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Hello,
I am building a model using preclinical data from pigs , I was trying to estimate the total hepatic and renal clearance using the parent and metabolite preclinical data in pigs. I noticed that the body weight used in both total hepatic and renal clearance is the same for all individuals ( set to 40 kg in the attached screenshots). Also when I checked it in the parameter estimation section it is the same for all individual ( so both liver and kidney volumes are the same ) despite they are not in individual characteristics.
My question is : does that is overwritten with the individual characteristics values of body and organ weights in a further step in the simulation or should I manually edit it for each individual ?
I use PK-sim version 11.2.
The text was updated successfully, but these errors were encountered:
Hello,
I am building a model using preclinical data from pigs , I was trying to estimate the total hepatic and renal clearance using the parent and metabolite preclinical data in pigs. I noticed that the body weight used in both total hepatic and renal clearance is the same for all individuals ( set to 40 kg in the attached screenshots). Also when I checked it in the parameter estimation section it is the same for all individual ( so both liver and kidney volumes are the same ) despite they are not in individual characteristics.
My question is : does that is overwritten with the individual characteristics values of body and organ weights in a further step in the simulation or should I manually edit it for each individual ?
I use PK-sim version 11.2.
The text was updated successfully, but these errors were encountered: