diff --git a/eng/pipelines/extra-platforms/runtime-extra-platforms-other.yml b/eng/pipelines/extra-platforms/runtime-extra-platforms-other.yml
index 667281dab508f..10b3e9baca01f 100644
--- a/eng/pipelines/extra-platforms/runtime-extra-platforms-other.yml
+++ b/eng/pipelines/extra-platforms/runtime-extra-platforms-other.yml
@@ -260,3 +260,39 @@ jobs:
           eq(dependencies.evaluate_paths.outputs['SetPathVars_mono_excluding_wasm.containsChange'], true),
           eq(dependencies.evaluate_paths.outputs['SetPathVars_runtimetests.containsChange'], true),
           eq(variables['isRollingBuild'], true))
+
+#
+# Mono CoreCLR runtime Test executions using live libraries in interpreter mode
+# Only when Mono is changed
+
+- template: /eng/pipelines/common/platform-matrix.yml
+  parameters:
+    jobTemplate: /eng/pipelines/common/global-build-job.yml
+    helixQueuesTemplate: /eng/pipelines/coreclr/templates/helix-queues-setup.yml
+    buildConfig: Release
+    runtimeFlavor: mono
+    platforms:
+      - osx_arm64
+    variables:
+      - name: timeoutPerTestInMinutes
+        value: 60
+      - name: timeoutPerTestCollectionInMinutes
+        value: 180
+    jobParameters:
+      testGroup: innerloop
+      nameSuffix: AllSubsets_Mono_Interpreter_RuntimeTests
+      runtimeVariant: monointerpreter
+      buildArgs: -s mono+libs+clr.hosts+clr.iltools -c Release
+      timeoutInMinutes: 180
+      condition: >-
+        or(
+          eq(dependencies.evaluate_paths.outputs['SetPathVars_mono_excluding_wasm.containsChange'], true),
+          eq(dependencies.evaluate_paths.outputs['SetPathVars_runtimetests.containsChange'], true),
+          eq(variables['isRollingBuild'], true))
+      postBuildSteps:
+        - template: /eng/pipelines/common/templates/runtimes/build-runtime-tests-and-send-to-helix.yml
+          parameters:
+            creator: dotnet-bot
+            testRunNamePrefixSuffix: Mono_Release
+      extraVariablesTemplates:
+        - template: /eng/pipelines/common/templates/runtimes/test-variables.yml