diff --git a/modules/nf-core/basicpy/main.nf b/modules/nf-core/basicpy/main.nf
index f129e54ba1a..cfcf9ac1ae8 100644
--- a/modules/nf-core/basicpy/main.nf
+++ b/modules/nf-core/basicpy/main.nf
@@ -32,6 +32,10 @@ process BASICPY {
     """
 
     stub:
+    // Exit if running this module with -profile conda / -profile mamba
+    if (workflow.profile.tokenize(',').intersect(['conda', 'mamba']).size() >= 1) {
+        error "Basicpy module does not support Conda. Please use Docker / Singularity instead."
+    }
     """
     touch ${prefix}.-dfp.tiff
     touch ${prefix}.-dfp.tiff