diff --git a/.kokoro/continuous/node14/system-test.cfg b/.kokoro/continuous/node14/system-test.cfg
index 9ba9ad1c7..c7c9507a8 100644
--- a/.kokoro/continuous/node14/system-test.cfg
+++ b/.kokoro/continuous/node14/system-test.cfg
@@ -8,5 +8,5 @@ env_vars: {
 
 env_vars: {
   key: "SECRET_MANAGER_KEYS"
-  value: "long-door-651-kokoro-system-test-service-account"
+  value: "long-door-651-kokoro-system-test-service-account,client-library-test-universe-domain-credential"
 }
\ No newline at end of file
diff --git a/.kokoro/presubmit/node14/system-test.cfg b/.kokoro/presubmit/node14/system-test.cfg
index 9ba9ad1c7..c7c9507a8 100644
--- a/.kokoro/presubmit/node14/system-test.cfg
+++ b/.kokoro/presubmit/node14/system-test.cfg
@@ -8,5 +8,5 @@ env_vars: {
 
 env_vars: {
   key: "SECRET_MANAGER_KEYS"
-  value: "long-door-651-kokoro-system-test-service-account"
+  value: "long-door-651-kokoro-system-test-service-account,client-library-test-universe-domain-credential"
 }
\ No newline at end of file
diff --git a/.kokoro/release/publish.cfg b/.kokoro/release/publish.cfg
index baea5db3c..019cc24a5 100644
--- a/.kokoro/release/publish.cfg
+++ b/.kokoro/release/publish.cfg
@@ -18,7 +18,7 @@ before_action {
 
 env_vars: {
   key: "SECRET_MANAGER_KEYS"
-  value: "releasetool-publish-reporter-app,releasetool-publish-reporter-googleapis-installation,releasetool-publish-reporter-pem"
+  value: "releasetool-publish-reporter-app,releasetool-publish-reporter-googleapis-installation,releasetool-publish-reporter-pem,client-library-test-universe-domain-credential"
 }
 
 # Download trampoline resources.
diff --git a/.kokoro/system-test.sh b/.kokoro/system-test.sh
index 0b3043d26..e219954ae 100755
--- a/.kokoro/system-test.sh
+++ b/.kokoro/system-test.sh
@@ -22,6 +22,12 @@ export NPM_CONFIG_PREFIX=${HOME}/.npm-global
 export GOOGLE_APPLICATION_CREDENTIALS=${KOKORO_GFILE_DIR}/secret_manager/long-door-651-kokoro-system-test-service-account
 export GCLOUD_PROJECT=long-door-651
 
+# For universe domain testing
+export TEST_UNIVERSE_DOMAIN_CREDENTIAL=${KOKORO_GFILE_DIR}/secret_manager/client-library-test-universe-domain-credential
+export TEST_UNIVERSE_DOMAIN=$(gcloud secrets versions access latest --project cloud-devrel-kokoro-resources --secret=client-library-test-universe-domain)
+export TEST_UNIVERSE_PROJECT_ID=$(gcloud secrets versions access latest --project cloud-devrel-kokoro-resources --secret=client-library-test-universe-project-id)
+export TEST_UNIVERSE_LOCATION=$(gcloud secrets versions access latest --project cloud-devrel-kokoro-resources --secret=client-library-test-universe-storage-location)
+
 cd $(dirname $0)/..
 
 # Run a pre-test hook, if a pre-system-test.sh is in the project
diff --git a/system-test/storage.ts b/system-test/storage.ts
index f192a614c..4b004c830 100644
--- a/system-test/storage.ts
+++ b/system-test/storage.ts
@@ -3866,6 +3866,68 @@ describe('storage', function () {
     });
   });
 
+  describe('universeDomainTests', () => {
+    let universeDomainStorage: Storage;
+    const bucketName = generateName();
+    const localFile = fs.readFileSync(FILES.logo.path);
+    let file: File;
+
+    before(async () => {
+      const TEST_UNIVERSE_DOMAIN = isNullOrUndefined('TEST_UNIVERSE_DOMAIN');
+      const TEST_PROJECT_ID = isNullOrUndefined('TEST_UNIVERSE_PROJECT_ID');
+      const TEST_UNIVERSE_LOCATION = isNullOrUndefined(
+        'TEST_UNIVERSE_LOCATION'
+      );
+      const CREDENTIAL_PATH = isNullOrUndefined(
+        'TEST_UNIVERSE_DOMAIN_CREDENTIAL'
+      );
+      // Create a client with universe domain credentials
+      universeDomainStorage = new Storage({
+        projectId: TEST_PROJECT_ID,
+        keyFilename: CREDENTIAL_PATH,
+        universeDomain: TEST_UNIVERSE_DOMAIN,
+      });
+
+      const [bucket] = await universeDomainStorage.createBucket(bucketName, {
+        location: TEST_UNIVERSE_LOCATION,
+      });
+
+      file = bucket.file('LogoToSign.jpg');
+      fs.createReadStream(FILES.logo.path).pipe(file.createWriteStream());
+    });
+
+    after(async () => {
+      await deleteFileAsync(file);
+      await deleteBucketAsync(bucket);
+    });
+
+    it('should get bucket', async () => {
+      const [buckets] = await universeDomainStorage.getBuckets();
+      const getBucket = buckets.filter(item => item.name === bucketName);
+      assert.strictEqual(getBucket[0].name, bucketName);
+    });
+
+    it('should get files', async () => {
+      const fileName = await universeDomainStorage
+        .bucket(bucketName)
+        .file(file.name).name;
+      assert.strictEqual(fileName, file.name);
+    });
+
+    it('should create a signed read url', async () => {
+      const [signedReadUrl] = await file.getSignedUrl({
+        version: 'v2',
+        action: 'read',
+        expires: Date.now() + 5000,
+        virtualHostedStyle: true,
+      });
+
+      const res = await fetch(signedReadUrl);
+      const body = await res.text();
+      assert.strictEqual(body, localFile.toString());
+    });
+  });
+
   async function deleteBucketAsync(bucket: Bucket, options?: {}) {
     // After files are deleted, eventual consistency may require a bit of a
     // delay to ensure that the bucket recognizes that the files don't exist
@@ -4015,4 +4077,12 @@ describe('storage', function () {
   function createFileWithContentPromise(content: string) {
     return bucket.file(`${generateName()}.txt`).save(content);
   }
+
+  function isNullOrUndefined(envVarName: string) {
+    const value = process.env[envVarName];
+    if (value === undefined || value === null) {
+      throw new Error(`Please set the ${envVarName} environment variable.`);
+    }
+    return value;
+  }
 });