diff --git a/eng/pipelines/libraries/fuzzing/deploy-to-onefuzz.yml b/eng/pipelines/libraries/fuzzing/deploy-to-onefuzz.yml
index a26558ee148ff..f718a0e46cbe3 100644
--- a/eng/pipelines/libraries/fuzzing/deploy-to-onefuzz.yml
+++ b/eng/pipelines/libraries/fuzzing/deploy-to-onefuzz.yml
@@ -65,6 +65,14 @@ extends:
 #         displayName: Send to OneFuzz
 
 # ONEFUZZ_TASK_WORKAROUND_START
+        - task: onefuzz-task@0
+          inputs:
+            onefuzzOSes: 'Windows'
+          env:
+            onefuzzDropDirectory: $(fuzzerProject)/deployment/Base64Fuzzer
+            SYSTEM_ACCESSTOKEN: $(System.AccessToken)
+          displayName: Send Base64Fuzzer to OneFuzz
+
         - task: onefuzz-task@0
           inputs:
             onefuzzOSes: 'Windows'
diff --git a/src/libraries/Fuzzing/DotnetFuzzing/Fuzzers/Base64Fuzzer.cs b/src/libraries/Fuzzing/DotnetFuzzing/Fuzzers/Base64Fuzzer.cs
new file mode 100644
index 0000000000000..11b4c1347e960
--- /dev/null
+++ b/src/libraries/Fuzzing/DotnetFuzzing/Fuzzers/Base64Fuzzer.cs
@@ -0,0 +1,120 @@
+// Licensed to the .NET Foundation under one or more agreements.
+// The .NET Foundation licenses this file to you under the MIT license.
+
+
+using System.Buffers;
+using System.Buffers.Text;
+
+namespace DotnetFuzzing.Fuzzers
+{
+    internal class Base64Fuzzer : IFuzzer
+    {
+        public string[] TargetAssemblies => [];
+
+        public string[] TargetCoreLibPrefixes => ["System.Buffers.Text"];
+
+        public void FuzzTarget(ReadOnlySpan<byte> bytes)
+        {
+            using PooledBoundedMemory<byte> inputPoisoned = PooledBoundedMemory<byte>.Rent(bytes, PoisonPagePlacement.After);
+            Span<byte> input = inputPoisoned.Span;
+            int maxEncodedLength = Base64.GetMaxEncodedToUtf8Length(bytes.Length);
+            using PooledBoundedMemory<byte> destPoisoned = PooledBoundedMemory<byte>.Rent(maxEncodedLength, PoisonPagePlacement.After);
+            Span<byte> encoderDest = destPoisoned.Span;
+            using PooledBoundedMemory<byte> decoderDestPoisoned = PooledBoundedMemory<byte>.Rent(Base64.GetMaxDecodedFromUtf8Length(maxEncodedLength), PoisonPagePlacement.After);
+            Span<byte> decoderDest = decoderDestPoisoned.Span;
+            { // IsFinalBlock = true
+                OperationStatus status = Base64.EncodeToUtf8(input, encoderDest, out int bytesConsumed, out int bytesEncoded);
+
+                Assert.Equal(OperationStatus.Done, status);
+                Assert.Equal(bytes.Length, bytesConsumed);
+                Assert.Equal(true, maxEncodedLength >= bytesEncoded && maxEncodedLength - 2 <= bytesEncoded);       
+                
+                status = Base64.DecodeFromUtf8(encoderDest.Slice(0, bytesEncoded), decoderDest, out int bytesRead, out int bytesDecoded);
+
+                Assert.Equal(OperationStatus.Done, status);
+                Assert.Equal(bytes.Length, bytesDecoded);
+                Assert.Equal(bytesEncoded, bytesRead);
+                Assert.SequenceEqual(bytes, decoderDest.Slice(0, bytesDecoded));
+            }
+
+            { // IsFinalBlock = false
+                encoderDest.Clear();
+                decoderDest.Clear();
+                OperationStatus status = Base64.EncodeToUtf8(input, encoderDest, out int bytesConsumed, out int bytesEncoded, isFinalBlock: false);
+                Span<byte> decodeInput = encoderDest.Slice(0, bytesEncoded);
+
+                if (bytes.Length % 3 == 0)
+                {
+                    Assert.Equal(OperationStatus.Done, status);
+                    Assert.Equal(bytes.Length, bytesConsumed);
+                    Assert.Equal(true, maxEncodedLength == bytesEncoded);
+
+                    status = Base64.DecodeFromUtf8(decodeInput, decoderDest, out int bytesRead, out int bytesDecoded, isFinalBlock: false);
+
+                    Assert.Equal(OperationStatus.Done, status);
+                    Assert.Equal(bytes.Length, bytesDecoded);
+                    Assert.Equal(bytesEncoded, bytesRead);
+                    Assert.SequenceEqual(bytes, decoderDest.Slice(0, bytesDecoded));
+                }
+                else
+                {
+                    Assert.Equal(OperationStatus.NeedMoreData, status);
+                    Assert.Equal(true, input.Length / 3 * 4 == bytesEncoded);
+
+                    status = Base64.DecodeFromUtf8(decodeInput, decoderDest, out int bytesRead, out int bytesDecoded, isFinalBlock: false);
+
+                    if (decodeInput.Length % 4 == 0)
+                    {
+                        Assert.Equal(OperationStatus.Done, status);
+                        Assert.Equal(bytesConsumed, bytesDecoded);
+                        Assert.Equal(bytesEncoded, bytesRead);
+                    }
+                    else
+                    {
+                        Assert.Equal(OperationStatus.NeedMoreData, status);
+                    }
+
+                    Assert.SequenceEqual(bytes.Slice(0, bytesDecoded), decoderDest.Slice(0, bytesDecoded));
+                }
+            }
+
+            { // Encode / decode in place
+                encoderDest.Clear();
+                input.CopyTo(encoderDest);
+                OperationStatus status = Base64.EncodeToUtf8InPlace(encoderDest, input.Length, out int bytesEncoded);
+
+                Assert.Equal(OperationStatus.Done, status);
+                Assert.Equal(true, maxEncodedLength >= bytesEncoded && maxEncodedLength - 2 <= bytesEncoded);
+
+                status = Base64.DecodeFromUtf8InPlace(encoderDest.Slice(0, bytesEncoded), out int bytesDecoded);
+
+                Assert.Equal(OperationStatus.Done, status);
+                Assert.Equal(bytes.Length, bytesDecoded);
+                Assert.SequenceEqual(bytes, encoderDest.Slice(0, bytesDecoded));
+            }
+
+            { // Decode the random input directly, Assert IsValid result matches with decoded result
+                decoderDest.Clear();
+                if (Base64.IsValid(input, out int decodedLength))
+                {
+                    int maxDecodedLength = Base64.GetMaxDecodedFromUtf8Length(input.Length);
+                    OperationStatus status = Base64.DecodeFromUtf8(input, decoderDest, out int bytesRead, out int bytesDecoded);
+                    Assert.Equal(OperationStatus.Done, status);
+                    Assert.Equal(input.Length, bytesRead);
+                    Assert.Equal(decodedLength, bytesDecoded);
+                    Assert.Equal(true, maxDecodedLength >= bytesDecoded);
+
+                    status = Base64.DecodeFromUtf8InPlace(input, out int inPlaceDecoded);
+                    Assert.Equal(OperationStatus.Done, status);
+                    Assert.Equal(bytesDecoded, inPlaceDecoded);
+                    Assert.SequenceEqual<byte>(input.Slice(0, inPlaceDecoded), decoderDest.Slice(0, bytesDecoded));
+                }
+                else
+                {
+                    Assert.Equal(OperationStatus.InvalidData, Base64.DecodeFromUtf8(input, decoderDest, out int _, out int bytesDecoded));
+                    Assert.Equal(OperationStatus.InvalidData, Base64.DecodeFromUtf8InPlace(input, out int inPlaceDecoded));
+                }
+            }
+        }
+    }
+}