diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/001_Competitive_Inhibition/001_plotDDIRatioAUCPredictedVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/001_Competitive_Inhibition/001_plotDDIRatioAUCPredictedVsObserved.png
index 1b874d0..a7301d8 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/001_Competitive_Inhibition/001_plotDDIRatioAUCPredictedVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/001_Competitive_Inhibition/001_plotDDIRatioAUCPredictedVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/001_Competitive_Inhibition/002_plotDDIRatioAUCResidualsVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/001_Competitive_Inhibition/002_plotDDIRatioAUCResidualsVsObserved.png
index caf1434..938d820 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/001_Competitive_Inhibition/002_plotDDIRatioAUCResidualsVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/001_Competitive_Inhibition/002_plotDDIRatioAUCResidualsVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/001_Competitive_Inhibition/003_plotDDIRatioCMAXPredictedVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/001_Competitive_Inhibition/003_plotDDIRatioCMAXPredictedVsObserved.png
index cb0f012..62111db 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/001_Competitive_Inhibition/003_plotDDIRatioCMAXPredictedVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/001_Competitive_Inhibition/003_plotDDIRatioCMAXPredictedVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/001_Competitive_Inhibition/004_plotDDIRatioCMAXResidualsVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/001_Competitive_Inhibition/004_plotDDIRatioCMAXResidualsVsObserved.png
index bc23d2d..889d299 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/001_Competitive_Inhibition/004_plotDDIRatioCMAXResidualsVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/001_Competitive_Inhibition/004_plotDDIRatioCMAXResidualsVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/002_Induction/001_plotDDIRatioAUCPredictedVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/002_Induction/001_plotDDIRatioAUCPredictedVsObserved.png
index 2184b50..bc7acc6 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/002_Induction/001_plotDDIRatioAUCPredictedVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/002_Induction/001_plotDDIRatioAUCPredictedVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/002_Induction/002_plotDDIRatioAUCResidualsVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/002_Induction/002_plotDDIRatioAUCResidualsVsObserved.png
index 5305539..9755256 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/002_Induction/002_plotDDIRatioAUCResidualsVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/002_Induction/002_plotDDIRatioAUCResidualsVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/002_Induction/003_plotDDIRatioCMAXPredictedVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/002_Induction/003_plotDDIRatioCMAXPredictedVsObserved.png
index bb77ede..75815c4 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/002_Induction/003_plotDDIRatioCMAXPredictedVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/002_Induction/003_plotDDIRatioCMAXPredictedVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/002_Induction/004_plotDDIRatioCMAXResidualsVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/002_Induction/004_plotDDIRatioCMAXResidualsVsObserved.png
index ef77380..3aa4883 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/002_Induction/004_plotDDIRatioCMAXResidualsVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/002_Induction/004_plotDDIRatioCMAXResidualsVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/003_Mechanism_based_Inactivation/001_plotDDIRatioAUCPredictedVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/003_Mechanism_based_Inactivation/001_plotDDIRatioAUCPredictedVsObserved.png
index 1c27e27..8617137 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/003_Mechanism_based_Inactivation/001_plotDDIRatioAUCPredictedVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/003_Mechanism_based_Inactivation/001_plotDDIRatioAUCPredictedVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/003_Mechanism_based_Inactivation/002_plotDDIRatioAUCResidualsVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/003_Mechanism_based_Inactivation/002_plotDDIRatioAUCResidualsVsObserved.png
index 2b3d07f..5822d6c 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/003_Mechanism_based_Inactivation/002_plotDDIRatioAUCResidualsVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/003_Mechanism_based_Inactivation/002_plotDDIRatioAUCResidualsVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/003_Mechanism_based_Inactivation/003_plotDDIRatioCMAXPredictedVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/003_Mechanism_based_Inactivation/003_plotDDIRatioCMAXPredictedVsObserved.png
index 99b83a8..cfcf768 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/003_Mechanism_based_Inactivation/003_plotDDIRatioCMAXPredictedVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/003_Mechanism_based_Inactivation/003_plotDDIRatioCMAXPredictedVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/003_Mechanism_based_Inactivation/004_plotDDIRatioCMAXResidualsVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/003_Mechanism_based_Inactivation/004_plotDDIRatioCMAXResidualsVsObserved.png
index c6729f2..cc1deba 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/003_Mechanism_based_Inactivation/004_plotDDIRatioCMAXResidualsVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/003_Mechanism_based_Inactivation/004_plotDDIRatioCMAXResidualsVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_plotDDIRatioAUCPredictedVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_plotDDIRatioAUCPredictedVsObserved.png
index 6810a98..35338e0 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_plotDDIRatioAUCPredictedVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_plotDDIRatioAUCPredictedVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/001_Clarithromycin/001_plotDDIRatioAUCPredictedVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/001_Clarithromycin/001_plotDDIRatioAUCPredictedVsObserved.png
index 76edbb8..c374632 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/001_Clarithromycin/001_plotDDIRatioAUCPredictedVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/001_Clarithromycin/001_plotDDIRatioAUCPredictedVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/001_Clarithromycin/002_plotDDIRatioAUCResidualsVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/001_Clarithromycin/002_plotDDIRatioAUCResidualsVsObserved.png
index 9163c28..1cc54d5 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/001_Clarithromycin/002_plotDDIRatioAUCResidualsVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/001_Clarithromycin/002_plotDDIRatioAUCResidualsVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/001_Clarithromycin/003_plotDDIRatioCMAXPredictedVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/001_Clarithromycin/003_plotDDIRatioCMAXPredictedVsObserved.png
index 710b60f..7fcb16e 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/001_Clarithromycin/003_plotDDIRatioCMAXPredictedVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/001_Clarithromycin/003_plotDDIRatioCMAXPredictedVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/001_Clarithromycin/004_plotDDIRatioCMAXResidualsVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/001_Clarithromycin/004_plotDDIRatioCMAXResidualsVsObserved.png
index dcec373..eca2d39 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/001_Clarithromycin/004_plotDDIRatioCMAXResidualsVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/001_Clarithromycin/004_plotDDIRatioCMAXResidualsVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/002_Efavirenz/001_plotDDIRatioAUCPredictedVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/002_Efavirenz/001_plotDDIRatioAUCPredictedVsObserved.png
index b723115..572d4f6 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/002_Efavirenz/001_plotDDIRatioAUCPredictedVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/002_Efavirenz/001_plotDDIRatioAUCPredictedVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/002_Efavirenz/002_plotDDIRatioAUCResidualsVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/002_Efavirenz/002_plotDDIRatioAUCResidualsVsObserved.png
index aaa458e..c842b87 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/002_Efavirenz/002_plotDDIRatioAUCResidualsVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/002_Efavirenz/002_plotDDIRatioAUCResidualsVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/002_Efavirenz/003_plotDDIRatioCMAXPredictedVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/002_Efavirenz/003_plotDDIRatioCMAXPredictedVsObserved.png
index 8371374..78da9f9 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/002_Efavirenz/003_plotDDIRatioCMAXPredictedVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/002_Efavirenz/003_plotDDIRatioCMAXPredictedVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/002_Efavirenz/004_plotDDIRatioCMAXResidualsVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/002_Efavirenz/004_plotDDIRatioCMAXResidualsVsObserved.png
index 981a885..6e298a6 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/002_Efavirenz/004_plotDDIRatioCMAXResidualsVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/002_Efavirenz/004_plotDDIRatioCMAXResidualsVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/003_Erythromycin/001_plotDDIRatioAUCPredictedVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/003_Erythromycin/001_plotDDIRatioAUCPredictedVsObserved.png
index cc90589..82f21fd 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/003_Erythromycin/001_plotDDIRatioAUCPredictedVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/003_Erythromycin/001_plotDDIRatioAUCPredictedVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/003_Erythromycin/002_plotDDIRatioAUCResidualsVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/003_Erythromycin/002_plotDDIRatioAUCResidualsVsObserved.png
index 8d54ea8..4c1c5ef 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/003_Erythromycin/002_plotDDIRatioAUCResidualsVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/003_Erythromycin/002_plotDDIRatioAUCResidualsVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/003_Erythromycin/003_plotDDIRatioCMAXPredictedVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/003_Erythromycin/003_plotDDIRatioCMAXPredictedVsObserved.png
index a07b168..8d68cbf 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/003_Erythromycin/003_plotDDIRatioCMAXPredictedVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/003_Erythromycin/003_plotDDIRatioCMAXPredictedVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/003_Erythromycin/004_plotDDIRatioCMAXResidualsVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/003_Erythromycin/004_plotDDIRatioCMAXResidualsVsObserved.png
index 028452d..4d8ae98 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/003_Erythromycin/004_plotDDIRatioCMAXResidualsVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/003_Erythromycin/004_plotDDIRatioCMAXResidualsVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/004_Fluvoxamine/001_plotDDIRatioAUCPredictedVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/004_Fluvoxamine/001_plotDDIRatioAUCPredictedVsObserved.png
index a7fb213..88ed949 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/004_Fluvoxamine/001_plotDDIRatioAUCPredictedVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/004_Fluvoxamine/001_plotDDIRatioAUCPredictedVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/004_Fluvoxamine/002_plotDDIRatioAUCResidualsVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/004_Fluvoxamine/002_plotDDIRatioAUCResidualsVsObserved.png
index eac6d12..8166f2b 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/004_Fluvoxamine/002_plotDDIRatioAUCResidualsVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/004_Fluvoxamine/002_plotDDIRatioAUCResidualsVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/004_Fluvoxamine/003_plotDDIRatioCMAXPredictedVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/004_Fluvoxamine/003_plotDDIRatioCMAXPredictedVsObserved.png
index 042d5b5..20ef4de 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/004_Fluvoxamine/003_plotDDIRatioCMAXPredictedVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/004_Fluvoxamine/003_plotDDIRatioCMAXPredictedVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/004_Fluvoxamine/004_plotDDIRatioCMAXResidualsVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/004_Fluvoxamine/004_plotDDIRatioCMAXResidualsVsObserved.png
index ffc1fbd..c099b66 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/004_Fluvoxamine/004_plotDDIRatioCMAXResidualsVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/004_Fluvoxamine/004_plotDDIRatioCMAXResidualsVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/005_Itraconazole/001_plotDDIRatioAUCPredictedVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/005_Itraconazole/001_plotDDIRatioAUCPredictedVsObserved.png
index b28d3bc..d579e80 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/005_Itraconazole/001_plotDDIRatioAUCPredictedVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/005_Itraconazole/001_plotDDIRatioAUCPredictedVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/005_Itraconazole/002_plotDDIRatioAUCResidualsVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/005_Itraconazole/002_plotDDIRatioAUCResidualsVsObserved.png
index cb6c39e..c9319a3 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/005_Itraconazole/002_plotDDIRatioAUCResidualsVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/005_Itraconazole/002_plotDDIRatioAUCResidualsVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/005_Itraconazole/003_plotDDIRatioCMAXPredictedVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/005_Itraconazole/003_plotDDIRatioCMAXPredictedVsObserved.png
index d903638..8a3ff96 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/005_Itraconazole/003_plotDDIRatioCMAXPredictedVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/005_Itraconazole/003_plotDDIRatioCMAXPredictedVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/005_Itraconazole/004_plotDDIRatioCMAXResidualsVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/005_Itraconazole/004_plotDDIRatioCMAXResidualsVsObserved.png
index 6ee1954..851ad37 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/005_Itraconazole/004_plotDDIRatioCMAXResidualsVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/005_Itraconazole/004_plotDDIRatioCMAXResidualsVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/006_Rifampicin/001_plotDDIRatioAUCPredictedVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/006_Rifampicin/001_plotDDIRatioAUCPredictedVsObserved.png
index 1c5b040..1e4f94a 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/006_Rifampicin/001_plotDDIRatioAUCPredictedVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/006_Rifampicin/001_plotDDIRatioAUCPredictedVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/006_Rifampicin/002_plotDDIRatioAUCResidualsVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/006_Rifampicin/002_plotDDIRatioAUCResidualsVsObserved.png
index 7d11a89..22f23d8 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/006_Rifampicin/002_plotDDIRatioAUCResidualsVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/006_Rifampicin/002_plotDDIRatioAUCResidualsVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/006_Rifampicin/003_plotDDIRatioCMAXPredictedVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/006_Rifampicin/003_plotDDIRatioCMAXPredictedVsObserved.png
index dcbc296..a7122d2 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/006_Rifampicin/003_plotDDIRatioCMAXPredictedVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/006_Rifampicin/003_plotDDIRatioCMAXPredictedVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/006_Rifampicin/004_plotDDIRatioCMAXResidualsVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/006_Rifampicin/004_plotDDIRatioCMAXResidualsVsObserved.png
index aedfc79..d9f481d 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/006_Rifampicin/004_plotDDIRatioCMAXResidualsVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/006_Rifampicin/004_plotDDIRatioCMAXResidualsVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/007_Verapamil/001_plotDDIRatioAUCPredictedVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/007_Verapamil/001_plotDDIRatioAUCPredictedVsObserved.png
index 11b6f2a..64b54b9 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/007_Verapamil/001_plotDDIRatioAUCPredictedVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/007_Verapamil/001_plotDDIRatioAUCPredictedVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/007_Verapamil/002_plotDDIRatioAUCResidualsVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/007_Verapamil/002_plotDDIRatioAUCResidualsVsObserved.png
index f848815..c8c83ff 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/007_Verapamil/002_plotDDIRatioAUCResidualsVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/007_Verapamil/002_plotDDIRatioAUCResidualsVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/007_Verapamil/003_plotDDIRatioCMAXPredictedVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/007_Verapamil/003_plotDDIRatioCMAXPredictedVsObserved.png
index 1e90f01..fe82ec4 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/007_Verapamil/003_plotDDIRatioCMAXPredictedVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/007_Verapamil/003_plotDDIRatioCMAXPredictedVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/007_Verapamil/004_plotDDIRatioCMAXResidualsVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/007_Verapamil/004_plotDDIRatioCMAXResidualsVsObserved.png
index f75d064..5c23fa1 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/007_Verapamil/004_plotDDIRatioCMAXResidualsVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/007_Verapamil/004_plotDDIRatioCMAXResidualsVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_plotDDIRatioAUCResidualsVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_plotDDIRatioAUCResidualsVsObserved.png
index f4afd1d..8961c5f 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_plotDDIRatioAUCResidualsVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_plotDDIRatioAUCResidualsVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/001_Alfentanil/001_plotDDIRatioAUCPredictedVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/001_Alfentanil/001_plotDDIRatioAUCPredictedVsObserved.png
index 99ae188..dd0ba00 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/001_Alfentanil/001_plotDDIRatioAUCPredictedVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/001_Alfentanil/001_plotDDIRatioAUCPredictedVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/001_Alfentanil/002_plotDDIRatioAUCResidualsVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/001_Alfentanil/002_plotDDIRatioAUCResidualsVsObserved.png
index 8bba217..61c8794 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/001_Alfentanil/002_plotDDIRatioAUCResidualsVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/001_Alfentanil/002_plotDDIRatioAUCResidualsVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/001_Alfentanil/003_plotDDIRatioCMAXPredictedVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/001_Alfentanil/003_plotDDIRatioCMAXPredictedVsObserved.png
index c9c1586..8e1af3f 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/001_Alfentanil/003_plotDDIRatioCMAXPredictedVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/001_Alfentanil/003_plotDDIRatioCMAXPredictedVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/001_Alfentanil/004_plotDDIRatioCMAXResidualsVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/001_Alfentanil/004_plotDDIRatioCMAXResidualsVsObserved.png
index 4168e0a..544e64b 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/001_Alfentanil/004_plotDDIRatioCMAXResidualsVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/001_Alfentanil/004_plotDDIRatioCMAXResidualsVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/002_Alprazolam/001_plotDDIRatioAUCPredictedVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/002_Alprazolam/001_plotDDIRatioAUCPredictedVsObserved.png
index 9546e9f..b2396dd 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/002_Alprazolam/001_plotDDIRatioAUCPredictedVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/002_Alprazolam/001_plotDDIRatioAUCPredictedVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/002_Alprazolam/002_plotDDIRatioAUCResidualsVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/002_Alprazolam/002_plotDDIRatioAUCResidualsVsObserved.png
index 4e8a3f2..7ae3bed 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/002_Alprazolam/002_plotDDIRatioAUCResidualsVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/002_Alprazolam/002_plotDDIRatioAUCResidualsVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/002_Alprazolam/003_plotDDIRatioCMAXPredictedVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/002_Alprazolam/003_plotDDIRatioCMAXPredictedVsObserved.png
index 55e44d6..717ebbe 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/002_Alprazolam/003_plotDDIRatioCMAXPredictedVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/002_Alprazolam/003_plotDDIRatioCMAXPredictedVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/002_Alprazolam/004_plotDDIRatioCMAXResidualsVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/002_Alprazolam/004_plotDDIRatioCMAXResidualsVsObserved.png
index f42f465..30d9914 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/002_Alprazolam/004_plotDDIRatioCMAXResidualsVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/002_Alprazolam/004_plotDDIRatioCMAXResidualsVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/003_Midazolam/001_plotDDIRatioAUCPredictedVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/003_Midazolam/001_plotDDIRatioAUCPredictedVsObserved.png
index 5970aea..7e09ee9 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/003_Midazolam/001_plotDDIRatioAUCPredictedVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/003_Midazolam/001_plotDDIRatioAUCPredictedVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/003_Midazolam/002_plotDDIRatioAUCResidualsVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/003_Midazolam/002_plotDDIRatioAUCResidualsVsObserved.png
index 0e14d81..d289f4d 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/003_Midazolam/002_plotDDIRatioAUCResidualsVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/003_Midazolam/002_plotDDIRatioAUCResidualsVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/003_Midazolam/003_plotDDIRatioCMAXPredictedVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/003_Midazolam/003_plotDDIRatioCMAXPredictedVsObserved.png
index 53d6383..f0e56ab 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/003_Midazolam/003_plotDDIRatioCMAXPredictedVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/003_Midazolam/003_plotDDIRatioCMAXPredictedVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/003_Midazolam/004_plotDDIRatioCMAXResidualsVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/003_Midazolam/004_plotDDIRatioCMAXResidualsVsObserved.png
index f494b1e..735295e 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/003_Midazolam/004_plotDDIRatioCMAXResidualsVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/003_Midazolam/004_plotDDIRatioCMAXResidualsVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/004_Triazolam/001_plotDDIRatioAUCPredictedVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/004_Triazolam/001_plotDDIRatioAUCPredictedVsObserved.png
index db0c0c6..a173bbf 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/004_Triazolam/001_plotDDIRatioAUCPredictedVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/004_Triazolam/001_plotDDIRatioAUCPredictedVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/004_Triazolam/002_plotDDIRatioAUCResidualsVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/004_Triazolam/002_plotDDIRatioAUCResidualsVsObserved.png
index fbf2441..3200f27 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/004_Triazolam/002_plotDDIRatioAUCResidualsVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/004_Triazolam/002_plotDDIRatioAUCResidualsVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/004_Triazolam/003_plotDDIRatioCMAXPredictedVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/004_Triazolam/003_plotDDIRatioCMAXPredictedVsObserved.png
index 58fc422..945d003 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/004_Triazolam/003_plotDDIRatioCMAXPredictedVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/004_Triazolam/003_plotDDIRatioCMAXPredictedVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/004_Triazolam/004_plotDDIRatioCMAXResidualsVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/004_Triazolam/004_plotDDIRatioCMAXResidualsVsObserved.png
index 7d37be8..1d7ecae 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/004_Triazolam/004_plotDDIRatioCMAXResidualsVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/004_Triazolam/004_plotDDIRatioCMAXResidualsVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_plotDDIRatioCMAXPredictedVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_plotDDIRatioCMAXPredictedVsObserved.png
index 74dd9b1..17fcd01 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_plotDDIRatioCMAXPredictedVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_plotDDIRatioCMAXPredictedVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/004_plotDDIRatioCMAXResidualsVsObserved.png b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/004_plotDDIRatioCMAXResidualsVsObserved.png
index 28f105e..deca7a3 100644
Binary files a/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/004_plotDDIRatioCMAXResidualsVsObserved.png and b/DDI_Qualification_CYP3A4/images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/004_plotDDIRatioCMAXResidualsVsObserved.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/001_3_1_Clarithromycin_-_Midazolam_DDI/001_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/001_3_1_Clarithromycin_-_Midazolam_DDI/001_plotComparisonTimeProfile.png
index aeb8e5e..01947f6 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/001_3_1_Clarithromycin_-_Midazolam_DDI/001_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/001_3_1_Clarithromycin_-_Midazolam_DDI/001_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/001_3_1_Clarithromycin_-_Midazolam_DDI/002_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/001_3_1_Clarithromycin_-_Midazolam_DDI/002_plotComparisonTimeProfile.png
index d216459..8b554f8 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/001_3_1_Clarithromycin_-_Midazolam_DDI/002_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/001_3_1_Clarithromycin_-_Midazolam_DDI/002_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/001_3_1_Clarithromycin_-_Midazolam_DDI/003_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/001_3_1_Clarithromycin_-_Midazolam_DDI/003_plotComparisonTimeProfile.png
index 16b8b61..9778f06 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/001_3_1_Clarithromycin_-_Midazolam_DDI/003_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/001_3_1_Clarithromycin_-_Midazolam_DDI/003_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/001_3_1_Clarithromycin_-_Midazolam_DDI/004_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/001_3_1_Clarithromycin_-_Midazolam_DDI/004_plotComparisonTimeProfile.png
index b374b69..194e023 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/001_3_1_Clarithromycin_-_Midazolam_DDI/004_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/001_3_1_Clarithromycin_-_Midazolam_DDI/004_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/001_3_1_Clarithromycin_-_Midazolam_DDI/005_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/001_3_1_Clarithromycin_-_Midazolam_DDI/005_plotComparisonTimeProfile.png
index 2ae6a57..049edbd 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/001_3_1_Clarithromycin_-_Midazolam_DDI/005_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/001_3_1_Clarithromycin_-_Midazolam_DDI/005_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/001_3_1_Clarithromycin_-_Midazolam_DDI/006_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/001_3_1_Clarithromycin_-_Midazolam_DDI/006_plotComparisonTimeProfile.png
index 181e087..3739040 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/001_3_1_Clarithromycin_-_Midazolam_DDI/006_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/001_3_1_Clarithromycin_-_Midazolam_DDI/006_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/001_3_1_Clarithromycin_-_Midazolam_DDI/007_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/001_3_1_Clarithromycin_-_Midazolam_DDI/007_plotComparisonTimeProfile.png
index 7bfe55a..301b22d 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/001_3_1_Clarithromycin_-_Midazolam_DDI/007_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/001_3_1_Clarithromycin_-_Midazolam_DDI/007_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/001_3_1_Clarithromycin_-_Midazolam_DDI/008_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/001_3_1_Clarithromycin_-_Midazolam_DDI/008_plotComparisonTimeProfile.png
index 48e2446..b4b6e09 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/001_3_1_Clarithromycin_-_Midazolam_DDI/008_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/001_3_1_Clarithromycin_-_Midazolam_DDI/008_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/001_3_1_Clarithromycin_-_Midazolam_DDI/009_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/001_3_1_Clarithromycin_-_Midazolam_DDI/009_plotComparisonTimeProfile.png
index 1ade750..ddd1181 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/001_3_1_Clarithromycin_-_Midazolam_DDI/009_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/001_3_1_Clarithromycin_-_Midazolam_DDI/009_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/001_3_1_Clarithromycin_-_Midazolam_DDI/010_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/001_3_1_Clarithromycin_-_Midazolam_DDI/010_plotComparisonTimeProfile.png
index c6f0e2a..ec1a76f 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/001_3_1_Clarithromycin_-_Midazolam_DDI/010_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/001_3_1_Clarithromycin_-_Midazolam_DDI/010_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/002_3_2_Clarithromycin_-_Triazolam_DDI/001_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/002_3_2_Clarithromycin_-_Triazolam_DDI/001_plotComparisonTimeProfile.png
index 9f75ea9..4117eec 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/002_3_2_Clarithromycin_-_Triazolam_DDI/001_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/002_3_2_Clarithromycin_-_Triazolam_DDI/001_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/003_3_3_Erythromycin_-_Alfentanil_DDI/001_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/003_3_3_Erythromycin_-_Alfentanil_DDI/001_plotComparisonTimeProfile.png
index a97c7e7..5d649e2 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/003_3_3_Erythromycin_-_Alfentanil_DDI/001_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/003_3_3_Erythromycin_-_Alfentanil_DDI/001_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/003_3_3_Erythromycin_-_Alfentanil_DDI/002_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/003_3_3_Erythromycin_-_Alfentanil_DDI/002_plotComparisonTimeProfile.png
index 6cb22ed..8056827 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/003_3_3_Erythromycin_-_Alfentanil_DDI/002_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/003_3_3_Erythromycin_-_Alfentanil_DDI/002_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/004_3_4_Erythromycin_-_Alprazolam_DDI/001_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/004_3_4_Erythromycin_-_Alprazolam_DDI/001_plotComparisonTimeProfile.png
index 7b1dfe5..41484b0 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/004_3_4_Erythromycin_-_Alprazolam_DDI/001_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/004_3_4_Erythromycin_-_Alprazolam_DDI/001_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/005_3_5_Erythromycin_-_Midazolam_DDI/001_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/005_3_5_Erythromycin_-_Midazolam_DDI/001_plotComparisonTimeProfile.png
index dc1211b..9b871df 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/005_3_5_Erythromycin_-_Midazolam_DDI/001_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/005_3_5_Erythromycin_-_Midazolam_DDI/001_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/005_3_5_Erythromycin_-_Midazolam_DDI/002_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/005_3_5_Erythromycin_-_Midazolam_DDI/002_plotComparisonTimeProfile.png
index de4450b..3336b96 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/005_3_5_Erythromycin_-_Midazolam_DDI/002_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/005_3_5_Erythromycin_-_Midazolam_DDI/002_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/005_3_5_Erythromycin_-_Midazolam_DDI/003_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/005_3_5_Erythromycin_-_Midazolam_DDI/003_plotComparisonTimeProfile.png
index 76a1432..853e128 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/005_3_5_Erythromycin_-_Midazolam_DDI/003_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/005_3_5_Erythromycin_-_Midazolam_DDI/003_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/005_3_5_Erythromycin_-_Midazolam_DDI/004_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/005_3_5_Erythromycin_-_Midazolam_DDI/004_plotComparisonTimeProfile.png
index 3d1a65a..4b6dd88 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/005_3_5_Erythromycin_-_Midazolam_DDI/004_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/005_3_5_Erythromycin_-_Midazolam_DDI/004_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/005_3_5_Erythromycin_-_Midazolam_DDI/005_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/005_3_5_Erythromycin_-_Midazolam_DDI/005_plotComparisonTimeProfile.png
index 233816d..04554dc 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/005_3_5_Erythromycin_-_Midazolam_DDI/005_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/005_3_5_Erythromycin_-_Midazolam_DDI/005_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/005_3_5_Erythromycin_-_Midazolam_DDI/006_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/005_3_5_Erythromycin_-_Midazolam_DDI/006_plotComparisonTimeProfile.png
index 2d1c666..0b2fb44 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/005_3_5_Erythromycin_-_Midazolam_DDI/006_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/005_3_5_Erythromycin_-_Midazolam_DDI/006_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/006_3_6_Erythromycin_-_Triazolam_DDI/001_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/006_3_6_Erythromycin_-_Triazolam_DDI/001_plotComparisonTimeProfile.png
index c140391..95fafa9 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/006_3_6_Erythromycin_-_Triazolam_DDI/001_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/006_3_6_Erythromycin_-_Triazolam_DDI/001_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/006_3_6_Erythromycin_-_Triazolam_DDI/002_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/006_3_6_Erythromycin_-_Triazolam_DDI/002_plotComparisonTimeProfile.png
index 98c29cd..6f74e6f 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/006_3_6_Erythromycin_-_Triazolam_DDI/002_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/006_3_6_Erythromycin_-_Triazolam_DDI/002_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/007_3_7_Fluvoxamine_-_Alprazolam_DDI/001_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/007_3_7_Fluvoxamine_-_Alprazolam_DDI/001_plotComparisonTimeProfile.png
index 8b760a0..428a74b 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/007_3_7_Fluvoxamine_-_Alprazolam_DDI/001_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/007_3_7_Fluvoxamine_-_Alprazolam_DDI/001_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/007_3_7_Fluvoxamine_-_Alprazolam_DDI/002_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/007_3_7_Fluvoxamine_-_Alprazolam_DDI/002_plotComparisonTimeProfile.png
index 23baab0..f97ffda 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/007_3_7_Fluvoxamine_-_Alprazolam_DDI/002_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/007_3_7_Fluvoxamine_-_Alprazolam_DDI/002_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/008_3_8_Fluvoxamine_-_Midazolam_DDI/001_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/008_3_8_Fluvoxamine_-_Midazolam_DDI/001_plotComparisonTimeProfile.png
index 4138414..75b0413 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/008_3_8_Fluvoxamine_-_Midazolam_DDI/001_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/008_3_8_Fluvoxamine_-_Midazolam_DDI/001_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/008_3_8_Fluvoxamine_-_Midazolam_DDI/002_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/008_3_8_Fluvoxamine_-_Midazolam_DDI/002_plotComparisonTimeProfile.png
index 3aab20a..bafab8b 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/008_3_8_Fluvoxamine_-_Midazolam_DDI/002_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/008_3_8_Fluvoxamine_-_Midazolam_DDI/002_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/009_3_9_Itraconazole_-_Alprazolam_DDI/001_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/009_3_9_Itraconazole_-_Alprazolam_DDI/001_plotComparisonTimeProfile.png
index d033fcc..1a68efb 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/009_3_9_Itraconazole_-_Alprazolam_DDI/001_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/009_3_9_Itraconazole_-_Alprazolam_DDI/001_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/010_3_10_Itraconazole_-_Midazolam_DDI/001_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/010_3_10_Itraconazole_-_Midazolam_DDI/001_plotComparisonTimeProfile.png
index b8d1cd2..0b9c6d2 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/010_3_10_Itraconazole_-_Midazolam_DDI/001_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/010_3_10_Itraconazole_-_Midazolam_DDI/001_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/010_3_10_Itraconazole_-_Midazolam_DDI/002_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/010_3_10_Itraconazole_-_Midazolam_DDI/002_plotComparisonTimeProfile.png
index 4d77056..78e3e40 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/010_3_10_Itraconazole_-_Midazolam_DDI/002_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/010_3_10_Itraconazole_-_Midazolam_DDI/002_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/010_3_10_Itraconazole_-_Midazolam_DDI/003_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/010_3_10_Itraconazole_-_Midazolam_DDI/003_plotComparisonTimeProfile.png
index 707e2f4..421eefe 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/010_3_10_Itraconazole_-_Midazolam_DDI/003_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/010_3_10_Itraconazole_-_Midazolam_DDI/003_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/010_3_10_Itraconazole_-_Midazolam_DDI/004_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/010_3_10_Itraconazole_-_Midazolam_DDI/004_plotComparisonTimeProfile.png
index 6aaabbb..9a221f2 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/010_3_10_Itraconazole_-_Midazolam_DDI/004_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/010_3_10_Itraconazole_-_Midazolam_DDI/004_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/010_3_10_Itraconazole_-_Midazolam_DDI/005_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/010_3_10_Itraconazole_-_Midazolam_DDI/005_plotComparisonTimeProfile.png
index 8a7a9df..e69c009 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/010_3_10_Itraconazole_-_Midazolam_DDI/005_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/010_3_10_Itraconazole_-_Midazolam_DDI/005_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/010_3_10_Itraconazole_-_Midazolam_DDI/006_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/010_3_10_Itraconazole_-_Midazolam_DDI/006_plotComparisonTimeProfile.png
index be367bb..4d70e25 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/010_3_10_Itraconazole_-_Midazolam_DDI/006_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/010_3_10_Itraconazole_-_Midazolam_DDI/006_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/010_3_10_Itraconazole_-_Midazolam_DDI/007_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/010_3_10_Itraconazole_-_Midazolam_DDI/007_plotComparisonTimeProfile.png
index 47c5f86..ac9cf40 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/010_3_10_Itraconazole_-_Midazolam_DDI/007_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/010_3_10_Itraconazole_-_Midazolam_DDI/007_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/010_3_10_Itraconazole_-_Midazolam_DDI/008_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/010_3_10_Itraconazole_-_Midazolam_DDI/008_plotComparisonTimeProfile.png
index 8f1cc03..9f24bd1 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/010_3_10_Itraconazole_-_Midazolam_DDI/008_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/010_3_10_Itraconazole_-_Midazolam_DDI/008_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/010_3_10_Itraconazole_-_Midazolam_DDI/009_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/010_3_10_Itraconazole_-_Midazolam_DDI/009_plotComparisonTimeProfile.png
index ce35695..8904e28 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/010_3_10_Itraconazole_-_Midazolam_DDI/009_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/010_3_10_Itraconazole_-_Midazolam_DDI/009_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/011_3_11_Itraconazole_-_Triazolam_DDI/001_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/011_3_11_Itraconazole_-_Triazolam_DDI/001_plotComparisonTimeProfile.png
index bc79c9c..55a7527 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/011_3_11_Itraconazole_-_Triazolam_DDI/001_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/011_3_11_Itraconazole_-_Triazolam_DDI/001_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/011_3_11_Itraconazole_-_Triazolam_DDI/002_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/011_3_11_Itraconazole_-_Triazolam_DDI/002_plotComparisonTimeProfile.png
index 53f0a59..fd66c86 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/011_3_11_Itraconazole_-_Triazolam_DDI/002_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/011_3_11_Itraconazole_-_Triazolam_DDI/002_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/012_3_12_Verapamil_-_Midazolam_DDI/001_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/012_3_12_Verapamil_-_Midazolam_DDI/001_plotComparisonTimeProfile.png
index c8347f9..e19ca0f 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/012_3_12_Verapamil_-_Midazolam_DDI/001_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/012_3_12_Verapamil_-_Midazolam_DDI/001_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/012_3_12_Verapamil_-_Midazolam_DDI/002_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/012_3_12_Verapamil_-_Midazolam_DDI/002_plotComparisonTimeProfile.png
index 37d5dd9..b3e0028 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/012_3_12_Verapamil_-_Midazolam_DDI/002_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/012_3_12_Verapamil_-_Midazolam_DDI/002_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/012_3_12_Verapamil_-_Midazolam_DDI/003_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/012_3_12_Verapamil_-_Midazolam_DDI/003_plotComparisonTimeProfile.png
index 252245f..bd5f4fb 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/012_3_12_Verapamil_-_Midazolam_DDI/003_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/012_3_12_Verapamil_-_Midazolam_DDI/003_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/013_3_13_Efavirenz_-_Alfentanil_DDI/001_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/013_3_13_Efavirenz_-_Alfentanil_DDI/001_plotComparisonTimeProfile.png
index 6406085..c2550e9 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/013_3_13_Efavirenz_-_Alfentanil_DDI/001_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/013_3_13_Efavirenz_-_Alfentanil_DDI/001_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/013_3_13_Efavirenz_-_Alfentanil_DDI/002_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/013_3_13_Efavirenz_-_Alfentanil_DDI/002_plotComparisonTimeProfile.png
index cc33eb7..e5e91ad 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/013_3_13_Efavirenz_-_Alfentanil_DDI/002_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/013_3_13_Efavirenz_-_Alfentanil_DDI/002_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/014_3_14_Efavirenz_-_Midazolam_DDI/001_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/014_3_14_Efavirenz_-_Midazolam_DDI/001_plotComparisonTimeProfile.png
index e97ced7..a4f9603 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/014_3_14_Efavirenz_-_Midazolam_DDI/001_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/014_3_14_Efavirenz_-_Midazolam_DDI/001_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/014_3_14_Efavirenz_-_Midazolam_DDI/002_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/014_3_14_Efavirenz_-_Midazolam_DDI/002_plotComparisonTimeProfile.png
index 237356c..c73880f 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/014_3_14_Efavirenz_-_Midazolam_DDI/002_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/014_3_14_Efavirenz_-_Midazolam_DDI/002_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/014_3_14_Efavirenz_-_Midazolam_DDI/003_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/014_3_14_Efavirenz_-_Midazolam_DDI/003_plotComparisonTimeProfile.png
index cf9d457..cb32a49 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/014_3_14_Efavirenz_-_Midazolam_DDI/003_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/014_3_14_Efavirenz_-_Midazolam_DDI/003_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/015_3_15_Rifampicin_-_Alfentanil_DDI/001_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/015_3_15_Rifampicin_-_Alfentanil_DDI/001_plotComparisonTimeProfile.png
index 22158dc..1fe2f92 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/015_3_15_Rifampicin_-_Alfentanil_DDI/001_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/015_3_15_Rifampicin_-_Alfentanil_DDI/001_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/015_3_15_Rifampicin_-_Alfentanil_DDI/002_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/015_3_15_Rifampicin_-_Alfentanil_DDI/002_plotComparisonTimeProfile.png
index 36bbf2a..e15578d 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/015_3_15_Rifampicin_-_Alfentanil_DDI/002_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/015_3_15_Rifampicin_-_Alfentanil_DDI/002_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/015_3_15_Rifampicin_-_Alfentanil_DDI/003_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/015_3_15_Rifampicin_-_Alfentanil_DDI/003_plotComparisonTimeProfile.png
index c9909f6..4ca5efb 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/015_3_15_Rifampicin_-_Alfentanil_DDI/003_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/015_3_15_Rifampicin_-_Alfentanil_DDI/003_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/015_3_15_Rifampicin_-_Alfentanil_DDI/004_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/015_3_15_Rifampicin_-_Alfentanil_DDI/004_plotComparisonTimeProfile.png
index f0cbd10..54b9644 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/015_3_15_Rifampicin_-_Alfentanil_DDI/004_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/015_3_15_Rifampicin_-_Alfentanil_DDI/004_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/015_3_15_Rifampicin_-_Alfentanil_DDI/005_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/015_3_15_Rifampicin_-_Alfentanil_DDI/005_plotComparisonTimeProfile.png
index bc72ebf..ffd303f 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/015_3_15_Rifampicin_-_Alfentanil_DDI/005_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/015_3_15_Rifampicin_-_Alfentanil_DDI/005_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/015_3_15_Rifampicin_-_Alfentanil_DDI/006_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/015_3_15_Rifampicin_-_Alfentanil_DDI/006_plotComparisonTimeProfile.png
index e4dde71..e682075 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/015_3_15_Rifampicin_-_Alfentanil_DDI/006_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/015_3_15_Rifampicin_-_Alfentanil_DDI/006_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/015_3_15_Rifampicin_-_Alfentanil_DDI/007_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/015_3_15_Rifampicin_-_Alfentanil_DDI/007_plotComparisonTimeProfile.png
index 84d554a..27fe66c 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/015_3_15_Rifampicin_-_Alfentanil_DDI/007_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/015_3_15_Rifampicin_-_Alfentanil_DDI/007_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/015_3_15_Rifampicin_-_Alfentanil_DDI/008_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/015_3_15_Rifampicin_-_Alfentanil_DDI/008_plotComparisonTimeProfile.png
index 91cee59..9be3c74 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/015_3_15_Rifampicin_-_Alfentanil_DDI/008_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/015_3_15_Rifampicin_-_Alfentanil_DDI/008_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/015_3_15_Rifampicin_-_Alfentanil_DDI/009_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/015_3_15_Rifampicin_-_Alfentanil_DDI/009_plotComparisonTimeProfile.png
index 6e36541..9fa0689 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/015_3_15_Rifampicin_-_Alfentanil_DDI/009_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/015_3_15_Rifampicin_-_Alfentanil_DDI/009_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/015_3_15_Rifampicin_-_Alfentanil_DDI/010_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/015_3_15_Rifampicin_-_Alfentanil_DDI/010_plotComparisonTimeProfile.png
index ee3c2f0..997684d 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/015_3_15_Rifampicin_-_Alfentanil_DDI/010_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/015_3_15_Rifampicin_-_Alfentanil_DDI/010_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/016_3_16_Rifampicin_-_Alprazolam_DDI/001_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/016_3_16_Rifampicin_-_Alprazolam_DDI/001_plotComparisonTimeProfile.png
index 1419f49..930565f 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/016_3_16_Rifampicin_-_Alprazolam_DDI/001_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/016_3_16_Rifampicin_-_Alprazolam_DDI/001_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/016_3_16_Rifampicin_-_Alprazolam_DDI/002_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/016_3_16_Rifampicin_-_Alprazolam_DDI/002_plotComparisonTimeProfile.png
index 65d2674..d74888b 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/016_3_16_Rifampicin_-_Alprazolam_DDI/002_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/016_3_16_Rifampicin_-_Alprazolam_DDI/002_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/016_3_16_Rifampicin_-_Alprazolam_DDI/003_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/016_3_16_Rifampicin_-_Alprazolam_DDI/003_plotComparisonTimeProfile.png
index 8a91ab4..bf03e65 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/016_3_16_Rifampicin_-_Alprazolam_DDI/003_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/016_3_16_Rifampicin_-_Alprazolam_DDI/003_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/001_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/001_plotComparisonTimeProfile.png
index 09e1abc..3099e32 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/001_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/001_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/002_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/002_plotComparisonTimeProfile.png
index ac314c5..1a02214 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/002_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/002_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/003_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/003_plotComparisonTimeProfile.png
index 2b8da16..ecc4a88 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/003_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/003_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/004_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/004_plotComparisonTimeProfile.png
index c8e196e..203f33c 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/004_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/004_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/005_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/005_plotComparisonTimeProfile.png
index 0860b20..7a0ddc1 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/005_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/005_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/006_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/006_plotComparisonTimeProfile.png
index a7c369e..8885a4b 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/006_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/006_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/007_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/007_plotComparisonTimeProfile.png
index 881f5b5..ede290c 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/007_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/007_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/008_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/008_plotComparisonTimeProfile.png
index b79720f..2c883c2 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/008_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/008_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/009_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/009_plotComparisonTimeProfile.png
index 9bda6fa..c548eb9 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/009_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/009_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/010_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/010_plotComparisonTimeProfile.png
index 098eb76..6c6ef92 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/010_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/010_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/011_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/011_plotComparisonTimeProfile.png
index 37bfe38..9fb0562 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/011_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/011_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/012_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/012_plotComparisonTimeProfile.png
index 19da6c0..b14a18b 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/012_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/012_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/013_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/013_plotComparisonTimeProfile.png
index 885371f..e8ee8cb 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/013_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/013_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/014_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/014_plotComparisonTimeProfile.png
index 38eab2b..db19b91 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/014_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/014_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/015_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/015_plotComparisonTimeProfile.png
index 50b8971..c827796 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/015_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/015_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/016_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/016_plotComparisonTimeProfile.png
index a52a47a..476b448 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/016_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/016_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/017_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/017_plotComparisonTimeProfile.png
index 0d051e4..a16441d 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/017_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/017_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/018_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/018_plotComparisonTimeProfile.png
index 545b8e3..de32887 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/018_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/018_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/019_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/019_plotComparisonTimeProfile.png
index e42811f..76de1b1 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/019_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/019_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/020_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/020_plotComparisonTimeProfile.png
index 78b3379..544fa77 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/020_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/020_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/021_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/021_plotComparisonTimeProfile.png
index 18def8d..4627a9a 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/021_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/021_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/022_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/022_plotComparisonTimeProfile.png
index 37033b9..5eb81a3 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/022_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/022_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/023_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/023_plotComparisonTimeProfile.png
index d54021f..c1a916c 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/023_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/023_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/024_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/024_plotComparisonTimeProfile.png
index d252b19..1f4f553 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/024_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/024_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/025_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/025_plotComparisonTimeProfile.png
index a1ac5d5..8303c54 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/025_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/017_3_17_Rifampicin_-_Midazolam_DDI/025_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/018_3_18_Rifampicin_-_Triazolam_DDI/001_plotComparisonTimeProfile.png b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/018_3_18_Rifampicin_-_Triazolam_DDI/001_plotComparisonTimeProfile.png
index 5a3cd22..e6d24d5 100644
Binary files a/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/018_3_18_Rifampicin_-_Triazolam_DDI/001_plotComparisonTimeProfile.png and b/DDI_Qualification_CYP3A4/images/003_3_Concentration-Time_Profiles/018_3_18_Rifampicin_-_Triazolam_DDI/001_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_CYP3A4/report.md b/DDI_Qualification_CYP3A4/report.md
index 9e3b581..e82086a 100644
--- a/DDI_Qualification_CYP3A4/report.md
+++ b/DDI_Qualification_CYP3A4/report.md
@@ -3,10 +3,10 @@
 
 
 
-| Version                         | 1.0-OSP9.0                                                   |
+| Version                         | 1.0-OSP9.1                                                   |
 | ------------------------------- | ------------------------------------------------------------ |
 | Qualification Plan Release      | https://github.com/Open-Systems-Pharmacology/Qualification-DDI-CYP3A4/releases/tag/v1.0 |
-| OSP Version                     | 9.0                                                          |
+| OSP Version                     | 9.1                                                          |
 | Qualification Framework Version | 2.2                                                          |
 
 
@@ -531,9 +531,9 @@ In the plots,
 
 ![004_plotDDIRatioCMAXResidualsVsObserved.png](images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/004_plotDDIRatioCMAXResidualsVsObserved.png)
 
-GMFE (AUC) = 1.398725 
+GMFE (AUC) = 1.398739 
 
-GMFE (CMAX) = 1.370608 
+GMFE (CMAX) = 1.370621 
 
 |AUC                       |Number|Ratio [%]|
 |-------------------------:|-----:|--------:|
@@ -557,7 +557,7 @@ GMFE (CMAX) = 1.370608
 |354   |Clarithromycin, 500 mg, PO, MD BID (4 days)                                                                                                                                                                                       |Midazolam, PO |5.871              |5.5556            |1.0568            |2.6201              |-                  |-                  |Markert 2013        |
 |1099  |Clarithromycin, 500 mg, PO, MD BID (5 days)                                                                                                                                                                                       |Midazolam, PO |7.8476             |4.84              |1.6214            |3.177               |2.69               |1.181              |Prueksaritanont 2017|
 |2030  |Clarithromycin, 500 mg, PO, MD BID (7 days)                                                                                                                                                                                       |Midazolam, PO |9.0373             |8                 |1.1297            |3.1442              |2.75               |1.1433             |Quinney 2008        |
-|2004  |Clarithromycin, 250 mg, PO, MD BID (3 days)                                                                                                                                                                                       |Midazolam, PO |1.4921             |1.9               |0.78531           |1.258               |1.75               |0.71885            |van Dyk 2018        |
+|2004  |Clarithromycin, 250 mg, PO, MD BID (3 days)                                                                                                                                                                                       |Midazolam, PO |1.4904             |1.9               |0.78442           |1.2571              |1.75               |0.71833            |van Dyk 2018        |
 |469   |Clarithromycin, 250 mg, PO, MD BID (5 days)                                                                                                                                                                                       |Midazolam, PO |2.3757             |3.5716            |0.66518           |1.5939              |2.44               |0.65325            |Yeates 1996         |
 |1102  |Clarithromycin, 500 mg, PO, MD OD (2 days)                                                                                                                                                                                        |Triazolam, PO |3.5766             |5.06              |0.70684           |2.0063              |1.968              |1.0194             |Greenblatt 1998a    |
 |779   |Erythromycin, 500 mg, PO, SD                                                                                                                                                                                                      |Alfentanil, IV|1.0294             |1.0262            |1.0031            |1                   |-                  |-                  |Bartkowski 1989     |
@@ -732,9 +732,9 @@ GMFE (CMAX) = 1.451894
 
 ![004_plotDDIRatioCMAXResidualsVsObserved.png](images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/001_Mechanism/003_Mechanism_based_Inactivation/004_plotDDIRatioCMAXResidualsVsObserved.png)
 
-GMFE (AUC) = 1.271545 
+GMFE (AUC) = 1.271597 
 
-GMFE (CMAX) = 1.240603 
+GMFE (CMAX) = 1.240656 
 
 |AUC                       |Number|Ratio [%]|
 |-------------------------:|-----:|--------:|
@@ -760,9 +760,9 @@ GMFE (CMAX) = 1.240603
 
 ![004_plotDDIRatioCMAXResidualsVsObserved.png](images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/002_Perpetrator/001_Clarithromycin/004_plotDDIRatioCMAXResidualsVsObserved.png)
 
-GMFE (AUC) = 1.257076 
+GMFE (AUC) = 1.257206 
 
-GMFE (CMAX) = 1.235171 
+GMFE (CMAX) = 1.235284 
 
 |AUC                       |Number|Ratio [%]|
 |-------------------------:|-----:|--------:|
@@ -996,9 +996,9 @@ GMFE (CMAX) = 1.242657
 
 ![004_plotDDIRatioCMAXResidualsVsObserved.png](images/002_2_Qualification_of_Use_Case_CYP3A4-mediated_DDI/003_Victim/003_Midazolam/004_plotDDIRatioCMAXResidualsVsObserved.png)
 
-GMFE (AUC) = 1.413926 
+GMFE (AUC) = 1.413945 
 
-GMFE (CMAX) = 1.432132 
+GMFE (CMAX) = 1.432152 
 
 |AUC                       |Number|Ratio [%]|
 |-------------------------:|-----:|--------:|
diff --git a/DDI_Qualification_CYP3A4/report.pdf b/DDI_Qualification_CYP3A4/report.pdf
index 176659c..4afe755 100644
Binary files a/DDI_Qualification_CYP3A4/report.pdf and b/DDI_Qualification_CYP3A4/report.pdf differ
diff --git a/DDI_Qualification_UGT/images/002_2_Qualification_of_Use_Case_UGT-mediated_DDI/001_plotDDIRatioAUCPredictedVsObserved.png b/DDI_Qualification_UGT/images/002_2_Qualification_of_Use_Case_UGT-mediated_DDI/001_plotDDIRatioAUCPredictedVsObserved.png
index f42dc02..dff3b36 100644
Binary files a/DDI_Qualification_UGT/images/002_2_Qualification_of_Use_Case_UGT-mediated_DDI/001_plotDDIRatioAUCPredictedVsObserved.png and b/DDI_Qualification_UGT/images/002_2_Qualification_of_Use_Case_UGT-mediated_DDI/001_plotDDIRatioAUCPredictedVsObserved.png differ
diff --git a/DDI_Qualification_UGT/images/002_2_Qualification_of_Use_Case_UGT-mediated_DDI/002_plotDDIRatioAUCResidualsVsObserved.png b/DDI_Qualification_UGT/images/002_2_Qualification_of_Use_Case_UGT-mediated_DDI/002_plotDDIRatioAUCResidualsVsObserved.png
index 31934e4..978bc7f 100644
Binary files a/DDI_Qualification_UGT/images/002_2_Qualification_of_Use_Case_UGT-mediated_DDI/002_plotDDIRatioAUCResidualsVsObserved.png and b/DDI_Qualification_UGT/images/002_2_Qualification_of_Use_Case_UGT-mediated_DDI/002_plotDDIRatioAUCResidualsVsObserved.png differ
diff --git a/DDI_Qualification_UGT/images/002_2_Qualification_of_Use_Case_UGT-mediated_DDI/003_plotDDIRatioCMAXPredictedVsObserved.png b/DDI_Qualification_UGT/images/002_2_Qualification_of_Use_Case_UGT-mediated_DDI/003_plotDDIRatioCMAXPredictedVsObserved.png
index aa73c17..a278a30 100644
Binary files a/DDI_Qualification_UGT/images/002_2_Qualification_of_Use_Case_UGT-mediated_DDI/003_plotDDIRatioCMAXPredictedVsObserved.png and b/DDI_Qualification_UGT/images/002_2_Qualification_of_Use_Case_UGT-mediated_DDI/003_plotDDIRatioCMAXPredictedVsObserved.png differ
diff --git a/DDI_Qualification_UGT/images/002_2_Qualification_of_Use_Case_UGT-mediated_DDI/004_plotDDIRatioCMAXResidualsVsObserved.png b/DDI_Qualification_UGT/images/002_2_Qualification_of_Use_Case_UGT-mediated_DDI/004_plotDDIRatioCMAXResidualsVsObserved.png
index 4e59436..cd87137 100644
Binary files a/DDI_Qualification_UGT/images/002_2_Qualification_of_Use_Case_UGT-mediated_DDI/004_plotDDIRatioCMAXResidualsVsObserved.png and b/DDI_Qualification_UGT/images/002_2_Qualification_of_Use_Case_UGT-mediated_DDI/004_plotDDIRatioCMAXResidualsVsObserved.png differ
diff --git a/DDI_Qualification_UGT/images/003_3_Concentration-Time_Profiles/001_3_1_Atazanavir_-_Raltegravir_DDI/001_plotComparisonTimeProfile.png b/DDI_Qualification_UGT/images/003_3_Concentration-Time_Profiles/001_3_1_Atazanavir_-_Raltegravir_DDI/001_plotComparisonTimeProfile.png
index 48a8ee1..7a81f82 100644
Binary files a/DDI_Qualification_UGT/images/003_3_Concentration-Time_Profiles/001_3_1_Atazanavir_-_Raltegravir_DDI/001_plotComparisonTimeProfile.png and b/DDI_Qualification_UGT/images/003_3_Concentration-Time_Profiles/001_3_1_Atazanavir_-_Raltegravir_DDI/001_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_UGT/images/003_3_Concentration-Time_Profiles/001_3_1_Atazanavir_-_Raltegravir_DDI/002_plotComparisonTimeProfile.png b/DDI_Qualification_UGT/images/003_3_Concentration-Time_Profiles/001_3_1_Atazanavir_-_Raltegravir_DDI/002_plotComparisonTimeProfile.png
index 769f309..d3e0dc4 100644
Binary files a/DDI_Qualification_UGT/images/003_3_Concentration-Time_Profiles/001_3_1_Atazanavir_-_Raltegravir_DDI/002_plotComparisonTimeProfile.png and b/DDI_Qualification_UGT/images/003_3_Concentration-Time_Profiles/001_3_1_Atazanavir_-_Raltegravir_DDI/002_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_UGT/images/003_3_Concentration-Time_Profiles/001_3_1_Atazanavir_-_Raltegravir_DDI/003_plotComparisonTimeProfile.png b/DDI_Qualification_UGT/images/003_3_Concentration-Time_Profiles/001_3_1_Atazanavir_-_Raltegravir_DDI/003_plotComparisonTimeProfile.png
index 7abd77c..0b6ff2d 100644
Binary files a/DDI_Qualification_UGT/images/003_3_Concentration-Time_Profiles/001_3_1_Atazanavir_-_Raltegravir_DDI/003_plotComparisonTimeProfile.png and b/DDI_Qualification_UGT/images/003_3_Concentration-Time_Profiles/001_3_1_Atazanavir_-_Raltegravir_DDI/003_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_UGT/images/003_3_Concentration-Time_Profiles/001_3_1_Atazanavir_-_Raltegravir_DDI/004_plotComparisonTimeProfile.png b/DDI_Qualification_UGT/images/003_3_Concentration-Time_Profiles/001_3_1_Atazanavir_-_Raltegravir_DDI/004_plotComparisonTimeProfile.png
index 0b423fa..338d455 100644
Binary files a/DDI_Qualification_UGT/images/003_3_Concentration-Time_Profiles/001_3_1_Atazanavir_-_Raltegravir_DDI/004_plotComparisonTimeProfile.png and b/DDI_Qualification_UGT/images/003_3_Concentration-Time_Profiles/001_3_1_Atazanavir_-_Raltegravir_DDI/004_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_UGT/images/003_3_Concentration-Time_Profiles/002_3_2_Mefenamic_acid_-_Dapagliflozin_DDI/001_plotComparisonTimeProfile.png b/DDI_Qualification_UGT/images/003_3_Concentration-Time_Profiles/002_3_2_Mefenamic_acid_-_Dapagliflozin_DDI/001_plotComparisonTimeProfile.png
index 5418937..f12a3f2 100644
Binary files a/DDI_Qualification_UGT/images/003_3_Concentration-Time_Profiles/002_3_2_Mefenamic_acid_-_Dapagliflozin_DDI/001_plotComparisonTimeProfile.png and b/DDI_Qualification_UGT/images/003_3_Concentration-Time_Profiles/002_3_2_Mefenamic_acid_-_Dapagliflozin_DDI/001_plotComparisonTimeProfile.png differ
diff --git a/DDI_Qualification_UGT/report.md b/DDI_Qualification_UGT/report.md
index 60f1b2f..026fcc9 100644
--- a/DDI_Qualification_UGT/report.md
+++ b/DDI_Qualification_UGT/report.md
@@ -3,10 +3,10 @@
 
 
 
-| Version                         | 1.1-OSP9.0                                                   |
+| Version                         | 1.1-OSP9.1                                                   |
 | ------------------------------- | ------------------------------------------------------------ |
 | Qualification Plan Release      | https://github.com/Open-Systems-Pharmacology/Qualification-DDI-UGT/releases/tag/v1.1 |
-| OSP Version                     | 9.0                                                          |
+| OSP Version                     | 9.1                                                          |
 | Qualification Framework Version | 2.2                                                          |
 
 
diff --git a/DDI_Qualification_UGT/report.pdf b/DDI_Qualification_UGT/report.pdf
index bb53e89..31eef51 100644
Binary files a/DDI_Qualification_UGT/report.pdf and b/DDI_Qualification_UGT/report.pdf differ
diff --git a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/001_Chapter_2_1__Montelukast_PK_Ratio_tables_and_Figures/001_plotPKRatioAUC.png b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/001_Chapter_2_1__Montelukast_PK_Ratio_tables_and_Figures/001_plotPKRatioAUC.png
index b920e38..39fb94f 100644
Binary files a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/001_Chapter_2_1__Montelukast_PK_Ratio_tables_and_Figures/001_plotPKRatioAUC.png and b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/001_Chapter_2_1__Montelukast_PK_Ratio_tables_and_Figures/001_plotPKRatioAUC.png differ
diff --git a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/002_Chapter_2_2__Montelukast_Concentration-Time_profiles_in_Children/001_plotPopulationTimeProfile.png b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/002_Chapter_2_2__Montelukast_Concentration-Time_profiles_in_Children/001_plotPopulationTimeProfile.png
index c65d16a..c8d90a9 100644
Binary files a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/002_Chapter_2_2__Montelukast_Concentration-Time_profiles_in_Children/001_plotPopulationTimeProfile.png and b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/002_Chapter_2_2__Montelukast_Concentration-Time_profiles_in_Children/001_plotPopulationTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/002_Chapter_2_2__Montelukast_Concentration-Time_profiles_in_Children/002_plotPopulationTimeProfile.png b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/002_Chapter_2_2__Montelukast_Concentration-Time_profiles_in_Children/002_plotPopulationTimeProfile.png
index 3d99aa8..eb1927c 100644
Binary files a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/002_Chapter_2_2__Montelukast_Concentration-Time_profiles_in_Children/002_plotPopulationTimeProfile.png and b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/002_Chapter_2_2__Montelukast_Concentration-Time_profiles_in_Children/002_plotPopulationTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/003_plotPKRatioAUC.png b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/003_plotPKRatioAUC.png
index 639e689..0b8d37c 100644
Binary files a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/003_plotPKRatioAUC.png and b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/003_plotPKRatioAUC.png differ
diff --git a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/002_Chapter_3_2__Montelukast_Diagnostics_Plots/001_plotGOFMergedPredictedVsObserved.png b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/002_Chapter_3_2__Montelukast_Diagnostics_Plots/001_plotGOFMergedPredictedVsObserved.png
index b1571fe..8e153e7 100644
Binary files a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/002_Chapter_3_2__Montelukast_Diagnostics_Plots/001_plotGOFMergedPredictedVsObserved.png and b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/002_Chapter_3_2__Montelukast_Diagnostics_Plots/001_plotGOFMergedPredictedVsObserved.png differ
diff --git a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/002_Chapter_3_2__Montelukast_Diagnostics_Plots/003_plotGOFMergedResidualsOverTime.png b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/002_Chapter_3_2__Montelukast_Diagnostics_Plots/003_plotGOFMergedResidualsOverTime.png
index eeed9fb..659173c 100644
Binary files a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/002_Chapter_3_2__Montelukast_Diagnostics_Plots/003_plotGOFMergedResidualsOverTime.png and b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/002_Chapter_3_2__Montelukast_Diagnostics_Plots/003_plotGOFMergedResidualsOverTime.png differ
diff --git a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/001_plotTimeProfile.png b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/001_plotTimeProfile.png
index c70b25b..05f6fbe 100644
Binary files a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/001_plotTimeProfile.png and b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/001_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/002_plotTimeProfile.png b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/002_plotTimeProfile.png
index b35d70f..355323d 100644
Binary files a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/002_plotTimeProfile.png and b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/002_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/003_plotTimeProfile.png b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/003_plotTimeProfile.png
index bd0f664..eb73955 100644
Binary files a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/003_plotTimeProfile.png and b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/003_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/004_plotTimeProfile.png b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/004_plotTimeProfile.png
index be20ab8..0d55326 100644
Binary files a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/004_plotTimeProfile.png and b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/004_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/005_plotTimeProfile.png b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/005_plotTimeProfile.png
index a28f0a5..486d51f 100644
Binary files a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/005_plotTimeProfile.png and b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/005_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/006_plotTimeProfile.png b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/006_plotTimeProfile.png
index 0afa3f8..98516d8 100644
Binary files a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/006_plotTimeProfile.png and b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/006_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/007_plotTimeProfile.png b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/007_plotTimeProfile.png
index e2e73ac..eb3e0fb 100644
Binary files a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/007_plotTimeProfile.png and b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/007_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/008_plotTimeProfile.png b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/008_plotTimeProfile.png
index 5da2f70..751c2a9 100644
Binary files a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/008_plotTimeProfile.png and b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/008_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/009_plotTimeProfile.png b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/009_plotTimeProfile.png
index 6c2b777..6f3dbf9 100644
Binary files a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/009_plotTimeProfile.png and b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/009_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/010_plotTimeProfile.png b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/010_plotTimeProfile.png
index 0c9c0fc..94412d9 100644
Binary files a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/010_plotTimeProfile.png and b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/010_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/011_plotTimeProfile.png b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/011_plotTimeProfile.png
index 42a19b2..8bc875d 100644
Binary files a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/011_plotTimeProfile.png and b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/011_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/012_plotTimeProfile.png b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/012_plotTimeProfile.png
index ca19d6c..114bb76 100644
Binary files a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/012_plotTimeProfile.png and b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/012_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/013_plotTimeProfile.png b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/013_plotTimeProfile.png
index e9ed0be..39c81e6 100644
Binary files a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/013_plotTimeProfile.png and b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/013_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/014_plotTimeProfile.png b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/014_plotTimeProfile.png
index f4e161a..51dca58 100644
Binary files a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/014_plotTimeProfile.png and b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/014_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/015_plotTimeProfile.png b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/015_plotTimeProfile.png
index dfe5114..9ba5c18 100644
Binary files a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/015_plotTimeProfile.png and b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/015_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/016_plotTimeProfile.png b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/016_plotTimeProfile.png
index 84c9790..d83dafa 100644
Binary files a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/016_plotTimeProfile.png and b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/016_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/017_plotTimeProfile.png b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/017_plotTimeProfile.png
index 9c7b1e3..dd7cc43 100644
Binary files a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/017_plotTimeProfile.png and b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/017_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/018_plotTimeProfile.png b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/018_plotTimeProfile.png
index 12d998e..ecde725 100644
Binary files a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/018_plotTimeProfile.png and b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/018_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/019_plotTimeProfile.png b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/019_plotTimeProfile.png
index 187ebf4..d0a046a 100644
Binary files a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/019_plotTimeProfile.png and b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/019_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/020_plotTimeProfile.png b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/020_plotTimeProfile.png
index bcf09fc..c714081 100644
Binary files a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/020_plotTimeProfile.png and b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/020_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/021_plotTimeProfile.png b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/021_plotTimeProfile.png
index 5068bcc..b95d61c 100644
Binary files a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/021_plotTimeProfile.png and b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/021_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/022_plotTimeProfile.png b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/022_plotTimeProfile.png
index 341731b..292b1f7 100644
Binary files a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/022_plotTimeProfile.png and b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/022_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/023_plotTimeProfile.png b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/023_plotTimeProfile.png
index 6e9bc87..48711a2 100644
Binary files a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/023_plotTimeProfile.png and b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/023_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/024_plotTimeProfile.png b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/024_plotTimeProfile.png
index 8ad490b..30bf6f3 100644
Binary files a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/024_plotTimeProfile.png and b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/003_Chapter_3_3__Montelukast_Concentration-Time_profiles_in_Adults/024_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/report.md b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/report.md
index ad831f7..ddc2d8c 100644
--- a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/report.md
+++ b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/report.md
@@ -4,10 +4,10 @@
 
 
 
-| Version                         | 1.1-OSP9.0                                                   |
+| Version                         | 1.1-OSP9.1                                                   |
 | ------------------------------- | ------------------------------------------------------------ |
 | Qualification Plan Release      | https://github.com/Open-Systems-Pharmacology/Pediatric_Qualification_Package_CYP2C8_Ontogeny/releases/tag/v1.1 |
-| OSP Version                     | 9.0                                                          |
+| OSP Version                     | 9.1                                                          |
 | Qualification Framework Version | 2.2                                                          |
 
 
diff --git a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/report.pdf b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/report.pdf
index 2ed5f25..d98257d 100644
Binary files a/Pediatric_Qualification_Package_CYP2C8_Ontogeny/report.pdf and b/Pediatric_Qualification_Package_CYP2C8_Ontogeny/report.pdf differ
diff --git a/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/001_Chapter_1__Introduction_to_Pediatric_Translation_and_CYP3A4_Ontogeny_Qualification/001_plotPKRatioAUC.png b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/001_Chapter_1__Introduction_to_Pediatric_Translation_and_CYP3A4_Ontogeny_Qualification/001_plotPKRatioAUC.png
deleted file mode 100644
index 5fa6650..0000000
Binary files a/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/001_Chapter_1__Introduction_to_Pediatric_Translation_and_CYP3A4_Ontogeny_Qualification/001_plotPKRatioAUC.png and /dev/null differ
diff --git a/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/001_Chapter_2_1__Sufentanil_PK_Ratio_tables_and_Figures/001_plotPKRatioAUC.png b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/001_Chapter_2_1__Sufentanil_PK_Ratio_tables_and_Figures/001_plotPKRatioAUC.png
index e6d2231..f0e79af 100644
Binary files a/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/001_Chapter_2_1__Sufentanil_PK_Ratio_tables_and_Figures/001_plotPKRatioAUC.png and b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/001_Chapter_2_1__Sufentanil_PK_Ratio_tables_and_Figures/001_plotPKRatioAUC.png differ
diff --git a/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/002_Chapter_2_2__Sufentanil_Concentration-Time_profiles_in_Children/001_plotTimeProfile.png b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/002_Chapter_2_2__Sufentanil_Concentration-Time_profiles_in_Children/001_plotTimeProfile.png
index 5e97b26..bd9a48e 100644
Binary files a/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/002_Chapter_2_2__Sufentanil_Concentration-Time_profiles_in_Children/001_plotTimeProfile.png and b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/002_Chapter_2_2__Sufentanil_Concentration-Time_profiles_in_Children/001_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/002_Chapter_2_2__Sufentanil_Concentration-Time_profiles_in_Children/002_plotTimeProfile.png b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/002_Chapter_2_2__Sufentanil_Concentration-Time_profiles_in_Children/002_plotTimeProfile.png
index f919922..78be333 100644
Binary files a/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/002_Chapter_2_2__Sufentanil_Concentration-Time_profiles_in_Children/002_plotTimeProfile.png and b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/002_Chapter_2_2__Sufentanil_Concentration-Time_profiles_in_Children/002_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/002_Chapter_2_2__Sufentanil_Concentration-Time_profiles_in_Children/003_plotTimeProfile.png b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/002_Chapter_2_2__Sufentanil_Concentration-Time_profiles_in_Children/003_plotTimeProfile.png
index 7f8de47..53024c9 100644
Binary files a/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/002_Chapter_2_2__Sufentanil_Concentration-Time_profiles_in_Children/003_plotTimeProfile.png and b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/002_Chapter_2_2__Sufentanil_Concentration-Time_profiles_in_Children/003_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/002_Chapter_2_2__Sufentanil_Concentration-Time_profiles_in_Children/004_plotTimeProfile.png b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/002_Chapter_2_2__Sufentanil_Concentration-Time_profiles_in_Children/004_plotTimeProfile.png
index e45bb20..231d7cb 100644
Binary files a/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/002_Chapter_2_2__Sufentanil_Concentration-Time_profiles_in_Children/004_plotTimeProfile.png and b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/002_Chapter_2_2__Sufentanil_Concentration-Time_profiles_in_Children/004_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/002_Chapter_2_2__Sufentanil_Concentration-Time_profiles_in_Children/005_plotTimeProfile.png b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/002_Chapter_2_2__Sufentanil_Concentration-Time_profiles_in_Children/005_plotTimeProfile.png
index b694437..361c1c9 100644
Binary files a/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/002_Chapter_2_2__Sufentanil_Concentration-Time_profiles_in_Children/005_plotTimeProfile.png and b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/002_Chapter_2_2__Sufentanil_Concentration-Time_profiles_in_Children/005_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/002_Chapter_2_2__Sufentanil_Concentration-Time_profiles_in_Children/006_plotTimeProfile.png b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/002_Chapter_2_2__Sufentanil_Concentration-Time_profiles_in_Children/006_plotTimeProfile.png
index 392621a..9c76b22 100644
Binary files a/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/002_Chapter_2_2__Sufentanil_Concentration-Time_profiles_in_Children/006_plotTimeProfile.png and b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/002_Chapter_2_2__Sufentanil_Concentration-Time_profiles_in_Children/006_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/003_Chapter_2_3__Alfentanil_PK_Ratio_tables_and_Figures/001_plotPKRatioAUC.png b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/003_Chapter_2_3__Alfentanil_PK_Ratio_tables_and_Figures/001_plotPKRatioAUC.png
index 8924c57..3c58e5a 100644
Binary files a/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/003_Chapter_2_3__Alfentanil_PK_Ratio_tables_and_Figures/001_plotPKRatioAUC.png and b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/003_Chapter_2_3__Alfentanil_PK_Ratio_tables_and_Figures/001_plotPKRatioAUC.png differ
diff --git a/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/004_Chapter_2_4__Alfentanil_Concentration-Time_profiles_in_Children/001_plotTimeProfile.png b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/004_Chapter_2_4__Alfentanil_Concentration-Time_profiles_in_Children/001_plotTimeProfile.png
index e608f17..4f56205 100644
Binary files a/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/004_Chapter_2_4__Alfentanil_Concentration-Time_profiles_in_Children/001_plotTimeProfile.png and b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/004_Chapter_2_4__Alfentanil_Concentration-Time_profiles_in_Children/001_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/004_Chapter_2_4__Alfentanil_Concentration-Time_profiles_in_Children/002_plotTimeProfile.png b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/004_Chapter_2_4__Alfentanil_Concentration-Time_profiles_in_Children/002_plotTimeProfile.png
index 47f991d..b2c7bd5 100644
Binary files a/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/004_Chapter_2_4__Alfentanil_Concentration-Time_profiles_in_Children/002_plotTimeProfile.png and b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/004_Chapter_2_4__Alfentanil_Concentration-Time_profiles_in_Children/002_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/004_Chapter_2_4__Alfentanil_Concentration-Time_profiles_in_Children/003_plotPopulationTimeProfile.png b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/004_Chapter_2_4__Alfentanil_Concentration-Time_profiles_in_Children/003_plotPopulationTimeProfile.png
index 78546fa..076ac6c 100644
Binary files a/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/004_Chapter_2_4__Alfentanil_Concentration-Time_profiles_in_Children/003_plotPopulationTimeProfile.png and b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/004_Chapter_2_4__Alfentanil_Concentration-Time_profiles_in_Children/003_plotPopulationTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/004_Chapter_2_4__Alfentanil_Concentration-Time_profiles_in_Children/004_plotPopulationTimeProfile.png b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/004_Chapter_2_4__Alfentanil_Concentration-Time_profiles_in_Children/004_plotPopulationTimeProfile.png
index 3b05a95..c43032a 100644
Binary files a/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/004_Chapter_2_4__Alfentanil_Concentration-Time_profiles_in_Children/004_plotPopulationTimeProfile.png and b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/004_Chapter_2_4__Alfentanil_Concentration-Time_profiles_in_Children/004_plotPopulationTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/005_plotPKRatioAUC.png b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/005_plotPKRatioAUC.png
new file mode 100644
index 0000000..45b48ef
Binary files /dev/null and b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification_results/005_plotPKRatioAUC.png differ
diff --git a/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_building_and_performance/002_Chapter_3_2__Sufentanil_Diagnostics_Plots/001_plotGOFMergedPredictedVsObserved.png b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_building_and_performance/002_Chapter_3_2__Sufentanil_Diagnostics_Plots/001_plotGOFMergedPredictedVsObserved.png
new file mode 100644
index 0000000..3c91552
Binary files /dev/null and b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_building_and_performance/002_Chapter_3_2__Sufentanil_Diagnostics_Plots/001_plotGOFMergedPredictedVsObserved.png differ
diff --git a/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_building_and_performance/002_Chapter_3_2__Sufentanil_Diagnostics_Plots/003_plotGOFMergedResidualsOverTime.png b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_building_and_performance/002_Chapter_3_2__Sufentanil_Diagnostics_Plots/003_plotGOFMergedResidualsOverTime.png
new file mode 100644
index 0000000..e1a3060
Binary files /dev/null and b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_building_and_performance/002_Chapter_3_2__Sufentanil_Diagnostics_Plots/003_plotGOFMergedResidualsOverTime.png differ
diff --git a/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_building_and_performance/003_Chapter_3_3__Sufentanil_Concentration-Time_profiles_in_Adults/001_plotTimeProfile.png b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_building_and_performance/003_Chapter_3_3__Sufentanil_Concentration-Time_profiles_in_Adults/001_plotTimeProfile.png
new file mode 100644
index 0000000..659e914
Binary files /dev/null and b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_building_and_performance/003_Chapter_3_3__Sufentanil_Concentration-Time_profiles_in_Adults/001_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_building_and_performance/003_Chapter_3_3__Sufentanil_Concentration-Time_profiles_in_Adults/002_plotTimeProfile.png b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_building_and_performance/003_Chapter_3_3__Sufentanil_Concentration-Time_profiles_in_Adults/002_plotTimeProfile.png
new file mode 100644
index 0000000..01ce255
Binary files /dev/null and b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_building_and_performance/003_Chapter_3_3__Sufentanil_Concentration-Time_profiles_in_Adults/002_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_building_and_performance/003_Chapter_3_3__Sufentanil_Concentration-Time_profiles_in_Adults/003_plotTimeProfile.png b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_building_and_performance/003_Chapter_3_3__Sufentanil_Concentration-Time_profiles_in_Adults/003_plotTimeProfile.png
new file mode 100644
index 0000000..df36734
Binary files /dev/null and b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_building_and_performance/003_Chapter_3_3__Sufentanil_Concentration-Time_profiles_in_Adults/003_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_building_and_performance/003_Chapter_3_3__Sufentanil_Concentration-Time_profiles_in_Adults/004_plotTimeProfile.png b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_building_and_performance/003_Chapter_3_3__Sufentanil_Concentration-Time_profiles_in_Adults/004_plotTimeProfile.png
new file mode 100644
index 0000000..d8c6d03
Binary files /dev/null and b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_building_and_performance/003_Chapter_3_3__Sufentanil_Concentration-Time_profiles_in_Adults/004_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_building_and_performance/003_Chapter_3_3__Sufentanil_Concentration-Time_profiles_in_Adults/005_plotTimeProfile.png b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_building_and_performance/003_Chapter_3_3__Sufentanil_Concentration-Time_profiles_in_Adults/005_plotTimeProfile.png
new file mode 100644
index 0000000..ed4b400
Binary files /dev/null and b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_building_and_performance/003_Chapter_3_3__Sufentanil_Concentration-Time_profiles_in_Adults/005_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_building_and_performance/003_Chapter_3_3__Sufentanil_Concentration-Time_profiles_in_Adults/006_plotTimeProfile.png b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_building_and_performance/003_Chapter_3_3__Sufentanil_Concentration-Time_profiles_in_Adults/006_plotTimeProfile.png
new file mode 100644
index 0000000..5159ccc
Binary files /dev/null and b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_building_and_performance/003_Chapter_3_3__Sufentanil_Concentration-Time_profiles_in_Adults/006_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_CYP3A4_Ontogeny/report.md b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/report.md
index c8d5b3a..3297c46 100644
--- a/Pediatric_Qualification_Package_CYP3A4_Ontogeny/report.md
+++ b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/report.md
@@ -4,10 +4,10 @@
 
 
 
-| Version                         | 1.1-OSP9.0                                                   |
+| Version                         | 1.2-OSP9.1                                                   |
 | ------------------------------- | ------------------------------------------------------------ |
-| Qualification Plan Release      | https://github.com/Open-Systems-Pharmacology/Pediatric_Qualification_Package_CYP3A4_Ontogeny/releases/tag/v1.1 |
-| OSP Version                     | 9.0                                                          |
+| Qualification Plan Release      | https://github.com/Open-Systems-Pharmacology/Pediatric_Qualification_Package_CYP3A4_Ontogeny/releases/tag/v1.2 |
+| OSP Version                     | 9.1                                                          |
 | Qualification Framework Version | 2.2                                                          |
 
 
@@ -73,7 +73,6 @@ To qualify the OSP suite for the pediatric translation of the pharmacokinetics o
 [4] [Alfentanil-Model, Whole-body PBPK model of Alfentanil. https://github.com/Open-Systems-Pharmacology/Alfentanil-Model](https://github.com/incei/Alfentanil-Model)
 
 [5] [Sufentanil-Model, Whole-body PBPK model of Sufentanil. https://github.com/Open-Systems-Pharmacology/Sufentanil-Model](https://github.com/incei/Sufentanil-Model)
-
 # Chapter 2: Pediatric translation qualification results
 ## Evaluation of Pediatric translation
 
@@ -90,8 +89,7 @@ The ratios of predicted over observed mean AUC or CL values from all compound we
 In the next sections the demographics as well as the evaluation results of the predictive performance of the specific compound PBPK models in children can be found.  
 
 
-
-![001_plotPKRatioAUC.png](images/001_Chapter_1__Introduction_to_Pediatric_Translation_and_CYP3A4_Ontogeny_Qualification/001_plotPKRatioAUC.png)
+![005_plotPKRatioAUC.png](images/002_Chapter_2__Pediatric_translation_qualification_results/005_plotPKRatioAUC.png)
 
 GMFE (AUC) = 1.254230 
 
@@ -323,10 +321,30 @@ Intrinsic clearance | 9.6138746106 l/min | Parameter Identification-Parameter Id
 Below you find the input goodness-of-fit visual diagnostic plots for sufentanil PBPK model performance (observed versus individually simulated plasma concentration and weighted residuals versus time) of all adult data.
 
 
+![001_plotGOFMergedPredictedVsObserved.png](images/003_Chapter_3__Adult_PBPK_model_building_and_performance/002_Chapter_3_2__Sufentanil_Diagnostics_Plots/001_plotGOFMergedPredictedVsObserved.png)
+
+GMFE = 1.402222 
+
+![003_plotGOFMergedResidualsOverTime.png](images/003_Chapter_3__Adult_PBPK_model_building_and_performance/002_Chapter_3_2__Sufentanil_Diagnostics_Plots/003_plotGOFMergedResidualsOverTime.png)
+
+GMFE = 1.402222 
+
 ## Chapter 3.3: Sufentanil Concentration-Time profiles in Adults
 #### Concentration-Time Profiles
 
 Simulated versus observed plasma concentration-time profiles of all data are listed below.
+![001_plotTimeProfile.png](images/003_Chapter_3__Adult_PBPK_model_building_and_performance/003_Chapter_3_3__Sufentanil_Concentration-Time_profiles_in_Adults/001_plotTimeProfile.png)
+
+![002_plotTimeProfile.png](images/003_Chapter_3__Adult_PBPK_model_building_and_performance/003_Chapter_3_3__Sufentanil_Concentration-Time_profiles_in_Adults/002_plotTimeProfile.png)
+
+![003_plotTimeProfile.png](images/003_Chapter_3__Adult_PBPK_model_building_and_performance/003_Chapter_3_3__Sufentanil_Concentration-Time_profiles_in_Adults/003_plotTimeProfile.png)
+
+![004_plotTimeProfile.png](images/003_Chapter_3__Adult_PBPK_model_building_and_performance/003_Chapter_3_3__Sufentanil_Concentration-Time_profiles_in_Adults/004_plotTimeProfile.png)
+
+![005_plotTimeProfile.png](images/003_Chapter_3__Adult_PBPK_model_building_and_performance/003_Chapter_3_3__Sufentanil_Concentration-Time_profiles_in_Adults/005_plotTimeProfile.png)
+
+![006_plotTimeProfile.png](images/003_Chapter_3__Adult_PBPK_model_building_and_performance/003_Chapter_3_3__Sufentanil_Concentration-Time_profiles_in_Adults/006_plotTimeProfile.png)
+
 ## Chapter 3.4: Alfentanil Input Tables
 ### Alfentanil model
 
diff --git a/Pediatric_Qualification_Package_CYP3A4_Ontogeny/report.pdf b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/report.pdf
index 864b851..a10178d 100644
Binary files a/Pediatric_Qualification_Package_CYP3A4_Ontogeny/report.pdf and b/Pediatric_Qualification_Package_CYP3A4_Ontogeny/report.pdf differ
diff --git a/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/001_Chapter_2_1__Amikacin_PK_Ratio_tables_and_Figures/001_plotPKRatioCL.png b/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/001_Chapter_2_1__Amikacin_PK_Ratio_tables_and_Figures/001_plotPKRatioCL.png
index 07e2036..2791b76 100644
Binary files a/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/001_Chapter_2_1__Amikacin_PK_Ratio_tables_and_Figures/001_plotPKRatioCL.png and b/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/001_Chapter_2_1__Amikacin_PK_Ratio_tables_and_Figures/001_plotPKRatioCL.png differ
diff --git a/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/003_Chapter_2_3__Vancomycin_PK_Ratio_tables_and_Figures/001_plotPKRatioCL.png b/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/003_Chapter_2_3__Vancomycin_PK_Ratio_tables_and_Figures/001_plotPKRatioCL.png
index e28125f..ffb074f 100644
Binary files a/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/003_Chapter_2_3__Vancomycin_PK_Ratio_tables_and_Figures/001_plotPKRatioCL.png and b/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/003_Chapter_2_3__Vancomycin_PK_Ratio_tables_and_Figures/001_plotPKRatioCL.png differ
diff --git a/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/001_plotPopulationTimeProfile.png b/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/001_plotPopulationTimeProfile.png
index 4a1cb94..3e5d0e8 100644
Binary files a/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/001_plotPopulationTimeProfile.png and b/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/001_plotPopulationTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/002_plotPopulationTimeProfile.png b/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/002_plotPopulationTimeProfile.png
index d7d56e1..224ba01 100644
Binary files a/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/002_plotPopulationTimeProfile.png and b/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/002_plotPopulationTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/003_plotPopulationTimeProfile.png b/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/003_plotPopulationTimeProfile.png
index e75f5f7..7723736 100644
Binary files a/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/003_plotPopulationTimeProfile.png and b/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/003_plotPopulationTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/004_plotPopulationTimeProfile.png b/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/004_plotPopulationTimeProfile.png
index ab15919..0eb147a 100644
Binary files a/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/004_plotPopulationTimeProfile.png and b/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/004_plotPopulationTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/005_plotPopulationTimeProfile.png b/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/005_plotPopulationTimeProfile.png
index 12cfa3a..5cf16a7 100644
Binary files a/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/005_plotPopulationTimeProfile.png and b/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/005_plotPopulationTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/006_plotPopulationTimeProfile.png b/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/006_plotPopulationTimeProfile.png
index 63e1caf..1861193 100644
Binary files a/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/006_plotPopulationTimeProfile.png and b/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/006_plotPopulationTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/007_plotPopulationTimeProfile.png b/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/007_plotPopulationTimeProfile.png
index 4b92837..81f06a8 100644
Binary files a/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/007_plotPopulationTimeProfile.png and b/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/007_plotPopulationTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/008_plotPopulationTimeProfile.png b/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/008_plotPopulationTimeProfile.png
index bbc4965..1c8006d 100644
Binary files a/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/008_plotPopulationTimeProfile.png and b/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/008_plotPopulationTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/009_plotPopulationTimeProfile.png b/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/009_plotPopulationTimeProfile.png
index 17d7cd7..8557b57 100644
Binary files a/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/009_plotPopulationTimeProfile.png and b/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/009_plotPopulationTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/010_plotPopulationTimeProfile.png b/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/010_plotPopulationTimeProfile.png
index 0e5f473..c2d4bac 100644
Binary files a/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/010_plotPopulationTimeProfile.png and b/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/010_plotPopulationTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/011_plotPopulationTimeProfile.png b/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/011_plotPopulationTimeProfile.png
index d408f0b..2b2e29f 100644
Binary files a/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/011_plotPopulationTimeProfile.png and b/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/011_plotPopulationTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/012_plotPopulationTimeProfile.png b/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/012_plotPopulationTimeProfile.png
index 82af145..793493a 100644
Binary files a/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/012_plotPopulationTimeProfile.png and b/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/004_Chapter_2_4__Vancomycin_Concentration-Time_profiles_in_Children/012_plotPopulationTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/005_plotPKRatioCL.png b/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/005_plotPKRatioCL.png
index 1fbc6be..20b98ba 100644
Binary files a/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/005_plotPKRatioCL.png and b/Pediatric_Qualification_Package_GFR_Ontogeny/images/002_Chapter_2__Pediatric_translation_qualification/005_plotPKRatioCL.png differ
diff --git a/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/002_Chapter_3_2__Amikacin_Concentration-Time_profiles_in_Adults/001_plotTimeProfile.png b/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/002_Chapter_3_2__Amikacin_Concentration-Time_profiles_in_Adults/001_plotTimeProfile.png
index df3fb67..d9a0530 100644
Binary files a/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/002_Chapter_3_2__Amikacin_Concentration-Time_profiles_in_Adults/001_plotTimeProfile.png and b/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/002_Chapter_3_2__Amikacin_Concentration-Time_profiles_in_Adults/001_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/002_Chapter_3_2__Amikacin_Concentration-Time_profiles_in_Adults/002_plotTimeProfile.png b/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/002_Chapter_3_2__Amikacin_Concentration-Time_profiles_in_Adults/002_plotTimeProfile.png
index 59c5e91..afb3782 100644
Binary files a/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/002_Chapter_3_2__Amikacin_Concentration-Time_profiles_in_Adults/002_plotTimeProfile.png and b/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/002_Chapter_3_2__Amikacin_Concentration-Time_profiles_in_Adults/002_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/002_Chapter_3_2__Amikacin_Concentration-Time_profiles_in_Adults/003_plotTimeProfile.png b/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/002_Chapter_3_2__Amikacin_Concentration-Time_profiles_in_Adults/003_plotTimeProfile.png
index 958eac9..4795a4c 100644
Binary files a/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/002_Chapter_3_2__Amikacin_Concentration-Time_profiles_in_Adults/003_plotTimeProfile.png and b/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/002_Chapter_3_2__Amikacin_Concentration-Time_profiles_in_Adults/003_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/002_Chapter_3_2__Amikacin_Concentration-Time_profiles_in_Adults/004_plotTimeProfile.png b/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/002_Chapter_3_2__Amikacin_Concentration-Time_profiles_in_Adults/004_plotTimeProfile.png
index 08f0850..38807ee 100644
Binary files a/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/002_Chapter_3_2__Amikacin_Concentration-Time_profiles_in_Adults/004_plotTimeProfile.png and b/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/002_Chapter_3_2__Amikacin_Concentration-Time_profiles_in_Adults/004_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/002_Chapter_3_2__Amikacin_Concentration-Time_profiles_in_Adults/005_plotPopulationTimeProfile.png b/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/002_Chapter_3_2__Amikacin_Concentration-Time_profiles_in_Adults/005_plotPopulationTimeProfile.png
index 98e27e1..aab0a31 100644
Binary files a/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/002_Chapter_3_2__Amikacin_Concentration-Time_profiles_in_Adults/005_plotPopulationTimeProfile.png and b/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/002_Chapter_3_2__Amikacin_Concentration-Time_profiles_in_Adults/005_plotPopulationTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/002_Chapter_3_2__Amikacin_Concentration-Time_profiles_in_Adults/006_plotPopulationTimeProfile.png b/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/002_Chapter_3_2__Amikacin_Concentration-Time_profiles_in_Adults/006_plotPopulationTimeProfile.png
index 6be45c9..a46eab5 100644
Binary files a/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/002_Chapter_3_2__Amikacin_Concentration-Time_profiles_in_Adults/006_plotPopulationTimeProfile.png and b/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/002_Chapter_3_2__Amikacin_Concentration-Time_profiles_in_Adults/006_plotPopulationTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/004_Chapter_3_4__Vancomycin_Diagnostics_Plots/001_plotGOFMergedPredictedVsObserved.png b/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/004_Chapter_3_4__Vancomycin_Diagnostics_Plots/001_plotGOFMergedPredictedVsObserved.png
index b04fe89..635b394 100644
Binary files a/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/004_Chapter_3_4__Vancomycin_Diagnostics_Plots/001_plotGOFMergedPredictedVsObserved.png and b/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/004_Chapter_3_4__Vancomycin_Diagnostics_Plots/001_plotGOFMergedPredictedVsObserved.png differ
diff --git a/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/004_Chapter_3_4__Vancomycin_Diagnostics_Plots/003_plotGOFMergedResidualsOverTime.png b/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/004_Chapter_3_4__Vancomycin_Diagnostics_Plots/003_plotGOFMergedResidualsOverTime.png
index 5a0095c..13a8363 100644
Binary files a/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/004_Chapter_3_4__Vancomycin_Diagnostics_Plots/003_plotGOFMergedResidualsOverTime.png and b/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/004_Chapter_3_4__Vancomycin_Diagnostics_Plots/003_plotGOFMergedResidualsOverTime.png differ
diff --git a/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/005_Chapter_3_5__Vancomycin_Concentration-Time_profiles_in_Adults/001_plotTimeProfile.png b/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/005_Chapter_3_5__Vancomycin_Concentration-Time_profiles_in_Adults/001_plotTimeProfile.png
index b242f03..0a96572 100644
Binary files a/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/005_Chapter_3_5__Vancomycin_Concentration-Time_profiles_in_Adults/001_plotTimeProfile.png and b/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/005_Chapter_3_5__Vancomycin_Concentration-Time_profiles_in_Adults/001_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/005_Chapter_3_5__Vancomycin_Concentration-Time_profiles_in_Adults/002_plotTimeProfile.png b/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/005_Chapter_3_5__Vancomycin_Concentration-Time_profiles_in_Adults/002_plotTimeProfile.png
index 4e6c515..74690d4 100644
Binary files a/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/005_Chapter_3_5__Vancomycin_Concentration-Time_profiles_in_Adults/002_plotTimeProfile.png and b/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/005_Chapter_3_5__Vancomycin_Concentration-Time_profiles_in_Adults/002_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/005_Chapter_3_5__Vancomycin_Concentration-Time_profiles_in_Adults/003_plotTimeProfile.png b/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/005_Chapter_3_5__Vancomycin_Concentration-Time_profiles_in_Adults/003_plotTimeProfile.png
index 0150600..cbd22cb 100644
Binary files a/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/005_Chapter_3_5__Vancomycin_Concentration-Time_profiles_in_Adults/003_plotTimeProfile.png and b/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/005_Chapter_3_5__Vancomycin_Concentration-Time_profiles_in_Adults/003_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/005_Chapter_3_5__Vancomycin_Concentration-Time_profiles_in_Adults/004_plotTimeProfile.png b/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/005_Chapter_3_5__Vancomycin_Concentration-Time_profiles_in_Adults/004_plotTimeProfile.png
index dd05347..683782d 100644
Binary files a/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/005_Chapter_3_5__Vancomycin_Concentration-Time_profiles_in_Adults/004_plotTimeProfile.png and b/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/005_Chapter_3_5__Vancomycin_Concentration-Time_profiles_in_Adults/004_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/005_Chapter_3_5__Vancomycin_Concentration-Time_profiles_in_Adults/005_plotTimeProfile.png b/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/005_Chapter_3_5__Vancomycin_Concentration-Time_profiles_in_Adults/005_plotTimeProfile.png
index a09f7e7..094080e 100644
Binary files a/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/005_Chapter_3_5__Vancomycin_Concentration-Time_profiles_in_Adults/005_plotTimeProfile.png and b/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/005_Chapter_3_5__Vancomycin_Concentration-Time_profiles_in_Adults/005_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/005_Chapter_3_5__Vancomycin_Concentration-Time_profiles_in_Adults/006_plotTimeProfile.png b/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/005_Chapter_3_5__Vancomycin_Concentration-Time_profiles_in_Adults/006_plotTimeProfile.png
index 246e8f3..cd65051 100644
Binary files a/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/005_Chapter_3_5__Vancomycin_Concentration-Time_profiles_in_Adults/006_plotTimeProfile.png and b/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/005_Chapter_3_5__Vancomycin_Concentration-Time_profiles_in_Adults/006_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/005_Chapter_3_5__Vancomycin_Concentration-Time_profiles_in_Adults/007_plotTimeProfile.png b/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/005_Chapter_3_5__Vancomycin_Concentration-Time_profiles_in_Adults/007_plotTimeProfile.png
index 2172e6b..d8c5e47 100644
Binary files a/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/005_Chapter_3_5__Vancomycin_Concentration-Time_profiles_in_Adults/007_plotTimeProfile.png and b/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/005_Chapter_3_5__Vancomycin_Concentration-Time_profiles_in_Adults/007_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/005_Chapter_3_5__Vancomycin_Concentration-Time_profiles_in_Adults/008_plotTimeProfile.png b/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/005_Chapter_3_5__Vancomycin_Concentration-Time_profiles_in_Adults/008_plotTimeProfile.png
index a005d0f..a3f2b22 100644
Binary files a/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/005_Chapter_3_5__Vancomycin_Concentration-Time_profiles_in_Adults/008_plotTimeProfile.png and b/Pediatric_Qualification_Package_GFR_Ontogeny/images/003_Chapter_3__Adult_PBPK_model_performance/005_Chapter_3_5__Vancomycin_Concentration-Time_profiles_in_Adults/008_plotTimeProfile.png differ
diff --git a/Pediatric_Qualification_Package_GFR_Ontogeny/report.md b/Pediatric_Qualification_Package_GFR_Ontogeny/report.md
index faf37d6..8f1e782 100644
--- a/Pediatric_Qualification_Package_GFR_Ontogeny/report.md
+++ b/Pediatric_Qualification_Package_GFR_Ontogeny/report.md
@@ -3,10 +3,10 @@
 
 
 
-| Version                         | 1.1-OSP9.0                                                   |
+| Version                         | 1.1-OSP9.1                                                   |
 | ------------------------------- | ------------------------------------------------------------ |
 | Qualification Plan Release      | https://github.com/Open-Systems-Pharmacology/Pediatric_Qualification_Package_GFR_Ontogeny/releases/tag/v1.1 |
-| OSP Version                     | 9.0                                                          |
+| OSP Version                     | 9.1                                                          |
 | Qualification Framework Version | 2.2                                                          |
 
 
diff --git a/Pediatric_Qualification_Package_GFR_Ontogeny/report.pdf b/Pediatric_Qualification_Package_GFR_Ontogeny/report.pdf
index 175fd84..2922a17 100644
Binary files a/Pediatric_Qualification_Package_GFR_Ontogeny/report.pdf and b/Pediatric_Qualification_Package_GFR_Ontogeny/report.pdf differ