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Kuhnz 1996 #72

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ReneGeci opened this issue Sep 28, 2022 · 0 comments
Open

Kuhnz 1996 #72

ReneGeci opened this issue Sep 28, 2022 · 0 comments

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@ReneGeci
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hello,

the Kuhnz 1996 (study ID 7012) indicates a treatment of 0.06 mg IV at time 0h.
However, data points after 168 h show another sudden peak in the plasma concentration.

The paper indicates that this is because a second IV was performed, but this information is missing in the Times of Administration entry. I am still not entirely sure I understand the standard nomenclature correctly, but maybe sth like "0-168". Although, this would also not be entirely correct, because this would still miss the information that subjects were given "daily oral doses of 0.06 mg
ethinyloestradiol for 8 days" before the second IV was performed. So maybe it would be more clean to split the 2 profiles? The paper itself (fig 1) also shows them as two independent lines...

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