diff --git a/litestar/_openapi/schema_generation/plugins/struct.py b/litestar/_openapi/schema_generation/plugins/struct.py
index 7ac0dd0220..e8fa8e273e 100644
--- a/litestar/_openapi/schema_generation/plugins/struct.py
+++ b/litestar/_openapi/schema_generation/plugins/struct.py
@@ -1,6 +1,6 @@
 from __future__ import annotations
 
-from typing import TYPE_CHECKING
+from typing import TYPE_CHECKING, Literal
 
 import msgspec
 from msgspec import Struct
@@ -20,10 +20,11 @@ class StructSchemaPlugin(OpenAPISchemaPlugin):
     def is_plugin_supported_field(self, field_definition: FieldDefinition) -> bool:
         return not field_definition.is_union and field_definition.is_subclass_of(Struct)
 
-    def to_openapi_schema(self, field_definition: FieldDefinition, schema_creator: SchemaCreator) -> Schema:
-        def is_field_required(field: msgspec.inspect.Field) -> bool:
-            return field.required or field.default_factory is Empty
+    @staticmethod
+    def _is_field_required(field: msgspec.inspect.Field) -> bool:
+        return field.required or field.default_factory is Empty
 
+    def to_openapi_schema(self, field_definition: FieldDefinition, schema_creator: SchemaCreator) -> Schema:
         type_hints = field_definition.get_type_hints(include_extras=True, resolve_generics=True)
         struct_info: msgspec.inspect.StructType = msgspec.inspect.type_info(field_definition.type_)  # type: ignore[assignment]
         struct_fields = struct_info.fields
@@ -41,14 +42,24 @@ def is_field_required(field: msgspec.inspect.Field) -> bool:
                 **field_definition_kwargs,
             )
 
+        required = [
+            field.encode_name
+            for field in struct_fields
+            if self._is_field_required(field=field) and not is_optional_union(type_hints[field.name])
+        ]
+
+        # Support tagged unions: https://jcristharif.com/msgspec/structs.html#tagged-unions
+        # These structs contain a tag_field and a tag. Since these fields are added
+        # dynamically, they are not present within the regular struct fields and don't
+        # have any type annotation associated with them, so we create a FieldDefinition
+        # manually
+        if struct_info.tag_field:
+            # using a Literal here will set these as a const in the schema
+            property_fields[struct_info.tag_field] = FieldDefinition.from_annotation(Literal[struct_info.tag])  # pyright: ignore
+            required.append(struct_info.tag_field)
+
         return schema_creator.create_component_schema(
             field_definition,
-            required=sorted(
-                [
-                    field.encode_name
-                    for field in struct_fields
-                    if is_field_required(field=field) and not is_optional_union(type_hints[field.name])
-                ]
-            ),
+            required=sorted(required),
             property_fields=property_fields,
         )
diff --git a/tests/unit/test_contrib/test_msgspec.py b/tests/unit/test_contrib/test_msgspec.py
index 2c0c177ec4..9c0f77ddf6 100644
--- a/tests/unit/test_contrib/test_msgspec.py
+++ b/tests/unit/test_contrib/test_msgspec.py
@@ -8,6 +8,7 @@
 from msgspec import Meta, Struct, field
 from typing_extensions import Annotated
 
+from litestar import Litestar, post
 from litestar.dto import DTOField, Mark, MsgspecDTO, dto_field
 from litestar.dto.data_structures import DTOFieldDefinition
 from litestar.typing import FieldDefinition
@@ -131,3 +132,64 @@ class Model(Struct):
     fields = list(dto_type.generate_field_definitions(Model))
     assert fields[0].dto_field == DTOField("read-only")
     assert fields[1].dto_field == DTOField("read-only")
+
+
+def test_tag_field_included_in_schema() -> None:
+    # default tag field, default tag value
+    class Model(Struct, tag=True):
+        regular_field: str
+
+    # default tag field, custom tag value
+    class Model2(Struct, tag=2):
+        regular_field: str
+
+    # custom tag field, custom tag value
+    class Model3(Struct, tag_field="foo", tag="bar"):
+        regular_field: str
+
+    @post("/1")
+    def handler(data: Model) -> None:
+        return None
+
+    @post("/2")
+    def handler_2(data: Model2) -> None:
+        return None
+
+    @post("/3")
+    def handler_3(data: Model3) -> None:
+        return None
+
+    components = Litestar(
+        [handler, handler_2, handler_3],
+        signature_types=[Model, Model2, Model3],
+    ).openapi_schema.components.to_schema()["schemas"]
+
+    assert components["test_tag_field_included_in_schema.Model"] == {
+        "properties": {
+            "regular_field": {"type": "string"},
+            "type": {"type": "string", "const": "Model"},
+        },
+        "type": "object",
+        "required": ["regular_field", "type"],
+        "title": "Model",
+    }
+
+    assert components["test_tag_field_included_in_schema.Model2"] == {
+        "properties": {
+            "regular_field": {"type": "string"},
+            "type": {"type": "integer", "const": 2},
+        },
+        "type": "object",
+        "required": ["regular_field", "type"],
+        "title": "Model2",
+    }
+
+    assert components["test_tag_field_included_in_schema.Model3"] == {
+        "properties": {
+            "regular_field": {"type": "string"},
+            "foo": {"type": "string", "const": "bar"},
+        },
+        "type": "object",
+        "required": ["foo", "regular_field"],
+        "title": "Model3",
+    }