diff --git a/charts/kube-prometheus-stack/Chart.yaml b/charts/kube-prometheus-stack/Chart.yaml
index ac06103719f4..da4424caeb20 100644
--- a/charts/kube-prometheus-stack/Chart.yaml
+++ b/charts/kube-prometheus-stack/Chart.yaml
@@ -21,7 +21,7 @@ name: kube-prometheus-stack
 sources:
   - https://github.com/prometheus-community/helm-charts
   - https://github.com/prometheus-operator/kube-prometheus
-version: 46.4.2
+version: 46.5.0
 appVersion: v0.65.1
 kubeVersion: ">=1.16.0-0"
 home: https://github.com/prometheus-operator/kube-prometheus
diff --git a/charts/kube-prometheus-stack/templates/alertmanager/alertmanager.yaml b/charts/kube-prometheus-stack/templates/alertmanager/alertmanager.yaml
index 4786af0f3c25..7eaff9fa0729 100644
--- a/charts/kube-prometheus-stack/templates/alertmanager/alertmanager.yaml
+++ b/charts/kube-prometheus-stack/templates/alertmanager/alertmanager.yaml
@@ -59,13 +59,13 @@ spec:
 {{- end }}
 {{- if .Values.alertmanager.alertmanagerSpec.alertmanagerConfigSelector }}
   alertmanagerConfigSelector:
-{{ toYaml .Values.alertmanager.alertmanagerSpec.alertmanagerConfigSelector | indent 4}}
+{{ tpl (toYaml .Values.alertmanager.alertmanagerSpec.alertmanagerConfigSelector | indent 4) . }}
 {{ else }}
   alertmanagerConfigSelector: {}
 {{- end }}
 {{- if .Values.alertmanager.alertmanagerSpec.alertmanagerConfigNamespaceSelector }}
   alertmanagerConfigNamespaceSelector:
-{{ toYaml .Values.alertmanager.alertmanagerSpec.alertmanagerConfigNamespaceSelector | indent 4}}
+{{ tpl (toYaml .Values.alertmanager.alertmanagerSpec.alertmanagerConfigNamespaceSelector | indent 4) . }}
 {{ else }}
   alertmanagerConfigNamespaceSelector: {}
 {{- end }}
diff --git a/charts/kube-prometheus-stack/templates/prometheus/prometheus.yaml b/charts/kube-prometheus-stack/templates/prometheus/prometheus.yaml
index de08ae89b09e..47e709f869c6 100644
--- a/charts/kube-prometheus-stack/templates/prometheus/prometheus.yaml
+++ b/charts/kube-prometheus-stack/templates/prometheus/prometheus.yaml
@@ -146,7 +146,7 @@ spec:
   serviceAccountName: {{ template "kube-prometheus-stack.prometheus.serviceAccountName" . }}
 {{- if .Values.prometheus.prometheusSpec.serviceMonitorSelector }}
   serviceMonitorSelector:
-{{ toYaml .Values.prometheus.prometheusSpec.serviceMonitorSelector | indent 4 }}
+{{ tpl (toYaml .Values.prometheus.prometheusSpec.serviceMonitorSelector | indent 4) . }}
 {{ else if .Values.prometheus.prometheusSpec.serviceMonitorSelectorNilUsesHelmValues  }}
   serviceMonitorSelector:
     matchLabels:
@@ -156,13 +156,13 @@ spec:
 {{- end }}
 {{- if .Values.prometheus.prometheusSpec.serviceMonitorNamespaceSelector }}
   serviceMonitorNamespaceSelector:
-{{ toYaml .Values.prometheus.prometheusSpec.serviceMonitorNamespaceSelector | indent 4 }}
+{{ tpl (toYaml .Values.prometheus.prometheusSpec.serviceMonitorNamespaceSelector | indent 4) . }}
 {{ else }}
   serviceMonitorNamespaceSelector: {}
 {{- end }}
 {{- if .Values.prometheus.prometheusSpec.podMonitorSelector }}
   podMonitorSelector:
-{{ toYaml .Values.prometheus.prometheusSpec.podMonitorSelector | indent 4 }}
+{{ tpl (toYaml .Values.prometheus.prometheusSpec.podMonitorSelector | indent 4) . }}
 {{ else if .Values.prometheus.prometheusSpec.podMonitorSelectorNilUsesHelmValues  }}
   podMonitorSelector:
     matchLabels:
@@ -172,13 +172,13 @@ spec:
 {{- end }}
 {{- if .Values.prometheus.prometheusSpec.podMonitorNamespaceSelector }}
   podMonitorNamespaceSelector:
-{{ toYaml .Values.prometheus.prometheusSpec.podMonitorNamespaceSelector | indent 4 }}
+{{ tpl (toYaml .Values.prometheus.prometheusSpec.podMonitorNamespaceSelector | indent 4) . }}
 {{ else }}
   podMonitorNamespaceSelector: {}
 {{- end }}
 {{- if .Values.prometheus.prometheusSpec.probeSelector }}
   probeSelector:
-{{ toYaml .Values.prometheus.prometheusSpec.probeSelector | indent 4 }}
+{{ tpl (toYaml .Values.prometheus.prometheusSpec.probeSelector | indent 4) . }}
 {{ else if .Values.prometheus.prometheusSpec.probeSelectorNilUsesHelmValues  }}
   probeSelector:
     matchLabels:
@@ -188,7 +188,7 @@ spec:
 {{- end }}
 {{- if .Values.prometheus.prometheusSpec.probeNamespaceSelector }}
   probeNamespaceSelector:
-{{ toYaml .Values.prometheus.prometheusSpec.probeNamespaceSelector | indent 4 }}
+{{ tpl (toYaml .Values.prometheus.prometheusSpec.probeNamespaceSelector | indent 4) . }}
 {{ else }}
   probeNamespaceSelector: {}
 {{- end }}
@@ -216,14 +216,14 @@ spec:
 {{- end }}
 {{- if .Values.prometheus.prometheusSpec.ruleNamespaceSelector }}
   ruleNamespaceSelector:
-{{ toYaml .Values.prometheus.prometheusSpec.ruleNamespaceSelector | indent 4 }}
+{{ tpl (toYaml .Values.prometheus.prometheusSpec.ruleNamespaceSelector | indent 4) . }}
 {{ else }}
   ruleNamespaceSelector: {}
 {{- end }}
 {{- if not (has "agent" .Values.prometheus.prometheusSpec.enableFeatures) }}
 {{- if .Values.prometheus.prometheusSpec.ruleSelector }}
   ruleSelector:
-{{ toYaml .Values.prometheus.prometheusSpec.ruleSelector | indent 4}}
+{{ tpl (toYaml .Values.prometheus.prometheusSpec.ruleSelector | indent 4) . }}
 {{- else if .Values.prometheus.prometheusSpec.ruleSelectorNilUsesHelmValues }}
   ruleSelector:
     matchLabels:
@@ -232,6 +232,22 @@ spec:
   ruleSelector: {}
 {{- end }}
 {{- end }}
+{{- if .Values.prometheus.prometheusSpec.scrapeConfigSelector }}
+  scrapeConfigSelector:
+{{ tpl (toYaml .Values.prometheus.prometheusSpec.scrapeConfigSelector | indent 4) . }}
+{{ else if .Values.prometheus.prometheusSpec.scrapeConfigSelectorNilUsesHelmValues  }}
+  scrapeConfigSelector:
+    matchLabels:
+      release: {{ $.Release.Name | quote }}
+{{ else }}
+  scrapeConfigSelector: {}
+{{- end }}
+{{- if .Values.prometheus.prometheusSpec.scrapeConfigNamespaceSelector }}
+  scrapeConfigNamespaceSelector:
+{{ tpl (toYaml .Values.prometheus.prometheusSpec.scrapeConfigNamespaceSelector | indent 4) . }}
+{{ else }}
+  scrapeConfigNamespaceSelector: {}
+{{- end }}
 {{- if .Values.prometheus.prometheusSpec.storageSpec }}
   storage:
 {{ tpl (toYaml .Values.prometheus.prometheusSpec.storageSpec | indent 4) . }}
diff --git a/charts/kube-prometheus-stack/templates/thanos-ruler/ruler.yaml b/charts/kube-prometheus-stack/templates/thanos-ruler/ruler.yaml
index cf678b5448ad..505d68b025d8 100644
--- a/charts/kube-prometheus-stack/templates/thanos-ruler/ruler.yaml
+++ b/charts/kube-prometheus-stack/templates/thanos-ruler/ruler.yaml
@@ -50,13 +50,13 @@ spec:
 {{- end }}
 {{- if .Values.thanosRuler.thanosRulerSpec.ruleNamespaceSelector }}
   ruleNamespaceSelector:
-{{ toYaml .Values.thanosRuler.thanosRulerSpec.ruleNamespaceSelector | indent 4 }}
+{{ tpl (toYaml .Values.thanosRuler.thanosRulerSpec.ruleNamespaceSelector | indent 4) . }}
 {{ else }}
   ruleNamespaceSelector: {}
 {{- end }}
 {{- if .Values.thanosRuler.thanosRulerSpec.ruleSelector }}
   ruleSelector:
-{{ toYaml .Values.thanosRuler.thanosRulerSpec.ruleSelector | indent 4}}
+{{ tpl (toYaml .Values.thanosRuler.thanosRulerSpec.ruleSelector | indent 4) .}}
 {{- else if .Values.thanosRuler.thanosRulerSpec.ruleSelectorNilUsesHelmValues }}
   ruleSelector:
     matchLabels:
diff --git a/charts/kube-prometheus-stack/values.yaml b/charts/kube-prometheus-stack/values.yaml
index 231809130ead..7018316ee553 100644
--- a/charts/kube-prometheus-stack/values.yaml
+++ b/charts/kube-prometheus-stack/values.yaml
@@ -3028,6 +3028,28 @@ prometheus:
     #   matchLabels:
     #     prometheus: somelabel
 
+    ## If true, a nil or {} value for prometheus.prometheusSpec.scrapeConfigSelector will cause the
+    ## prometheus resource to be created with selectors based on values in the helm deployment,
+    ## which will also match the scrapeConfigs created
+    ##
+    scrapeConfigSelectorNilUsesHelmValues: true
+
+    ## scrapeConfigs to be selected for target discovery.
+    ## If {}, select all scrapeConfigs
+    ##
+    scrapeConfigSelector: {}
+    ## Example which selects scrapeConfigs with label "prometheus" set to "somelabel"
+    # scrapeConfig:
+    #   matchLabels:
+    #     prometheus: somelabel
+
+    ## If nil, select own namespace. Namespaces to be selected for scrapeConfig discovery.
+    scrapeConfigNamespaceSelector: {}
+    ## Example which selects scrapeConfig in namespaces with label "prometheus" set to "somelabel"
+    # scrapeConfigsNamespaceSelector:
+    #   matchLabels:
+    #     prometheus: somelabel
+
     ## How long to retain metrics
     ##
     retention: 10d