D[L]=_[g[u[L]-1]-1]);return[P,D]}largest_original_cluster_labels(u,h,g){const S=u.length,v=new Uint32Array(h+1).fill(0),w=new Uint32Array(h+1).fill(0);for(let P=0;P<S;P++){const L=u[P],m=g[P];v[m]=L,w[m]++}let D=0;for(let P=0;P<h+1;P++){const L=v[P];D=Math.max(D,L);for(let m=0;m<h+1;m++)m!==P&&L===v[m]&&(w[P]<w[m]||w[P]===w[m]&&P<m)&&(v[P]=0)}const _=new Uint32Array(S).fill(0);for(let P=0;P<S;P++)_[P]=v[g[P]];return[D,_]}bwlabel(u,h,g=26,S=!1,v=!1){const w=Date.now(),D=h[0]*h[1]*h[2],_=new Uint32Array(D).fill(0);if(![6,18,26].includes(g))return log.info("bwlabel: conn must be 6, 18 or 26."),[0,_];if(h[0]<2||h[1]<2||h[2]<1)return log.info("bwlabel: img must be 2 or 3-dimensional"),[0,_];if(S)for(let N=0;N<D;N++)u[N]!==0&&(_[N]=1);else _.set(u);let[P,L,m]=this.do_initial_labelling(_,h,g);L===void 0&&(L=new Uint32Array);const[k,e]=this.translate_labels(m,h,L,P);if(log.info(g+" neighbor clustering into "+k+" regions in "+(Date.now()-w)+"ms"),v){const[N,B]=this.largest_original_cluster_labels(_,k,e);return[N,B]}return[k,e]}async createConnectedLabelImage(u,h=26,g=!1,S=!1){var m,k;const v=this.getVolumeIndexByID(u),w=Uint32Array.from(((m=this.volumes[v].dims)==null?void 0:m.slice(1,4))??[]),D=Uint32Array.from(((k=this.volumes[v].img)==null?void 0:k.slice())??[]),[_,P]=this.bwlabel(D,w,h,g,S),L=this.volumes[v].clone();L.opacity=.5,L.colormap="random";for(let e=0;e<L.img.length;e++)L.img[e]=P[e];return L.cal_min=0,L.cal_max=_,L}async scalecropUint8(u,h=0,g=255,S,v){const w=u.length,D=new Uint8Array(w);for(let _=0;_<w;_++){let P=u[_];P=h+v*(P-S),P=Math.max(P,h),P=Math.min(P,g),D[_]=P}return D}async scalecropFloat32(u,h=0,g=1,S,v){const w=u.length,D=new Float32Array(w);for(let _=0;_<w;_++){let P=u[_];P=h+v*(P-S),P=Math.max(P,h),P=Math.min(P,g),D[_]=P}return D}getScale(u,h=0,g=255,S=0,v=.999){let w=u.global_min,D=u.global_max;if(u.hdr.datatypeCode===2)return[w,1];if((!isFinite(S)||!isFinite(v))&&isFinite(u.cal_min)&&isFinite(u.cal_max)&&u.cal_max>u.cal_min){w=u.cal_min,D=u.cal_max;const H=(g-h)/(D-w);return log.info(" Robust Rescale:  min: "+w+"  max: "+D+" scale: "+H),console.log("Robust Rescale:  min: "+w+"  max: "+D+" scale: "+H),[w,H]}const _=u.img,P=u.hdr.dims[1]*u.hdr.dims[2]*u.hdr.dims[3];if(u.hdr.scl_slope!==1||u.hdr.scl_inter!==0){const H=u.img,y=new Float32Array(u.img.length);for(let Y=0;Y<P;Y++)y[Y]=H[Y]*u.hdr.scl_slope+u.hdr.scl_inter}if(w<0&&log.warn("WARNING: Input image has value(s) below 0.0 !"),log.info(" Input:    min: "+w+"  max: "+D),S===0&&v===1)return[w,1];let L=0;for(let H=0;H<P;H++)Math.abs(_[H])>=1e-15&&L++;const m=1e3,k=(D-w)/m,e=new Array(m).fill(0);for(let H=0;H<P;H++){const y=_[H];let Y=Math.floor((y-w)/k);Y=Math.min(Y,m-1),e[Y]++}const N=new Array(m).fill(0);N[0]=e[0];for(let H=1;H<m;H++)N[H]=N[H-1]+e[H];let B=Math.floor(S*P),Q=0;for(;Q<m&&!(N[Q]>=B);)Q++;const e0=w;for(w=Q*k+e0,B=P-Math.floor((1-v)*L),Q=0;Q<m-1&&!(N[Q+1]>=B);)Q++;D=Q*k+e0;let j=1;return w!==D&&(j=(g-h)/(D-w)),log.info(" Rescale:  min: "+w+"  max: "+D+" scale: "+j),[w,j]}conformVox2Vox(u,h,g=256,S=1,v=!1){const w=h.flat(),D=fromValues$3(w[0],w[1],w[2],w[3],w[4],w[5],w[6],w[7],w[8],w[9],w[10],w[11],w[12],w[13],w[14],w[15]),_=fromValues$1(u[1]/2,u[2]/2,u[3]/2,1),P=create$1(),L=create$3();transpose(L,D),transformMat4(P,_,L);const m=fromValues$2(P[0],P[1],P[2]),k=fromValues$2(S,S,S);let e=fromValues$3(-1,0,0,0,0,0,1,0,0,-1,0,0,0,0,0,1);v&&(e=fromValues$3(1,0,0,0,0,1,0,0,0,0,1,0,0,0,0,1)),transpose(e,e);const N=fromValues$1(g,g,g,1),B=create$3();scale$3(B,e,k);const Q=fromValues$1(N[0],N[1],N[2],1);transformMat4(Q,Q,B),scale$1(Q,Q,.5);const e0=create$2();subtract$1(e0,m,fromValues$2(Q[0],Q[1],Q[2]));const j=create$3();transpose(j,B),j[3]=e0[0],j[7]=e0[1],j[11]=e0[2];const H=create$3();invert(H,j);const y=create$3();mul(y,D,H);const Y=create$3();return invert(Y,y),[j,y,Y]}async createNiftiArray(u=[256,256,256],h=[1,1,1],g=[1,0,0,-128,0,1,0,-128,0,0,1,-128,0,0,0,1],S=2,v=new Uint8Array){return await NVImage.createNiftiArray(u,h,g,S,v)}async niftiArray2NVImage(u=new Uint8Array){return await NVImage.loadFromUrl({url:u})}async loadFromUrl(u){return await NVImage.loadFromUrl({url:u})}async conform(u,h=!1,g=!0,S=!1,v=!1){const _=this.conformVox2Vox(u.hdr.dims,u.hdr.affine.flat(),256,1,h),P=_[0],L=_[2],m=256*256*256,k=new Float32Array(m),e=new Float32Array(u.img),N=u.hdr.dims[1]*u.hdr.dims[2]*u.hdr.dims[3];if(u.hdr.scl_slope!==1||u.hdr.scl_inter!==0)for(let f0=0;f0<N;f0++)e[f0]=e[f0]*u.hdr.scl_slope+u.hdr.scl_inter;const B=u.hdr.dims[1],Q=u.hdr.dims[2],e0=u.hdr.dims[3],j=B*Q;let H=-1;function y(f0,o0,c0){return f0+o0*B+c0*j}const Y=L[0],G=L[4],Z=L[8];if(g)for(let f0=0;f0<256;f0++)for(let o0=0;o0<256;o0++){const c0=o0*L[1]+f0*L[2]+L[3],d0=o0*L[5]+f0*L[6]+L[7],v0=o0*L[9]+f0*L[10]+L[11];for(let g0=0;g0<256;g0++){const T0=g0*Y+c0,x0=g0*G+d0,M0=g0*Z+v0,ee=Math.floor(T0),re=Math.floor(x0),Fe=Math.floor(M0);if(H++,ee<0||re<0||Fe<0)continue;const Oe=Math.ceil(T0),ke=Math.ceil(x0),I0=Math.ceil(M0);if(Oe>=B||ke>=Q||I0>=e0)continue;const Be=T0-ee,Ge=x0-re,ti=M0-Fe,ai=1-Be,ri=1-Ge,qe=1-ti,be=y(ee,re,Fe);let J0=0;J0+=e[be]*ai*ri*qe,J0+=e[be+j]*ai*ri*ti,J0+=e[be+B]*ai*Ge*qe,J0+=e[be+B+j]*ai*Ge*ti,J0+=e[be+1]*Be*ri*qe,J0+=e[be+1+j]*Be*ri*ti,J0+=e[be+1+B]*Be*Ge*qe,J0+=e[be+1+B+j]*Be*Ge*ti,k[H]=J0}}else for(let f0=0;f0<256;f0++)for(let o0=0;o0<256;o0++){const c0=o0*L[1]+f0*L[2]+L[3],d0=o0*L[5]+f0*L[6]+L[7],v0=o0*L[9]+f0*L[10]+L[11];for(let g0=0;g0<256;g0++){const T0=Math.round(g0*Y+c0),x0=Math.round(g0*G+d0),M0=Math.round(g0*Z+v0);H++,!(T0<0||x0<0||M0<0)&&(T0>=B||x0>=Q||M0>=e0||(k[H]=e[y(T0,x0,M0)]))}}let i0=0;v&&(i0=NaN);let z=new Uint8Array;if(S){const f0=await this.getScale(u,0,1,i0),o0=await this.scalecropFloat32(k,0,1,f0[0],f0[1]);z=await this.createNiftiArray([256,256,256],[1,1,1],Array.from(P),16,new Uint8Array(o0.buffer))}else{const f0=await this.getScale(u,0,255,i0),o0=await this.scalecropUint8(k,0,255,f0[0],f0[1]);z=await this.createNiftiArray([256,256,256],[1,1,1],Array.from(P),2,o0)}return await this.niftiArray2NVImage(z)}setRenderDrawAmbientOcclusion(u){if(!this.renderShader)throw new Error("renderShader undefined");this.renderDrawAmbientOcclusion=u,this.renderShader.use(this.gl),this.gl.uniform1fv(this.renderShader.uniforms.renderDrawAmbientOcclusion,[this.renderDrawAmbientOcclusion,1]),this.drawScene()}setColorMap(u,h){this.setColormap(u,h)}setColormapNegative(u,h){const g=this.getVolumeIndexByID(u);this.volumes[g].colormapNegative=h,this.updateGLVolume()}setModulationImage(u,h,g=0){const S=this.getVolumeIndexByID(u);let v=null;h.length>0&&(v=this.getVolumeIndexByID(h)),this.volumes[S].modulationImage=v,this.volumes[S].modulateAlpha=g,this.updateGLVolume()}setGamma(u=1){cmapper.gamma=u,this.updateGLVolume()}async loadDeferred4DVolumes(u){const h=this.getVolumeIndexByID(u),g=this.volumes[h];if(g.nTotalFrame4D<=g.nFrame4D)return;let S;g.fileObject?S=await NVImage.loadFromFile({file:g.fileObject}):S=await NVImage.loadFromUrl({url:g.url}),S&&(g.img=S.img.slice(),g.nTotalFrame4D=S.nTotalFrame4D,g.nFrame4D=S.nFrame4D,this.updateGLVolume())}setFrame4D(u,h){const g=this.getVolumeIndexByID(u),S=this.volumes[g];h>S.nFrame4D-1&&(h=S.nFrame4D-1),h<0&&(h=0),h!==S.frame4D&&(S.frame4D=h,this.updateGLVolume(),this.onFrameChange(S,h),this.createOnLocationChange())}getFrame4D(u){const h=this.getVolumeIndexByID(u);return this.volumes[h].frame4D}colormapFromKey(u){return cmapper.colormapFromKey(u)}colormap(u="",h=!1){return cmapper.colormap(u,h)}createColormapTexture(u=null,h=0,g=256){return u!==null&&this.gl.deleteTexture(u),h<1||g<1?null:(u=this.gl.createTexture(),this.gl.activeTexture(TEXTURE1_COLORMAPS),this.gl.bindTexture(this.gl.TEXTURE_2D,u),this.gl.texStorage2D(this.gl.TEXTURE_2D,1,this.gl.RGBA8,g,h),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MIN_FILTER,this.gl.LINEAR),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MAG_FILTER,this.gl.LINEAR),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_WRAP_R,this.gl.CLAMP_TO_EDGE),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_WRAP_S,this.gl.CLAMP_TO_EDGE),this.gl.pixelStorei(this.gl.UNPACK_ALIGNMENT,1),u)}addColormapList(u="",h=NaN,g=NaN,S=!1,v=!1,w=!0,D=!1){u.length<1&&(w=!1),this.colormapLists.push({name:u,min:h,max:g,alphaThreshold:S,negative:v,visible:w,invert:D})}refreshColormaps(){if(this.colormapLists=[],this.volumes.length<1&&this.meshes.length<1)return;const u=this.volumes.length;if(u>0)for(let w=0;w<u;w++){const D=this.volumes[w],_=negMinMax(D.cal_min,D.cal_max,D.cal_minNeg,D.cal_maxNeg);this.addColormapList(D.colormapNegative,_[0],_[1],D.alphaThreshold!==void 0,!0,D.colorbarVisible,D.colormapInvert),this.addColormapList(D.colormap,D.cal_min,D.cal_max,D.alphaThreshold!==void 0,!1,D.colorbarVisible,D.colormapInvert)}const h=this.meshes.length;if(h>0)for(let w=0;w<h;w++){const D=this.meshes[w];if(!D.colorbarVisible)continue;const _=D.layers.length;if("edgeColormap"in D&&"edges"in D&&D.edges!==void 0){const P=negMinMax(D.edgeMin,D.edgeMax,NaN,NaN);this.addColormapList(D.edgeColormapNegative,P[0],P[1],!1,!0,!0,D.colormapInvert),this.addColormapList(D.edgeColormap,D.edgeMin,D.edgeMax,!1,!1,!0,D.colormapInvert)}if(!(_<1))for(let P=0;P<_;P++){const L=this.meshes[w].layers[P];if(!L.colorbarVisible||L.colormap.length<1)continue;const m=negMinMax(L.cal_min,L.cal_max,L.cal_minNeg,L.cal_maxNeg);this.addColormapList(L.colormapNegative,m[0],m[1],L.alphaThreshold,!0,!0,L.colormapInvert),this.addColormapList(L.colormap,L.cal_min,L.cal_max,L.alphaThreshold,!1,!0,L.colormapInvert)}}const g=this.colormapLists.length;if(g<1)return;this.colormapTexture=this.createColormapTexture(this.colormapTexture,g+1);let S=new Uint8ClampedArray;function v(w){const D=new Uint8ClampedArray(S.length+w.length);D.set(S),D.set(w,S.length),S=D}for(let w=0;w<g;w++)v(Array.from(this.colormap(this.colormapLists[w].name,this.colormapLists[w].invert)));return v(Array.from(this.drawLut.lut)),this.gl.texSubImage2D(this.gl.TEXTURE_2D,0,0,0,256,g+1,this.gl.RGBA,this.gl.UNSIGNED_BYTE,S),this}sliceScale(u=!1){var w;let h=this.screenFieldOfViewMM(0);u&&(h=this.screenFieldOfViewVox(0));const g=Math.max(h[0],Math.max(h[1],h[2])),S=[h[0]/g,h[1]/g,h[2]/g];if(!((w=this.back)!=null&&w.dims))throw new Error("back.dims undefined");const v=[this.back.dims[1],this.back.dims[2],this.back.dims[3]];return{volScale:S,vox:v,longestAxis:g,dimsMM:h}}tileIndex(u,h){for(let g=0;g<this.screenSlices.length;g++){const S=this.screenSlices[g].leftTopWidthHeight;if(u>S[0]&&h>S[1]&&u<S[0]+S[2]&&h<S[1]+S[3])return g}return-1}inRenderTile(u,h){const g=this.tileIndex(u,h);return g>=0&&this.screenSlices[g].axCorSag===4?g:-1}sliceScroll3D(u=0){if(u!==0){if(this.volumes.length>0&&this.scene.clipPlaneDepthAziElev[0]<1.8){const h=this.scene.clipPlaneDepthAziElev.slice();return u>0&&(h[0]=Math.min(1.5,h[0]+.025)),u<0&&(h[0]=Math.max(-1.5,h[0]-.025)),h[0]!==this.scene.clipPlaneDepthAziElev[0]?(this.scene.clipPlaneDepthAziElev=h,this.setClipPlane(this.scene.clipPlaneDepthAziElev)):void 0}u>0&&(this.scene.volScaleMultiplier=Math.min(2,this.scene.volScaleMultiplier*1.1)),u<0&&(this.scene.volScaleMultiplier=Math.max(.5,this.scene.volScaleMultiplier*.9)),this.drawScene()}}deleteThumbnail(){this.bmpTexture&&(this.gl.deleteTexture(this.bmpTexture),this.bmpTexture=null,this.thumbnailVisible=!1)}inGraphTile(u,h){if(this.graph.opacity<=0||this.volumes.length<1||this.volumes[0].nFrame4D<1||!this.graph.plotLTWH||this.graph.plotLTWH[2]<1||this.graph.plotLTWH[3]<1)return!1;const g=[(u-this.graph.LTWH[0])/this.graph.LTWH[2],(h-this.graph.LTWH[1])/this.graph.LTWH[3]];return g[0]>0&&g[1]>0&&g[0]<=1&&g[1]<=1}mouseClick(u,h,g=0,S=!0){if(u*=this.uiData.dpr,h*=this.uiData.dpr,this.canvas.focus(),this.thumbnailVisible){this.thumbnailVisible=!1,Promise.all([this.loadVolumes(this.deferredVolumes),this.loadMeshes(this.deferredMeshes)]).catch(v=>{throw v});return}if(this.inGraphTile(u,h)){if(!this.graph.plotLTWH)throw new Error("plotLTWH undefined");const v=[(u-this.graph.plotLTWH[0])/this.graph.plotLTWH[2],(h-this.graph.plotLTWH[1])/this.graph.plotLTWH[3]];if(v[0]>0&&v[1]>0&&v[0]<=1&&v[1]<=1){const w=Math.round(v[0]*(this.volumes[0].nFrame4D-1));this.setFrame4D(this.volumes[0].id,w);return}v[0]>.5&&v[1]>1&&this.loadDeferred4DVolumes(this.volumes[0].id).catch(w=>{throw w});return}if(this.inRenderTile(u,h)>=0){this.sliceScroll3D(g),this.drawScene();return}if(!(this.screenSlices.length<1||this.gl.canvas.height<1||this.gl.canvas.width<1))for(let v=0;v<this.screenSlices.length;v++){const w=this.screenSlices[v].axCorSag;if(this.drawPenAxCorSag>=0&&this.drawPenAxCorSag!==w||w>2)continue;const D=this.screenXY2TextureFrac(u,h,v,!1);if(!(D[0]<0)){if(!S){this.scene.crosshairPos[2-w]=g,this.drawScene();return}if(g!==0){let _=1;g<0&&(_=-1);const P=[0,0,0];P[2-w]=_,this.moveCrosshairInVox(P[0],P[1],P[2]),this.drawScene(),this.createOnLocationChange(w);return}if(this.opts.isForceMouseClickToVoxelCenters?this.scene.crosshairPos=clone$1(this.vox2frac(this.frac2vox(D))):this.scene.crosshairPos=clone$1(D),this.opts.drawingEnabled){const _=this.frac2vox(this.scene.crosshairPos);if(this.opts.clickToSegment){const P=this.opts.clickToSegmentRadius,L=this.opts.clickToSegmentSteps,m=this.opts.clickToSegmentBright?Number.POSITIVE_INFINITY:Number.NEGATIVE_INFINITY;this.drawPenFillPts=[],this.drawPenAxCorSag=w;for(let e=1;e<=L;e++){const N=e/L*2*Math.PI;let B=_[0]+P*Math.cos(N),Q=_[1]+P*Math.sin(N);const e0=_[2];B=Math.round(B),Q=Math.round(Q),this.drawPt(B,Q,e0,this.opts.penValue),this.drawPenFillPts.push([B,Q,_[2]]),e===L&&this.drawFloodFill([B,Q,_[2]],0,m,NaN,NaN,this.opts.floodFillNeighbors)}this.drawScene(),this.createOnLocationChange(w);const k=this.getDescriptives(0,[],!0);this.onClickToSegment({mL:k.volumeML,mm3:k.volumeMM3});return}if(!isFinite(this.opts.penValue)||this.opts.penValue<0||Object.is(this.opts.penValue,-0)){isFinite(this.opts.penValue)?this.drawFloodFill(_,Math.abs(this.opts.penValue),this.opts.penValue,NaN,NaN,this.opts.floodFillNeighbors):this.drawFloodFill(_,0,this.opts.penValue,NaN,NaN,this.opts.floodFillNeighbors);return}if(isNaN(this.drawPenLocation[0]))this.drawPenAxCorSag=w,this.drawPenFillPts=[],this.drawPt(..._,this.opts.penValue);else{if(_[0]===this.drawPenLocation[0]&&_[1]===this.drawPenLocation[1]&&_[2]===this.drawPenLocation[2])return;this.drawPenLine(_,this.drawPenLocation,this.opts.penValue)}this.drawPenLocation=_,this.opts.isFilledPen&&this.drawPenFillPts.push(_),this.refreshDrawing(!1)}this.drawScene(),this.createOnLocationChange(w);return}}}drawRuler(){let u=[],h=[];for(let _=0;_<this.screenSlices.length;_++)if(this.screenSlices[_].axCorSag!==4&&this.screenSlices[_].fovMM.length>1){h=this.screenSlices[_].leftTopWidthHeight,u=this.screenSlices[_].fovMM;break}if(h.length<4)return;const S=100/u[0]*h[2],v=h[0]+.5*h[2]-.5*S,w=h[1]+h[3]-2*this.opts.rulerWidth,D=[v,w,v+S,w];this.drawRuler10cm(D)}drawRuler10cm(u){if(!this.lineShader)throw new Error("lineShader undefined");this.gl.bindVertexArray(this.genericVAO),this.lineShader.use(this.gl),this.gl.uniform4fv(this.lineShader.uniforms.lineColor,this.opts.rulerColor),this.gl.uniform2fv(this.lineShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.uniform1f(this.lineShader.uniforms.thickness,this.opts.rulerWidth),this.gl.uniform4fv(this.lineShader.uniforms.startXYendXY,u),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4);const h=-.1*(u[0]-u[2]),g=u[1],S=g-2*this.opts.rulerWidth,v=g-4*this.opts.rulerWidth;for(let w=0;w<11;w++){const D=u[0]+w*h,_=[D,g,D,S];w%5===0&&(_[3]=v),this.gl.uniform4fv(this.lineShader.uniforms.startXYendXY,_),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4)}this.gl.bindVertexArray(this.unusedVAO)}screenXY2mm(u,h,g=-1){let S;for(let v=0;v<this.screenSlices.length;v++){let w=v;if(g>=0&&(w=g),this.screenSlices[w].axCorSag>2)continue;const _=this.screenSlices[w].leftTopWidthHeight;if(u<_[0]||h<_[1]||u>_[0]+_[2]||h>_[1]+_[3]||(S=this.screenXY2TextureFrac(u,h,w,!1),S[0]<0))continue;const P=this.frac2mm(S);return fromValues$1(P[0],P[1],P[2],w)}return fromValues$1(NaN,NaN,NaN,NaN)}dragForPanZoom(u){const h=this.screenXY2mm(u[2],u[3]);if(isNaN(h[0]))return;const g=this.screenXY2mm(u[0],u[1],h[3]);if(isNaN(g[0])||isNaN(h[0])||isNaN(h[3]))return;const S=create$1(),v=this.uiData.pan2DxyzmmAtMouseDown[3];sub(S,h,g),this.scene.pan2Dxyzmm[0]=this.uiData.pan2DxyzmmAtMouseDown[0]+v*S[0],this.scene.pan2Dxyzmm[1]=this.uiData.pan2DxyzmmAtMouseDown[1]+v*S[1],this.scene.pan2Dxyzmm[2]=this.uiData.pan2DxyzmmAtMouseDown[2]+v*S[2],this.canvas.focus()}dragForCenterButton(u){this.dragForPanZoom(u)}dragForSlicer3D(u){let h=this.uiData.pan2DxyzmmAtMouseDown[3];const g=u[3]-u[1];h+=g*.01,h=Math.max(h,.1),h=Math.min(h,10);const v=this.scene.pan2Dxyzmm[3]-h;this.opts.yoke3Dto2DZoom&&(this.scene.volScaleMultiplier=h),this.scene.pan2Dxyzmm[3]=h;const w=this.frac2mm(this.scene.crosshairPos);this.scene.pan2Dxyzmm[0]+=v*w[0],this.scene.pan2Dxyzmm[1]+=v*w[1],this.scene.pan2Dxyzmm[2]+=v*w[2]}drawMeasurementTool(u){const h=this.gl;if(h.bindVertexArray(this.genericVAO),h.depthFunc(h.ALWAYS),h.enable(h.BLEND),h.blendFunc(h.SRC_ALPHA,h.ONE_MINUS_SRC_ALPHA),!this.lineShader)throw new Error("lineShader undefined");this.lineShader.use(this.gl),h.uniform4fv(this.lineShader.uniforms.lineColor,this.opts.rulerColor),h.uniform2fv(this.lineShader.uniforms.canvasWidthHeight,[h.canvas.width,h.canvas.height]),h.uniform1f(this.lineShader.uniforms.thickness,this.opts.rulerWidth),h.uniform4fv(this.lineShader.uniforms.startXYendXY,u),h.drawArrays(h.TRIANGLE_STRIP,0,4);const g=this.opts.rulerColor;g[3]=1,h.uniform4fv(this.lineShader.uniforms.lineColor,g);const S=this.opts.rulerWidth;h.uniform1f(this.lineShader.uniforms.thickness,S*2);let v=[u[0],u[1]-S,u[0],u[1]+S];h.uniform4fv(this.lineShader.uniforms.startXYendXY,v),h.drawArrays(h.TRIANGLE_STRIP,0,4),v=[u[2],u[3]-S,u[2],u[3]+S],h.uniform4fv(this.lineShader.uniforms.startXYendXY,v),h.drawArrays(h.TRIANGLE_STRIP,0,4);let w=this.canvasPos2frac([u[0],u[1]]),D=this.canvasPos2frac([u[2],u[3]]);if(w[0]>=0&&D[0]>=0){const _=this.frac2mm(w);w=fromValues$2(_[0],_[1],_[2]);const P=this.frac2mm(D);D=fromValues$2(P[0],P[1],P[2]);const L=create$2();sub$1(L,w,D);const m=len(L);let k=2;m>9&&(k=1),m>99&&(k=0);const e=m.toFixed(k);this.drawTextBetween(u,e,1,g)}h.bindVertexArray(this.unusedVAO)}drawRect(u,h=[1,0,0,-1]){if(h[3]<0&&(h=this.opts.crosshairColor),!this.rectShader)throw new Error("rectShader undefined");this.rectShader.use(this.gl),this.gl.enable(this.gl.BLEND),this.gl.uniform4fv(this.rectShader.uniforms.lineColor,h),this.gl.uniform2fv(this.rectShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.uniform4f(this.rectShader.uniforms.leftTopWidthHeight,u[0],u[1],u[2],u[3]),this.gl.bindVertexArray(this.genericVAO),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),this.gl.bindVertexArray(this.unusedVAO)}drawCircle(u,h=this.opts.fontColor,g=1){if(!this.circleShader)throw new Error("circleShader undefined");this.circleShader.use(this.gl),this.gl.enable(this.gl.BLEND),this.gl.uniform4fv(this.circleShader.uniforms.circleColor,h),this.gl.uniform2fv(this.circleShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.uniform4f(this.circleShader.uniforms.leftTopWidthHeight,u[0],u[1],u[2],u[3]),this.gl.uniform1f(this.circleShader.uniforms.fillPercent,g),this.gl.uniform4fv(this.circleShader.uniforms.circleColor,h),this.gl.bindVertexArray(this.genericVAO),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),this.gl.bindVertexArray(this.unusedVAO)}drawSelectionBox(u){this.drawRect(u,this.opts.selectionBoxColor)}effectiveCanvasHeight(){return this.gl.canvas.height-this.colorbarHeight}effectiveCanvasWidth(){return this.gl.canvas.width-this.getLegendPanelWidth()}getAllLabels(){const S=this.meshes.filter(w=>w.type==="connectome").flatMap(w=>w.nodes).map(w=>w.label).filter(w=>w!==void 0);return[...this.document.labels,...S]}getBulletMarginWidth(){let u=0;const h=this.getAllLabels();if(h.length===0)return 0;const g=h.length===1?h[0].style.bulletScale:h.reduce((w,D)=>w.style.bulletScale>D.style.bulletScale?w:D).style.bulletScale,S=h.length===1?h[0]:h.reduce((w,D)=>{const _=this.opts.textHeight*this.gl.canvas.height*w.style.textScale,P=this.opts.textHeight*this.gl.canvas.height*D.style.textScale;return this.textHeight(_,w.text)>this.textHeight(P,D.text)?w:D}),v=this.opts.textHeight*this.gl.canvas.height*S.style.textScale;return u=this.textHeight(v,S.text)*g,u+=v,u}getLegendPanelWidth(){const u=this.getAllLabels();if(!this.opts.showLegend||u.length===0)return 0;const g=this.opts.textHeight*this.gl.canvas.height*1;let S=0;const v=u.reduce((P,L)=>{const m=this.opts.textHeight*this.gl.canvas.height*P.style.textScale,k=this.opts.textHeight*this.gl.canvas.height*L.style.textScale;return this.textWidth(m,P.text)>this.textWidth(k,L.text)?P:L}),w=this.opts.textHeight*this.gl.canvas.height*v.style.textScale,D=this.textWidth(w,v.text),_=this.getBulletMarginWidth();return D&&(S=_+D,S+=g*2),S>=this.gl.canvas.width?0:S}getLegendPanelHeight(){const u=this.getAllLabels();let h=0;const S=this.opts.textHeight*this.gl.canvas.height*1;for(const v of u){const w=this.opts.textHeight*this.gl.canvas.height*v.style.textScale,D=this.textHeight(w,v.text);h+=D}return h&&(h+=S/2*(u.length+1)),h}reserveColorbarPanel(){let u=Math.max(this.opts.textHeight,.01);u=u*Math.min(this.gl.canvas.height,this.gl.canvas.width);const h=3*u,g=[0,this.gl.canvas.height-h,this.gl.canvas.width,h];return this.colorbarHeight=g[3]+1,g}drawColorbarCore(u=0,h=[0,0,0,0],g=!1,S=0,v=1,w){if(h[2]<=0||h[3]<=0)return;let D=Math.max(this.opts.textHeight,.01);D=D*Math.min(this.gl.canvas.height,this.gl.canvas.width);let _=D;const P=3*D;let L=D;if(h[3]<P){if(h[3]<3)return;_=1,L=h[3]-2}this.gl.disable(this.gl.DEPTH_TEST),this.colorbarHeight=h[3]+1;const m=[h[0]+_,h[1],h[2]-2*_,L],k=[m[0]-1,m[1]-1,m[2]+2,m[3]+2];if(this.drawRect(k,this.opts.crosshairColor),!this.colorbarShader)throw new Error("colorbarShader undefined");this.colorbarShader.use(this.gl),this.gl.activeTexture(TEXTURE1_COLORMAPS),this.gl.bindTexture(this.gl.TEXTURE_2D,this.colormapTexture),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MIN_FILTER,this.gl.NEAREST),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MAG_FILTER,this.gl.NEAREST);const e=u;if(this.gl.uniform1f(this.colorbarShader.uniforms.layer,e),this.gl.uniform2fv(this.colorbarShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.disable(this.gl.CULL_FACE),g){const Z=[m[0]+m[2],m[1],-m[2],m[3]];this.gl.uniform4fv(this.colorbarShader.uniforms.leftTopWidthHeight,Z)}else this.gl.uniform4fv(this.colorbarShader.uniforms.leftTopWidthHeight,m);this.gl.bindVertexArray(this.genericVAO),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),this.gl.bindVertexArray(this.unusedVAO),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MIN_FILTER,this.gl.LINEAR),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MAG_FILTER,this.gl.LINEAR);let N=0;if(w&&v<0&&g?(N=v,v=0):w&&S>0&&(N=S,S=0),S===v||D<1)return;const B=Math.abs(v-S);let[Q,e0]=tickSpacing(S,v);e0<S&&(e0+=Q);function j(Z){return Z.toFixed(6).replace(/\.?0*$/,"")}let H=e0;const y=[0,m[1]+m[3]-D*.5,2,D*.75],Y=y[1]+y[3],G=1;for(;H<=v;){y[0]=m[0]+(H-S)/B*m[2],this.drawRect(y);const Z=j(G*H);this.drawTextBelow([y[0],Y],Z),H+=Q}if(N!==0){const Z=[m[0]+(N-S)/B*m[2],m[1]-m[3]*.25,2,m[3]*1.5];this.drawRect(Z)}}drawColorbar(){const u=this.colormapLists,h=u.length;if(h<1)return;let g=0;for(let _=0;_<h;_++)u[_].visible&&g++;if(g<1)return;let S=this.reserveColorbarPanel(),v=Math.max(this.opts.textHeight,.01);v=v*Math.min(this.gl.canvas.height,this.gl.canvas.width);const w=3*v;let D=S[2]/g;(S[2]<=0||S[3]<=0)&&(D=this.gl.canvas.width/g,S=[0,this.gl.canvas.height-w,D,w]),S[2]=D;for(let _=0;_<h;_++)u[_].visible&&(this.drawColorbarCore(_,S,u[_].negative,u[_].min,u[_].max,u[_].alphaThreshold),S[0]+=D)}textWidth(u,h){if(!h)return 0;let g=0;const S=new TextEncoder().encode(h);for(let v=0;v<h.length;v++)g+=u*this.fontMets.mets[S[v]].xadv;return g}textHeight(u,h){if(!h)return 0;const g=new Set(Array.from(h)),S=new TextEncoder().encode(Array.from(g).join("")),w=Object.values(this.fontMets.mets).filter((D,_)=>S.includes(_)).reduce((D,_)=>D.lbwh[3]>_.lbwh[3]?D:_).lbwh[3];return u*w}drawChar(u,h,g){if(!this.fontShader)throw new Error("fontShader undefined");const S=this.fontMets.mets[g],v=u[0]+h*S.lbwh[0],w=-(h*S.lbwh[1]),D=h*S.lbwh[2],_=h*S.lbwh[3],P=u[1]+(w-_)+h;return this.gl.uniform4f(this.fontShader.uniforms.leftTopWidthHeight,v,P,D,_),this.gl.uniform4fv(this.fontShader.uniforms.uvLeftTopWidthHeight,S.uv_lbwh),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),h*S.xadv}drawLoadingText(u){if(!this.canvas)throw new Error("canvas undefined");this.gl.viewport(0,0,this.gl.canvas.width,this.gl.canvas.height),this.gl.enable(this.gl.CULL_FACE),this.gl.enable(this.gl.BLEND),this.drawTextBelow([this.canvas.width/2,this.canvas.height/2],u,3)}drawText(u,h,g=1,S=null){if(this.opts.textHeight<=0)return;if(!this.fontShader)throw new Error("fontShader undefined");this.fontShader.use(this.gl);const v=this.opts.textHeight*Math.min(this.gl.canvas.height,this.gl.canvas.width)*g;this.gl.enable(this.gl.BLEND),this.gl.uniform2f(this.fontShader.uniforms.canvasWidthHeight,this.gl.canvas.width,this.gl.canvas.height),S===null&&(S=this.opts.fontColor),this.gl.uniform4fv(this.fontShader.uniforms.fontColor,S);let w=v/this.fontMets.size*this.fontMets.distanceRange;w=Math.max(w,1),this.gl.uniform1f(this.fontShader.uniforms.screenPxRange,w);const D=new TextEncoder().encode(h);this.gl.bindVertexArray(this.genericVAO);for(let _=0;_<h.length;_++)u[0]+=this.drawChar(u,v,D[_]);this.gl.bindVertexArray(this.unusedVAO)}drawTextRight(u,h,g=1,S=null){this.opts.textHeight<=0||(u[1]-=.5*this.opts.textHeight*this.gl.canvas.height,this.drawText(u,h,g,S))}drawTextLeft(u,h,g=1,S=null){if(this.opts.textHeight<=0)return;const v=this.opts.textHeight*this.gl.canvas.height*g;u[0]-=this.textWidth(v,h),u[1]-=.5*v,this.drawText(u,h,g,S)}drawTextRightBelow(u,h,g=1,S=null){this.opts.textHeight<=0||this.drawText(u,h,g,S)}drawTextBetween(u,h,g=1,S=null){if(this.opts.textHeight<=0)return;const v=[(u[0]+u[2])*.5,(u[1]+u[3])*.5],w=this.opts.textHeight*this.gl.canvas.height*g,D=this.textWidth(w,h);v[0]-=.5*D,v[1]-=.5*w;const _=[v[0]-1,v[1]-1,D+2,w+2];let P=S;P===null&&(P=this.opts.crosshairColor),P&&P[0]+P[1]+P[2]>.8?P=[0,0,0,.5]:P=[1,1,1,.5],this.drawRect(_,P),this.drawText(v,h,g,S)}drawTextBelow(u,h,g=1,S=null){if(this.opts.textHeight<=0)return;if(!this.canvas)throw new Error("canvas undefined");let v=this.opts.textHeight*this.gl.canvas.height*g,w=this.textWidth(v,h);w>this.canvas.width&&(g*=(this.canvas.width-2)/w,v=this.opts.textHeight*this.gl.canvas.height*g,w=this.textWidth(v,h)),u[0]-=.5*this.textWidth(v,h),u[0]=Math.max(u[0],1),u[0]=Math.min(u[0],this.canvas.width-w-1),this.drawText(u,h,g,S)}updateInterpolation(u,h=!1){let g=this.gl.LINEAR;!h&&this.opts.isNearestInterpolation&&(g=this.gl.NEAREST),u===0?this.gl.activeTexture(TEXTURE0_BACK_VOL):this.gl.activeTexture(TEXTURE2_OVERLAY_VOL),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_MIN_FILTER,g),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_MAG_FILTER,g)}setAtlasOutline(u){this.opts.atlasOutline=u,this.updateGLVolume(),this.drawScene()}setInterpolation(u){this.opts.isNearestInterpolation=u;const h=this.volumes.length;if(!(h<1)){for(let g=0;g<h;g++)this.updateInterpolation(g);this.drawScene()}}calculateMvpMatrix2D(u,h,g,S=1/0,v=0,w=0,D=0,_){this.gl.viewport(u[0],this.gl.canvas.height-(u[1]+u[3]),u[2],u[3]);let L=h[0],m=g[0],k=[L,h[1]],e=[m-L,g[1]-h[1]];_&&(k=[g[0],h[1]],e=[h[0]-g[0],g[1]-h[1]],L=-g[0],m=-h[0]);const N=2*Math.max(Math.abs(h[2]),Math.abs(g[2])),B=create$3();let Q=.01,e0=N*8;if(S!==1/0){let Z=_;D===0&&(w===0||w===180)&&(Z=!Z);let i0=N*1.8-v;Z||(i0=N*1.8+v),Q=i0-S,e0=i0+S}ortho(B,L,m,h[1],g[1],Q,e0);const j=create$3();j[0]=-1;const H=fromValues$2(0,0,-N*1.8);translate(j,j,H),rotateX(j,j,deg2rad(270-D)),rotateZ(j,j,deg2rad(w-180));const y=create$3();invert(y,j);const Y=create$3();transpose(Y,y);const G=create$3();return multiply(G,B,j),{modelViewProjectionMatrix:G,modelMatrix:j,normalMatrix:Y,leftTopMM:k,fovMM:e}}swizzleVec3MM(u,h){return h===1?u=swizzleVec3(u,[0,2,1]):h===2&&(u=swizzleVec3(u,[1,2,0])),u}screenFieldOfViewVox(u=0){const h=clone$1(this.volumeObject3D.fieldOfViewDeObliqueMM);return this.swizzleVec3MM(h,u)}screenFieldOfViewMM(u=0,h=!1){if(!h&&!this.opts.isSliceMM)return this.screenFieldOfViewVox(u);const g=this.volumeObject3D.extentsMin,S=this.volumeObject3D.extentsMax;let v=fromValues$2(g[0],g[1],g[2]),w=fromValues$2(S[0],S[1],S[2]);v=this.swizzleVec3MM(v,u),w=this.swizzleVec3MM(w,u);const D=create$2();return subtract$1(D,w,v),D}screenFieldOfViewExtendedVox(u=0){const h=this.volumes[0].extentsMinOrtho,g=this.volumes[0].extentsMaxOrtho;let S=fromValues$2(h[0],h[1],h[2]),v=fromValues$2(g[0],g[1],g[2]);const w=create$3();S=this.swizzleVec3MM(S,u),v=this.swizzleVec3MM(v,u);const D=create$2();return subtract$1(D,v,S),{mnMM:S,mxMM:v,rotation:w,fovMM:D}}screenFieldOfViewExtendedMM(u=0){if(!this.volumeObject3D)throw new Error("volumeObject3D undefined");const h=this.volumeObject3D.extentsMin,g=this.volumeObject3D.extentsMax;let S=fromValues$2(h[0],h[1],h[2]),v=fromValues$2(g[0],g[1],g[2]);const w=create$3();S=this.swizzleVec3MM(S,u),v=this.swizzleVec3MM(v,u);const D=create$2();return subtract$1(D,v,S),{mnMM:S,mxMM:v,rotation:w,fovMM:D}}drawSliceOrientationText(u,h){this.gl.viewport(0,0,this.gl.canvas.width,this.gl.canvas.height);let g="S";h===0&&(g="A");let S=this.opts.isRadiologicalConvention?"R":"L";if(h===2&&(S=this.opts.sagittalNoseLeft?"A":"P"),this.opts.isCornerOrientationText){this.drawTextRightBelow([u[0],u[1]],S+g);return}this.drawTextBelow([u[0]+u[2]*.5,u[1]],g),this.drawTextRight([u[0],u[1]+u[3]*.5],S)}xyMM2xyzMM(u,h){let g=2;u===1&&(g=1),u===2&&(g=0);let S=[0,0,0],v=[1,1,0],w=[1,0,1];S[g]=h,v[g]=h,w[g]=h,S=this.frac2mm(S),v=this.frac2mm(v),w=this.frac2mm(w),S=this.swizzleVec3MM(fromValues$2(S[0],S[1],S[2]),u),v=this.swizzleVec3MM(fromValues$2(v[0],v[1],v[2]),u),w=this.swizzleVec3MM(fromValues$2(w[0],w[1],w[2]),u);const D=(v[0]-S[0])*(w[1]-S[1])-(w[0]-S[0])*(v[1]-S[1]);let _=(v[0]-S[0])*(w[2]-S[2])-(w[0]-S[0])*(v[2]-S[2]);_/=D;let P=(v[1]-S[1])*(w[2]-S[2])-(w[1]-S[1])*(v[2]-S[2]);P/=D;const L=[0,0,0,0,0];return L[0]=S[0],L[1]=S[1],L[2]=S[2],L[3]=P,L[4]=_,L}draw2D(u,h,g=NaN){let S=this.volumes[0].frac2mm.slice(),v=this.screenFieldOfViewExtendedMM(h),w=create$3();this.opts.isSliceMM||(S=this.volumes[0].frac2mmOrtho.slice(),w=clone$2(this.volumes[0].mm2ortho),v=this.screenFieldOfViewExtendedVox(h));let D=this.opts.isRadiologicalConvention&&h<2;g===1/0||g===-1/0?(D=g!==1/0,h===1&&(D=!D)):this.opts.sagittalNoseLeft&&h===2&&(D=!D);let _=0,P=0;h===2?P=D?90:-90:h===1?P=D?180:0:(P=D?180:0,_=D?-90:90);const L=this.gl;if(u[2]===0||u[3]===0){const e0=L.canvas.width/v.fovMM[0],j=L.canvas.height/v.fovMM[1],H=Math.min(e0,j),y=e0/H,Y=j/H;v.fovMM[0]*=y,v.fovMM[1]*=Y;let G=(v.mnMM[0]+v.mxMM[0])*.5;v.mnMM[0]=G-v.fovMM[0]*.5,v.mxMM[0]=G+v.fovMM[0]*.5,G=(v.mnMM[1]+v.mxMM[1])*.5,v.mnMM[1]=G-v.fovMM[1]*.5,v.mxMM[1]=G+v.fovMM[1]*.5,u=[0,0,L.canvas.width,L.canvas.height]}if(isNaN(g)){const e0=this.scene.pan2Dxyzmm,j=this.swizzleVec3MM(fromValues$2(e0[0],e0[1],e0[2]),h),H=this.scene.pan2Dxyzmm[3];v.mnMM[0]-=j[0],v.mxMM[0]-=j[0],v.mnMM[1]-=j[1],v.mxMM[1]-=j[1],v.mnMM[0]/=H,v.mxMM[0]/=H,v.mnMM[1]/=H,v.mxMM[1]/=H}let m=2;h===1&&(m=1),h===2&&(m=0);let k=this.scene.crosshairPos[m],e=this.frac2mm(this.scene.crosshairPos);!isNaN(g)&&g!==1/0&&g!==-1/0&&(e=this.frac2mm([.5,.5,.5]),e[m]=g,k=this.mm2frac(e)[m]);const N=e[m];L.clear(L.DEPTH_BUFFER_BIT);let B=this.calculateMvpMatrix2D(u,v.mnMM,v.mxMM,1/0,0,P,_,D);if(g===1/0||g===-1/0){const e0=u.slice();this.draw3D(u,B.modelViewProjectionMatrix,B.modelMatrix,B.normalMatrix,P,_);const j=this.screenSlices[this.screenSlices.length-1];j.leftTopWidthHeight=e0,j.axCorSag=h,j.sliceFrac=1/0,j.AxyzMxy=this.xyMM2xyzMM(h,k),j.leftTopMM=B.leftTopMM,j.fovMM=B.fovMM;return}L.enable(L.DEPTH_TEST),L.blendFunc(L.SRC_ALPHA,L.ONE_MINUS_SRC_ALPHA),L.disable(L.BLEND),L.depthFunc(L.GREATER),L.disable(L.CULL_FACE);let Q=this.sliceMMShader;if(this.opts.isV1SliceShader&&(Q=this.sliceV1Shader),!Q)throw new Error("slice Shader undefined");if(Q.use(this.gl),L.uniform1f(Q.uniforms.overlayOutlineWidth,this.overlayOutlineWidth),L.uniform1f(Q.uniforms.overlayAlphaShader,this.overlayAlphaShader),L.uniform1i(Q.uniforms.isAlphaClipDark,this.isAlphaClipDark?1:0),L.uniform1i(Q.uniforms.backgroundMasksOverlays,this.backgroundMasksOverlays),L.uniform1f(Q.uniforms.drawOpacity,this.drawOpacity),L.enable(L.BLEND),L.blendFunc(L.SRC_ALPHA,L.ONE_MINUS_SRC_ALPHA),L.uniform1f(Q.uniforms.opacity,this.volumes[0].opacity),L.uniform1i(Q.uniforms.axCorSag,h),L.uniform1f(Q.uniforms.slice,k),L.uniformMatrix4fv(Q.uniforms.frac2mm,!1,S),L.uniformMatrix4fv(Q.uniforms.mvpMtx,!1,B.modelViewProjectionMatrix.slice()),L.bindVertexArray(this.genericVAO),L.drawArrays(L.TRIANGLE_STRIP,0,4),L.bindVertexArray(this.unusedVAO),this.screenSlices.push({leftTopWidthHeight:u,axCorSag:h,sliceFrac:k,AxyzMxy:this.xyMM2xyzMM(h,k),leftTopMM:B.leftTopMM,screen2frac:[],fovMM:B.fovMM}),isNaN(g)&&this.drawCrosshairs3D(!0,1,B.modelViewProjectionMatrix,!0,this.opts.isSliceMM),this.opts.meshThicknessOn2D>0){this.opts.meshThicknessOn2D!==1/0&&(B=this.calculateMvpMatrix2D(u,v.mnMM,v.mxMM,this.opts.meshThicknessOn2D,N,P,_,D));const e0=clone$2(B.modelViewProjectionMatrix);multiply(e0,e0,w),this.drawMesh3D(!0,1,e0,B.modelMatrix,B.normalMatrix)}isNaN(g)&&this.drawCrosshairs3D(!1,.15,B.modelViewProjectionMatrix,!0,this.opts.isSliceMM),this.drawSliceOrientationText(u,h),this.readyForSync=!0}calculateMvpMatrix(u,h=[0,0,0,0],g,S){(h[2]===0||h[3]===0)&&(h=[0,0,this.gl.canvas.width,this.gl.canvas.height]);const v=h[2]/h[3];let w=this.furthestFromPivot;const D=this.pivot3D,_=create$3();w=.8*w/this.scene.volScaleMultiplier,v<1?ortho(_,-w,w,-w/v,w/v,w*.01,w*8):ortho(_,-w*v,w*v,-w,w,w*.01,w*8);const P=create$3();P[0]=-1;const L=fromValues$2(0,0,-w*1.8);translate(P,P,L),this.position&&translate(P,P,this.position),rotateX(P,P,deg2rad(270-S)),rotateZ(P,P,deg2rad(g-180)),translate(P,P,[-D[0],-D[1],-D[2]]);const m=create$3();invert(m,P);const k=create$3();transpose(k,m);const e=create$3();return multiply(e,_,P),[e,P,k]}calculateModelMatrix(u,h){if(!this.back)throw new Error("back undefined");const g=create$3();if(g[0]=-1,rotateX(g,g,deg2rad(270-h)),rotateZ(g,g,deg2rad(u-180)),this.back.obliqueRAS){const S=clone$2(this.back.obliqueRAS);multiply(g,g,S)}return g}calculateRayDirection(u,h){const g=this.calculateModelMatrix(u,h),S=fromValues$3(1,0,0,0,0,-1,0,0,0,0,-1,0,0,0,0,1),v=create$3();multiply(v,S,g);const w=create$3();invert(w,v);const D=fromValues$1(0,0,-1,1);transformMat4(D,D,w);const _=fromValues$2(D[0],D[1],D[2]);normalize$1(_,_);const P=5e-5;return Math.abs(_[0])<P&&(_[0]=P),Math.abs(_[1])<P&&(_[1]=P),Math.abs(_[2])<P&&(_[2]=P),_}sceneExtentsMinMax(u=!0){let h=fromValues$2(0,0,0),g=fromValues$2(0,0,0);if(this.volumes.length>0){if(!this.volumeObject3D)throw new Error("volumeObject3D undefined");h=fromValues$2(this.volumeObject3D.extentsMin[0],this.volumeObject3D.extentsMin[1],this.volumeObject3D.extentsMin[2]),g=fromValues$2(this.volumeObject3D.extentsMax[0],this.volumeObject3D.extentsMax[1],this.volumeObject3D.extentsMax[2]),u||(h=fromValues$2(this.volumes[0].extentsMinOrtho[0],this.volumes[0].extentsMinOrtho[1],this.volumes[0].extentsMinOrtho[2]),g=fromValues$2(this.volumes[0].extentsMaxOrtho[0],this.volumes[0].extentsMaxOrtho[1],this.volumes[0].extentsMaxOrtho[2]))}if(this.meshes.length>0){if(this.volumes.length<1){const v=this.meshes[0].extentsMin,w=this.meshes[0].extentsMax;h=fromValues$2(v[0],v[1],v[2]),g=fromValues$2(w[0],w[1],w[2])}for(let v=0;v<this.meshes.length;v++){const w=this.meshes[v].extentsMin,D=this.meshes[v].extentsMax,_=fromValues$2(w[0],w[1],w[2]);min(h,h,_);const P=fromValues$2(D[0],D[1],D[2]);max$2(g,g,P)}}const S=create$2();return subtract$1(S,g,h),[h,g,S]}setPivot3D(){const[u,h]=this.sceneExtentsMinMax(),g=create$2();add$1(g,u,h),scale$2(g,g,.5),this.pivot3D=[g[0],g[1],g[2]],subtract$1(g,h,u),this.extentsMin=u,this.extentsMax=h,this.furthestFromPivot=length$1(g)*.5}getMaxVols(){if(this.volumes.length<1)return 0;let u=0;for(let h=0;h<this.volumes.length;h++)u=Math.max(u,this.volumes[h].nFrame4D);return u}detectPartialllyLoaded4D(){if(this.volumes.length<1)return!1;for(let u=0;u<this.volumes.length;u++)if(this.volumes[u].nFrame4D<this.volumes[u].hdr.dims[4])return!0;return!1}drawGraph(){if(this.getMaxVols()<2)return;const u=this.graph;let h=0;if(this.graph.autoSizeMultiplanar&&this.opts.sliceType===3)for(let o0=0;o0<this.screenSlices.length;o0++){const c0=this.screenSlices[o0].axCorSag;if(c0===0&&(h=this.screenSlices[o0].leftTopWidthHeight[1]),c0!==2)continue;const d0=this.screenSlices[o0].leftTopWidthHeight.slice();d0[1]===h?(u.LTWH[0]=d0[0]+d0[2],u.LTWH[1]=d0[1]):(u.LTWH[0]=d0[0],u.LTWH[1]=d0[1]+d0[3]),u.LTWH[2]=d0[2],u.LTWH[3]=d0[2]}if(u.opacity<=0||u.LTWH[2]<=5||u.LTWH[3]<=5||u.LTWH[0]+u.LTWH[2]>this.gl.canvas.width||u.LTWH[1]+u.LTWH[3]>this.gl.canvas.height)return;u.backColor=[.15,.15,.15,u.opacity],u.lineColor=[1,1,1,1],this.opts.backColor[0]+this.opts.backColor[1]+this.opts.backColor[2]>1.5&&(u.backColor=[.95,.95,.95,u.opacity],u.lineColor=[0,0,0,1]),u.textColor=u.lineColor.slice(),u.lineThickness=4,u.lineAlpha=1,u.lines=[];const g=[];if(u.vols.length<1)this.volumes[0]!=null&&g.push(0);else for(let o0=0;o0<u.vols.length;o0++){const c0=u.vols[o0];this.volumes[c0]==null||this.volumes[c0].nFrame4D<2||g.push(c0)}if(g.length<1)return;const S=this.volumes[g[0]].nFrame4D;if(this.graph.selectedColumn=this.volumes[g[0]].frame4D,S<2){log.debug("Unable to generate a graph: Selected volume is 3D not 4D");return}for(let o0=0;o0<g.length;o0++){u.lines[o0]=[];const c0=this.frac2vox(this.scene.crosshairPos),d0=this.volumes[g[o0]];let v0=d0.nFrame4D;v0=Math.min(v0,S);for(let g0=0;g0<v0;g0++){const T0=d0.getValue(c0[0],c0[1],c0[2],g0);u.lines[o0].push(T0)}}u.lineRGB=[[1,0,0],[0,.7,0],[0,0,1],[1,1,0],[1,0,1],[0,1,1],[1,1,1],[0,0,0]];let v=u.lines[0][0],w=u.lines[0][0];for(let o0=0;o0<u.lines.length;o0++)for(let c0=0;c0<u.lines[o0].length;c0++){const d0=u.lines[o0][c0];v=Math.min(d0,v),w=Math.max(d0,w)}if(u.normalizeValues&&w>v){const o0=w-v;for(let c0=0;c0<u.lines.length;c0++)for(let d0=0;d0<u.lines[c0].length;d0++){const v0=u.lines[c0][d0];u.lines[c0][d0]=(v0-v)/o0}v=0,w=1}v>=w&&(w=v+1),this.drawRect(u.LTWH,u.backColor);const[D,_,P]=tickSpacing(v,w),L=Math.max(0,-1*Math.floor(Math.log(D)/Math.log(10)));v=Math.min(_,v),w=Math.max(P,w);function m(o0){return o0.toFixed(6).replace(/\.?0*$/,"")}const e=.07*(Math.min(u.LTWH[2],u.LTWH[3])/(this.fontMets.size*this.uiData.dpr));let N=this.opts.textHeight*this.gl.canvas.height*e;N<16&&(N=0);let B=0,Q=_;if(N>0)for(;Q<=w;){const o0=Q.toFixed(L),c0=this.textWidth(N,o0);B=Math.max(c0,B),Q+=D}const e0=.05,j=Math.abs(u.LTWH[2]),H=Math.abs(u.LTWH[3]),y=[u.LTWH[0]+e0*j+B,u.LTWH[1]+e0*H,u.LTWH[2]-B-2*e0*j,u.LTWH[3]-N-2*e0*H];this.graph.LTWH=u.LTWH,this.graph.plotLTWH=y,this.drawRect(y,this.opts.backColor);const Y=w-v,G=y[3]/Y,Z=y[2]/(u.lines[0].length-1),i0=y[1]+y[3];Q=_+.5*D;const z=u.lineColor.slice();for(z[3]=.25*u.lineColor[3];Q<=w;){const o0=i0-(Q-v)*G;this.drawLine([y[0],o0,y[0]+y[2],o0],.5*u.lineThickness,z),Q+=D}Q=_;const f=.5*u.lineThickness;for(;Q<=w;){const o0=i0-(Q-v)*G;this.drawLine([y[0]-f,o0,y[0]+y[2]+u.lineThickness,o0],u.lineThickness,u.lineColor);const c0=Q.toFixed(L);N>0&&this.drawTextLeft([y[0]-6,o0],c0,e,u.textColor),Q+=D}let f0=1;for(;u.lines[0].length/f0>20;)f0*=5;for(let o0=0;o0<u.lines[0].length;o0+=f0){const c0=o0*Z+y[0];let d0=u.lineThickness;if(o0%2===1)d0*=.5,this.drawLine([c0,y[1],c0,y[1]+y[3]],d0,z);else{const v0=m(o0);N>0&&this.drawTextBelow([c0,2+y[1]+y[3]],v0,e,u.textColor),this.drawLine([c0,y[1],c0,y[1]+y[3]],d0,u.lineColor)}}for(let o0=0;o0<u.lines.length;o0++){let c0=[1,0,0,u.lineAlpha];o0<u.lineRGB.length&&(c0=[u.lineRGB[o0][0],u.lineRGB[o0][1],u.lineRGB[o0][2],u.lineAlpha]);for(let d0=1;d0<u.lines[o0].length;d0++){const v0=(d0-1)*Z,g0=d0*Z,T0=(u.lines[o0][d0-1]-v)*G,x0=(u.lines[o0][d0]-v)*G,M0=[y[0]+v0,y[1]+y[3]-T0,y[0]+g0,y[1]+y[3]-x0];this.drawLine(M0,u.lineThickness,c0)}}if(u.selectedColumn>=0&&u.selectedColumn<u.lines[0].length){const o0=u.selectedColumn*Z+y[0];this.drawLine([o0,y[1],o0,y[1]+y[3]],u.lineThickness,[u.lineRGB[3][0],u.lineRGB[3][1],u.lineRGB[3][2],1])}this.detectPartialllyLoaded4D()&&this.drawTextBelow([y[0]+y[2],y[1]+y[3]+N*.5],"...",e,u.textColor)}depthPicker(u,h){if(!this.uiData.mouseDepthPicker)return;this.uiData.mouseDepthPicker=!1;const g=this.gl,S=this.mousePos[0]*u[2]/u[2],v=g.canvas.height-this.mousePos[1]*u[3]/u[3]-1,w=new Uint8Array(4);if(g.readPixels(S,v,1,1,g.RGBA,g.UNSIGNED_BYTE,w),this.selectedObjectId=w[3],this.selectedObjectId===this.VOLUME_ID){this.scene.crosshairPos=new Float32Array(w.slice(0,3)).map(k=>k/255);return}const D=unpackFloatFromVec4i(w);if(D>1)return;const _=(this.mousePos[0]-u[0])/u[2],P=(g.canvas.height-this.mousePos[1]-u[1])/u[3],L=unProject(_,P,D,h),m=this.mm2frac(L,0,!0);m[0]<0||m[0]>1||m[1]<0||m[1]>1||m[2]<0||m[2]>1||(this.scene.crosshairPos=this.mm2frac(L,0,!0))}drawImage3D(u,h,g){if(this.volumes.length===0)return;const S=this.gl,v=this.calculateRayDirection(h,g),w=this.volumeObject3D;if(w){S.enable(S.BLEND),S.blendFunc(S.SRC_ALPHA,S.ONE_MINUS_SRC_ALPHA),S.enable(S.CULL_FACE),S.cullFace(S.FRONT);let D=this.renderShader;if(this.uiData.mouseDepthPicker&&(D=this.pickingImageShader),D.use(this.gl),S.uniform1i(D.uniforms.backgroundMasksOverlays,this.backgroundMasksOverlays),this.gradientTextureAmount>0){S.activeTexture(TEXTURE6_GRADIENT),S.bindTexture(S.TEXTURE_3D,this.gradientTexture);const _=this.calculateModelMatrix(h,g),P=create$3();invert(P,_);const L=create$3();transpose(L,P),S.uniformMatrix4fv(D.uniforms.normMtx,!1,L)}this.drawBitmap&&this.drawBitmap.length>8?S.uniform2f(D.uniforms.renderDrawAmbientOcclusionXY,this.renderDrawAmbientOcclusion,this.drawOpacity):S.uniform2f(D.uniforms.renderDrawAmbientOcclusionXY,this.renderDrawAmbientOcclusion,0),S.uniformMatrix4fv(D.uniforms.mvpMtx,!1,u),S.uniformMatrix4fv(D.uniforms.matRAS,!1,this.back.matRAS),S.uniform3fv(D.uniforms.rayDir,v),this.gradientTextureAmount<0?S.uniform4fv(D.uniforms.clipPlane,[this.scene.crosshairPos[0],this.scene.crosshairPos[1],this.scene.crosshairPos[2],30]):S.uniform4fv(D.uniforms.clipPlane,this.scene.clipPlane),S.uniform1f(D.uniforms.drawOpacity,1),S.bindVertexArray(w.vao),S.drawElements(w.mode,w.indexCount,S.UNSIGNED_SHORT,0),S.bindVertexArray(this.unusedVAO)}}drawOrientationCube(u,h=0,g=0){if(!this.opts.isOrientCube)return;const S=.05*Math.min(u[2],u[3]);if(S<5)return;const v=this.gl;v.enable(v.CULL_FACE),v.cullFace(v.BACK),this.orientCubeShader.use(this.gl),v.bindVertexArray(this.orientCubeShaderVAO);const w=create$3(),D=create$3();ortho(D,0,v.canvas.width,0,v.canvas.height,-10*S,10*S);let _=0;u[1]===0&&(_=v.canvas.height-this.effectiveCanvasHeight()),translate(w,w,[1.8*S+u[0],_+1.8*S+u[1],0]),scale$3(w,w,[S,S,S]),rotateX(w,w,deg2rad(270-g)),rotateZ(w,w,deg2rad(-h));const P=create$3();multiply(P,D,w),v.uniformMatrix4fv(this.orientCubeShader.uniforms.u_matrix,!1,P),v.drawArrays(v.TRIANGLE_STRIP,0,168),v.bindVertexArray(this.unusedVAO),this.gl.disable(this.gl.CULL_FACE)}createOnLocationChange(u=NaN){const[h,g,S]=this.sceneExtentsMinMax(!0),v=Math.max(Math.max(S[0],S[1]),S[2]);function w(k){return Math.max(0,-Math.ceil(Math.log10(Math.abs(k))))}let D=w(v*.001);const _=this.frac2mm(this.scene.crosshairPos,0,!0);function P(k,e=0){return parseFloat(k.toFixed(e))}let L=P(_[0],D)+"×"+P(_[1],D)+"×"+P(_[2],D);if(this.volumes.length>0&&this.volumes[0].nFrame4D>0&&(L+="×"+P(this.volumes[0].frame4D)),this.volumes.length>0){let k=" = ";for(let B=0;B<this.volumes.length;B++){const Q=this.volumes[B].mm2vox(_);let e0=this.volumes[B].getValue(Q[0],Q[1],Q[2],this.volumes[B].frame4D);if(D=3,this.volumes[B].colormapLabel!==null){const j=Math.round(e0);j>=0&&j<this.volumes[B].colormapLabel.labels.length?k+=this.volumes[B].colormapLabel.labels[j]:k+="undefined("+P(e0,D)+")"}else k+=P(e0,D);this.volumes[B].imaginary&&(e0=this.volumes[B].getValue(Q[0],Q[1],Q[2],this.volumes[B].frame4D,!0),e0>=0&&(k+="+"),k+=P(e0,D)),k+="   "}L+=k;const e=this.back.dimsRAS,N=e[1]*e[2]*e[3];if(this.drawBitmap&&this.drawBitmap.length===N){const B=this.frac2vox(this.scene.crosshairPos),Q=B[0]+B[1]*e[1]+B[2]*e[1]*e[2];L+=" "+this.drawLut.labels[this.drawBitmap[Q]]}}const m={mm:this.frac2mm(this.scene.crosshairPos,0,!0),axCorSag:u,vox:this.frac2vox(this.scene.crosshairPos),frac:this.scene.crosshairPos,xy:[this.mousePos[0],this.mousePos[1]],values:this.volumes.map(k=>{const e=this.frac2mm(this.scene.crosshairPos,0,!0),N=k.mm2vox(e),B=k.getValue(N[0],N[1],N[2],k.frame4D);return{name:k.name,value:B,id:k.id,mm:e,vox:N}}),string:L};this.onLocationChange(m)}addLabel(u,h,g){const S={textColor:this.opts.legendTextColor,textScale:1,textAlignment:"left",lineWidth:0,lineColor:this.opts.legendTextColor,lineTerminator:"none",bulletScale:0,bulletColor:this.opts.legendTextColor},v=h?{...S,...h}:{...S},w=new NVLabel3D(u,v,g);return this.document.labels.push(w),w}calculateScreenPoint(u,h,g){const S=create$1();return transformMat4(S,[...u,1],h),S[3]!==0&&(S[0]=(S[0]/S[3]+1)*.5*g[2],S[1]=(1-S[1]/S[3])*.5*g[3],S[2]/=S[3],S[0]+=g[0],S[1]+=g[1]),S}getLabelAtPoint(u){log.debug("screenPoint",u);const h=this.getLegendPanelHeight(),g=this.getLegendPanelWidth(),S=this.gl.canvas.width-g;let v=(this.canvas.height-h)/2;if(log.debug("panelrect",S,v,S+g,v+h),u[0]<S||u[1]<v||u[0]>S+g||u[1]>v+h)return null;const D=this.opts.textHeight*Math.min(this.gl.canvas.height,this.gl.canvas.width)*1,_=this.getAllLabels();for(const P of _){const L=this.opts.textHeight*this.gl.canvas.height*P.style.textScale,m=this.textHeight(L,P.text);if(u[1]>=v&&u[1]<=v+m+D/2)return P;v+=m,v+=D/2}return null}drawLabelLine(u,h,g,S,v=!1){const w=Array.isArray(u.points)&&Array.isArray(u.points[0])?u.points:[u.points];for(const D of w){const _=this.calculateScreenPoint(D,g,S);v?this.drawDottedLine([...h,_[0],_[1]],u.style.lineWidth,u.style.lineColor):this.draw3DLine(h,[_[0],_[1],_[2]],u.style.lineWidth,u.style.lineColor)}}draw3DLabel(u,h,g,S,v=0,w,D=!1){const _=u.text,P=h[0],L=h[1],m=this.opts.textHeight*Math.min(this.gl.canvas.height,this.gl.canvas.width)*1,k=this.textHeight(u.style.textScale,_)*m;if(u.style.lineWidth>0&&Array.isArray(u.points)&&this.drawLabelLine(u,[P,L+k],g,S,D),u.style.bulletScale){const N=u.style.bulletScale*k,B=k-N,Q=L+B/2+N/2,e0=P+(v-N)/2;this.drawCircle([e0,Q,N,N],u.style.bulletColor)}let e=P;if(u.style.textAlignment!=="left"){const N=this.textWidth(u.style.textScale,u.text)*m;if(u.style.textAlignment==="right")e=P+w-m*1.5-N;else{const B=w-(v||m);e+=(B-N)/2}}else e+=v;this.drawText([e,L],_,u.style.textScale,u.style.textColor)}draw3DLabels(u,h,g=!1){const S=this.getAllLabels();if(!this.opts.showLegend||S.length===0)return;if(!this.canvas)throw new Error("canvas undefined");const v=this.gl;v.disable(v.CULL_FACE),v.viewport(0,0,this.canvas.width,this.canvas.height);const D=this.opts.textHeight*Math.min(this.gl.canvas.height,this.gl.canvas.width)*1,_=this.getBulletMarginWidth(),P=this.getLegendPanelHeight(),L=this.getLegendPanelWidth(),m=v.canvas.width-L;let k=(this.canvas.height-P)/2;this.drawRect([v.canvas.width-L,k,L-D,P],this.opts.legendBackgroundColor);const e=v.getParameter(v.BLEND),N=v.getParameter(v.DEPTH_FUNC);g||(v.disable(v.BLEND),v.depthFunc(v.GREATER));for(const B of S){this.draw3DLabel(B,[m,k],u,h,_,L,g);const Q=this.opts.textHeight*this.gl.canvas.height*B.style.textScale,e0=this.textHeight(Q,B.text);k+=e0,k+=D/2}g||(v.depthFunc(N),e&&v.enable(v.BLEND))}draw3D(u=[0,0,0,0],h=null,g=null,S=null,v=null,w=0){const D=v!==null;this.setPivot3D(),D||(v=this.scene.renderAzimuth,w=this.scene.renderElevation);const _=this.gl;h===null&&([h,g,S]=this.calculateMvpMatrix(null,u,v,w));let P=[...u];if(u[2]===0||u[3]===0?(u=[0,0,_.canvas.width,_.canvas.height],P=[...u],this.screenSlices.push({leftTopWidthHeight:u,axCorSag:4,sliceFrac:0,AxyzMxy:[],leftTopMM:[],fovMM:[isRadiological(g),0]})):(this.screenSlices.push({leftTopWidthHeight:u.slice(),axCorSag:4,sliceFrac:0,AxyzMxy:[],leftTopMM:[],fovMM:[isRadiological(g),0]}),u[1]=_.canvas.height-u[3]-u[1]),_.enable(_.DEPTH_TEST),_.depthFunc(_.ALWAYS),_.depthMask(!0),_.clearDepth(0),this.draw3DLabels(h,P,!1),_.viewport(u[0],u[1],u[2],u[3]),this.volumes.length>0&&(this.updateInterpolation(0,!0),this.updateInterpolation(1,!0),this.drawImage3D(h,v,w)),this.updateInterpolation(0),this.updateInterpolation(1),D||this.drawCrosshairs3D(!0,1,h),this.drawMesh3D(!0,1,h,g,S),this.uiData.mouseDepthPicker){this.depthPicker(u,h),this.createOnLocationChange(),this.draw3D(u,h,g,S,v,w);return}this.opts.meshXRay>0&&this.drawMesh3D(!1,this.opts.meshXRay,h,g,S),this.draw3DLabels(h,P,!1),_.viewport(u[0],u[1],u[2],u[3]),D||this.drawCrosshairs3D(!1,.15,h),_.viewport(0,0,_.canvas.width,_.canvas.height),this.drawOrientationCube(u,v,w);const L="azimuth: "+this.scene.renderAzimuth.toFixed(0)+" elevation: "+this.scene.renderElevation.toFixed(0);return this.readyForSync=!0,this.sync(),this.draw3DLabels(h,P,!0),L}drawMesh3D(u=!0,h=1,g,S,v){if(this.meshes.length<1)return;const w=this.gl;g||([g,S,v]=this.calculateMvpMatrix(this.volumeObject3D,void 0,this.scene.renderAzimuth,this.scene.renderElevation)),w.enable(w.DEPTH_TEST),w.blendFunc(w.SRC_ALPHA,w.ONE_MINUS_SRC_ALPHA),w.disable(w.BLEND),w.depthFunc(w.GREATER),w.disable(w.CULL_FACE),u?(w.disable(w.BLEND),w.depthFunc(w.GREATER)):(w.enable(w.BLEND),w.depthFunc(w.ALWAYS),w.enable(w.CULL_FACE)),w.cullFace(w.BACK);let D=this.meshShaders[0].shader,_=!1;for(let P=0;P<this.meshes.length;P++)if(this.meshes[P].visible!==!1&&(D=this.meshShaders[this.meshes[P].meshShaderIndex].shader,this.uiData.mouseDepthPicker&&(D=this.pickingMeshShader),D.use(this.gl),w.uniformMatrix4fv(D.uniforms.mvpMtx,!1,g),w.uniformMatrix4fv(D.uniforms.normMtx,!1,v),w.uniform1f(D.uniforms.opacity,h),!(this.meshes[P].indexCount<3))){if(this.meshes[P].offsetPt0&&(this.meshes[P].fiberSides<3||this.meshes[P].fiberRadius<=0)){_=!0;continue}D.isMatcap&&(w.activeTexture(TEXTURE5_MATCAP),w.bindTexture(w.TEXTURE_2D,this.matCapTexture)),w.bindVertexArray(this.meshes[P].vao),w.drawElements(w.TRIANGLES,this.meshes[P].indexCount,w.UNSIGNED_INT,0),w.bindVertexArray(this.unusedVAO)}if(!_){w.enable(w.BLEND),w.depthFunc(w.ALWAYS);return}D=this.fiberShader,D.use(this.gl),w.uniformMatrix4fv(D.uniforms.mvpMtx,!1,g),w.uniform1f(D.uniforms.opacity,h);for(let P=0;P<this.meshes.length;P++)this.meshes[P].indexCount<3||this.meshes[P].offsetPt0&&(this.meshes[P].fiberSides>=3&&this.meshes[P].fiberRadius>0||(w.bindVertexArray(this.meshes[P].vaoFiber),w.drawElements(w.LINE_STRIP,this.meshes[P].indexCount,w.UNSIGNED_INT,0),w.bindVertexArray(this.unusedVAO)));w.enable(w.BLEND),w.depthFunc(w.ALWAYS),this.readyForSync=!0}drawCrosshairs3D(u=!0,h=1,g=null,S=!1,v=!0){if(!this.opts.show3Dcrosshair&&!S||this.opts.crosshairWidth<=0&&S)return;const w=this.gl,D=this.frac2mm(this.scene.crosshairPos,0,v);if(this.crosshairs3D===null||this.crosshairs3D.mm[0]!==D[0]||this.crosshairs3D.mm[1]!==D[1]||this.crosshairs3D.mm[2]!==D[2]){this.crosshairs3D!==null&&(w.deleteBuffer(this.crosshairs3D.indexBuffer),w.deleteBuffer(this.crosshairs3D.vertexBuffer));const[L,m,k]=this.sceneExtentsMinMax(v);let e=1;if(this.volumes.length>0){if(!this.back)throw new Error("back undefined");e=.5*Math.min(Math.min(this.back.pixDims[1],this.back.pixDims[2]),this.back.pixDims[3])}else(k[0]<50||k[0]>1e3)&&(e=k[0]*.02);e*=this.opts.crosshairWidth,this.crosshairs3D=NiivueObject3D.generateCrosshairs(this.gl,1,D,L,m,e,20,this.opts.crosshairGap),this.crosshairs3D.mm=D}if(!this.surfaceShader)throw new Error("surfaceShader undefined");const _=this.surfaceShader;_.use(this.gl),g==null&&([g]=this.calculateMvpMatrix(this.crosshairs3D,void 0,this.scene.renderAzimuth,this.scene.renderElevation)),w.uniformMatrix4fv(_.uniforms.mvpMtx,!1,g),w.bindBuffer(w.ELEMENT_ARRAY_BUFFER,this.crosshairs3D.indexBuffer),w.enable(w.DEPTH_TEST);const P=[...this.opts.crosshairColor];u?(w.disable(w.BLEND),w.depthFunc(w.GREATER)):(w.enable(w.BLEND),w.blendFunc(w.SRC_ALPHA,w.ONE_MINUS_SRC_ALPHA),w.depthFunc(w.ALWAYS)),P[3]=h,w.uniform4fv(_.uniforms.surfaceColor,P),w.bindVertexArray(this.crosshairs3D.vao),w.drawElements(w.TRIANGLES,this.crosshairs3D.indexCount,w.UNSIGNED_INT,0),w.bindVertexArray(this.unusedVAO)}mm2frac(u,h=0,g=!1){if(this.volumes.length<1){const S=fromValues$2(.1,.5,.5),[v,w,D]=this.sceneExtentsMinMax();return S[0]=(u[0]-v[0])/D[0],S[1]=(u[1]-v[1])/D[1],S[2]=(u[2]-v[2])/D[2],isFinite(S)||(isFinite(S[0])||(S[0]=.5),isFinite(S[1])||(S[1]=.5),isFinite(S[2])||(S[2]=.5),this.meshes.length<1&&log.error("mm2frac() not finite: objects not (yet) loaded.")),S}return this.volumes[h].convertMM2Frac(u,g||this.opts.isSliceMM)}vox2frac(u,h=0){return this.volumes[h].convertVox2Frac(u)}frac2vox(u,h=0){return this.volumes.length<=h?[0,0,0]:this.volumes[h].convertFrac2Vox(u)}moveCrosshairInVox(u,h,g){const S=this.frac2vox(this.scene.crosshairPos);S[0]+=u,S[1]+=h,S[2]+=g,S[0]=clamp(S[0],0,this.volumes[0].dimsRAS[1]-1),S[1]=clamp(S[1],0,this.volumes[0].dimsRAS[2]-1),S[2]=clamp(S[2],0,this.volumes[0].dimsRAS[3]-1),this.scene.crosshairPos=this.vox2frac(S),this.createOnLocationChange(),this.drawScene()}frac2mm(u,h=0,g=!1){const S=fromValues$1(u[0],u[1],u[2],1);if(this.volumes.length>0)return this.volumes[h].convertFrac2MM(u,g||this.opts.isSliceMM);{const[v,w]=this.sceneExtentsMinMax(),D=(_,P,L)=>_*(1-L)+P*L;S[0]=D(v[0],w[0],u[0]),S[1]=D(v[1],w[1],u[1]),S[2]=D(v[2],w[2],u[2])}return S}screenXY2TextureFrac(u,h,g,S=!0){const v=fromValues$2(-1,-1,-1),w=this.screenSlices[g].axCorSag;if(w>2)return v;const D=this.screenSlices[g].leftTopWidthHeight.slice();let _=!1;D[2]<0&&(_=!0,D[0]+=D[2],D[2]=-D[2]);let P=(u-D[0])/D[2];_&&(P=1-P);const L=1-(h-D[1])/D[3];if(P<0||P>1||L<0||L>1||this.screenSlices[g].AxyzMxy.length<4)return v;let m=fromValues$2(0,0,0);m[0]=this.screenSlices[g].leftTopMM[0]+P*this.screenSlices[g].fovMM[0],m[1]=this.screenSlices[g].leftTopMM[1]+L*this.screenSlices[g].fovMM[1];const k=this.screenSlices[g].AxyzMxy;m[2]=k[2]+k[4]*(m[1]-k[1])-k[3]*(m[0]-k[0]),w===1&&(m=swizzleVec3(m,[0,2,1])),w===2&&(m=swizzleVec3(m,[2,0,1]));const e=this.mm2frac(m);return S&&(e[0]<0||e[0]>1||e[1]<0||e[1]>1||e[2]<0||e[2]>1)?v:e}canvasPos2frac(u){for(let h=0;h<this.screenSlices.length;h++){const g=this.screenXY2TextureFrac(u[0],u[1],h);if(g[0]>=0)return g}return[-1,-1,-1]}scaleSlice(u,h,g=0,S=0){const v=this.effectiveCanvasWidth()-g,w=this.effectiveCanvasHeight()-S;let D=v/u;h*D>w&&(D=w/h);const _=u*D,P=h*D;return[(v-_)*.5,(w-P)*.5,_,P,D]}drawThumbnail(){if(!this.bmpShader)throw new Error("bmpShader undefined");this.bmpShader.use(this.gl),this.gl.uniform2f(this.bmpShader.uniforms.canvasWidthHeight,this.gl.canvas.width,this.gl.canvas.height);let u=this.gl.canvas.height,h=this.gl.canvas.height*this.bmpTextureWH;h>this.gl.canvas.width&&(u=this.gl.canvas.width/this.bmpTextureWH,h=this.gl.canvas.width),this.gl.uniform4f(this.bmpShader.uniforms.leftTopWidthHeight,0,0,h,u),this.gl.bindVertexArray(this.genericVAO),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),this.gl.bindVertexArray(this.unusedVAO)}drawLine(u,h=1,g=[1,0,0,-1]){if(this.gl.bindVertexArray(this.genericVAO),!this.lineShader)throw new Error("lineShader undefined");this.lineShader.use(this.gl),g[3]<0&&(g=this.opts.crosshairColor),this.gl.uniform4fv(this.lineShader.uniforms.lineColor,g),this.gl.uniform2fv(this.lineShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.uniform1f(this.lineShader.uniforms.thickness,h),this.gl.uniform4fv(this.lineShader.uniforms.startXYendXY,u),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),this.gl.bindVertexArray(this.unusedVAO)}draw3DLine(u,h,g=1,S=[1,0,0,-1]){if(this.gl.bindVertexArray(this.genericVAO),!this.line3DShader)throw new Error("line3DShader undefined");this.line3DShader.use(this.gl),S[3]<0&&(S=this.opts.crosshairColor),this.gl.uniform4fv(this.line3DShader.uniforms.lineColor,S),this.gl.uniform2fv(this.line3DShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.uniform1f(this.line3DShader.uniforms.thickness,g),this.gl.uniform2fv(this.line3DShader.uniforms.startXY,u),this.gl.uniform3fv(this.line3DShader.uniforms.endXYZ,h),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),this.gl.bindVertexArray(this.unusedVAO)}drawDottedLine(u,h=1,g=[1,0,0,-1]){if(this.gl.bindVertexArray(this.genericVAO),!this.lineShader)throw new Error("lineShader undefined");this.lineShader.use(this.gl);const S=g[3]<0?[...this.opts.crosshairColor]:[...g];S[3]=.3;const v=fromValues(u[2]-u[0],u[3]-u[1]),w=length(v);normalize(v,v);const _=this.opts.textHeight*Math.min(this.gl.canvas.height,this.gl.canvas.width)*1;scale(v,v,_/2);const P=length(v);let L=Math.floor(w/P);w%P&&L++;const m=[u[0],u[1]];this.gl.uniform4fv(this.lineShader.uniforms.lineColor,S),this.gl.uniform2fv(this.lineShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.uniform1f(this.lineShader.uniforms.thickness,h);for(let k=0;k<L-1;k++){if(k%2){m[0]+=v[0],m[1]+=v[1];continue}const e=[m[0],m[1],m[0]+v[0],m[1]+v[1]];this.gl.uniform4fv(this.lineShader.uniforms.startXYendXY,e),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),m[0]+=v[0],m[1]+=v[1]}this.gl.bindVertexArray(this.unusedVAO)}drawGraphLine(u,h=[1,0,0,.5],g=2){this.drawLine(u,g,h)}drawCrossLinesMM(u,h,g,S,v){if(u<0||this.screenSlices.length<=u)return;const w=this.screenSlices[u];let D=w.sliceFrac;D===1/0&&log.warn("Rendering approximate cross lines in world view mode"),D===1/0&&(D=.5);let P=S.slice(),L=v.slice();const m=Math.max(1,this.opts.crosshairWidth);h===1&&(P=g.slice()),h===2&&(P=g.slice(),L=S.slice());function k(e){const N=fromValues(0,0);return N[0]=w.leftTopWidthHeight[0]+(e[0]-w.leftTopMM[0])/w.fovMM[0]*w.leftTopWidthHeight[2],N[1]=w.leftTopWidthHeight[1]+w.leftTopWidthHeight[3]-(e[1]-w.leftTopMM[1])/w.fovMM[1]*w.leftTopWidthHeight[3],N}if(P.length>0&&h===0){const e=D,N=1;for(let B=0;B<P.length;B++){const Q=this.frac2mm([.5,.5,.5]);Q[N]=P[B];let e0=this.mm2frac(Q);e0=e0[N];let j=this.frac2mm([0,e0,e]);j=swizzleVec3(j,[0,1,2]);let H=this.frac2mm([1,e0,e]);H=swizzleVec3(H,[0,1,2]),j=k(j),H=k(H),this.drawLine([j[0],j[1],H[0],H[1]],m)}}if(P.length>0&&h===1){const e=D,N=2;for(let B=0;B<P.length;B++){const Q=this.frac2mm([.5,.5,.5]);Q[N]=P[B];let e0=this.mm2frac(Q);e0=e0[N];let j=this.frac2mm([0,e,e0]);j=swizzleVec3(j,[0,2,1]);let H=this.frac2mm([1,e,e0]);H=swizzleVec3(H,[0,2,1]),j=k(j),H=k(H),this.drawLine([j[0],j[1],H[0],H[1]],m)}}if(P.length>0&&h===2){const e=D,N=2;for(let B=0;B<P.length;B++){const Q=this.frac2mm([.5,.5,.5]);Q[N]=P[B];let e0=this.mm2frac(Q);e0=e0[N];let j=this.frac2mm([e,0,e0]);j=swizzleVec3(j,[1,2,0]);let H=this.frac2mm([e,1,e0]);H=swizzleVec3(H,[1,2,0]),j=k(j),H=k(H),this.drawLine([j[0],j[1],H[0],H[1]],m)}}if(L.length>0&&h===0){const e=D,N=0;for(let B=0;B<L.length;B++){const Q=this.frac2mm([.5,.5,.5]);Q[N]=L[B];let e0=this.mm2frac(Q);e0=e0[N];let j=this.frac2mm([e0,0,e]);j=swizzleVec3(j,[0,1,2]);let H=this.frac2mm([e0,1,e]);H=swizzleVec3(H,[0,1,2]),j=k(j),H=k(H),this.drawLine([j[0],j[1],H[0],H[1]],m)}}if(L.length>0&&h===1){const e=D,N=0;for(let B=0;B<L.length;B++){const Q=this.frac2mm([.5,.5,.5]);Q[N]=L[B];let e0=this.mm2frac(Q);e0=e0[N];let j=this.frac2mm([e0,e,0]);j=swizzleVec3(j,[0,2,1]);let H=this.frac2mm([e0,e,1]);H=swizzleVec3(H,[0,2,1]),j=k(j),H=k(H),this.drawLine([j[0],j[1],H[0],H[1]],m)}}if(L.length>0&&h===2){const e=D,N=1;for(let B=0;B<L.length;B++){const Q=this.frac2mm([.5,.5,.5]);Q[N]=L[B];let e0=this.mm2frac(Q);e0=e0[N];let j=this.frac2mm([e,e0,0]);j=swizzleVec3(j,[1,2,0]);let H=this.frac2mm([e,e0,1]);H=swizzleVec3(H,[1,2,0]),j=k(j),H=k(H),this.drawLine([j[0],j[1],H[0],H[1]],m)}}}drawCrossLines(u,h,g,S,v){if(u<0||this.screenSlices.length<=u)return;if(this.opts.isSliceMM)return this.drawCrossLinesMM(u,h,g,S,v);if(this.screenSlices[u].sliceFrac===1/0)return this.drawCrossLinesMM(u,h,g,S,v);const w=this.screenSlices[u];let D=S.slice(),_=v.slice();if(h===1&&(D=g.slice()),h===2&&(D=g.slice(),_=S.slice()),D.length>0){const P=w.leftTopWidthHeight.slice();let L=2;h===0&&(L=1);const m=this.frac2mm([.5,.5,.5]);for(let k=0;k<D.length;k++){m[L]=D[k];const e=this.mm2frac(m);this.drawRect([P[0],P[1]+P[3]-e[L]*P[3],P[2],1])}}if(_.length>0){const P=w.leftTopWidthHeight.slice(),L=w.fovMM[0]<0;let m=0;h===2&&(m=1);const k=this.frac2mm([.5,.5,.5]);for(let e=0;e<_.length;e++){k[m]=_[e];const N=this.mm2frac(k);L?this.drawRect([P[0]+(P[2]-N[m]*P[2]),P[1],1,P[3]]):this.drawRect([P[0]+N[m]*P[2],P[1],1,P[3]])}}}drawMosaic(u){if(this.volumes.length===0){log.debug("Unable to draw mosaic until voxel-based image is loaded");return}this.screenSlices=[];const h=this.screenFieldOfViewMM(0,!0),g=this.screenFieldOfViewMM(0);u=u.replaceAll(";"," ;").trim();const S=[],v=[],w=[],D=u.split(/\s+/);let _=1;const P=this.opts.textHeight;let L=0,m=0;for(let k=0;k<2;k++){let e=!1,N=!1;e=!1;let B=0,Q=0,e0=0,j=0,H=!1,y=0;for(let Z=0;Z<D.length;Z++){const i0=D[Z];if(i0.includes("X")){N=!0;continue}if(i0.includes("L")){H=!i0.includes("-");continue}if(i0.includes("V")||i0.includes("H")){Z++;continue}i0.includes("A")&&(y=0),i0.includes("C")&&(y=1),i0.includes("S")&&(y=2),i0.includes("R")&&(e=!0),i0.includes(";")&&(e0+=B,j=Math.max(j,Q),B=0,Q=0);const z=parseFloat(i0);if(isNaN(z))continue;let f=0,f0=0,o0=g;if(e&&(o0=h),y===2?f=o0[1]:f=o0[0],y===0?f0=o0[1]:f0=o0[2],k===0)e||(y===0&&S.push(z),y===1&&v.push(z),y===2&&w.push(z));else{const c0=[L+_*Q,m+_*e0,_*f,_*f0];if(this.opts.textHeight=H?P:0,e){let d0=z<0?-1/0:1/0;Object.is(z,-0)&&(d0=-1/0),this.draw2D(c0,y,d0)}else this.draw2D(c0,y,z);N&&this.drawCrossLines(this.screenSlices.length-1,y,S,v,w),e=!1,N=!1}Q+=f,B=Math.max(B,f0)}if(e0+=B,j=Math.max(j,Q),j<=0||e0<=0)break;const Y=this.gl.canvas.width/j,G=this.effectiveCanvasHeight()/e0;_=Math.min(Y,G),this.opts.centerMosaic&&(L=Math.floor(.5*(this.gl.canvas.width-j*_)),m=Math.floor(.5*(this.effectiveCanvasHeight()-e0*_)))}this.opts.textHeight=P}drawSceneCore(){if(!this.initialized)return;if(this.colorbarHeight=0,this.gl.clearColor(this.opts.backColor[0],this.opts.backColor[1],this.opts.backColor[2],this.opts.backColor[3]),this.gl.clear(this.gl.COLOR_BUFFER_BIT|this.gl.DEPTH_BUFFER_BIT),this.bmpTexture&&this.thumbnailVisible){this.drawThumbnail();return}let u="";if(this.volumes.length===0||typeof this.volumes[0].dims>"u"){if(this.meshes.length>0){this.screenSlices=[],this.opts.sliceType=4,this.draw3D(),this.opts.isColorbar&&this.drawColorbar();return}this.drawLoadingText(this.loadingText);return}if(this.back===null)return;if(this.uiData.isDragging&&this.scene.clipPlaneDepthAziElev[0]<1.8&&this.inRenderTile(this.uiData.dragStart[0],this.uiData.dragStart[1])>=0){const v=this.uiData.dragStart[0]-this.uiData.dragEnd[0],w=this.uiData.dragStart[1]-this.uiData.dragEnd[1],D=this.uiData.dragClipPlaneStartDepthAziElev.slice();if(D[1]-=v,D[1]=D[1]%360,D[2]+=w,D[1]!==this.scene.clipPlaneDepthAziElev[1]||D[2]!==this.scene.clipPlaneDepthAziElev[2])return this.scene.clipPlaneDepthAziElev=D,this.setClipPlane(this.scene.clipPlaneDepthAziElev)}if(this.sliceMosaicString.length<1&&this.opts.sliceType===4){this.opts.isColorbar&&this.reserveColorbarPanel(),this.screenSlices=[],this.draw3D(),this.opts.isColorbar&&this.drawColorbar();return}this.opts.isColorbar&&this.reserveColorbarPanel();const h=this.getMaxVols(),g=this.opts.sliceType===3&&h>1&&this.graph.autoSizeMultiplanar&&this.graph.opacity>0;if(this.sliceMosaicString.length>0)this.drawMosaic(this.sliceMosaicString);else if(this.gl.viewport(0,0,this.gl.canvas.width,this.gl.canvas.height),this.screenSlices=[],this.opts.sliceType===0)this.draw2D([0,0,0,0],0);else if(this.opts.sliceType===1)this.draw2D([0,0,0,0],1);else if(this.opts.sliceType===2)this.draw2D([0,0,0,0],2);else{let v=!1;this.opts.multiplanarForceRender?(v=!0,this.opts.multiplanarForceRender?this.opts.multiplanarShowRender=1:this.opts.multiplanarShowRender=2,delete this.opts.multiplanarForceRender):this.opts.multiplanarShowRender===1&&(v=!0);const w=isFinite(this.drawPenLocation[0])&&this.opts.drawingEnabled,{volScale:D}=this.sliceScale();typeof this.opts.multiplanarPadPixels!="number"&&log.debug("multiplanarPadPixels must be numeric");const _=parseFloat(`${this.opts.multiplanarPadPixels}`),P=this.scaleSlice(D[0]+D[1],D[1]+D[2],_*1,_*1),L=Math.max(Math.max(D[1],D[2]),D[0]),m=this.scaleSlice(D[0]+D[0]+D[1],Math.max(D[1],D[2]),_*2),k=this.scaleSlice(D[0]+D[0]+D[1]+L,Math.max(D[1],D[2]),_*3),e=this.scaleSlice(L,D[1]+D[2]+D[2],0,_*2),N=this.scaleSlice(L,D[1]+D[2]+D[2]+L,0,_*3);let B=!w&&(h<2||!g),Q=!1,e0=!1,j=!1;if(this.opts.multiplanarLayout===1?Q=!0:this.opts.multiplanarLayout===2?e0=!0:this.opts.multiplanarLayout===3?j=!0:e[4]>m[4]&&e[4]>P[4]?Q=!0:m[4]>P[4]?j=!0:e0=!0,Q){let H=e;v||this.opts.multiplanarShowRender===2&&N[4]>=e[4]?H=N:B=!1;const y=D[0]*H[4],Y=D[1]*H[4],G=D[2]*H[4],Z=L*H[4];this.draw2D([H[0],H[1],y,Y],0),this.draw2D([H[0],H[1]+Y+_,y,G],1),this.draw2D([H[0],H[1]+Y+_+G+_,Y,G],2),B&&this.draw3D([H[0],H[1]+Y+G+G+_*3,Z,Z])}else if(j){let H=m;v||this.opts.multiplanarShowRender===2&&k[4]>=m[4]?H=k:B=!1;const y=D[0]*H[4],Y=D[1]*H[4],G=D[2]*H[4];this.draw2D([H[0],H[1],y,Y],0),this.draw2D([H[0]+y+_,H[1],y,G],1),this.draw2D([H[0]+y+y+_*2,H[1],Y,G],2),B&&this.draw3D([H[0]+y+y+Y+_*3,H[1],H[3],H[3]])}else if(e0){v||(B=!1),this.opts.multiplanarShowRender===2&&(B=!0);const H=P,y=D[0]*H[4],Y=D[1]*H[4],G=D[2]*H[4];this.draw2D([H[0],H[1]+G+_,y,Y],0),this.draw2D([H[0],H[1],y,G],1),this.draw2D([H[0]+y+_,H[1],Y,G],2),B&&this.draw3D([H[0]+y+_,H[1]+G+_,Y,Y])}}if(this.opts.isRuler&&this.drawRuler(),this.opts.isColorbar&&this.drawColorbar(),g&&this.drawGraph(),this.uiData.isDragging){if(this.uiData.mouseButtonCenterDown){this.dragForCenterButton([this.uiData.dragStart[0],this.uiData.dragStart[1],this.uiData.dragEnd[0],this.uiData.dragEnd[1]]);return}if(this.opts.dragMode===4){this.dragForSlicer3D([this.uiData.dragStart[0],this.uiData.dragStart[1],this.uiData.dragEnd[0],this.uiData.dragEnd[1]]);return}if(this.opts.dragMode===3){this.dragForPanZoom([this.uiData.dragStart[0],this.uiData.dragStart[1],this.uiData.dragEnd[0],this.uiData.dragEnd[1]]);return}if(this.inRenderTile(this.uiData.dragStart[0],this.uiData.dragStart[1])>=0)return;if(this.opts.dragMode===2){this.drawMeasurementTool([this.uiData.dragStart[0],this.uiData.dragStart[1],this.uiData.dragEnd[0],this.uiData.dragEnd[1]]);return}const v=Math.abs(this.uiData.dragStart[0]-this.uiData.dragEnd[0]),w=Math.abs(this.uiData.dragStart[1]-this.uiData.dragEnd[1]);this.drawSelectionBox([Math.min(this.uiData.dragStart[0],this.uiData.dragEnd[0]),Math.min(this.uiData.dragStart[1],this.uiData.dragEnd[1]),v,w])}const S=this.frac2mm([this.scene.crosshairPos[0],this.scene.crosshairPos[1],this.scene.crosshairPos[2]]);return u=S[0].toFixed(2)+"×"+S[1].toFixed(2)+"×"+S[2].toFixed(2),this.readyForSync=!0,this.sync(),u}drawScene(){if(this.isBusy){this.needsRefresh=!0;return}this.isBusy=!1,this.needsRefresh=!1;let u=this.drawSceneCore();return this._gl!==null&&this.gl.finish(),this.needsRefresh&&(u=this.drawScene()),u}get gl(){if(!this._gl)throw new Error("unable to get WebGL context. Maybe the browser doesn't support WebGL2.");return this._gl}set gl(u){this._gl=u}},niimathOperators_default={bptfm:{args:["hp","lp"],help:"Same as bptf but does not remove mean (emulates fslmaths < 5.0.7)"},bwlabel:{args:["conn"],help:"Connected component labelling for non-zero voxels (conn sets neighbors: 6, 18, 26)"},c2h:{args:[],help:"reverse h2c transform"},ceil:{args:[],help:"round voxels upwards to the nearest integer"},conform:{args:[],help:"reslice to 1mm size in coronal slice direction with 256^3 voxels"},crop:{args:["tmin","tsize"],help:"remove volumes, starts with 0 not 1! Inputting -1 for a size will set it to the full range"},dehaze:{args:["mode"],help:"set dark voxels to zero (mode 1..5; higher yields more surviving voxels)"},detrend:{args:[],help:"remove linear trend (and mean) from input"},demean:{args:[],help:"remove average signal across volumes (requires 4D input)"},edt:{args:[],help:"estimate Euler Distance Transform (distance field). Assumes isotropic input"},close:{args:["thr","dx1","dx2"],help:"morphological close that binarizes with `thr`, dilates with `dx1` and erodes with `dx2` (fills bubbles with `thr`)"},floor:{args:[],help:"round voxels downwards to the nearest integer"},h2c:{args:[],help:"convert CT scans from 'Hounsfield' to 'Cormack' units to emphasize soft tissue contrast"},mesh:{args:[],help:"meshify requires 'd'ark, 'm'edium, 'b'right or numeric isosurface ('niimath bet -mesh -i d mesh.gii')",subOperations:{i:{args:["isovalue"],help:"'d'ark, 'm'edium, 'b'right or numeric isosurface"},a:{args:["atlasFile"],help:"roi based atlas to mesh"},b:{args:["fillBubbles"],help:"fill bubbles"},l:{args:["onlyLargest"],help:"only largest"},o:{args:["originalMC"],help:"original marching cubes"},q:{args:["quality"],help:"quality"},s:{args:["postSmooth"],help:"post smooth"},r:{args:["reduceFraction"],help:"reduce fraction"},v:{args:["verbose"],help:"verbose"}}},hollow:{args:["threshold","thickness"],help:"hollow out a mesh"},mod:{args:[],help:"modulus fractional remainder - same as '-rem' but includes fractions"},otsu:{args:["mode"],help:"binarize image using Otsu's method (mode 1..5; higher yields more bright voxels)"},power:{args:["exponent"],help:"raise the current image by following exponent"},qform:{args:["code"],help:"set qform_code"},sform:{args:["code"],help:"set sform_code"},p:{args:["threads"],help:"set maximum number of parallel threads. DISABLED: recompile for OpenMP support"},resize:{args:["X","Y","Z","m"],help:"grow (>1) or shrink (<1) image. Method <m> (0=nearest,1=linear,2=spline,3=Lanczos,4=Mitchell)"},round:{args:[],help:"round voxels to the nearest integer"},sobel:{args:[],help:"fast edge detection"},sobel_binary:{args:[],help:"sobel creating binary edge"},tensor_2lower:{args:[],help:"convert FSL style upper triangle image to NIfTI standard lower triangle order"},tensor_2upper:{args:[],help:"convert NIfTI standard lower triangle image to FSL style upper triangle order"},tensor_decomp_lower:{args:[],help:"as tensor_decomp except input stores lower diagonal (AFNI, ANTS, Camino convention)"},trunc:{args:[],help:"truncates the decimal value from floating point value and returns integer value"},unsharp:{args:["sigma","scl"],help:"edge enhancing unsharp mask (sigma in mm, not voxels; 1.0 is typical)"},dog:{args:["sPos","sNeg"],help:"difference of gaussian with zero-crossing edges (positive and negative sigma mm)"},dogr:{args:["sPos","sNeg"],help:"as dog, without zero-crossing (raw rather than binarized data)"},dogx:{args:["sPos","sNeg"],help:"as dog, zero-crossing for 2D sagittal slices"},dogy:{args:["sPos","sNeg"],help:"as dog, zero-crossing for 2D coronal slices"},dogz:{args:["sPos","sNeg"],help:"as dog, zero-crossing for 2D axial slices"},add:{args:["input"],help:"add following input to current image"},sub:{args:["input"],help:"subtract following input from current image"},mul:{args:["input"],help:"multiply current image by following input"},div:{args:["input"],help:"divide current image by following input"},rem:{args:["number"],help:"modulus remainder - divide current image by following input and take remainder"},mas:{args:["file"],help:"use (following image>0) to mask current image"},thr:{args:["number"],help:"use following number to threshold current image (zero anything below the number)"},thrp:{args:["input"],help:"use following percentage (0-100) of ROBUST RANGE to threshold current image (zero anything below the number)"},thrP:{args:["input"],help:"use following percentage (0-100) of ROBUST RANGE of non-zero voxels and threshold below"},uthr:{args:["number"],help:"use following number to upper-threshold current image (zero anything above the number)"},uthrp:{args:["input"],help:"use following percentage (0-100) of ROBUST RANGE to upper-threshold current image (zero anything above the number)"},uthrP:{args:["input"],help:"use following percentage (0-100) of ROBUST RANGE of non-zero voxels and threshold above"},clamp:{args:["input"],help:"use following percentage (0-100) of ROBUST RANGE to threshold current image (anything below set to this threshold)"},uclamp:{args:["input"],help:"use following percentage (0-100) of ROBUST RANGE to threshold current image (anything above set to this threshold)"},max:{args:["input"],help:"take maximum of following input and current image"},min:{args:["input"],help:"take minimum of following input and current image"},seed:{args:["number"],help:"seed random number generator with following number"},restart:{args:["file"],help:"replace the current image with input for future processing operations"},save:{args:[],help:"save the current working image to the input filename"},inm:{args:["mean"],help:"(-i i ip.c) intensity normalisation (per 3D volume mean)"},ing:{args:["mean"],help:"(-I i ip.c) intensity normalisation, global 4D mean)"},s:{args:["sigma"],help:"create a gauss kernel of sigma mm and perform mean filtering"},exp:{args:[],help:"exponential"},log:{args:[],help:"natural logarithm"},sin:{args:[],help:"sine function"},cos:{args:[],help:"cosine function"},tan:{args:[],help:"tangent function"},asin:{args:[],help:"arc sine function"},acos:{args:[],help:"arc cosine function"},atan:{args:[],help:"arc tangent function"},sqr:{args:[],help:"square"},sqrt:{args:[],help:"square root"},recip:{args:[],help:"reciprocal (1/current image)"},abs:{args:[],help:"absolute value"},bin:{args:[],help:"use (current image>0) to binarise"},binv:{args:[],help:"binarise and invert (binarisation and logical inversion)"},fillh:{args:[],help:"fill holes in a binary mask (holes are internal - i.e. do not touch the edge of the FOV)"},fillh26:{args:[],help:"fill holes using 26 connectivity"},index:{args:[],help:"replace each nonzero voxel with a unique (subject to wrapping) index number"},grid:{args:["value","spacing"],help:"add a 3D grid of intensity <value> with grid spacing <spacing>"},edge:{args:[],help:"edge strength"},tfce:{args:["H","E","connectivity"],help:"enhance with TFCE, e.g. -tfce 2 0.5 6 (maybe change 6 to 26 for skeletons)"},tfceS:{args:["H","E","connectivity","X","Y","Z","tfce_thresh"],help:"show support area for voxel (X,Y,Z)"},nan:{args:[],help:"replace NaNs (improper numbers) with 0"},nanm:{args:[],help:"make NaN (improper number) mask with 1 for NaN voxels, 0 otherwise"},rand:{args:[],help:"add uniform noise (range 0:1)"},randn:{args:[],help:"add Gaussian noise (mean=0 sigma=1)"},range:{args:[],help:"set the output calmin/max to full data range"},tensor_decomp:{args:[],help:"convert a 4D (6-timepoint )tensor image into L1,2,3,FA,MD,MO,V1,2,3 (remaining image in pipeline is FA)"},kernel:{subOperations:{"3D":{args:[],help:"3x3x3 box centered on target voxel (set as default kernel)"},"2D":{args:[],help:"3x3x1 box centered on target voxel"},box:{args:["size"],help:"all voxels in a cube of width <size> mm centered on target voxel"},boxv:{args:["size"],help:"all voxels in a cube of width <size> voxels centered on target voxel, CAUTION: size should be an odd number"},boxv3:{args:["X","Y","Z"],help:"all voxels in a cuboid of dimensions X x Y x Z centered on target voxel, CAUTION: size should be an odd number"},gauss:{args:["sigma"],help:"gaussian kernel (sigma in mm, not voxels)"},sphere:{args:["size"],help:"all voxels in a sphere of radius <size> mm centered on target voxel"},file:{args:["filename"],help:"use external file as kernel"}}},dilM:{args:[],help:"Mean Dilation of non-zero voxels"},dilD:{args:[],help:"Maximum Dilation of non-zero voxels (emulating output of fslmaths 6.0.1, max not modal)"},dilF:{args:[],help:"Maximum filtering of all voxels"},dilall:{args:[],help:"Apply -dilM repeatedly until the entire FOV is covered"},ero:{args:[],help:"Erode by zeroing non-zero voxels when zero voxels found in kernel"},eroF:{args:[],help:"Minimum filtering of all voxels"},fmedian:{args:[],help:"Median Filtering"},fmean:{args:[],help:"Mean filtering, kernel weighted (conventionally used with gauss kernel)"},fmeanu:{args:[],help:"Mean filtering, kernel weighted, un-normalized (gives edge effects)"},subsamp2:{args:[],help:"downsamples image by a factor of 2 (keeping new voxels centered on old)"},subsamp2offc:{args:[],help:"downsamples image by a factor of 2 (non-centered)"},Tmean:{args:[],help:"mean across time"},Tstd:{args:[],help:"standard deviation across time"},Tmax:{args:[],help:"max across time"},Tmaxn:{args:[],help:"time index of max across time"},Tmin:{args:[],help:"min across time"},Tmedian:{args:[],help:"median across time"},Tperc:{args:["percentage"],help:"nth percentile (0-100) of FULL RANGE across time"},Tar1:{args:[],help:"temporal AR(1) coefficient (use -odt float and probably demean first)"},pval:{args:[],help:"Nonparametric uncorrected P-value, assuming timepoints are the permutations; first timepoint is actual (unpermuted) stats image"},pval0:{args:[],help:"Same as -pval, but treat zeros as missing data"},cpval:{args:[],help:"Same as -pval, but gives FWE corrected P-values"},ztop:{args:[],help:"Convert Z-stat to (uncorrected) P"},ptoz:{args:[],help:"Convert (uncorrected) P to Z"},ztopc:{args:[],help:"Convert Z-stat to (uncorrected but clamped) P"},ptozc:{args:[],help:"Convert (uncorrected but clamped) P to Z"},rank:{args:[],help:"Convert data to ranks (over T dim)"},ranknorm:{args:[],help:"Transform to Normal dist via ranks"},roi:{args:["xmin","xsize","ymin","ysize","zmin","zsize","tmin","tsize"],help:"zero outside roi (using voxel coordinates). Inputting -1 for a size will set it to the full image extent for that dimension"},bptf:{args:["hp_sigma","lp_sigma"],help:"(-t in ip.c) Bandpass temporal filtering; nonlinear highpass and Gaussian linear lowpass (with sigmas in volumes, not seconds); set either sigma<0 to skip that filter"},roc:{args:["AROC-thresh","outfile","truth"],help:"take (normally binary) truth and test current image in ROC analysis against truth. <AROC-thresh> is usually 0.05 and is limit of Area-under-ROC measure FP axis. <outfile> is a text file of the ROC curve (triplets of values: FP TP threshold). If the truth image contains negative voxels these get excluded from all calculations. If <AROC-thresh> is positive then the [4Dnoiseonly] option needs to be set, and the FP rate is determined from this noise-only data, and is set to be the fraction of timepoints where any FP (anywhere) is seen, as found in the noise-only 4d-dataset. This is then controlling the FWE rate. If <AROC-thresh> is negative the FP rate is calculated from the zero-value parts of the <truth> image, this time averaging voxelwise FP rate over all timepoints. In both cases the TP rate is the average fraction of truth=positive voxels correctly found"}},Niimath=class{constructor(){this.worker=null,this.operators=niimathOperators_default}init(){return this.worker=new Worker(new URL(""+new URL("worker-Jat8hhVx.js",import.meta.url).href,import.meta.url),{type:"module"}),new Promise((T,u)=>{this.worker.onmessage=h=>{h.data&&h.data.type==="ready"&&T(!0)},this.worker.onerror=h=>{u(new Error(`Worker failed to load: ${h.message}`))}})}image(T){return new ImageProcessor({worker:this.worker,file:T,operators:this.operators})}},ImageProcessor=class{constructor({worker:T,file:u,operators:h}){this.worker=T,this.file=u,this.operators=h,this.commands=[],this._generateMethods()}_addCommand(T,...u){return this.commands.push(T,...u.map(String)),this}_generateMethods(){Object.keys(this.operators).forEach(T=>{const u=this.operators[T];T==="kernel"?Object.keys(u.subOperations).forEach(h=>{const g=u.subOperations[h];this[`kernel${h.charAt(0).toUpperCase()+h.slice(1)}`]=(...S)=>{if(S.length!==g.args.length)throw new Error(`Expected ${g.args.length} arguments for kernel ${h}, but got ${S.length}`);return this._addCommand("-kernel",h,...S)}}):T==="mesh"?this.mesh=(h={})=>{const g=[];return Object.keys(h).forEach(S=>{if(u.subOperations[S]){const v=u.subOperations[S],w=h[S];if(v.args.length>0&&w===void 0)throw new Error(`Sub-option -${S} requires a value.`);g.push(`-${S}`),v.args.length>0&&g.push(w)}else throw new Error(`Invalid sub-option -${S} for mesh.`)}),this._addCommand("-mesh",...g)}:this[T]=(...h)=>{if(h.length<u.args.length||!u.optional&&h.length>u.args.length)throw new Error(`Expected ${u.args.length} arguments for ${T}, but got ${h.length}`);return this._addCommand(`-${T}`,...h)}})}async run(T="output.nii"){return new Promise((u,h)=>{this.worker.onmessage=S=>{if(S.data.type==="error")h(new Error(S.data.message));else{const{blob:v,exitCode:w}=S.data;w===0?u(v):h(new Error(`niimath processing failed with exit code ${w}`))}};const g=[this.file.name,...this.commands,T];this.worker===null&&h(new Error("Worker not initialized. Did you await the init() method?")),this.worker.postMessage({blob:this.file,cmd:g,outName:T})})}};const brainChopOpts={batchSize:1,numOfChan:1,isColorEnable:!0,isAutoColors:!0,bgLabelValue:0,drawBoundingVolume:!1,isGPU:!0,isBrainCropMaskBased:!0,showPhase1Output:!1,isPostProcessEnable:!0,isContoursViewEnable:!1,browserArrayBufferMaxZDim:30,telemetryFlag:!1,chartXaxisStepPercent:10,uiSampleName:"BC_UI_Sample",atlasSelectedColorTable:"Fire"},inferenceModelsList=[{id:1,type:"Segmentation",path:"/models/model5_gw_ae/model.json",modelName:"⚡ Tissue GWM (light)",labelsPath:"./models/model5_gw_ae/labels.json",colorsPath:"./models/model5_gw_ae/colorLUT.json",colormapPath:"./models/model5_gw_ae/colormap3.json",preModelId:null,preModelPostProcess:!1,isBatchOverlapEnable:!1,numOverlapBatches:0,enableTranspose:!0,enableCrop:!0,cropPadding:18,autoThreshold:0,enableQuantileNorm:!1,filterOutWithPreMask:!1,enableSeqConv:!1,textureSize:0,warning:null,inferenceDelay:100,description:"Gray and white matter segmentation model. Operates on full T1 image in a single pass, but uses only 5 filters per layer. Can work on integrated graphics cards but is barely large enough to provide good accuracy. Still more accurate than the subvolume model."},{id:2,type:"Segmentation",path:"/models/model20chan3cls/model.json",modelName:"🔪 Tissue GWM (High Acc)",labelsPath:"./models/model20chan3cls/labels.json",colorsPath:"./models/model20chan3cls/colorLUT.json",colormapPath:"./models/model20chan3cls/colormap.json",preModelId:null,preModelPostProcess:!1,isBatchOverlapEnable:!1,numOverlapBatches:0,enableTranspose:!0,enableCrop:!0,cropPadding:0,autoThreshold:.2,enableQuantileNorm:!0,filterOutWithPreMask:!1,enableSeqConv:!1,textureSize:0,warning:"This model may need dedicated graphics card.  For more info please check with Browser Resources <i class='fa fa-cogs'></i>.",inferenceDelay:100,description:"Gray and white matter segmentation model. Operates on full T1 image in a single pass but needs a dedicated graphics card to operate. Provides the best accuracy with hard cropping for better speed"},{id:3,type:"Segmentation",path:"/models/model20chan3cls/model.json",modelName:"🔪 Tissue GWM (High Acc, Low Mem)",labelsPath:"./models/model20chan3cls/labels.json",colorsPath:"./models/model20chan3cls/colorLUT.json",colormapPath:"./models/model20chan3cls/colormap.json",preModelId:null,preModelPostProcess:!1,isBatchOverlapEnable:!1,numOverlapBatches:0,enableTranspose:!0,enableCrop:!0,cropPadding:0,autoThreshold:.2,enableQuantileNorm:!0,filterOutWithPreMask:!1,enableSeqConv:!0,textureSize:0,warning:"This model may need dedicated graphics card.  For more info please check with Browser Resources <i class='fa fa-cogs'></i>.",inferenceDelay:100,description:"Gray and white matter segmentation model. Operates on full T1 image in a single pass but needs a dedicated graphics card to operate. Provides high accuracy and fit low memory available but slower"},{id:4,type:"Atlas",path:"/models/model30chan18cls/model.json",modelName:"🪓 Subcortical + GWM (High Mem, Fast)",labelsPath:"./models/model30chan18cls/labels.json",colorsPath:"./models/model30chan18cls/colorLUT.json",colormapPath:"./models/model30chan18cls/colormap.json",preModelId:null,preModelPostProcess:!1,isBatchOverlapEnable:!1,numOverlapBatches:200,enableTranspose:!0,enableCrop:!0,cropPadding:0,autoThreshold:.2,enableQuantileNorm:!1,filterOutWithPreMask:!1,enableSeqConv:!1,textureSize:0,warning:"This model may need dedicated graphics card.  For more info please check with Browser Resources <i class='fa fa-cogs'></i>.",inferenceDelay:100,description:"Parcellation of the brain into 17 regions: gray and white matter plus subcortical areas. This is a robust model able to handle range of data quality, including varying saturation, and even clinical scans. It may work on infant brains, but your mileage may vary."},{id:5,type:"Atlas",path:"/models/model30chan18cls/model.json",modelName:"🪓 Subcortical + GWM (Low Mem, Slow)",labelsPath:"./models/model30chan18cls/labels.json",colorsPath:"./models/model30chan18cls/colorLUT.json",colormapPath:"./models/model30chan18cls/colormap.json",preModelId:null,preModelPostProcess:!1,isBatchOverlapEnable:!1,numOverlapBatches:200,enableTranspose:!0,enableCrop:!0,cropPadding:0,autoThreshold:.2,enableQuantileNorm:!1,filterOutWithPreMask:!1,enableSeqConv:!0,textureSize:0,warning:"This model may need dedicated graphics card.  For more info please check with Browser Resources <i class='fa fa-cogs'></i>.",inferenceDelay:100,description:"Parcellation of the brain into 17 regions: gray and white matter plus subcortical areas. This is a robust model able to handle range of data quality, including varying saturation, and even clinical scans. 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Float32Array(w);for(let _=0;_<w;_++){let P=u[_];P=h+v*(P-S),P=Math.max(P,h),P=Math.min(P,g),D[_]=P}return D}getScale(u,h=0,g=255,S=0,v=.999){let w=u.global_min,D=u.global_max;if(u.hdr.datatypeCode===2)return[w,1];if((!isFinite(S)||!isFinite(v))&&isFinite(u.cal_min)&&isFinite(u.cal_max)&&u.cal_max>u.cal_min){w=u.cal_min,D=u.cal_max;const H=(g-h)/(D-w);return log.info(" Robust Rescale:  min: "+w+"  max: "+D+" scale: "+H),console.log("Robust Rescale:  min: "+w+"  max: "+D+" scale: "+H),[w,H]}const _=u.img,P=u.hdr.dims[1]*u.hdr.dims[2]*u.hdr.dims[3];if(u.hdr.scl_slope!==1||u.hdr.scl_inter!==0){const H=u.img,y=new Float32Array(u.img.length);for(let Y=0;Y<P;Y++)y[Y]=H[Y]*u.hdr.scl_slope+u.hdr.scl_inter}if(w<0&&log.warn("WARNING: Input image has value(s) below 0.0 !"),log.info(" Input:    min: "+w+"  max: "+D),S===0&&v===1)return[w,1];let L=0;for(let H=0;H<P;H++)Math.abs(_[H])>=1e-15&&L++;const m=1e3,k=(D-w)/m,e=new Array(m).fill(0);for(let H=0;H<P;H++){const y=_[H];let Y=Math.floor((y-w)/k);Y=Math.min(Y,m-1),e[Y]++}const N=new Array(m).fill(0);N[0]=e[0];for(let H=1;H<m;H++)N[H]=N[H-1]+e[H];let B=Math.floor(S*P),Q=0;for(;Q<m&&!(N[Q]>=B);)Q++;const e0=w;for(w=Q*k+e0,B=P-Math.floor((1-v)*L),Q=0;Q<m-1&&!(N[Q+1]>=B);)Q++;D=Q*k+e0;let j=1;return w!==D&&(j=(g-h)/(D-w)),log.info(" Rescale:  min: "+w+"  max: "+D+" scale: "+j),[w,j]}conformVox2Vox(u,h,g=256,S=1,v=!1){const w=h.flat(),D=fromValues$3(w[0],w[1],w[2],w[3],w[4],w[5],w[6],w[7],w[8],w[9],w[10],w[11],w[12],w[13],w[14],w[15]),_=fromValues$1(u[1]/2,u[2]/2,u[3]/2,1),P=create$1(),L=create$3();transpose(L,D),transformMat4(P,_,L);const m=fromValues$2(P[0],P[1],P[2]),k=fromValues$2(S,S,S);let e=fromValues$3(-1,0,0,0,0,0,1,0,0,-1,0,0,0,0,0,1);v&&(e=fromValues$3(1,0,0,0,0,1,0,0,0,0,1,0,0,0,0,1)),transpose(e,e);const N=fromValues$1(g,g,g,1),B=create$3();scale$3(B,e,k);const Q=fromValues$1(N[0],N[1],N[2],1);transformMat4(Q,Q,B),scale$1(Q,Q,.5);const e0=create$2();subtract$1(e0,m,fromValues$2(Q[0],Q[1],Q[2]));const j=create$3();transpose(j,B),j[3]=e0[0],j[7]=e0[1],j[11]=e0[2];const H=create$3();invert(H,j);const y=create$3();mul(y,D,H);const Y=create$3();return invert(Y,y),[j,y,Y]}async createNiftiArray(u=[256,256,256],h=[1,1,1],g=[1,0,0,-128,0,1,0,-128,0,0,1,-128,0,0,0,1],S=2,v=new Uint8Array){return await NVImage.createNiftiArray(u,h,g,S,v)}async niftiArray2NVImage(u=new Uint8Array){return await NVImage.loadFromUrl({url:u})}async loadFromUrl(u){return await NVImage.loadFromUrl({url:u})}async conform(u,h=!1,g=!0,S=!1,v=!1){const _=this.conformVox2Vox(u.hdr.dims,u.hdr.affine.flat(),256,1,h),P=_[0],L=_[2],m=256*256*256,k=new Float32Array(m),e=new Float32Array(u.img),N=u.hdr.dims[1]*u.hdr.dims[2]*u.hdr.dims[3];if(u.hdr.scl_slope!==1||u.hdr.scl_inter!==0)for(let f0=0;f0<N;f0++)e[f0]=e[f0]*u.hdr.scl_slope+u.hdr.scl_inter;const B=u.hdr.dims[1],Q=u.hdr.dims[2],e0=u.hdr.dims[3],j=B*Q;let H=-1;function y(f0,o0,c0){return f0+o0*B+c0*j}const Y=L[0],G=L[4],Z=L[8];if(g)for(let f0=0;f0<256;f0++)for(let o0=0;o0<256;o0++){const c0=o0*L[1]+f0*L[2]+L[3],d0=o0*L[5]+f0*L[6]+L[7],v0=o0*L[9]+f0*L[10]+L[11];for(let g0=0;g0<256;g0++){const T0=g0*Y+c0,x0=g0*G+d0,M0=g0*Z+v0,ee=Math.floor(T0),re=Math.floor(x0),Fe=Math.floor(M0);if(H++,ee<0||re<0||Fe<0)continue;const Oe=Math.ceil(T0),ke=Math.ceil(x0),I0=Math.ceil(M0);if(Oe>=B||ke>=Q||I0>=e0)continue;const Be=T0-ee,Ge=x0-re,ti=M0-Fe,ai=1-Be,ri=1-Ge,qe=1-ti,be=y(ee,re,Fe);let J0=0;J0+=e[be]*ai*ri*qe,J0+=e[be+j]*ai*ri*ti,J0+=e[be+B]*ai*Ge*qe,J0+=e[be+B+j]*ai*Ge*ti,J0+=e[be+1]*Be*ri*qe,J0+=e[be+1+j]*Be*ri*ti,J0+=e[be+1+B]*Be*Ge*qe,J0+=e[be+1+B+j]*Be*Ge*ti,k[H]=J0}}else for(let f0=0;f0<256;f0++)for(let o0=0;o0<256;o0++){const c0=o0*L[1]+f0*L[2]+L[3],d0=o0*L[5]+f0*L[6]+L[7],v0=o0*L[9]+f0*L[10]+L[11];for(let g0=0;g0<256;g0++){const T0=Math.round(g0*Y+c0),x0=Math.round(g0*G+d0),M0=Math.round(g0*Z+v0);H++,!(T0<0||x0<0||M0<0)&&(T0>=B||x0>=Q||M0>=e0||(k[H]=e[y(T0,x0,M0)]))}}let i0=0;v&&(i0=NaN);let z=new Uint8Array;if(S){const f0=await this.getScale(u,0,1,i0),o0=await this.scalecropFloat32(k,0,1,f0[0],f0[1]);z=await this.createNiftiArray([256,256,256],[1,1,1],Array.from(P),16,new Uint8Array(o0.buffer))}else{const f0=await this.getScale(u,0,255,i0),o0=await this.scalecropUint8(k,0,255,f0[0],f0[1]);z=await this.createNiftiArray([256,256,256],[1,1,1],Array.from(P),2,o0)}return await this.niftiArray2NVImage(z)}setRenderDrawAmbientOcclusion(u){if(!this.renderShader)throw new Error("renderShader undefined");this.renderDrawAmbientOcclusion=u,this.renderShader.use(this.gl),this.gl.uniform1fv(this.renderShader.uniforms.renderDrawAmbientOcclusion,[this.renderDrawAmbientOcclusion,1]),this.drawScene()}setColorMap(u,h){this.setColormap(u,h)}setColormapNegative(u,h){const g=this.getVolumeIndexByID(u);this.volumes[g].colormapNegative=h,this.updateGLVolume()}setModulationImage(u,h,g=0){const S=this.getVolumeIndexByID(u);let v=null;h.length>0&&(v=this.getVolumeIndexByID(h)),this.volumes[S].modulationImage=v,this.volumes[S].modulateAlpha=g,this.updateGLVolume()}setGamma(u=1){cmapper.gamma=u,this.updateGLVolume()}async loadDeferred4DVolumes(u){const h=this.getVolumeIndexByID(u),g=this.volumes[h];if(g.nTotalFrame4D<=g.nFrame4D)return;let S;g.fileObject?S=await NVImage.loadFromFile({file:g.fileObject}):S=await NVImage.loadFromUrl({url:g.url}),S&&(g.img=S.img.slice(),g.nTotalFrame4D=S.nTotalFrame4D,g.nFrame4D=S.nFrame4D,this.updateGLVolume())}setFrame4D(u,h){const g=this.getVolumeIndexByID(u),S=this.volumes[g];h>S.nFrame4D-1&&(h=S.nFrame4D-1),h<0&&(h=0),h!==S.frame4D&&(S.frame4D=h,this.updateGLVolume(),this.onFrameChange(S,h),this.createOnLocationChange())}getFrame4D(u){const h=this.getVolumeIndexByID(u);return this.volumes[h].frame4D}colormapFromKey(u){return cmapper.colormapFromKey(u)}colormap(u="",h=!1){return cmapper.colormap(u,h)}createColormapTexture(u=null,h=0,g=256){return u!==null&&this.gl.deleteTexture(u),h<1||g<1?null:(u=this.gl.createTexture(),this.gl.activeTexture(TEXTURE1_COLORMAPS),this.gl.bindTexture(this.gl.TEXTURE_2D,u),this.gl.texStorage2D(this.gl.TEXTURE_2D,1,this.gl.RGBA8,g,h),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MIN_FILTER,this.gl.LINEAR),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MAG_FILTER,this.gl.LINEAR),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_WRAP_R,this.gl.CLAMP_TO_EDGE),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_WRAP_S,this.gl.CLAMP_TO_EDGE),this.gl.pixelStorei(this.gl.UNPACK_ALIGNMENT,1),u)}addColormapList(u="",h=NaN,g=NaN,S=!1,v=!1,w=!0,D=!1){u.length<1&&(w=!1),this.colormapLists.push({name:u,min:h,max:g,alphaThreshold:S,negative:v,visible:w,invert:D})}refreshColormaps(){if(this.colormapLists=[],this.volumes.length<1&&this.meshes.length<1)return;const u=this.volumes.length;if(u>0)for(let w=0;w<u;w++){const D=this.volumes[w],_=negMinMax(D.cal_min,D.cal_max,D.cal_minNeg,D.cal_maxNeg);this.addColormapList(D.colormapNegative,_[0],_[1],D.alphaThreshold!==void 0,!0,D.colorbarVisible,D.colormapInvert),this.addColormapList(D.colormap,D.cal_min,D.cal_max,D.alphaThreshold!==void 0,!1,D.colorbarVisible,D.colormapInvert)}const h=this.meshes.length;if(h>0)for(let w=0;w<h;w++){const D=this.meshes[w];if(!D.colorbarVisible)continue;const _=D.layers.length;if("edgeColormap"in D&&"edges"in D&&D.edges!==void 0){const P=negMinMax(D.edgeMin,D.edgeMax,NaN,NaN);this.addColormapList(D.edgeColormapNegative,P[0],P[1],!1,!0,!0,D.colormapInvert),this.addColormapList(D.edgeColormap,D.edgeMin,D.edgeMax,!1,!1,!0,D.colormapInvert)}if(!(_<1))for(let P=0;P<_;P++){const L=this.meshes[w].layers[P];if(!L.colorbarVisible||L.colormap.length<1)continue;const m=negMinMax(L.cal_min,L.cal_max,L.cal_minNeg,L.cal_maxNeg);this.addColormapList(L.colormapNegative,m[0],m[1],L.alphaThreshold,!0,!0,L.colormapInvert),this.addColormapList(L.colormap,L.cal_min,L.cal_max,L.alphaThreshold,!1,!0,L.colormapInvert)}}const g=this.colormapLists.length;if(g<1)return;this.colormapTexture=this.createColormapTexture(this.colormapTexture,g+1);let S=new Uint8ClampedArray;function v(w){const D=new Uint8ClampedArray(S.length+w.length);D.set(S),D.set(w,S.length),S=D}for(let w=0;w<g;w++)v(Array.from(this.colormap(this.colormapLists[w].name,this.colormapLists[w].invert)));return v(Array.from(this.drawLut.lut)),this.gl.texSubImage2D(this.gl.TEXTURE_2D,0,0,0,256,g+1,this.gl.RGBA,this.gl.UNSIGNED_BYTE,S),this}sliceScale(u=!1){var w;let h=this.screenFieldOfViewMM(0);u&&(h=this.screenFieldOfViewVox(0));const g=Math.max(h[0],Math.max(h[1],h[2])),S=[h[0]/g,h[1]/g,h[2]/g];if(!((w=this.back)!=null&&w.dims))throw new Error("back.dims undefined");const v=[this.back.dims[1],this.back.dims[2],this.back.dims[3]];return{volScale:S,vox:v,longestAxis:g,dimsMM:h}}tileIndex(u,h){for(let g=0;g<this.screenSlices.length;g++){const S=this.screenSlices[g].leftTopWidthHeight;if(u>S[0]&&h>S[1]&&u<S[0]+S[2]&&h<S[1]+S[3])return g}return-1}inRenderTile(u,h){const g=this.tileIndex(u,h);return g>=0&&this.screenSlices[g].axCorSag===4?g:-1}sliceScroll3D(u=0){if(u!==0){if(this.volumes.length>0&&this.scene.clipPlaneDepthAziElev[0]<1.8){const h=this.scene.clipPlaneDepthAziElev.slice();return u>0&&(h[0]=Math.min(1.5,h[0]+.025)),u<0&&(h[0]=Math.max(-1.5,h[0]-.025)),h[0]!==this.scene.clipPlaneDepthAziElev[0]?(this.scene.clipPlaneDepthAziElev=h,this.setClipPlane(this.scene.clipPlaneDepthAziElev)):void 0}u>0&&(this.scene.volScaleMultiplier=Math.min(2,this.scene.volScaleMultiplier*1.1)),u<0&&(this.scene.volScaleMultiplier=Math.max(.5,this.scene.volScaleMultiplier*.9)),this.drawScene()}}deleteThumbnail(){this.bmpTexture&&(this.gl.deleteTexture(this.bmpTexture),this.bmpTexture=null,this.thumbnailVisible=!1)}inGraphTile(u,h){if(this.graph.opacity<=0||this.volumes.length<1||this.volumes[0].nFrame4D<1||!this.graph.plotLTWH||this.graph.plotLTWH[2]<1||this.graph.plotLTWH[3]<1)return!1;const g=[(u-this.graph.LTWH[0])/this.graph.LTWH[2],(h-this.graph.LTWH[1])/this.graph.LTWH[3]];return g[0]>0&&g[1]>0&&g[0]<=1&&g[1]<=1}mouseClick(u,h,g=0,S=!0){if(u*=this.uiData.dpr,h*=this.uiData.dpr,this.canvas.focus(),this.thumbnailVisible){this.thumbnailVisible=!1,Promise.all([this.loadVolumes(this.deferredVolumes),this.loadMeshes(this.deferredMeshes)]).catch(v=>{throw v});return}if(this.inGraphTile(u,h)){if(!this.graph.plotLTWH)throw new Error("plotLTWH undefined");const v=[(u-this.graph.plotLTWH[0])/this.graph.plotLTWH[2],(h-this.graph.plotLTWH[1])/this.graph.plotLTWH[3]];if(v[0]>0&&v[1]>0&&v[0]<=1&&v[1]<=1){const w=Math.round(v[0]*(this.volumes[0].nFrame4D-1));this.setFrame4D(this.volumes[0].id,w);return}v[0]>.5&&v[1]>1&&this.loadDeferred4DVolumes(this.volumes[0].id).catch(w=>{throw w});return}if(this.inRenderTile(u,h)>=0){this.sliceScroll3D(g),this.drawScene();return}if(!(this.screenSlices.length<1||this.gl.canvas.height<1||this.gl.canvas.width<1))for(let v=0;v<this.screenSlices.length;v++){const w=this.screenSlices[v].axCorSag;if(this.drawPenAxCorSag>=0&&this.drawPenAxCorSag!==w||w>2)continue;const D=this.screenXY2TextureFrac(u,h,v,!1);if(!(D[0]<0)){if(!S){this.scene.crosshairPos[2-w]=g,this.drawScene();return}if(g!==0){let _=1;g<0&&(_=-1);const P=[0,0,0];P[2-w]=_,this.moveCrosshairInVox(P[0],P[1],P[2]),this.drawScene(),this.createOnLocationChange(w);return}if(this.opts.isForceMouseClickToVoxelCenters?this.scene.crosshairPos=clone$1(this.vox2frac(this.frac2vox(D))):this.scene.crosshairPos=clone$1(D),this.opts.drawingEnabled){const _=this.frac2vox(this.scene.crosshairPos);if(this.opts.clickToSegment){const P=this.opts.clickToSegmentRadius,L=this.opts.clickToSegmentSteps,m=this.opts.clickToSegmentBright?Number.POSITIVE_INFINITY:Number.NEGATIVE_INFINITY;this.drawPenFillPts=[],this.drawPenAxCorSag=w;for(let e=1;e<=L;e++){const N=e/L*2*Math.PI;let B=_[0]+P*Math.cos(N),Q=_[1]+P*Math.sin(N);const e0=_[2];B=Math.round(B),Q=Math.round(Q),this.drawPt(B,Q,e0,this.opts.penValue),this.drawPenFillPts.push([B,Q,_[2]]),e===L&&this.drawFloodFill([B,Q,_[2]],0,m,NaN,NaN,this.opts.floodFillNeighbors)}this.drawScene(),this.createOnLocationChange(w);const k=this.getDescriptives(0,[],!0);this.onClickToSegment({mL:k.volumeML,mm3:k.volumeMM3});return}if(!isFinite(this.opts.penValue)||this.opts.penValue<0||Object.is(this.opts.penValue,-0)){isFinite(this.opts.penValue)?this.drawFloodFill(_,Math.abs(this.opts.penValue),this.opts.penValue,NaN,NaN,this.opts.floodFillNeighbors):this.drawFloodFill(_,0,this.opts.penValue,NaN,NaN,this.opts.floodFillNeighbors);return}if(isNaN(this.drawPenLocation[0]))this.drawPenAxCorSag=w,this.drawPenFillPts=[],this.drawPt(..._,this.opts.penValue);else{if(_[0]===this.drawPenLocation[0]&&_[1]===this.drawPenLocation[1]&&_[2]===this.drawPenLocation[2])return;this.drawPenLine(_,this.drawPenLocation,this.opts.penValue)}this.drawPenLocation=_,this.opts.isFilledPen&&this.drawPenFillPts.push(_),this.refreshDrawing(!1)}this.drawScene(),this.createOnLocationChange(w);return}}}drawRuler(){let u=[],h=[];for(let _=0;_<this.screenSlices.length;_++)if(this.screenSlices[_].axCorSag!==4&&this.screenSlices[_].fovMM.length>1){h=this.screenSlices[_].leftTopWidthHeight,u=this.screenSlices[_].fovMM;break}if(h.length<4)return;const S=100/u[0]*h[2],v=h[0]+.5*h[2]-.5*S,w=h[1]+h[3]-2*this.opts.rulerWidth,D=[v,w,v+S,w];this.drawRuler10cm(D)}drawRuler10cm(u){if(!this.lineShader)throw new Error("lineShader undefined");this.gl.bindVertexArray(this.genericVAO),this.lineShader.use(this.gl),this.gl.uniform4fv(this.lineShader.uniforms.lineColor,this.opts.rulerColor),this.gl.uniform2fv(this.lineShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.uniform1f(this.lineShader.uniforms.thickness,this.opts.rulerWidth),this.gl.uniform4fv(this.lineShader.uniforms.startXYendXY,u),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4);const h=-.1*(u[0]-u[2]),g=u[1],S=g-2*this.opts.rulerWidth,v=g-4*this.opts.rulerWidth;for(let w=0;w<11;w++){const D=u[0]+w*h,_=[D,g,D,S];w%5===0&&(_[3]=v),this.gl.uniform4fv(this.lineShader.uniforms.startXYendXY,_),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4)}this.gl.bindVertexArray(this.unusedVAO)}screenXY2mm(u,h,g=-1){let S;for(let v=0;v<this.screenSlices.length;v++){let w=v;if(g>=0&&(w=g),this.screenSlices[w].axCorSag>2)continue;const _=this.screenSlices[w].leftTopWidthHeight;if(u<_[0]||h<_[1]||u>_[0]+_[2]||h>_[1]+_[3]||(S=this.screenXY2TextureFrac(u,h,w,!1),S[0]<0))continue;const P=this.frac2mm(S);return fromValues$1(P[0],P[1],P[2],w)}return fromValues$1(NaN,NaN,NaN,NaN)}dragForPanZoom(u){const h=this.screenXY2mm(u[2],u[3]);if(isNaN(h[0]))return;const g=this.screenXY2mm(u[0],u[1],h[3]);if(isNaN(g[0])||isNaN(h[0])||isNaN(h[3]))return;const S=create$1(),v=this.uiData.pan2DxyzmmAtMouseDown[3];sub(S,h,g),this.scene.pan2Dxyzmm[0]=this.uiData.pan2DxyzmmAtMouseDown[0]+v*S[0],this.scene.pan2Dxyzmm[1]=this.uiData.pan2DxyzmmAtMouseDown[1]+v*S[1],this.scene.pan2Dxyzmm[2]=this.uiData.pan2DxyzmmAtMouseDown[2]+v*S[2],this.canvas.focus()}dragForCenterButton(u){this.dragForPanZoom(u)}dragForSlicer3D(u){let h=this.uiData.pan2DxyzmmAtMouseDown[3];const g=u[3]-u[1];h+=g*.01,h=Math.max(h,.1),h=Math.min(h,10);const v=this.scene.pan2Dxyzmm[3]-h;this.opts.yoke3Dto2DZoom&&(this.scene.volScaleMultiplier=h),this.scene.pan2Dxyzmm[3]=h;const w=this.frac2mm(this.scene.crosshairPos);this.scene.pan2Dxyzmm[0]+=v*w[0],this.scene.pan2Dxyzmm[1]+=v*w[1],this.scene.pan2Dxyzmm[2]+=v*w[2]}drawMeasurementTool(u){const h=this.gl;if(h.bindVertexArray(this.genericVAO),h.depthFunc(h.ALWAYS),h.enable(h.BLEND),h.blendFunc(h.SRC_ALPHA,h.ONE_MINUS_SRC_ALPHA),!this.lineShader)throw new Error("lineShader undefined");this.lineShader.use(this.gl),h.uniform4fv(this.lineShader.uniforms.lineColor,this.opts.rulerColor),h.uniform2fv(this.lineShader.uniforms.canvasWidthHeight,[h.canvas.width,h.canvas.height]),h.uniform1f(this.lineShader.uniforms.thickness,this.opts.rulerWidth),h.uniform4fv(this.lineShader.uniforms.startXYendXY,u),h.drawArrays(h.TRIANGLE_STRIP,0,4);const g=this.opts.rulerColor;g[3]=1,h.uniform4fv(this.lineShader.uniforms.lineColor,g);const S=this.opts.rulerWidth;h.uniform1f(this.lineShader.uniforms.thickness,S*2);let v=[u[0],u[1]-S,u[0],u[1]+S];h.uniform4fv(this.lineShader.uniforms.startXYendXY,v),h.drawArrays(h.TRIANGLE_STRIP,0,4),v=[u[2],u[3]-S,u[2],u[3]+S],h.uniform4fv(this.lineShader.uniforms.startXYendXY,v),h.drawArrays(h.TRIANGLE_STRIP,0,4);let w=this.canvasPos2frac([u[0],u[1]]),D=this.canvasPos2frac([u[2],u[3]]);if(w[0]>=0&&D[0]>=0){const _=this.frac2mm(w);w=fromValues$2(_[0],_[1],_[2]);const P=this.frac2mm(D);D=fromValues$2(P[0],P[1],P[2]);const L=create$2();sub$1(L,w,D);const m=len(L);let k=2;m>9&&(k=1),m>99&&(k=0);const e=m.toFixed(k);this.drawTextBetween(u,e,1,g)}h.bindVertexArray(this.unusedVAO)}drawRect(u,h=[1,0,0,-1]){if(h[3]<0&&(h=this.opts.crosshairColor),!this.rectShader)throw new Error("rectShader undefined");this.rectShader.use(this.gl),this.gl.enable(this.gl.BLEND),this.gl.uniform4fv(this.rectShader.uniforms.lineColor,h),this.gl.uniform2fv(this.rectShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.uniform4f(this.rectShader.uniforms.leftTopWidthHeight,u[0],u[1],u[2],u[3]),this.gl.bindVertexArray(this.genericVAO),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),this.gl.bindVertexArray(this.unusedVAO)}drawCircle(u,h=this.opts.fontColor,g=1){if(!this.circleShader)throw new Error("circleShader undefined");this.circleShader.use(this.gl),this.gl.enable(this.gl.BLEND),this.gl.uniform4fv(this.circleShader.uniforms.circleColor,h),this.gl.uniform2fv(this.circleShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.uniform4f(this.circleShader.uniforms.leftTopWidthHeight,u[0],u[1],u[2],u[3]),this.gl.uniform1f(this.circleShader.uniforms.fillPercent,g),this.gl.uniform4fv(this.circleShader.uniforms.circleColor,h),this.gl.bindVertexArray(this.genericVAO),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),this.gl.bindVertexArray(this.unusedVAO)}drawSelectionBox(u){this.drawRect(u,this.opts.selectionBoxColor)}effectiveCanvasHeight(){return this.gl.canvas.height-this.colorbarHeight}effectiveCanvasWidth(){return this.gl.canvas.width-this.getLegendPanelWidth()}getAllLabels(){const S=this.meshes.filter(w=>w.type==="connectome").flatMap(w=>w.nodes).map(w=>w.label).filter(w=>w!==void 0);return[...this.document.labels,...S]}getBulletMarginWidth(){let u=0;const h=this.getAllLabels();if(h.length===0)return 0;const g=h.length===1?h[0].style.bulletScale:h.reduce((w,D)=>w.style.bulletScale>D.style.bulletScale?w:D).style.bulletScale,S=h.length===1?h[0]:h.reduce((w,D)=>{const _=this.opts.textHeight*this.gl.canvas.height*w.style.textScale,P=this.opts.textHeight*this.gl.canvas.height*D.style.textScale;return this.textHeight(_,w.text)>this.textHeight(P,D.text)?w:D}),v=this.opts.textHeight*this.gl.canvas.height*S.style.textScale;return u=this.textHeight(v,S.text)*g,u+=v,u}getLegendPanelWidth(){const u=this.getAllLabels();if(!this.opts.showLegend||u.length===0)return 0;const g=this.opts.textHeight*this.gl.canvas.height*1;let S=0;const v=u.reduce((P,L)=>{const m=this.opts.textHeight*this.gl.canvas.height*P.style.textScale,k=this.opts.textHeight*this.gl.canvas.height*L.style.textScale;return this.textWidth(m,P.text)>this.textWidth(k,L.text)?P:L}),w=this.opts.textHeight*this.gl.canvas.height*v.style.textScale,D=this.textWidth(w,v.text),_=this.getBulletMarginWidth();return D&&(S=_+D,S+=g*2),S>=this.gl.canvas.width?0:S}getLegendPanelHeight(){const u=this.getAllLabels();let h=0;const S=this.opts.textHeight*this.gl.canvas.height*1;for(const v of u){const w=this.opts.textHeight*this.gl.canvas.height*v.style.textScale,D=this.textHeight(w,v.text);h+=D}return h&&(h+=S/2*(u.length+1)),h}reserveColorbarPanel(){let u=Math.max(this.opts.textHeight,.01);u=u*Math.min(this.gl.canvas.height,this.gl.canvas.width);const h=3*u,g=[0,this.gl.canvas.height-h,this.gl.canvas.width,h];return this.colorbarHeight=g[3]+1,g}drawColorbarCore(u=0,h=[0,0,0,0],g=!1,S=0,v=1,w){if(h[2]<=0||h[3]<=0)return;let D=Math.max(this.opts.textHeight,.01);D=D*Math.min(this.gl.canvas.height,this.gl.canvas.width);let _=D;const P=3*D;let L=D;if(h[3]<P){if(h[3]<3)return;_=1,L=h[3]-2}this.gl.disable(this.gl.DEPTH_TEST),this.colorbarHeight=h[3]+1;const m=[h[0]+_,h[1],h[2]-2*_,L],k=[m[0]-1,m[1]-1,m[2]+2,m[3]+2];if(this.drawRect(k,this.opts.crosshairColor),!this.colorbarShader)throw new Error("colorbarShader undefined");this.colorbarShader.use(this.gl),this.gl.activeTexture(TEXTURE1_COLORMAPS),this.gl.bindTexture(this.gl.TEXTURE_2D,this.colormapTexture),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MIN_FILTER,this.gl.NEAREST),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MAG_FILTER,this.gl.NEAREST);const e=u;if(this.gl.uniform1f(this.colorbarShader.uniforms.layer,e),this.gl.uniform2fv(this.colorbarShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.disable(this.gl.CULL_FACE),g){const Z=[m[0]+m[2],m[1],-m[2],m[3]];this.gl.uniform4fv(this.colorbarShader.uniforms.leftTopWidthHeight,Z)}else this.gl.uniform4fv(this.colorbarShader.uniforms.leftTopWidthHeight,m);this.gl.bindVertexArray(this.genericVAO),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),this.gl.bindVertexArray(this.unusedVAO),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MIN_FILTER,this.gl.LINEAR),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MAG_FILTER,this.gl.LINEAR);let N=0;if(w&&v<0&&g?(N=v,v=0):w&&S>0&&(N=S,S=0),S===v||D<1)return;const B=Math.abs(v-S);let[Q,e0]=tickSpacing(S,v);e0<S&&(e0+=Q);function j(Z){return Z.toFixed(6).replace(/\.?0*$/,"")}let H=e0;const y=[0,m[1]+m[3]-D*.5,2,D*.75],Y=y[1]+y[3],G=1;for(;H<=v;){y[0]=m[0]+(H-S)/B*m[2],this.drawRect(y);const Z=j(G*H);this.drawTextBelow([y[0],Y],Z),H+=Q}if(N!==0){const Z=[m[0]+(N-S)/B*m[2],m[1]-m[3]*.25,2,m[3]*1.5];this.drawRect(Z)}}drawColorbar(){const u=this.colormapLists,h=u.length;if(h<1)return;let g=0;for(let _=0;_<h;_++)u[_].visible&&g++;if(g<1)return;let S=this.reserveColorbarPanel(),v=Math.max(this.opts.textHeight,.01);v=v*Math.min(this.gl.canvas.height,this.gl.canvas.width);const w=3*v;let D=S[2]/g;(S[2]<=0||S[3]<=0)&&(D=this.gl.canvas.width/g,S=[0,this.gl.canvas.height-w,D,w]),S[2]=D;for(let _=0;_<h;_++)u[_].visible&&(this.drawColorbarCore(_,S,u[_].negative,u[_].min,u[_].max,u[_].alphaThreshold),S[0]+=D)}textWidth(u,h){if(!h)return 0;let g=0;const S=new TextEncoder().encode(h);for(let v=0;v<h.length;v++)g+=u*this.fontMets.mets[S[v]].xadv;return g}textHeight(u,h){if(!h)return 0;const g=new Set(Array.from(h)),S=new TextEncoder().encode(Array.from(g).join("")),w=Object.values(this.fontMets.mets).filter((D,_)=>S.includes(_)).reduce((D,_)=>D.lbwh[3]>_.lbwh[3]?D:_).lbwh[3];return u*w}drawChar(u,h,g){if(!this.fontShader)throw new Error("fontShader undefined");const S=this.fontMets.mets[g],v=u[0]+h*S.lbwh[0],w=-(h*S.lbwh[1]),D=h*S.lbwh[2],_=h*S.lbwh[3],P=u[1]+(w-_)+h;return this.gl.uniform4f(this.fontShader.uniforms.leftTopWidthHeight,v,P,D,_),this.gl.uniform4fv(this.fontShader.uniforms.uvLeftTopWidthHeight,S.uv_lbwh),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),h*S.xadv}drawLoadingText(u){if(!this.canvas)throw new Error("canvas undefined");this.gl.viewport(0,0,this.gl.canvas.width,this.gl.canvas.height),this.gl.enable(this.gl.CULL_FACE),this.gl.enable(this.gl.BLEND),this.drawTextBelow([this.canvas.width/2,this.canvas.height/2],u,3)}drawText(u,h,g=1,S=null){if(this.opts.textHeight<=0)return;if(!this.fontShader)throw new Error("fontShader undefined");this.fontShader.use(this.gl);const v=this.opts.textHeight*Math.min(this.gl.canvas.height,this.gl.canvas.width)*g;this.gl.enable(this.gl.BLEND),this.gl.uniform2f(this.fontShader.uniforms.canvasWidthHeight,this.gl.canvas.width,this.gl.canvas.height),S===null&&(S=this.opts.fontColor),this.gl.uniform4fv(this.fontShader.uniforms.fontColor,S);let w=v/this.fontMets.size*this.fontMets.distanceRange;w=Math.max(w,1),this.gl.uniform1f(this.fontShader.uniforms.screenPxRange,w);const D=new TextEncoder().encode(h);this.gl.bindVertexArray(this.genericVAO);for(let _=0;_<h.length;_++)u[0]+=this.drawChar(u,v,D[_]);this.gl.bindVertexArray(this.unusedVAO)}drawTextRight(u,h,g=1,S=null){this.opts.textHeight<=0||(u[1]-=.5*this.opts.textHeight*this.gl.canvas.height,this.drawText(u,h,g,S))}drawTextLeft(u,h,g=1,S=null){if(this.opts.textHeight<=0)return;const v=this.opts.textHeight*this.gl.canvas.height*g;u[0]-=this.textWidth(v,h),u[1]-=.5*v,this.drawText(u,h,g,S)}drawTextRightBelow(u,h,g=1,S=null){this.opts.textHeight<=0||this.drawText(u,h,g,S)}drawTextBetween(u,h,g=1,S=null){if(this.opts.textHeight<=0)return;const v=[(u[0]+u[2])*.5,(u[1]+u[3])*.5],w=this.opts.textHeight*this.gl.canvas.height*g,D=this.textWidth(w,h);v[0]-=.5*D,v[1]-=.5*w;const _=[v[0]-1,v[1]-1,D+2,w+2];let P=S;P===null&&(P=this.opts.crosshairColor),P&&P[0]+P[1]+P[2]>.8?P=[0,0,0,.5]:P=[1,1,1,.5],this.drawRect(_,P),this.drawText(v,h,g,S)}drawTextBelow(u,h,g=1,S=null){if(this.opts.textHeight<=0)return;if(!this.canvas)throw new Error("canvas undefined");let v=this.opts.textHeight*this.gl.canvas.height*g,w=this.textWidth(v,h);w>this.canvas.width&&(g*=(this.canvas.width-2)/w,v=this.opts.textHeight*this.gl.canvas.height*g,w=this.textWidth(v,h)),u[0]-=.5*this.textWidth(v,h),u[0]=Math.max(u[0],1),u[0]=Math.min(u[0],this.canvas.width-w-1),this.drawText(u,h,g,S)}updateInterpolation(u,h=!1){let g=this.gl.LINEAR;!h&&this.opts.isNearestInterpolation&&(g=this.gl.NEAREST),u===0?this.gl.activeTexture(TEXTURE0_BACK_VOL):this.gl.activeTexture(TEXTURE2_OVERLAY_VOL),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_MIN_FILTER,g),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_MAG_FILTER,g)}setAtlasOutline(u){this.opts.atlasOutline=u,this.updateGLVolume(),this.drawScene()}setInterpolation(u){this.opts.isNearestInterpolation=u;const h=this.volumes.length;if(!(h<1)){for(let g=0;g<h;g++)this.updateInterpolation(g);this.drawScene()}}calculateMvpMatrix2D(u,h,g,S=1/0,v=0,w=0,D=0,_){this.gl.viewport(u[0],this.gl.canvas.height-(u[1]+u[3]),u[2],u[3]);let L=h[0],m=g[0],k=[L,h[1]],e=[m-L,g[1]-h[1]];_&&(k=[g[0],h[1]],e=[h[0]-g[0],g[1]-h[1]],L=-g[0],m=-h[0]);const N=2*Math.max(Math.abs(h[2]),Math.abs(g[2])),B=create$3();let Q=.01,e0=N*8;if(S!==1/0){let Z=_;D===0&&(w===0||w===180)&&(Z=!Z);let i0=N*1.8-v;Z||(i0=N*1.8+v),Q=i0-S,e0=i0+S}ortho(B,L,m,h[1],g[1],Q,e0);const j=create$3();j[0]=-1;const H=fromValues$2(0,0,-N*1.8);translate(j,j,H),rotateX(j,j,deg2rad(270-D)),rotateZ(j,j,deg2rad(w-180));const y=create$3();invert(y,j);const Y=create$3();transpose(Y,y);const G=create$3();return multiply(G,B,j),{modelViewProjectionMatrix:G,modelMatrix:j,normalMatrix:Y,leftTopMM:k,fovMM:e}}swizzleVec3MM(u,h){return h===1?u=swizzleVec3(u,[0,2,1]):h===2&&(u=swizzleVec3(u,[1,2,0])),u}screenFieldOfViewVox(u=0){const h=clone$1(this.volumeObject3D.fieldOfViewDeObliqueMM);return this.swizzleVec3MM(h,u)}screenFieldOfViewMM(u=0,h=!1){if(!h&&!this.opts.isSliceMM)return this.screenFieldOfViewVox(u);const g=this.volumeObject3D.extentsMin,S=this.volumeObject3D.extentsMax;let v=fromValues$2(g[0],g[1],g[2]),w=fromValues$2(S[0],S[1],S[2]);v=this.swizzleVec3MM(v,u),w=this.swizzleVec3MM(w,u);const D=create$2();return subtract$1(D,w,v),D}screenFieldOfViewExtendedVox(u=0){const h=this.volumes[0].extentsMinOrtho,g=this.volumes[0].extentsMaxOrtho;let S=fromValues$2(h[0],h[1],h[2]),v=fromValues$2(g[0],g[1],g[2]);const w=create$3();S=this.swizzleVec3MM(S,u),v=this.swizzleVec3MM(v,u);const D=create$2();return subtract$1(D,v,S),{mnMM:S,mxMM:v,rotation:w,fovMM:D}}screenFieldOfViewExtendedMM(u=0){if(!this.volumeObject3D)throw new Error("volumeObject3D undefined");const h=this.volumeObject3D.extentsMin,g=this.volumeObject3D.extentsMax;let S=fromValues$2(h[0],h[1],h[2]),v=fromValues$2(g[0],g[1],g[2]);const w=create$3();S=this.swizzleVec3MM(S,u),v=this.swizzleVec3MM(v,u);const D=create$2();return subtract$1(D,v,S),{mnMM:S,mxMM:v,rotation:w,fovMM:D}}drawSliceOrientationText(u,h){this.gl.viewport(0,0,this.gl.canvas.width,this.gl.canvas.height);let g="S";h===0&&(g="A");let S=this.opts.isRadiologicalConvention?"R":"L";if(h===2&&(S=this.opts.sagittalNoseLeft?"A":"P"),this.opts.isCornerOrientationText){this.drawTextRightBelow([u[0],u[1]],S+g);return}this.drawTextBelow([u[0]+u[2]*.5,u[1]],g),this.drawTextRight([u[0],u[1]+u[3]*.5],S)}xyMM2xyzMM(u,h){let g=2;u===1&&(g=1),u===2&&(g=0);let S=[0,0,0],v=[1,1,0],w=[1,0,1];S[g]=h,v[g]=h,w[g]=h,S=this.frac2mm(S),v=this.frac2mm(v),w=this.frac2mm(w),S=this.swizzleVec3MM(fromValues$2(S[0],S[1],S[2]),u),v=this.swizzleVec3MM(fromValues$2(v[0],v[1],v[2]),u),w=this.swizzleVec3MM(fromValues$2(w[0],w[1],w[2]),u);const D=(v[0]-S[0])*(w[1]-S[1])-(w[0]-S[0])*(v[1]-S[1]);let _=(v[0]-S[0])*(w[2]-S[2])-(w[0]-S[0])*(v[2]-S[2]);_/=D;let P=(v[1]-S[1])*(w[2]-S[2])-(w[1]-S[1])*(v[2]-S[2]);P/=D;const L=[0,0,0,0,0];return L[0]=S[0],L[1]=S[1],L[2]=S[2],L[3]=P,L[4]=_,L}draw2D(u,h,g=NaN){let S=this.volumes[0].frac2mm.slice(),v=this.screenFieldOfViewExtendedMM(h),w=create$3();this.opts.isSliceMM||(S=this.volumes[0].frac2mmOrtho.slice(),w=clone$2(this.volumes[0].mm2ortho),v=this.screenFieldOfViewExtendedVox(h));let D=this.opts.isRadiologicalConvention&&h<2;g===1/0||g===-1/0?(D=g!==1/0,h===1&&(D=!D)):this.opts.sagittalNoseLeft&&h===2&&(D=!D);let _=0,P=0;h===2?P=D?90:-90:h===1?P=D?180:0:(P=D?180:0,_=D?-90:90);const L=this.gl;if(u[2]===0||u[3]===0){const e0=L.canvas.width/v.fovMM[0],j=L.canvas.height/v.fovMM[1],H=Math.min(e0,j),y=e0/H,Y=j/H;v.fovMM[0]*=y,v.fovMM[1]*=Y;let G=(v.mnMM[0]+v.mxMM[0])*.5;v.mnMM[0]=G-v.fovMM[0]*.5,v.mxMM[0]=G+v.fovMM[0]*.5,G=(v.mnMM[1]+v.mxMM[1])*.5,v.mnMM[1]=G-v.fovMM[1]*.5,v.mxMM[1]=G+v.fovMM[1]*.5,u=[0,0,L.canvas.width,L.canvas.height]}if(isNaN(g)){const e0=this.scene.pan2Dxyzmm,j=this.swizzleVec3MM(fromValues$2(e0[0],e0[1],e0[2]),h),H=this.scene.pan2Dxyzmm[3];v.mnMM[0]-=j[0],v.mxMM[0]-=j[0],v.mnMM[1]-=j[1],v.mxMM[1]-=j[1],v.mnMM[0]/=H,v.mxMM[0]/=H,v.mnMM[1]/=H,v.mxMM[1]/=H}let m=2;h===1&&(m=1),h===2&&(m=0);let k=this.scene.crosshairPos[m],e=this.frac2mm(this.scene.crosshairPos);!isNaN(g)&&g!==1/0&&g!==-1/0&&(e=this.frac2mm([.5,.5,.5]),e[m]=g,k=this.mm2frac(e)[m]);const N=e[m];L.clear(L.DEPTH_BUFFER_BIT);let B=this.calculateMvpMatrix2D(u,v.mnMM,v.mxMM,1/0,0,P,_,D);if(g===1/0||g===-1/0){const e0=u.slice();this.draw3D(u,B.modelViewProjectionMatrix,B.modelMatrix,B.normalMatrix,P,_);const j=this.screenSlices[this.screenSlices.length-1];j.leftTopWidthHeight=e0,j.axCorSag=h,j.sliceFrac=1/0,j.AxyzMxy=this.xyMM2xyzMM(h,k),j.leftTopMM=B.leftTopMM,j.fovMM=B.fovMM;return}L.enable(L.DEPTH_TEST),L.blendFunc(L.SRC_ALPHA,L.ONE_MINUS_SRC_ALPHA),L.disable(L.BLEND),L.depthFunc(L.GREATER),L.disable(L.CULL_FACE);let Q=this.sliceMMShader;if(this.opts.isV1SliceShader&&(Q=this.sliceV1Shader),!Q)throw new Error("slice Shader undefined");if(Q.use(this.gl),L.uniform1f(Q.uniforms.overlayOutlineWidth,this.overlayOutlineWidth),L.uniform1f(Q.uniforms.overlayAlphaShader,this.overlayAlphaShader),L.uniform1i(Q.uniforms.isAlphaClipDark,this.isAlphaClipDark?1:0),L.uniform1i(Q.uniforms.backgroundMasksOverlays,this.backgroundMasksOverlays),L.uniform1f(Q.uniforms.drawOpacity,this.drawOpacity),L.enable(L.BLEND),L.blendFunc(L.SRC_ALPHA,L.ONE_MINUS_SRC_ALPHA),L.uniform1f(Q.uniforms.opacity,this.volumes[0].opacity),L.uniform1i(Q.uniforms.axCorSag,h),L.uniform1f(Q.uniforms.slice,k),L.uniformMatrix4fv(Q.uniforms.frac2mm,!1,S),L.uniformMatrix4fv(Q.uniforms.mvpMtx,!1,B.modelViewProjectionMatrix.slice()),L.bindVertexArray(this.genericVAO),L.drawArrays(L.TRIANGLE_STRIP,0,4),L.bindVertexArray(this.unusedVAO),this.screenSlices.push({leftTopWidthHeight:u,axCorSag:h,sliceFrac:k,AxyzMxy:this.xyMM2xyzMM(h,k),leftTopMM:B.leftTopMM,screen2frac:[],fovMM:B.fovMM}),isNaN(g)&&this.drawCrosshairs3D(!0,1,B.modelViewProjectionMatrix,!0,this.opts.isSliceMM),this.opts.meshThicknessOn2D>0){this.opts.meshThicknessOn2D!==1/0&&(B=this.calculateMvpMatrix2D(u,v.mnMM,v.mxMM,this.opts.meshThicknessOn2D,N,P,_,D));const e0=clone$2(B.modelViewProjectionMatrix);multiply(e0,e0,w),this.drawMesh3D(!0,1,e0,B.modelMatrix,B.normalMatrix)}isNaN(g)&&this.drawCrosshairs3D(!1,.15,B.modelViewProjectionMatrix,!0,this.opts.isSliceMM),this.drawSliceOrientationText(u,h),this.readyForSync=!0}calculateMvpMatrix(u,h=[0,0,0,0],g,S){(h[2]===0||h[3]===0)&&(h=[0,0,this.gl.canvas.width,this.gl.canvas.height]);const v=h[2]/h[3];let w=this.furthestFromPivot;const D=this.pivot3D,_=create$3();w=.8*w/this.scene.volScaleMultiplier,v<1?ortho(_,-w,w,-w/v,w/v,w*.01,w*8):ortho(_,-w*v,w*v,-w,w,w*.01,w*8);const P=create$3();P[0]=-1;const L=fromValues$2(0,0,-w*1.8);translate(P,P,L),this.position&&translate(P,P,this.position),rotateX(P,P,deg2rad(270-S)),rotateZ(P,P,deg2rad(g-180)),translate(P,P,[-D[0],-D[1],-D[2]]);const m=create$3();invert(m,P);const k=create$3();transpose(k,m);const e=create$3();return multiply(e,_,P),[e,P,k]}calculateModelMatrix(u,h){if(!this.back)throw new Error("back undefined");const g=create$3();if(g[0]=-1,rotateX(g,g,deg2rad(270-h)),rotateZ(g,g,deg2rad(u-180)),this.back.obliqueRAS){const S=clone$2(this.back.obliqueRAS);multiply(g,g,S)}return g}calculateRayDirection(u,h){const g=this.calculateModelMatrix(u,h),S=fromValues$3(1,0,0,0,0,-1,0,0,0,0,-1,0,0,0,0,1),v=create$3();multiply(v,S,g);const w=create$3();invert(w,v);const D=fromValues$1(0,0,-1,1);transformMat4(D,D,w);const _=fromValues$2(D[0],D[1],D[2]);normalize$1(_,_);const P=5e-5;return Math.abs(_[0])<P&&(_[0]=P),Math.abs(_[1])<P&&(_[1]=P),Math.abs(_[2])<P&&(_[2]=P),_}sceneExtentsMinMax(u=!0){let h=fromValues$2(0,0,0),g=fromValues$2(0,0,0);if(this.volumes.length>0){if(!this.volumeObject3D)throw new Error("volumeObject3D undefined");h=fromValues$2(this.volumeObject3D.extentsMin[0],this.volumeObject3D.extentsMin[1],this.volumeObject3D.extentsMin[2]),g=fromValues$2(this.volumeObject3D.extentsMax[0],this.volumeObject3D.extentsMax[1],this.volumeObject3D.extentsMax[2]),u||(h=fromValues$2(this.volumes[0].extentsMinOrtho[0],this.volumes[0].extentsMinOrtho[1],this.volumes[0].extentsMinOrtho[2]),g=fromValues$2(this.volumes[0].extentsMaxOrtho[0],this.volumes[0].extentsMaxOrtho[1],this.volumes[0].extentsMaxOrtho[2]))}if(this.meshes.length>0){if(this.volumes.length<1){const v=this.meshes[0].extentsMin,w=this.meshes[0].extentsMax;h=fromValues$2(v[0],v[1],v[2]),g=fromValues$2(w[0],w[1],w[2])}for(let v=0;v<this.meshes.length;v++){const w=this.meshes[v].extentsMin,D=this.meshes[v].extentsMax,_=fromValues$2(w[0],w[1],w[2]);min(h,h,_);const P=fromValues$2(D[0],D[1],D[2]);max$2(g,g,P)}}const S=create$2();return subtract$1(S,g,h),[h,g,S]}setPivot3D(){const[u,h]=this.sceneExtentsMinMax(),g=create$2();add$1(g,u,h),scale$2(g,g,.5),this.pivot3D=[g[0],g[1],g[2]],subtract$1(g,h,u),this.extentsMin=u,this.extentsMax=h,this.furthestFromPivot=length$1(g)*.5}getMaxVols(){if(this.volumes.length<1)return 0;let u=0;for(let h=0;h<this.volumes.length;h++)u=Math.max(u,this.volumes[h].nFrame4D);return u}detectPartialllyLoaded4D(){if(this.volumes.length<1)return!1;for(let u=0;u<this.volumes.length;u++)if(this.volumes[u].nFrame4D<this.volumes[u].hdr.dims[4])return!0;return!1}drawGraph(){if(this.getMaxVols()<2)return;const u=this.graph;let h=0;if(this.graph.autoSizeMultiplanar&&this.opts.sliceType===3)for(let o0=0;o0<this.screenSlices.length;o0++){const c0=this.screenSlices[o0].axCorSag;if(c0===0&&(h=this.screenSlices[o0].leftTopWidthHeight[1]),c0!==2)continue;const d0=this.screenSlices[o0].leftTopWidthHeight.slice();d0[1]===h?(u.LTWH[0]=d0[0]+d0[2],u.LTWH[1]=d0[1]):(u.LTWH[0]=d0[0],u.LTWH[1]=d0[1]+d0[3]),u.LTWH[2]=d0[2],u.LTWH[3]=d0[2]}if(u.opacity<=0||u.LTWH[2]<=5||u.LTWH[3]<=5||u.LTWH[0]+u.LTWH[2]>this.gl.canvas.width||u.LTWH[1]+u.LTWH[3]>this.gl.canvas.height)return;u.backColor=[.15,.15,.15,u.opacity],u.lineColor=[1,1,1,1],this.opts.backColor[0]+this.opts.backColor[1]+this.opts.backColor[2]>1.5&&(u.backColor=[.95,.95,.95,u.opacity],u.lineColor=[0,0,0,1]),u.textColor=u.lineColor.slice(),u.lineThickness=4,u.lineAlpha=1,u.lines=[];const g=[];if(u.vols.length<1)this.volumes[0]!=null&&g.push(0);else for(let o0=0;o0<u.vols.length;o0++){const c0=u.vols[o0];this.volumes[c0]==null||this.volumes[c0].nFrame4D<2||g.push(c0)}if(g.length<1)return;const S=this.volumes[g[0]].nFrame4D;if(this.graph.selectedColumn=this.volumes[g[0]].frame4D,S<2){log.debug("Unable to generate a graph: Selected volume is 3D not 4D");return}for(let o0=0;o0<g.length;o0++){u.lines[o0]=[];const c0=this.frac2vox(this.scene.crosshairPos),d0=this.volumes[g[o0]];let v0=d0.nFrame4D;v0=Math.min(v0,S);for(let g0=0;g0<v0;g0++){const T0=d0.getValue(c0[0],c0[1],c0[2],g0);u.lines[o0].push(T0)}}u.lineRGB=[[1,0,0],[0,.7,0],[0,0,1],[1,1,0],[1,0,1],[0,1,1],[1,1,1],[0,0,0]];let v=u.lines[0][0],w=u.lines[0][0];for(let o0=0;o0<u.lines.length;o0++)for(let c0=0;c0<u.lines[o0].length;c0++){const d0=u.lines[o0][c0];v=Math.min(d0,v),w=Math.max(d0,w)}if(u.normalizeValues&&w>v){const o0=w-v;for(let c0=0;c0<u.lines.length;c0++)for(let d0=0;d0<u.lines[c0].length;d0++){const v0=u.lines[c0][d0];u.lines[c0][d0]=(v0-v)/o0}v=0,w=1}v>=w&&(w=v+1),this.drawRect(u.LTWH,u.backColor);const[D,_,P]=tickSpacing(v,w),L=Math.max(0,-1*Math.floor(Math.log(D)/Math.log(10)));v=Math.min(_,v),w=Math.max(P,w);function m(o0){return o0.toFixed(6).replace(/\.?0*$/,"")}const e=.07*(Math.min(u.LTWH[2],u.LTWH[3])/(this.fontMets.size*this.uiData.dpr));let N=this.opts.textHeight*this.gl.canvas.height*e;N<16&&(N=0);let B=0,Q=_;if(N>0)for(;Q<=w;){const o0=Q.toFixed(L),c0=this.textWidth(N,o0);B=Math.max(c0,B),Q+=D}const e0=.05,j=Math.abs(u.LTWH[2]),H=Math.abs(u.LTWH[3]),y=[u.LTWH[0]+e0*j+B,u.LTWH[1]+e0*H,u.LTWH[2]-B-2*e0*j,u.LTWH[3]-N-2*e0*H];this.graph.LTWH=u.LTWH,this.graph.plotLTWH=y,this.drawRect(y,this.opts.backColor);const Y=w-v,G=y[3]/Y,Z=y[2]/(u.lines[0].length-1),i0=y[1]+y[3];Q=_+.5*D;const z=u.lineColor.slice();for(z[3]=.25*u.lineColor[3];Q<=w;){const o0=i0-(Q-v)*G;this.drawLine([y[0],o0,y[0]+y[2],o0],.5*u.lineThickness,z),Q+=D}Q=_;const f=.5*u.lineThickness;for(;Q<=w;){const o0=i0-(Q-v)*G;this.drawLine([y[0]-f,o0,y[0]+y[2]+u.lineThickness,o0],u.lineThickness,u.lineColor);const c0=Q.toFixed(L);N>0&&this.drawTextLeft([y[0]-6,o0],c0,e,u.textColor),Q+=D}let f0=1;for(;u.lines[0].length/f0>20;)f0*=5;for(let o0=0;o0<u.lines[0].length;o0+=f0){const c0=o0*Z+y[0];let d0=u.lineThickness;if(o0%2===1)d0*=.5,this.drawLine([c0,y[1],c0,y[1]+y[3]],d0,z);else{const v0=m(o0);N>0&&this.drawTextBelow([c0,2+y[1]+y[3]],v0,e,u.textColor),this.drawLine([c0,y[1],c0,y[1]+y[3]],d0,u.lineColor)}}for(let o0=0;o0<u.lines.length;o0++){let c0=[1,0,0,u.lineAlpha];o0<u.lineRGB.length&&(c0=[u.lineRGB[o0][0],u.lineRGB[o0][1],u.lineRGB[o0][2],u.lineAlpha]);for(let d0=1;d0<u.lines[o0].length;d0++){const v0=(d0-1)*Z,g0=d0*Z,T0=(u.lines[o0][d0-1]-v)*G,x0=(u.lines[o0][d0]-v)*G,M0=[y[0]+v0,y[1]+y[3]-T0,y[0]+g0,y[1]+y[3]-x0];this.drawLine(M0,u.lineThickness,c0)}}if(u.selectedColumn>=0&&u.selectedColumn<u.lines[0].length){const o0=u.selectedColumn*Z+y[0];this.drawLine([o0,y[1],o0,y[1]+y[3]],u.lineThickness,[u.lineRGB[3][0],u.lineRGB[3][1],u.lineRGB[3][2],1])}this.detectPartialllyLoaded4D()&&this.drawTextBelow([y[0]+y[2],y[1]+y[3]+N*.5],"...",e,u.textColor)}depthPicker(u,h){if(!this.uiData.mouseDepthPicker)return;this.uiData.mouseDepthPicker=!1;const g=this.gl,S=this.mousePos[0]*u[2]/u[2],v=g.canvas.height-this.mousePos[1]*u[3]/u[3]-1,w=new Uint8Array(4);if(g.readPixels(S,v,1,1,g.RGBA,g.UNSIGNED_BYTE,w),this.selectedObjectId=w[3],this.selectedObjectId===this.VOLUME_ID){this.scene.crosshairPos=new Float32Array(w.slice(0,3)).map(k=>k/255);return}const D=unpackFloatFromVec4i(w);if(D>1)return;const _=(this.mousePos[0]-u[0])/u[2],P=(g.canvas.height-this.mousePos[1]-u[1])/u[3],L=unProject(_,P,D,h),m=this.mm2frac(L,0,!0);m[0]<0||m[0]>1||m[1]<0||m[1]>1||m[2]<0||m[2]>1||(this.scene.crosshairPos=this.mm2frac(L,0,!0))}drawImage3D(u,h,g){if(this.volumes.length===0)return;const S=this.gl,v=this.calculateRayDirection(h,g),w=this.volumeObject3D;if(w){S.enable(S.BLEND),S.blendFunc(S.SRC_ALPHA,S.ONE_MINUS_SRC_ALPHA),S.enable(S.CULL_FACE),S.cullFace(S.FRONT);let D=this.renderShader;if(this.uiData.mouseDepthPicker&&(D=this.pickingImageShader),D.use(this.gl),S.uniform1i(D.uniforms.backgroundMasksOverlays,this.backgroundMasksOverlays),this.gradientTextureAmount>0){S.activeTexture(TEXTURE6_GRADIENT),S.bindTexture(S.TEXTURE_3D,this.gradientTexture);const _=this.calculateModelMatrix(h,g),P=create$3();invert(P,_);const L=create$3();transpose(L,P),S.uniformMatrix4fv(D.uniforms.normMtx,!1,L)}this.drawBitmap&&this.drawBitmap.length>8?S.uniform2f(D.uniforms.renderDrawAmbientOcclusionXY,this.renderDrawAmbientOcclusion,this.drawOpacity):S.uniform2f(D.uniforms.renderDrawAmbientOcclusionXY,this.renderDrawAmbientOcclusion,0),S.uniformMatrix4fv(D.uniforms.mvpMtx,!1,u),S.uniformMatrix4fv(D.uniforms.matRAS,!1,this.back.matRAS),S.uniform3fv(D.uniforms.rayDir,v),this.gradientTextureAmount<0?S.uniform4fv(D.uniforms.clipPlane,[this.scene.crosshairPos[0],this.scene.crosshairPos[1],this.scene.crosshairPos[2],30]):S.uniform4fv(D.uniforms.clipPlane,this.scene.clipPlane),S.uniform1f(D.uniforms.drawOpacity,1),S.bindVertexArray(w.vao),S.drawElements(w.mode,w.indexCount,S.UNSIGNED_SHORT,0),S.bindVertexArray(this.unusedVAO)}}drawOrientationCube(u,h=0,g=0){if(!this.opts.isOrientCube)return;const S=.05*Math.min(u[2],u[3]);if(S<5)return;const v=this.gl;v.enable(v.CULL_FACE),v.cullFace(v.BACK),this.orientCubeShader.use(this.gl),v.bindVertexArray(this.orientCubeShaderVAO);const w=create$3(),D=create$3();ortho(D,0,v.canvas.width,0,v.canvas.height,-10*S,10*S);let _=0;u[1]===0&&(_=v.canvas.height-this.effectiveCanvasHeight()),translate(w,w,[1.8*S+u[0],_+1.8*S+u[1],0]),scale$3(w,w,[S,S,S]),rotateX(w,w,deg2rad(270-g)),rotateZ(w,w,deg2rad(-h));const P=create$3();multiply(P,D,w),v.uniformMatrix4fv(this.orientCubeShader.uniforms.u_matrix,!1,P),v.drawArrays(v.TRIANGLE_STRIP,0,168),v.bindVertexArray(this.unusedVAO),this.gl.disable(this.gl.CULL_FACE)}createOnLocationChange(u=NaN){const[h,g,S]=this.sceneExtentsMinMax(!0),v=Math.max(Math.max(S[0],S[1]),S[2]);function w(k){return Math.max(0,-Math.ceil(Math.log10(Math.abs(k))))}let D=w(v*.001);const _=this.frac2mm(this.scene.crosshairPos,0,!0);function P(k,e=0){return parseFloat(k.toFixed(e))}let L=P(_[0],D)+"×"+P(_[1],D)+"×"+P(_[2],D);if(this.volumes.length>0&&this.volumes[0].nFrame4D>0&&(L+="×"+P(this.volumes[0].frame4D)),this.volumes.length>0){let k=" = ";for(let B=0;B<this.volumes.length;B++){const Q=this.volumes[B].mm2vox(_);let e0=this.volumes[B].getValue(Q[0],Q[1],Q[2],this.volumes[B].frame4D);if(D=3,this.volumes[B].colormapLabel!==null){const j=Math.round(e0);j>=0&&j<this.volumes[B].colormapLabel.labels.length?k+=this.volumes[B].colormapLabel.labels[j]:k+="undefined("+P(e0,D)+")"}else k+=P(e0,D);this.volumes[B].imaginary&&(e0=this.volumes[B].getValue(Q[0],Q[1],Q[2],this.volumes[B].frame4D,!0),e0>=0&&(k+="+"),k+=P(e0,D)),k+="   "}L+=k;const e=this.back.dimsRAS,N=e[1]*e[2]*e[3];if(this.drawBitmap&&this.drawBitmap.length===N){const B=this.frac2vox(this.scene.crosshairPos),Q=B[0]+B[1]*e[1]+B[2]*e[1]*e[2];L+=" "+this.drawLut.labels[this.drawBitmap[Q]]}}const m={mm:this.frac2mm(this.scene.crosshairPos,0,!0),axCorSag:u,vox:this.frac2vox(this.scene.crosshairPos),frac:this.scene.crosshairPos,xy:[this.mousePos[0],this.mousePos[1]],values:this.volumes.map(k=>{const e=this.frac2mm(this.scene.crosshairPos,0,!0),N=k.mm2vox(e),B=k.getValue(N[0],N[1],N[2],k.frame4D);return{name:k.name,value:B,id:k.id,mm:e,vox:N}}),string:L};this.onLocationChange(m)}addLabel(u,h,g){const S={textColor:this.opts.legendTextColor,textScale:1,textAlignment:"left",lineWidth:0,lineColor:this.opts.legendTextColor,lineTerminator:"none",bulletScale:0,bulletColor:this.opts.legendTextColor},v=h?{...S,...h}:{...S},w=new NVLabel3D(u,v,g);return this.document.labels.push(w),w}calculateScreenPoint(u,h,g){const S=create$1();return transformMat4(S,[...u,1],h),S[3]!==0&&(S[0]=(S[0]/S[3]+1)*.5*g[2],S[1]=(1-S[1]/S[3])*.5*g[3],S[2]/=S[3],S[0]+=g[0],S[1]+=g[1]),S}getLabelAtPoint(u){log.debug("screenPoint",u);const h=this.getLegendPanelHeight(),g=this.getLegendPanelWidth(),S=this.gl.canvas.width-g;let v=(this.canvas.height-h)/2;if(log.debug("panelrect",S,v,S+g,v+h),u[0]<S||u[1]<v||u[0]>S+g||u[1]>v+h)return null;const D=this.opts.textHeight*Math.min(this.gl.canvas.height,this.gl.canvas.width)*1,_=this.getAllLabels();for(const P of _){const L=this.opts.textHeight*this.gl.canvas.height*P.style.textScale,m=this.textHeight(L,P.text);if(u[1]>=v&&u[1]<=v+m+D/2)return P;v+=m,v+=D/2}return null}drawLabelLine(u,h,g,S,v=!1){const w=Array.isArray(u.points)&&Array.isArray(u.points[0])?u.points:[u.points];for(const D of w){const _=this.calculateScreenPoint(D,g,S);v?this.drawDottedLine([...h,_[0],_[1]],u.style.lineWidth,u.style.lineColor):this.draw3DLine(h,[_[0],_[1],_[2]],u.style.lineWidth,u.style.lineColor)}}draw3DLabel(u,h,g,S,v=0,w,D=!1){const _=u.text,P=h[0],L=h[1],m=this.opts.textHeight*Math.min(this.gl.canvas.height,this.gl.canvas.width)*1,k=this.textHeight(u.style.textScale,_)*m;if(u.style.lineWidth>0&&Array.isArray(u.points)&&this.drawLabelLine(u,[P,L+k],g,S,D),u.style.bulletScale){const N=u.style.bulletScale*k,B=k-N,Q=L+B/2+N/2,e0=P+(v-N)/2;this.drawCircle([e0,Q,N,N],u.style.bulletColor)}let e=P;if(u.style.textAlignment!=="left"){const N=this.textWidth(u.style.textScale,u.text)*m;if(u.style.textAlignment==="right")e=P+w-m*1.5-N;else{const B=w-(v||m);e+=(B-N)/2}}else e+=v;this.drawText([e,L],_,u.style.textScale,u.style.textColor)}draw3DLabels(u,h,g=!1){const S=this.getAllLabels();if(!this.opts.showLegend||S.length===0)return;if(!this.canvas)throw new Error("canvas undefined");const v=this.gl;v.disable(v.CULL_FACE),v.viewport(0,0,this.canvas.width,this.canvas.height);const D=this.opts.textHeight*Math.min(this.gl.canvas.height,this.gl.canvas.width)*1,_=this.getBulletMarginWidth(),P=this.getLegendPanelHeight(),L=this.getLegendPanelWidth(),m=v.canvas.width-L;let k=(this.canvas.height-P)/2;this.drawRect([v.canvas.width-L,k,L-D,P],this.opts.legendBackgroundColor);const e=v.getParameter(v.BLEND),N=v.getParameter(v.DEPTH_FUNC);g||(v.disable(v.BLEND),v.depthFunc(v.GREATER));for(const B of S){this.draw3DLabel(B,[m,k],u,h,_,L,g);const Q=this.opts.textHeight*this.gl.canvas.height*B.style.textScale,e0=this.textHeight(Q,B.text);k+=e0,k+=D/2}g||(v.depthFunc(N),e&&v.enable(v.BLEND))}draw3D(u=[0,0,0,0],h=null,g=null,S=null,v=null,w=0){const D=v!==null;this.setPivot3D(),D||(v=this.scene.renderAzimuth,w=this.scene.renderElevation);const _=this.gl;h===null&&([h,g,S]=this.calculateMvpMatrix(null,u,v,w));let P=[...u];if(u[2]===0||u[3]===0?(u=[0,0,_.canvas.width,_.canvas.height],P=[...u],this.screenSlices.push({leftTopWidthHeight:u,axCorSag:4,sliceFrac:0,AxyzMxy:[],leftTopMM:[],fovMM:[isRadiological(g),0]})):(this.screenSlices.push({leftTopWidthHeight:u.slice(),axCorSag:4,sliceFrac:0,AxyzMxy:[],leftTopMM:[],fovMM:[isRadiological(g),0]}),u[1]=_.canvas.height-u[3]-u[1]),_.enable(_.DEPTH_TEST),_.depthFunc(_.ALWAYS),_.depthMask(!0),_.clearDepth(0),this.draw3DLabels(h,P,!1),_.viewport(u[0],u[1],u[2],u[3]),this.volumes.length>0&&(this.updateInterpolation(0,!0),this.updateInterpolation(1,!0),this.drawImage3D(h,v,w)),this.updateInterpolation(0),this.updateInterpolation(1),D||this.drawCrosshairs3D(!0,1,h),this.drawMesh3D(!0,1,h,g,S),this.uiData.mouseDepthPicker){this.depthPicker(u,h),this.createOnLocationChange(),this.draw3D(u,h,g,S,v,w);return}this.opts.meshXRay>0&&this.drawMesh3D(!1,this.opts.meshXRay,h,g,S),this.draw3DLabels(h,P,!1),_.viewport(u[0],u[1],u[2],u[3]),D||this.drawCrosshairs3D(!1,.15,h),_.viewport(0,0,_.canvas.width,_.canvas.height),this.drawOrientationCube(u,v,w);const L="azimuth: "+this.scene.renderAzimuth.toFixed(0)+" elevation: "+this.scene.renderElevation.toFixed(0);return this.readyForSync=!0,this.sync(),this.draw3DLabels(h,P,!0),L}drawMesh3D(u=!0,h=1,g,S,v){if(this.meshes.length<1)return;const w=this.gl;g||([g,S,v]=this.calculateMvpMatrix(this.volumeObject3D,void 0,this.scene.renderAzimuth,this.scene.renderElevation)),w.enable(w.DEPTH_TEST),w.blendFunc(w.SRC_ALPHA,w.ONE_MINUS_SRC_ALPHA),w.disable(w.BLEND),w.depthFunc(w.GREATER),w.disable(w.CULL_FACE),u?(w.disable(w.BLEND),w.depthFunc(w.GREATER)):(w.enable(w.BLEND),w.depthFunc(w.ALWAYS),w.enable(w.CULL_FACE)),w.cullFace(w.BACK);let D=this.meshShaders[0].shader,_=!1;for(let P=0;P<this.meshes.length;P++)if(this.meshes[P].visible!==!1&&(D=this.meshShaders[this.meshes[P].meshShaderIndex].shader,this.uiData.mouseDepthPicker&&(D=this.pickingMeshShader),D.use(this.gl),w.uniformMatrix4fv(D.uniforms.mvpMtx,!1,g),w.uniformMatrix4fv(D.uniforms.normMtx,!1,v),w.uniform1f(D.uniforms.opacity,h),!(this.meshes[P].indexCount<3))){if(this.meshes[P].offsetPt0&&(this.meshes[P].fiberSides<3||this.meshes[P].fiberRadius<=0)){_=!0;continue}D.isMatcap&&(w.activeTexture(TEXTURE5_MATCAP),w.bindTexture(w.TEXTURE_2D,this.matCapTexture)),w.bindVertexArray(this.meshes[P].vao),w.drawElements(w.TRIANGLES,this.meshes[P].indexCount,w.UNSIGNED_INT,0),w.bindVertexArray(this.unusedVAO)}if(!_){w.enable(w.BLEND),w.depthFunc(w.ALWAYS);return}D=this.fiberShader,D.use(this.gl),w.uniformMatrix4fv(D.uniforms.mvpMtx,!1,g),w.uniform1f(D.uniforms.opacity,h);for(let P=0;P<this.meshes.length;P++)this.meshes[P].indexCount<3||this.meshes[P].offsetPt0&&(this.meshes[P].fiberSides>=3&&this.meshes[P].fiberRadius>0||(w.bindVertexArray(this.meshes[P].vaoFiber),w.drawElements(w.LINE_STRIP,this.meshes[P].indexCount,w.UNSIGNED_INT,0),w.bindVertexArray(this.unusedVAO)));w.enable(w.BLEND),w.depthFunc(w.ALWAYS),this.readyForSync=!0}drawCrosshairs3D(u=!0,h=1,g=null,S=!1,v=!0){if(!this.opts.show3Dcrosshair&&!S||this.opts.crosshairWidth<=0&&S)return;const w=this.gl,D=this.frac2mm(this.scene.crosshairPos,0,v);if(this.crosshairs3D===null||this.crosshairs3D.mm[0]!==D[0]||this.crosshairs3D.mm[1]!==D[1]||this.crosshairs3D.mm[2]!==D[2]){this.crosshairs3D!==null&&(w.deleteBuffer(this.crosshairs3D.indexBuffer),w.deleteBuffer(this.crosshairs3D.vertexBuffer));const[L,m,k]=this.sceneExtentsMinMax(v);let e=1;if(this.volumes.length>0){if(!this.back)throw new Error("back undefined");e=.5*Math.min(Math.min(this.back.pixDims[1],this.back.pixDims[2]),this.back.pixDims[3])}else(k[0]<50||k[0]>1e3)&&(e=k[0]*.02);e*=this.opts.crosshairWidth,this.crosshairs3D=NiivueObject3D.generateCrosshairs(this.gl,1,D,L,m,e,20,this.opts.crosshairGap),this.crosshairs3D.mm=D}if(!this.surfaceShader)throw new Error("surfaceShader undefined");const _=this.surfaceShader;_.use(this.gl),g==null&&([g]=this.calculateMvpMatrix(this.crosshairs3D,void 0,this.scene.renderAzimuth,this.scene.renderElevation)),w.uniformMatrix4fv(_.uniforms.mvpMtx,!1,g),w.bindBuffer(w.ELEMENT_ARRAY_BUFFER,this.crosshairs3D.indexBuffer),w.enable(w.DEPTH_TEST);const P=[...this.opts.crosshairColor];u?(w.disable(w.BLEND),w.depthFunc(w.GREATER)):(w.enable(w.BLEND),w.blendFunc(w.SRC_ALPHA,w.ONE_MINUS_SRC_ALPHA),w.depthFunc(w.ALWAYS)),P[3]=h,w.uniform4fv(_.uniforms.surfaceColor,P),w.bindVertexArray(this.crosshairs3D.vao),w.drawElements(w.TRIANGLES,this.crosshairs3D.indexCount,w.UNSIGNED_INT,0),w.bindVertexArray(this.unusedVAO)}mm2frac(u,h=0,g=!1){if(this.volumes.length<1){const S=fromValues$2(.1,.5,.5),[v,w,D]=this.sceneExtentsMinMax();return S[0]=(u[0]-v[0])/D[0],S[1]=(u[1]-v[1])/D[1],S[2]=(u[2]-v[2])/D[2],isFinite(S)||(isFinite(S[0])||(S[0]=.5),isFinite(S[1])||(S[1]=.5),isFinite(S[2])||(S[2]=.5),this.meshes.length<1&&log.error("mm2frac() not finite: objects not (yet) loaded.")),S}return this.volumes[h].convertMM2Frac(u,g||this.opts.isSliceMM)}vox2frac(u,h=0){return this.volumes[h].convertVox2Frac(u)}frac2vox(u,h=0){return this.volumes.length<=h?[0,0,0]:this.volumes[h].convertFrac2Vox(u)}moveCrosshairInVox(u,h,g){const S=this.frac2vox(this.scene.crosshairPos);S[0]+=u,S[1]+=h,S[2]+=g,S[0]=clamp(S[0],0,this.volumes[0].dimsRAS[1]-1),S[1]=clamp(S[1],0,this.volumes[0].dimsRAS[2]-1),S[2]=clamp(S[2],0,this.volumes[0].dimsRAS[3]-1),this.scene.crosshairPos=this.vox2frac(S),this.createOnLocationChange(),this.drawScene()}frac2mm(u,h=0,g=!1){const S=fromValues$1(u[0],u[1],u[2],1);if(this.volumes.length>0)return this.volumes[h].convertFrac2MM(u,g||this.opts.isSliceMM);{const[v,w]=this.sceneExtentsMinMax(),D=(_,P,L)=>_*(1-L)+P*L;S[0]=D(v[0],w[0],u[0]),S[1]=D(v[1],w[1],u[1]),S[2]=D(v[2],w[2],u[2])}return S}screenXY2TextureFrac(u,h,g,S=!0){const v=fromValues$2(-1,-1,-1),w=this.screenSlices[g].axCorSag;if(w>2)return v;const D=this.screenSlices[g].leftTopWidthHeight.slice();let _=!1;D[2]<0&&(_=!0,D[0]+=D[2],D[2]=-D[2]);let P=(u-D[0])/D[2];_&&(P=1-P);const L=1-(h-D[1])/D[3];if(P<0||P>1||L<0||L>1||this.screenSlices[g].AxyzMxy.length<4)return v;let m=fromValues$2(0,0,0);m[0]=this.screenSlices[g].leftTopMM[0]+P*this.screenSlices[g].fovMM[0],m[1]=this.screenSlices[g].leftTopMM[1]+L*this.screenSlices[g].fovMM[1];const k=this.screenSlices[g].AxyzMxy;m[2]=k[2]+k[4]*(m[1]-k[1])-k[3]*(m[0]-k[0]),w===1&&(m=swizzleVec3(m,[0,2,1])),w===2&&(m=swizzleVec3(m,[2,0,1]));const e=this.mm2frac(m);return S&&(e[0]<0||e[0]>1||e[1]<0||e[1]>1||e[2]<0||e[2]>1)?v:e}canvasPos2frac(u){for(let h=0;h<this.screenSlices.length;h++){const g=this.screenXY2TextureFrac(u[0],u[1],h);if(g[0]>=0)return g}return[-1,-1,-1]}scaleSlice(u,h,g=0,S=0){const v=this.effectiveCanvasWidth()-g,w=this.effectiveCanvasHeight()-S;let D=v/u;h*D>w&&(D=w/h);const _=u*D,P=h*D;return[(v-_)*.5,(w-P)*.5,_,P,D]}drawThumbnail(){if(!this.bmpShader)throw new Error("bmpShader undefined");this.bmpShader.use(this.gl),this.gl.uniform2f(this.bmpShader.uniforms.canvasWidthHeight,this.gl.canvas.width,this.gl.canvas.height);let u=this.gl.canvas.height,h=this.gl.canvas.height*this.bmpTextureWH;h>this.gl.canvas.width&&(u=this.gl.canvas.width/this.bmpTextureWH,h=this.gl.canvas.width),this.gl.uniform4f(this.bmpShader.uniforms.leftTopWidthHeight,0,0,h,u),this.gl.bindVertexArray(this.genericVAO),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),this.gl.bindVertexArray(this.unusedVAO)}drawLine(u,h=1,g=[1,0,0,-1]){if(this.gl.bindVertexArray(this.genericVAO),!this.lineShader)throw new Error("lineShader undefined");this.lineShader.use(this.gl),g[3]<0&&(g=this.opts.crosshairColor),this.gl.uniform4fv(this.lineShader.uniforms.lineColor,g),this.gl.uniform2fv(this.lineShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.uniform1f(this.lineShader.uniforms.thickness,h),this.gl.uniform4fv(this.lineShader.uniforms.startXYendXY,u),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),this.gl.bindVertexArray(this.unusedVAO)}draw3DLine(u,h,g=1,S=[1,0,0,-1]){if(this.gl.bindVertexArray(this.genericVAO),!this.line3DShader)throw new Error("line3DShader undefined");this.line3DShader.use(this.gl),S[3]<0&&(S=this.opts.crosshairColor),this.gl.uniform4fv(this.line3DShader.uniforms.lineColor,S),this.gl.uniform2fv(this.line3DShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.uniform1f(this.line3DShader.uniforms.thickness,g),this.gl.uniform2fv(this.line3DShader.uniforms.startXY,u),this.gl.uniform3fv(this.line3DShader.uniforms.endXYZ,h),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),this.gl.bindVertexArray(this.unusedVAO)}drawDottedLine(u,h=1,g=[1,0,0,-1]){if(this.gl.bindVertexArray(this.genericVAO),!this.lineShader)throw new Error("lineShader undefined");this.lineShader.use(this.gl);const S=g[3]<0?[...this.opts.crosshairColor]:[...g];S[3]=.3;const v=fromValues(u[2]-u[0],u[3]-u[1]),w=length(v);normalize(v,v);const _=this.opts.textHeight*Math.min(this.gl.canvas.height,this.gl.canvas.width)*1;scale(v,v,_/2);const P=length(v);let L=Math.floor(w/P);w%P&&L++;const m=[u[0],u[1]];this.gl.uniform4fv(this.lineShader.uniforms.lineColor,S),this.gl.uniform2fv(this.lineShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.uniform1f(this.lineShader.uniforms.thickness,h);for(let k=0;k<L-1;k++){if(k%2){m[0]+=v[0],m[1]+=v[1];continue}const e=[m[0],m[1],m[0]+v[0],m[1]+v[1]];this.gl.uniform4fv(this.lineShader.uniforms.startXYendXY,e),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),m[0]+=v[0],m[1]+=v[1]}this.gl.bindVertexArray(this.unusedVAO)}drawGraphLine(u,h=[1,0,0,.5],g=2){this.drawLine(u,g,h)}drawCrossLinesMM(u,h,g,S,v){if(u<0||this.screenSlices.length<=u)return;const w=this.screenSlices[u];let D=w.sliceFrac;D===1/0&&log.warn("Rendering approximate cross lines in world view mode"),D===1/0&&(D=.5);let P=S.slice(),L=v.slice();const m=Math.max(1,this.opts.crosshairWidth);h===1&&(P=g.slice()),h===2&&(P=g.slice(),L=S.slice());function k(e){const N=fromValues(0,0);return N[0]=w.leftTopWidthHeight[0]+(e[0]-w.leftTopMM[0])/w.fovMM[0]*w.leftTopWidthHeight[2],N[1]=w.leftTopWidthHeight[1]+w.leftTopWidthHeight[3]-(e[1]-w.leftTopMM[1])/w.fovMM[1]*w.leftTopWidthHeight[3],N}if(P.length>0&&h===0){const e=D,N=1;for(let B=0;B<P.length;B++){const Q=this.frac2mm([.5,.5,.5]);Q[N]=P[B];let e0=this.mm2frac(Q);e0=e0[N];let j=this.frac2mm([0,e0,e]);j=swizzleVec3(j,[0,1,2]);let H=this.frac2mm([1,e0,e]);H=swizzleVec3(H,[0,1,2]),j=k(j),H=k(H),this.drawLine([j[0],j[1],H[0],H[1]],m)}}if(P.length>0&&h===1){const e=D,N=2;for(let B=0;B<P.length;B++){const Q=this.frac2mm([.5,.5,.5]);Q[N]=P[B];let e0=this.mm2frac(Q);e0=e0[N];let j=this.frac2mm([0,e,e0]);j=swizzleVec3(j,[0,2,1]);let H=this.frac2mm([1,e,e0]);H=swizzleVec3(H,[0,2,1]),j=k(j),H=k(H),this.drawLine([j[0],j[1],H[0],H[1]],m)}}if(P.length>0&&h===2){const e=D,N=2;for(let B=0;B<P.length;B++){const Q=this.frac2mm([.5,.5,.5]);Q[N]=P[B];let e0=this.mm2frac(Q);e0=e0[N];let j=this.frac2mm([e,0,e0]);j=swizzleVec3(j,[1,2,0]);let H=this.frac2mm([e,1,e0]);H=swizzleVec3(H,[1,2,0]),j=k(j),H=k(H),this.drawLine([j[0],j[1],H[0],H[1]],m)}}if(L.length>0&&h===0){const e=D,N=0;for(let B=0;B<L.length;B++){const Q=this.frac2mm([.5,.5,.5]);Q[N]=L[B];let e0=this.mm2frac(Q);e0=e0[N];let j=this.frac2mm([e0,0,e]);j=swizzleVec3(j,[0,1,2]);let H=this.frac2mm([e0,1,e]);H=swizzleVec3(H,[0,1,2]),j=k(j),H=k(H),this.drawLine([j[0],j[1],H[0],H[1]],m)}}if(L.length>0&&h===1){const e=D,N=0;for(let B=0;B<L.length;B++){const Q=this.frac2mm([.5,.5,.5]);Q[N]=L[B];let e0=this.mm2frac(Q);e0=e0[N];let j=this.frac2mm([e0,e,0]);j=swizzleVec3(j,[0,2,1]);let H=this.frac2mm([e0,e,1]);H=swizzleVec3(H,[0,2,1]),j=k(j),H=k(H),this.drawLine([j[0],j[1],H[0],H[1]],m)}}if(L.length>0&&h===2){const e=D,N=1;for(let B=0;B<L.length;B++){const Q=this.frac2mm([.5,.5,.5]);Q[N]=L[B];let e0=this.mm2frac(Q);e0=e0[N];let j=this.frac2mm([e,e0,0]);j=swizzleVec3(j,[1,2,0]);let H=this.frac2mm([e,e0,1]);H=swizzleVec3(H,[1,2,0]),j=k(j),H=k(H),this.drawLine([j[0],j[1],H[0],H[1]],m)}}}drawCrossLines(u,h,g,S,v){if(u<0||this.screenSlices.length<=u)return;if(this.opts.isSliceMM)return this.drawCrossLinesMM(u,h,g,S,v);if(this.screenSlices[u].sliceFrac===1/0)return this.drawCrossLinesMM(u,h,g,S,v);const w=this.screenSlices[u];let D=S.slice(),_=v.slice();if(h===1&&(D=g.slice()),h===2&&(D=g.slice(),_=S.slice()),D.length>0){const P=w.leftTopWidthHeight.slice();let L=2;h===0&&(L=1);const m=this.frac2mm([.5,.5,.5]);for(let k=0;k<D.length;k++){m[L]=D[k];const e=this.mm2frac(m);this.drawRect([P[0],P[1]+P[3]-e[L]*P[3],P[2],1])}}if(_.length>0){const P=w.leftTopWidthHeight.slice(),L=w.fovMM[0]<0;let m=0;h===2&&(m=1);const k=this.frac2mm([.5,.5,.5]);for(let e=0;e<_.length;e++){k[m]=_[e];const N=this.mm2frac(k);L?this.drawRect([P[0]+(P[2]-N[m]*P[2]),P[1],1,P[3]]):this.drawRect([P[0]+N[m]*P[2],P[1],1,P[3]])}}}drawMosaic(u){if(this.volumes.length===0){log.debug("Unable to draw mosaic until voxel-based image is loaded");return}this.screenSlices=[];const h=this.screenFieldOfViewMM(0,!0),g=this.screenFieldOfViewMM(0);u=u.replaceAll(";"," ;").trim();const S=[],v=[],w=[],D=u.split(/\s+/);let _=1;const P=this.opts.textHeight;let L=0,m=0;for(let k=0;k<2;k++){let e=!1,N=!1;e=!1;let B=0,Q=0,e0=0,j=0,H=!1,y=0;for(let Z=0;Z<D.length;Z++){const i0=D[Z];if(i0.includes("X")){N=!0;continue}if(i0.includes("L")){H=!i0.includes("-");continue}if(i0.includes("V")||i0.includes("H")){Z++;continue}i0.includes("A")&&(y=0),i0.includes("C")&&(y=1),i0.includes("S")&&(y=2),i0.includes("R")&&(e=!0),i0.includes(";")&&(e0+=B,j=Math.max(j,Q),B=0,Q=0);const z=parseFloat(i0);if(isNaN(z))continue;let f=0,f0=0,o0=g;if(e&&(o0=h),y===2?f=o0[1]:f=o0[0],y===0?f0=o0[1]:f0=o0[2],k===0)e||(y===0&&S.push(z),y===1&&v.push(z),y===2&&w.push(z));else{const c0=[L+_*Q,m+_*e0,_*f,_*f0];if(this.opts.textHeight=H?P:0,e){let d0=z<0?-1/0:1/0;Object.is(z,-0)&&(d0=-1/0),this.draw2D(c0,y,d0)}else this.draw2D(c0,y,z);N&&this.drawCrossLines(this.screenSlices.length-1,y,S,v,w),e=!1,N=!1}Q+=f,B=Math.max(B,f0)}if(e0+=B,j=Math.max(j,Q),j<=0||e0<=0)break;const Y=this.gl.canvas.width/j,G=this.effectiveCanvasHeight()/e0;_=Math.min(Y,G),this.opts.centerMosaic&&(L=Math.floor(.5*(this.gl.canvas.width-j*_)),m=Math.floor(.5*(this.effectiveCanvasHeight()-e0*_)))}this.opts.textHeight=P}drawSceneCore(){if(!this.initialized)return;if(this.colorbarHeight=0,this.gl.clearColor(this.opts.backColor[0],this.opts.backColor[1],this.opts.backColor[2],this.opts.backColor[3]),this.gl.clear(this.gl.COLOR_BUFFER_BIT|this.gl.DEPTH_BUFFER_BIT),this.bmpTexture&&this.thumbnailVisible){this.drawThumbnail();return}let u="";if(this.volumes.length===0||typeof this.volumes[0].dims>"u"){if(this.meshes.length>0){this.screenSlices=[],this.opts.sliceType=4,this.draw3D(),this.opts.isColorbar&&this.drawColorbar();return}this.drawLoadingText(this.loadingText);return}if(this.back===null)return;if(this.uiData.isDragging&&this.scene.clipPlaneDepthAziElev[0]<1.8&&this.inRenderTile(this.uiData.dragStart[0],this.uiData.dragStart[1])>=0){const v=this.uiData.dragStart[0]-this.uiData.dragEnd[0],w=this.uiData.dragStart[1]-this.uiData.dragEnd[1],D=this.uiData.dragClipPlaneStartDepthAziElev.slice();if(D[1]-=v,D[1]=D[1]%360,D[2]+=w,D[1]!==this.scene.clipPlaneDepthAziElev[1]||D[2]!==this.scene.clipPlaneDepthAziElev[2])return this.scene.clipPlaneDepthAziElev=D,this.setClipPlane(this.scene.clipPlaneDepthAziElev)}if(this.sliceMosaicString.length<1&&this.opts.sliceType===4){this.opts.isColorbar&&this.reserveColorbarPanel(),this.screenSlices=[],this.draw3D(),this.opts.isColorbar&&this.drawColorbar();return}this.opts.isColorbar&&this.reserveColorbarPanel();const h=this.getMaxVols(),g=this.opts.sliceType===3&&h>1&&this.graph.autoSizeMultiplanar&&this.graph.opacity>0;if(this.sliceMosaicString.length>0)this.drawMosaic(this.sliceMosaicString);else if(this.gl.viewport(0,0,this.gl.canvas.width,this.gl.canvas.height),this.screenSlices=[],this.opts.sliceType===0)this.draw2D([0,0,0,0],0);else if(this.opts.sliceType===1)this.draw2D([0,0,0,0],1);else if(this.opts.sliceType===2)this.draw2D([0,0,0,0],2);else{let v=!1;this.opts.multiplanarForceRender?(v=!0,this.opts.multiplanarForceRender?this.opts.multiplanarShowRender=1:this.opts.multiplanarShowRender=2,delete this.opts.multiplanarForceRender):this.opts.multiplanarShowRender===1&&(v=!0);const w=isFinite(this.drawPenLocation[0])&&this.opts.drawingEnabled,{volScale:D}=this.sliceScale();typeof this.opts.multiplanarPadPixels!="number"&&log.debug("multiplanarPadPixels must be numeric");const _=parseFloat(`${this.opts.multiplanarPadPixels}`),P=this.scaleSlice(D[0]+D[1],D[1]+D[2],_*1,_*1),L=Math.max(Math.max(D[1],D[2]),D[0]),m=this.scaleSlice(D[0]+D[0]+D[1],Math.max(D[1],D[2]),_*2),k=this.scaleSlice(D[0]+D[0]+D[1]+L,Math.max(D[1],D[2]),_*3),e=this.scaleSlice(L,D[1]+D[2]+D[2],0,_*2),N=this.scaleSlice(L,D[1]+D[2]+D[2]+L,0,_*3);let B=!w&&(h<2||!g),Q=!1,e0=!1,j=!1;if(this.opts.multiplanarLayout===1?Q=!0:this.opts.multiplanarLayout===2?e0=!0:this.opts.multiplanarLayout===3?j=!0:e[4]>m[4]&&e[4]>P[4]?Q=!0:m[4]>P[4]?j=!0:e0=!0,Q){let H=e;v||this.opts.multiplanarShowRender===2&&N[4]>=e[4]?H=N:B=!1;const y=D[0]*H[4],Y=D[1]*H[4],G=D[2]*H[4],Z=L*H[4];this.draw2D([H[0],H[1],y,Y],0),this.draw2D([H[0],H[1]+Y+_,y,G],1),this.draw2D([H[0],H[1]+Y+_+G+_,Y,G],2),B&&this.draw3D([H[0],H[1]+Y+G+G+_*3,Z,Z])}else if(j){let H=m;v||this.opts.multiplanarShowRender===2&&k[4]>=m[4]?H=k:B=!1;const y=D[0]*H[4],Y=D[1]*H[4],G=D[2]*H[4];this.draw2D([H[0],H[1],y,Y],0),this.draw2D([H[0]+y+_,H[1],y,G],1),this.draw2D([H[0]+y+y+_*2,H[1],Y,G],2),B&&this.draw3D([H[0]+y+y+Y+_*3,H[1],H[3],H[3]])}else if(e0){v||(B=!1),this.opts.multiplanarShowRender===2&&(B=!0);const H=P,y=D[0]*H[4],Y=D[1]*H[4],G=D[2]*H[4];this.draw2D([H[0],H[1]+G+_,y,Y],0),this.draw2D([H[0],H[1],y,G],1),this.draw2D([H[0]+y+_,H[1],Y,G],2),B&&this.draw3D([H[0]+y+_,H[1]+G+_,Y,Y])}}if(this.opts.isRuler&&this.drawRuler(),this.opts.isColorbar&&this.drawColorbar(),g&&this.drawGraph(),this.uiData.isDragging){if(this.uiData.mouseButtonCenterDown){this.dragForCenterButton([this.uiData.dragStart[0],this.uiData.dragStart[1],this.uiData.dragEnd[0],this.uiData.dragEnd[1]]);return}if(this.opts.dragMode===4){this.dragForSlicer3D([this.uiData.dragStart[0],this.uiData.dragStart[1],this.uiData.dragEnd[0],this.uiData.dragEnd[1]]);return}if(this.opts.dragMode===3){this.dragForPanZoom([this.uiData.dragStart[0],this.uiData.dragStart[1],this.uiData.dragEnd[0],this.uiData.dragEnd[1]]);return}if(this.inRenderTile(this.uiData.dragStart[0],this.uiData.dragStart[1])>=0)return;if(this.opts.dragMode===2){this.drawMeasurementTool([this.uiData.dragStart[0],this.uiData.dragStart[1],this.uiData.dragEnd[0],this.uiData.dragEnd[1]]);return}const v=Math.abs(this.uiData.dragStart[0]-this.uiData.dragEnd[0]),w=Math.abs(this.uiData.dragStart[1]-this.uiData.dragEnd[1]);this.drawSelectionBox([Math.min(this.uiData.dragStart[0],this.uiData.dragEnd[0]),Math.min(this.uiData.dragStart[1],this.uiData.dragEnd[1]),v,w])}const S=this.frac2mm([this.scene.crosshairPos[0],this.scene.crosshairPos[1],this.scene.crosshairPos[2]]);return u=S[0].toFixed(2)+"×"+S[1].toFixed(2)+"×"+S[2].toFixed(2),this.readyForSync=!0,this.sync(),u}drawScene(){if(this.isBusy){this.needsRefresh=!0;return}this.isBusy=!1,this.needsRefresh=!1;let u=this.drawSceneCore();return this._gl!==null&&this.gl.finish(),this.needsRefresh&&(u=this.drawScene()),u}get gl(){if(!this._gl)throw new Error("unable to get WebGL context. Maybe the browser doesn't support WebGL2.");return this._gl}set gl(u){this._gl=u}},niimathOperators_default={bptfm:{args:["hp","lp"],help:"Same as bptf but does not remove mean (emulates fslmaths < 5.0.7)"},bwlabel:{args:["conn"],help:"Connected component labelling for non-zero voxels (conn sets neighbors: 6, 18, 26)"},c2h:{args:[],help:"reverse h2c transform"},ceil:{args:[],help:"round voxels upwards to the nearest integer"},conform:{args:[],help:"reslice to 1mm size in coronal slice direction with 256^3 voxels"},crop:{args:["tmin","tsize"],help:"remove volumes, starts with 0 not 1! Inputting -1 for a size will set it to the full range"},dehaze:{args:["mode"],help:"set dark voxels to zero (mode 1..5; higher yields more surviving voxels)"},detrend:{args:[],help:"remove linear trend (and mean) from input"},demean:{args:[],help:"remove average signal across volumes (requires 4D input)"},edt:{args:[],help:"estimate Euler Distance Transform (distance field). Assumes isotropic input"},close:{args:["thr","dx1","dx2"],help:"morphological close that binarizes with `thr`, dilates with `dx1` and erodes with `dx2` (fills bubbles with `thr`)"},floor:{args:[],help:"round voxels downwards to the nearest integer"},h2c:{args:[],help:"convert CT scans from 'Hounsfield' to 'Cormack' units to emphasize soft tissue contrast"},mesh:{args:[],help:"meshify requires 'd'ark, 'm'edium, 'b'right or numeric isosurface ('niimath bet -mesh -i d mesh.gii')",subOperations:{i:{args:["isovalue"],help:"'d'ark, 'm'edium, 'b'right or numeric isosurface"},a:{args:["atlasFile"],help:"roi based atlas to mesh"},b:{args:["fillBubbles"],help:"fill bubbles"},l:{args:["onlyLargest"],help:"only largest"},o:{args:["originalMC"],help:"original marching cubes"},q:{args:["quality"],help:"quality"},s:{args:["postSmooth"],help:"post smooth"},r:{args:["reduceFraction"],help:"reduce fraction"},v:{args:["verbose"],help:"verbose"}}},hollow:{args:["threshold","thickness"],help:"hollow out a mesh"},mod:{args:[],help:"modulus fractional remainder - same as '-rem' but includes fractions"},otsu:{args:["mode"],help:"binarize image using Otsu's method (mode 1..5; higher yields more bright voxels)"},power:{args:["exponent"],help:"raise the current image by following exponent"},qform:{args:["code"],help:"set qform_code"},sform:{args:["code"],help:"set sform_code"},p:{args:["threads"],help:"set maximum number of parallel threads. DISABLED: recompile for OpenMP support"},resize:{args:["X","Y","Z","m"],help:"grow (>1) or shrink (<1) image. Method <m> (0=nearest,1=linear,2=spline,3=Lanczos,4=Mitchell)"},round:{args:[],help:"round voxels to the nearest integer"},sobel:{args:[],help:"fast edge detection"},sobel_binary:{args:[],help:"sobel creating binary edge"},tensor_2lower:{args:[],help:"convert FSL style upper triangle image to NIfTI standard lower triangle order"},tensor_2upper:{args:[],help:"convert NIfTI standard lower triangle image to FSL style upper triangle order"},tensor_decomp_lower:{args:[],help:"as tensor_decomp except input stores lower diagonal (AFNI, ANTS, Camino convention)"},trunc:{args:[],help:"truncates the decimal value from floating point value and returns integer value"},unsharp:{args:["sigma","scl"],help:"edge enhancing unsharp mask (sigma in mm, not voxels; 1.0 is typical)"},dog:{args:["sPos","sNeg"],help:"difference of gaussian with zero-crossing edges (positive and negative sigma mm)"},dogr:{args:["sPos","sNeg"],help:"as dog, without zero-crossing (raw rather than binarized data)"},dogx:{args:["sPos","sNeg"],help:"as dog, zero-crossing for 2D sagittal slices"},dogy:{args:["sPos","sNeg"],help:"as dog, zero-crossing for 2D coronal slices"},dogz:{args:["sPos","sNeg"],help:"as dog, zero-crossing for 2D axial slices"},add:{args:["input"],help:"add following input to current image"},sub:{args:["input"],help:"subtract following input from current image"},mul:{args:["input"],help:"multiply current image by following input"},div:{args:["input"],help:"divide current image by following input"},rem:{args:["number"],help:"modulus remainder - divide current image by following input and take remainder"},mas:{args:["file"],help:"use (following image>0) to mask current image"},thr:{args:["number"],help:"use following number to threshold current image (zero anything below the number)"},thrp:{args:["input"],help:"use following percentage (0-100) of ROBUST RANGE to threshold current image (zero anything below the number)"},thrP:{args:["input"],help:"use following percentage (0-100) of ROBUST RANGE of non-zero voxels and threshold below"},uthr:{args:["number"],help:"use following number to upper-threshold current image (zero anything above the number)"},uthrp:{args:["input"],help:"use following percentage (0-100) of ROBUST RANGE to upper-threshold current image (zero anything above the number)"},uthrP:{args:["input"],help:"use following percentage (0-100) of ROBUST RANGE of non-zero voxels and threshold above"},clamp:{args:["input"],help:"use following percentage (0-100) of ROBUST RANGE to threshold current image (anything below set to this threshold)"},uclamp:{args:["input"],help:"use following percentage (0-100) of ROBUST RANGE to threshold current image (anything above set to this threshold)"},max:{args:["input"],help:"take maximum of following input and current image"},min:{args:["input"],help:"take minimum of following input and current image"},seed:{args:["number"],help:"seed random number generator with following number"},restart:{args:["file"],help:"replace the current image with input for future processing operations"},save:{args:[],help:"save the current working image to the input filename"},inm:{args:["mean"],help:"(-i i ip.c) intensity normalisation (per 3D volume mean)"},ing:{args:["mean"],help:"(-I i ip.c) intensity normalisation, global 4D mean)"},s:{args:["sigma"],help:"create a gauss kernel of sigma mm and perform mean filtering"},exp:{args:[],help:"exponential"},log:{args:[],help:"natural logarithm"},sin:{args:[],help:"sine function"},cos:{args:[],help:"cosine function"},tan:{args:[],help:"tangent function"},asin:{args:[],help:"arc sine function"},acos:{args:[],help:"arc cosine function"},atan:{args:[],help:"arc tangent function"},sqr:{args:[],help:"square"},sqrt:{args:[],help:"square root"},recip:{args:[],help:"reciprocal (1/current image)"},abs:{args:[],help:"absolute value"},bin:{args:[],help:"use (current image>0) to binarise"},binv:{args:[],help:"binarise and invert (binarisation and logical inversion)"},fillh:{args:[],help:"fill holes in a binary mask (holes are internal - i.e. do not touch the edge of the FOV)"},fillh26:{args:[],help:"fill holes using 26 connectivity"},index:{args:[],help:"replace each nonzero voxel with a unique (subject to wrapping) index number"},grid:{args:["value","spacing"],help:"add a 3D grid of intensity <value> with grid spacing <spacing>"},edge:{args:[],help:"edge strength"},tfce:{args:["H","E","connectivity"],help:"enhance with TFCE, e.g. -tfce 2 0.5 6 (maybe change 6 to 26 for skeletons)"},tfceS:{args:["H","E","connectivity","X","Y","Z","tfce_thresh"],help:"show support area for voxel (X,Y,Z)"},nan:{args:[],help:"replace NaNs (improper numbers) with 0"},nanm:{args:[],help:"make NaN (improper number) mask with 1 for NaN voxels, 0 otherwise"},rand:{args:[],help:"add uniform noise (range 0:1)"},randn:{args:[],help:"add Gaussian noise (mean=0 sigma=1)"},range:{args:[],help:"set the output calmin/max to full data range"},tensor_decomp:{args:[],help:"convert a 4D (6-timepoint )tensor image into L1,2,3,FA,MD,MO,V1,2,3 (remaining image in pipeline is FA)"},kernel:{subOperations:{"3D":{args:[],help:"3x3x3 box centered on target voxel (set as default kernel)"},"2D":{args:[],help:"3x3x1 box centered on target voxel"},box:{args:["size"],help:"all voxels in a cube of width <size> mm centered on target voxel"},boxv:{args:["size"],help:"all voxels in a cube of width <size> voxels centered on target voxel, CAUTION: size should be an odd number"},boxv3:{args:["X","Y","Z"],help:"all voxels in a cuboid of dimensions X x Y x Z centered on target voxel, CAUTION: size should be an odd number"},gauss:{args:["sigma"],help:"gaussian kernel (sigma in mm, not voxels)"},sphere:{args:["size"],help:"all voxels in a sphere of radius <size> mm centered on target voxel"},file:{args:["filename"],help:"use external file as kernel"}}},dilM:{args:[],help:"Mean Dilation of non-zero voxels"},dilD:{args:[],help:"Maximum Dilation of non-zero voxels (emulating output of fslmaths 6.0.1, max not modal)"},dilF:{args:[],help:"Maximum filtering of all voxels"},dilall:{args:[],help:"Apply -dilM repeatedly until the entire FOV is covered"},ero:{args:[],help:"Erode by zeroing non-zero voxels when zero voxels found in kernel"},eroF:{args:[],help:"Minimum filtering of all voxels"},fmedian:{args:[],help:"Median Filtering"},fmean:{args:[],help:"Mean filtering, kernel weighted (conventionally used with gauss kernel)"},fmeanu:{args:[],help:"Mean filtering, kernel weighted, un-normalized (gives edge effects)"},subsamp2:{args:[],help:"downsamples image by a factor of 2 (keeping new voxels centered on old)"},subsamp2offc:{args:[],help:"downsamples image by a factor of 2 (non-centered)"},Tmean:{args:[],help:"mean across time"},Tstd:{args:[],help:"standard deviation across time"},Tmax:{args:[],help:"max across time"},Tmaxn:{args:[],help:"time index of max across time"},Tmin:{args:[],help:"min across time"},Tmedian:{args:[],help:"median across time"},Tperc:{args:["percentage"],help:"nth percentile (0-100) of FULL RANGE across time"},Tar1:{args:[],help:"temporal AR(1) coefficient (use -odt float and probably demean first)"},pval:{args:[],help:"Nonparametric uncorrected P-value, assuming timepoints are the permutations; first timepoint is actual (unpermuted) stats image"},pval0:{args:[],help:"Same as -pval, but treat zeros as missing data"},cpval:{args:[],help:"Same as -pval, but gives FWE corrected P-values"},ztop:{args:[],help:"Convert Z-stat to (uncorrected) P"},ptoz:{args:[],help:"Convert (uncorrected) P to Z"},ztopc:{args:[],help:"Convert Z-stat to (uncorrected but clamped) P"},ptozc:{args:[],help:"Convert (uncorrected but clamped) P to Z"},rank:{args:[],help:"Convert data to ranks (over T dim)"},ranknorm:{args:[],help:"Transform to Normal dist via ranks"},roi:{args:["xmin","xsize","ymin","ysize","zmin","zsize","tmin","tsize"],help:"zero outside roi (using voxel coordinates). Inputting -1 for a size will set it to the full image extent for that dimension"},bptf:{args:["hp_sigma","lp_sigma"],help:"(-t in ip.c) Bandpass temporal filtering; nonlinear highpass and Gaussian linear lowpass (with sigmas in volumes, not seconds); set either sigma<0 to skip that filter"},roc:{args:["AROC-thresh","outfile","truth"],help:"take (normally binary) truth and test current image in ROC analysis against truth. <AROC-thresh> is usually 0.05 and is limit of Area-under-ROC measure FP axis. <outfile> is a text file of the ROC curve (triplets of values: FP TP threshold). If the truth image contains negative voxels these get excluded from all calculations. If <AROC-thresh> is positive then the [4Dnoiseonly] option needs to be set, and the FP rate is determined from this noise-only data, and is set to be the fraction of timepoints where any FP (anywhere) is seen, as found in the noise-only 4d-dataset. This is then controlling the FWE rate. If <AROC-thresh> is negative the FP rate is calculated from the zero-value parts of the <truth> image, this time averaging voxelwise FP rate over all timepoints. In both cases the TP rate is the average fraction of truth=positive voxels correctly found"}},Niimath=class{constructor(){this.worker=null,this.operators=niimathOperators_default}init(){return this.worker=new Worker(new URL(""+new URL("worker-Jat8hhVx.js",import.meta.url).href,import.meta.url),{type:"module"}),new Promise((T,u)=>{this.worker.onmessage=h=>{h.data&&h.data.type==="ready"&&T(!0)},this.worker.onerror=h=>{u(new Error(`Worker failed to load: ${h.message}`))}})}image(T){return new ImageProcessor({worker:this.worker,file:T,operators:this.operators})}},ImageProcessor=class{constructor({worker:T,file:u,operators:h}){this.worker=T,this.file=u,this.operators=h,this.commands=[],this._generateMethods()}_addCommand(T,...u){return this.commands.push(T,...u.map(String)),this}_generateMethods(){Object.keys(this.operators).forEach(T=>{const u=this.operators[T];T==="kernel"?Object.keys(u.subOperations).forEach(h=>{const g=u.subOperations[h];this[`kernel${h.charAt(0).toUpperCase()+h.slice(1)}`]=(...S)=>{if(S.length!==g.args.length)throw new Error(`Expected ${g.args.length} arguments for kernel ${h}, but got ${S.length}`);return this._addCommand("-kernel",h,...S)}}):T==="mesh"?this.mesh=(h={})=>{const g=[];return Object.keys(h).forEach(S=>{if(u.subOperations[S]){const v=u.subOperations[S],w=h[S];if(v.args.length>0&&w===void 0)throw new Error(`Sub-option -${S} requires a value.`);g.push(`-${S}`),v.args.length>0&&g.push(w)}else throw new Error(`Invalid sub-option -${S} for mesh.`)}),this._addCommand("-mesh",...g)}:this[T]=(...h)=>{if(h.length<u.args.length||!u.optional&&h.length>u.args.length)throw new Error(`Expected ${u.args.length} arguments for ${T}, but got ${h.length}`);return this._addCommand(`-${T}`,...h)}})}async run(T="output.nii"){return new Promise((u,h)=>{this.worker.onmessage=S=>{if(S.data.type==="error")h(new Error(S.data.message));else{const{blob:v,exitCode:w}=S.data;w===0?u(v):h(new Error(`niimath processing failed with exit code ${w}`))}};const g=[this.file.name,...this.commands,T];this.worker===null&&h(new Error("Worker not initialized. Did you await the init() method?")),this.worker.postMessage({blob:this.file,cmd:g,outName:T})})}};const brainChopOpts={batchSize:1,numOfChan:1,isColorEnable:!0,isAutoColors:!0,bgLabelValue:0,drawBoundingVolume:!1,isGPU:!0,isBrainCropMaskBased:!0,showPhase1Output:!1,isPostProcessEnable:!0,isContoursViewEnable:!1,browserArrayBufferMaxZDim:30,telemetryFlag:!1,chartXaxisStepPercent:10,uiSampleName:"BC_UI_Sample",atlasSelectedColorTable:"Fire"},inferenceModelsList=[{id:1,type:"Segmentation",path:"/models/model5_gw_ae/model.json",modelName:"⚡ Tissue GWM (light)",labelsPath:"./models/model5_gw_ae/labels.json",colorsPath:"./models/model5_gw_ae/colorLUT.json",colormapPath:"./models/model5_gw_ae/colormap3.json",preModelId:null,preModelPostProcess:!1,isBatchOverlapEnable:!1,numOverlapBatches:0,enableTranspose:!0,enableCrop:!0,cropPadding:18,autoThreshold:0,enableQuantileNorm:!1,filterOutWithPreMask:!1,enableSeqConv:!1,textureSize:0,warning:null,inferenceDelay:100,description:"Gray and white matter segmentation model. Operates on full T1 image in a single pass, but uses only 5 filters per layer. Can work on integrated graphics cards but is barely large enough to provide good accuracy. Still more accurate than the subvolume model."},{id:2,type:"Segmentation",path:"/models/model20chan3cls/model.json",modelName:"🔪 Tissue GWM (High Acc)",labelsPath:"./models/model20chan3cls/labels.json",colorsPath:"./models/model20chan3cls/colorLUT.json",colormapPath:"./models/model20chan3cls/colormap.json",preModelId:null,preModelPostProcess:!1,isBatchOverlapEnable:!1,numOverlapBatches:0,enableTranspose:!0,enableCrop:!0,cropPadding:0,autoThreshold:.2,enableQuantileNorm:!0,filterOutWithPreMask:!1,enableSeqConv:!1,textureSize:0,warning:"This model may need dedicated graphics card.  For more info please check with Browser Resources <i class='fa fa-cogs'></i>.",inferenceDelay:100,description:"Gray and white matter segmentation model. Operates on full T1 image in a single pass but needs a dedicated graphics card to operate. Provides the best accuracy with hard cropping for better speed"},{id:3,type:"Segmentation",path:"/models/model20chan3cls/model.json",modelName:"🔪 Tissue GWM (High Acc, Low Mem)",labelsPath:"./models/model20chan3cls/labels.json",colorsPath:"./models/model20chan3cls/colorLUT.json",colormapPath:"./models/model20chan3cls/colormap.json",preModelId:null,preModelPostProcess:!1,isBatchOverlapEnable:!1,numOverlapBatches:0,enableTranspose:!0,enableCrop:!0,cropPadding:0,autoThreshold:.2,enableQuantileNorm:!0,filterOutWithPreMask:!1,enableSeqConv:!0,textureSize:0,warning:"This model may need dedicated graphics card.  For more info please check with Browser Resources <i class='fa fa-cogs'></i>.",inferenceDelay:100,description:"Gray and white matter segmentation model. Operates on full T1 image in a single pass but needs a dedicated graphics card to operate. Provides high accuracy and fit low memory available but slower"},{id:4,type:"Atlas",path:"/models/model30chan18cls/model.json",modelName:"🪓 Subcortical + GWM (High Mem, Fast)",labelsPath:"./models/model30chan18cls/labels.json",colorsPath:"./models/model30chan18cls/colorLUT.json",colormapPath:"./models/model30chan18cls/colormap.json",preModelId:null,preModelPostProcess:!1,isBatchOverlapEnable:!1,numOverlapBatches:200,enableTranspose:!0,enableCrop:!0,cropPadding:0,autoThreshold:.2,enableQuantileNorm:!1,filterOutWithPreMask:!1,enableSeqConv:!1,textureSize:0,warning:"This model may need dedicated graphics card.  For more info please check with Browser Resources <i class='fa fa-cogs'></i>.",inferenceDelay:100,description:"Parcellation of the brain into 17 regions: gray and white matter plus subcortical areas. This is a robust model able to handle range of data quality, including varying saturation, and even clinical scans. It may work on infant brains, but your mileage may vary."},{id:5,type:"Atlas",path:"/models/model30chan18cls/model.json",modelName:"🪓 Subcortical + GWM (Low Mem, Slow)",labelsPath:"./models/model30chan18cls/labels.json",colorsPath:"./models/model30chan18cls/colorLUT.json",colormapPath:"./models/model30chan18cls/colormap.json",preModelId:null,preModelPostProcess:!1,isBatchOverlapEnable:!1,numOverlapBatches:200,enableTranspose:!0,enableCrop:!0,cropPadding:0,autoThreshold:.2,enableQuantileNorm:!1,filterOutWithPreMask:!1,enableSeqConv:!0,textureSize:0,warning:"This model may need dedicated graphics card.  For more info please check with Browser Resources <i class='fa fa-cogs'></i>.",inferenceDelay:100,description:"Parcellation of the brain into 17 regions: gray and white matter plus subcortical areas. This is a robust model able to handle range of data quality, including varying saturation, and even clinical scans. 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diff --git a/index.html b/index.html
index 191865b..9a222d9 100644
--- a/index.html
+++ b/index.html
@@ -6,7 +6,7 @@
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
   <link rel="stylesheet" href="./niivue.css" />
   <title>Niivue brain chop</title>
-  <script type="module" crossorigin src="./assets/index-BeZ2s21u.js"></script>
+  <script type="module" crossorigin src="./assets/index-CNZOlbQj.js"></script>
 </head>
 
 <body>