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Low number of genes #77

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jbague opened this issue Nov 29, 2023 · 2 comments
Open

Low number of genes #77

jbague opened this issue Nov 29, 2023 · 2 comments

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@jbague
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jbague commented Nov 29, 2023

Hi,
I am using a little selection of immunegenes from a panel of oncogenes from HTG experiment
and I have totally 1402 genes.
Can I run XCell following any instructions? My error is;

scores = rawEnrichmentAnalysis(Expresion_genica_parseado_v2, genes = Expresion_genica_parseado$Sample Name)
[1] "Num. of genes: 1402"
[1] "ERROR: not enough genes"
Error in return - 1 : argumento no-numérico para operador binario

Really thanks!!!

Jaume

@dviraran
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There is an internal check in xCell to use at least 5000 genes. The signatures are based on a panel of 10K genes, so attempting to use only 1402 genes will result in many signatures without any available gene. So, the short answer, you can't run xCell using only this subset.

Best,
Dvor

@jbague
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jbague commented Nov 29, 2023

Ok... On the other hand, what source I can use to add signatures at the function?

@jbague jbague closed this as completed Nov 29, 2023
@jbague jbague reopened this Nov 29, 2023
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