-
Notifications
You must be signed in to change notification settings - Fork 1
/
baumwelch.cc
170 lines (145 loc) · 8.34 KB
/
baumwelch.cc
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
#include "baumwelch.h"
baumWelch::baumWelch(obsSequence *data)
{
mObsSequence = data;
}
void baumWelch::computeBaumWelch(hmmResults *results ,modelProb *model)
{
mHmmResults = results;
mModelProb = model;
//////////////////////
// maximum likelihood estimation of the transition and emission probabilities
map<int,double> pseudo_count_obsD_int ;
map<int,double> pseudo_count_obsD_ext ;
map<int,double> pseudo_count_obsA_int ;
map<int,double> pseudo_count_obsA_ext ;
map<int,double> total_pseudo_count_obs_int ;
map<const char*,double> total_pseudo_count_obs_ext ;
//map<int,double> total_pseudo_count_obs_ext ;
map<int,double> proba_obsD_int ;
map<const char*,double> proba_obsD_ext ;
for ( int i = 1 ; i < mObsSequence->size()-1 ; ++i ) {
if (mObsSequence->at(i+1).getUlindi() == 'D'){
pseudo_count_obsD_int[mObsSequence->at(i+1).getDerived()] += mHmmResults->mfwd_stateI_scaled[i+1] * mHmmResults->mbwd_stateI_scaled[i+1] ;
pseudo_count_obsD_ext[mObsSequence->at(i+1).getDerived()] += mHmmResults->mfwd_stateE_scaled[i+1] * mHmmResults->mbwd_stateE_scaled[i+1] ;
}
else {
pseudo_count_obsA_int[mObsSequence->at(i+1).getDerived()] += mHmmResults->mfwd_stateI_scaled[i+1] * mHmmResults->mbwd_stateI_scaled[i+1] ;
pseudo_count_obsA_ext[mObsSequence->at(i+1).getDerived()] += mHmmResults->mfwd_stateE_scaled[i+1] * mHmmResults->mbwd_stateE_scaled[i+1] ;
}
}
for ( std::map<int,double>::iterator it = pseudo_count_obsD_int.begin(); it != pseudo_count_obsD_int.end(); ++it ) {
int derived = it->first ;
total_pseudo_count_obs_int[derived] += pseudo_count_obsD_int[derived] ;
//total_pseudo_count_obs_ext[derived] += pseudo_count_obsD_ext[derived] ;
if (derived != pseudo_count_obsD_int.rbegin()->first ){
total_pseudo_count_obs_ext["SNPs"] += pseudo_count_obsD_ext[derived];
}
else {
total_pseudo_count_obs_ext["fixed"] += pseudo_count_obsD_ext[derived];
}
}
for ( std::map<int,double>::iterator it = pseudo_count_obsA_int.begin(); it != pseudo_count_obsA_int.end(); ++it ) {
int derived = it->first ;
total_pseudo_count_obs_int[derived] += pseudo_count_obsA_int[derived] ;
//total_pseudo_count_obs_ext[derived] += pseudo_count_obsA_ext[derived] ;
if (derived != pseudo_count_obsD_int.rbegin()->first ){
total_pseudo_count_obs_ext["SNPs"] += pseudo_count_obsA_ext[derived];
}
else {
total_pseudo_count_obs_ext["fixed"] += pseudo_count_obsA_ext[derived];
}
}
for ( std::map<int,double>::iterator it = total_pseudo_count_obs_int.begin(); it != total_pseudo_count_obs_int.end(); ++it ) {
int derived = it->first ;
proba_obsD_int[derived] = pseudo_count_obsD_int[derived] / total_pseudo_count_obs_int[derived] ;
if (derived != total_pseudo_count_obs_int.rbegin()->first ) {
proba_obsD_ext["SNPs"] += pseudo_count_obsD_ext[derived] / total_pseudo_count_obs_ext["SNPs"] ;
// proba_obsD_ext["SNPs"] = proba_obsD_ext["SNPs"] * ( pseudo_count_obsD_ext[derived] / total_pseudo_count_obs_ext[derived] ) ;
}
else {
proba_obsD_ext["fixed"] = pseudo_count_obsD_ext[derived] / total_pseudo_count_obs_ext["fixed"] ;
//proba_obsD_ext["fixed"] = pseudo_count_obsD_ext[derived] / total_pseudo_count_obs_ext[derived] ;
}
}
// Update the emission probabilities
mModelProb->setProbFixDInternal(proba_obsD_int.rbegin()->second);
mModelProb->setProbFixDExternal(proba_obsD_ext["fixed"]);
//for ( int i=1; i<proba_obsD_int.size(); ++i)
for (std::map<int,double>::iterator it = proba_obsD_int.begin(); it != proba_obsD_int.end(); ++it)
{
int i = it->first ;
mModelProb->setProbSegregDInternalAt(i,proba_obsD_int[i]);
}
//mModelProb->setProbSegregDExternal(proba_obsD_ext["SNPs"]);
}
void baumWelch::computeBaumWelch3states(hmmResults *results ,modelProb *model)
{
mHmmResults = results;
mModelProb = model;
//////////////////////
// maximum likelihood estimation of the transition and emission probabilities
map<int,double> pseudo_count_obsD_int ;
map<int,double> pseudo_count_obsD_ext ;
map<int,double> pseudo_count_obsA_int ;
map<int,double> pseudo_count_obsA_ext ;
map<int,double> total_pseudo_count_obs_int ;
map<const char*,double> total_pseudo_count_obs_ext ;
//map<int,double> total_pseudo_count_obs_ext ;
map<int,double> proba_obsD_int ;
map<const char*,double> proba_obsD_ext ;
for ( int i = 1 ; i < mObsSequence->size()-1 ; ++i ) {
if (mObsSequence->at(i+1).getUlindi() == 'D'){
pseudo_count_obsD_int[mObsSequence->at(i+1).getDerived()] += mHmmResults->mfwd_stateI_scaled[i+1] * mHmmResults->mbwd_stateI_scaled[i+1] ;
pseudo_count_obsD_ext[mObsSequence->at(i+1).getDerived()] += mHmmResults->mfwd_stateE_scaled[i+1] * mHmmResults->mbwd_stateE_scaled[i+1] + mHmmResults->mfwd_stateLE_scaled[i+1] * mHmmResults->mbwd_stateLE_scaled[i+1];
}
else {
pseudo_count_obsA_int[mObsSequence->at(i+1).getDerived()] += mHmmResults->mfwd_stateI_scaled[i+1] * mHmmResults->mbwd_stateI_scaled[i+1] ;
pseudo_count_obsA_ext[mObsSequence->at(i+1).getDerived()] += mHmmResults->mfwd_stateE_scaled[i+1] * mHmmResults->mbwd_stateE_scaled[i+1] + mHmmResults->mfwd_stateLE_scaled[i+1] * mHmmResults->mbwd_stateLE_scaled[i+1];
}
}
for ( std::map<int,double>::iterator it = pseudo_count_obsD_int.begin(); it != pseudo_count_obsD_int.end(); ++it ) {
int derived = it->first ;
total_pseudo_count_obs_int[derived] += pseudo_count_obsD_int[derived] ;
//total_pseudo_count_obs_ext[derived] += pseudo_count_obsD_ext[derived] ;
if (derived != pseudo_count_obsD_int.rbegin()->first ){
total_pseudo_count_obs_ext["SNPs"] += pseudo_count_obsD_ext[derived];
}
else {
total_pseudo_count_obs_ext["fixed"] += pseudo_count_obsD_ext[derived];
}
}
for ( std::map<int,double>::iterator it = pseudo_count_obsA_int.begin(); it != pseudo_count_obsA_int.end(); ++it ) {
int derived = it->first ;
total_pseudo_count_obs_int[derived] += pseudo_count_obsA_int[derived] ;
//total_pseudo_count_obs_ext[derived] += pseudo_count_obsA_ext[derived] ;
if (derived != pseudo_count_obsD_int.rbegin()->first ){
total_pseudo_count_obs_ext["SNPs"] += pseudo_count_obsA_ext[derived];
}
else {
total_pseudo_count_obs_ext["fixed"] += pseudo_count_obsA_ext[derived];
}
}
for ( std::map<int,double>::iterator it = total_pseudo_count_obs_int.begin(); it != total_pseudo_count_obs_int.end(); ++it ) {
int derived = it->first ;
proba_obsD_int[derived] = pseudo_count_obsD_int[derived] / total_pseudo_count_obs_int[derived] ;
if (derived != total_pseudo_count_obs_int.rbegin()->first ) {
proba_obsD_ext["SNPs"] += pseudo_count_obsD_ext[derived] / total_pseudo_count_obs_ext["SNPs"] ;
// proba_obsD_ext["SNPs"] = proba_obsD_ext["SNPs"] * ( pseudo_count_obsD_ext[derived] / total_pseudo_count_obs_ext[derived] ) ;
}
else {
proba_obsD_ext["fixed"] = pseudo_count_obsD_ext[derived] / total_pseudo_count_obs_ext["fixed"] ;
//proba_obsD_ext["fixed"] = pseudo_count_obsD_ext[derived] / total_pseudo_count_obs_ext[derived] ;
}
}
// Update the emission probabilities
mModelProb->setProbFixDInternal(proba_obsD_int.rbegin()->second);
mModelProb->setProbFixDExternal(proba_obsD_ext["fixed"]);
//for ( int i=1; i<proba_obsD_int.size(); ++i)
for (std::map<int,double>::iterator it = proba_obsD_int.begin(); it != proba_obsD_int.end(); ++it)
{
int i = it->first ;
mModelProb->setProbSegregDInternalAt(i,proba_obsD_int[i]);
}
//mModelProb->setProbSegregDExternal(proba_obsD_ext["SNPs"]);
}