xCell for proteomics?

[fabiostrindade]

Hi,
I was wondering whether it is possible to use xCell to make cell-type enrichment analysis based on proteomics data.
And if so, should one use raw quantification (label-free, for instance) data?
Tks,
Fábio Trindade

[dviraran]

Hi,

The current version of xCell is not customizable. We are working hard to finalize a new version that will be customizable. xCell identifies genes/proteins that are differentially expressed in the cell type, so makes sense to train it with normalized data (but again, that will be possible only in the xCell 2.0).

Best,
Dvir

[fabiostrindade]

Hi Dvir,

Thanks for your feeback. I am giving it a try with normalized data. Let's see how it goes.

Best,
Fábio